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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Nicastrin
Summary
- UniProt ID
- Q92542
- Gene Symbol
-
- NCSTN
- KIAA0253
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Glycoprotein
- Notch signaling pathway
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| early endosome |
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| Golgi apparatus |
| sarcolemma |
| plasma membrane |
| membrane |
| melanosome |
| azurophil granule membrane |
| GO Term |
|---|
| growth factor receptor binding |
| protein-macromolecule adaptor activity |
| ATPase binding |
| aspartic endopeptidase activity, intramembrane cleaving |
Sequence
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 45 | N-linked (GlcNAc...) asparagine | |||
| 55 | N-linked (GlcNAc...) asparagine | |||
| 64 |
|
|||
| 65 |
|
|||
| 67 |
|
|||
| 70 |
|
|||
| 142 |
|
|
||
| 187 | N-linked (GlcNAc...) asparagine | |||
| 200 | N-linked (GlcNAc...) asparagine |
|
||
| 204 | N-linked (GlcNAc...) asparagine |
G43769HG
G83460ZZ
G70101JE
G80920RR
G83633GK
G62765YT
G64527OM
G90382BL
G23505EP
G15664MX
G72747WU
G90659AW
G05049YU
G49108TO
G37509XX
G25079LO
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| Amyloid fiber formation | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Degradation of the extracellular matrix | Homo sapiens |
| EPH-ephrin mediated repulsion of cells | Homo sapiens |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH3 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NOTCH4 Activation and Transmission of Signal to the Nucleus | Homo sapiens |
| NRIF signals cell death from the nucleus | Homo sapiens |
Human Protein Atlas