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Repository for lectin-assisted multimodality data
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Guidelines
MIRAGE
Proheparin-binding EGF-like growth factor
Summary
- UniProt ID
- Q99075
- Gene Symbol
-
- DTR
- DTS
- HBEGF
- HEGFL
- Gene ID
- 1839
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- Q99075
- PubChem
- Q99075
- The Human Metabolome Database
- HMDBP02701
- Re-Glyco
- Q99075
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Growth factor
- Heparin-binding
- Receptor
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| cell surface |
| endocytic vesicle membrane |
| clathrin-coated endocytic vesicle membrane |
Sequence
MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 32 |
|
|||
| 37 | O-linked (GalNAc...) threonine | |||
| 38 | O-linked (GalNAc...) serine |
|
||
| 44 | O-linked (GalNAc...) threonine | |||
| 46 |
|
|||
| 47 | O-linked (GalNAc...) threonine | |||
| 74 |
|
|||
| 75 | O-linked (GalNAc...) threonine | |||
| 77 |
|
|||
| 78 |
|
G57321FI
G53434XO
G48584BU
G29931IJ
G43417UB
G50757KG
G81006GJ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Homo sapiens |
| Clathrin-mediated endocytosis | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Downregulation of ERBB2 signaling | Homo sapiens |
| EGFR Transactivation by Gastrin | Homo sapiens |
| EGFR downregulation | Homo sapiens |
| EGFR interacts with phospholipase C-gamma | Homo sapiens |
| ERBB2 Activates PTK6 Signaling | Homo sapiens |
| ERBB2 Regulates Cell Motility | Homo sapiens |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050851 | glomerulosclerosis | |
| DOID:8677 | perinatal necrotizing enterocolitis |
