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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Summary
- UniProt ID
- Q9NQ66
- Gene Symbol
-
- PLCB1
- KIAA0581
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9NQ66
- PubChem
- Q9NQ66
- SwissLipids
- The Human Metabolome Database
- HMDBP00222
- The O-GlcNAc Database
- Q9NQ66
- O-GlcNAcAtlas
- Q9NQ66
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Cytoplasm
- Epilepsy
- Hydrolase
- Lipid degradation
- Membrane
- Nucleus
- Palmitate
- Phosphoprotein
- Reference proteome
- Transducer
- Gene Ontology (GO)
| GO Term |
|---|
| regulation of establishment of endothelial barrier |
| cellular response to ionomycin |
| cellular response to glyceraldehyde |
| GO Term |
|---|
| postsynaptic cytosol |
| cytoplasm |
| nuclear membrane |
| extracellular exosome |
| glutamatergic synapse |
| GABA-ergic synapse |
| nuclear speck |
| cytosol |
| chromatin |
| nucleus |
Sequence
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTPL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 187 |
|
|||
| 196 |
|
|||
| 197 |
|
|||
| 473 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Acetylcholine regulates insulin secretion | Homo sapiens |
| Ca2+ pathway | Homo sapiens |
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| G beta:gamma signalling through PLC beta | Homo sapiens |
| PLC beta mediated events | Homo sapiens |
| Presynaptic function of Kainate receptors | Homo sapiens |
| Synthesis of IP3 and IP4 in the cytosol | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10603 | glucose intolerance | |
| DOID:10652 | Alzheimer's disease | |
| DOID:114 | heart disease | |
| DOID:11716 | prediabetes syndrome | |
| DOID:11722 | myotonic dystrophy type 1 | |
| DOID:11832 | visual epilepsy | |
| DOID:11847 | coronary thrombosis | |
| DOID:11870 | Pick's disease | |
| DOID:12140 | Chagas disease | |
| DOID:12236 | primary biliary cholangitis |
