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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Klotho
Summary
- UniProt ID
- Q9UEF7
- Gene Symbol
-
- KL
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- Q9UEF7
- PubChem
- Q9UEF7
- The Human Metabolome Database
- HMDBP07765
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Disease variant
- Glycoprotein
- Glycosidase
- Hormone
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Vitamin D
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| plasma membrane |
| membrane |
| extracellular exosome |
| apical plasma membrane |
Sequence
MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLERFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 106 | N-linked (GlcNAc...) asparagine |
|
||
| 115 |
|
|||
| 159 | N-linked (GlcNAc...) asparagine | |||
| 283 | N-linked (GlcNAc...) asparagine |
|
||
| 344 | N-linked (GlcNAc...) asparagine |
|
||
| 607 | N-linked (GlcNAc...) asparagine |
|
||
| 612 | N-linked (GlcNAc...) asparagine |
|
||
| 630 |
|
|
||
| 694 | N-linked (GlcNAc...) asparagine |
|
G43417UB
G87661QW
G83460ZZ
G41071NU
G47448YK
G80920RR
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10629 | microphthalmia | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1074 | kidney failure | |
| DOID:10763 | hypertension | |
| DOID:10787 | premature menopause | |
| DOID:10825 | essential hypertension | |
| DOID:10914 | amnestic disorder | |
| DOID:10923 | sickle cell anemia | |
| DOID:10952 | nephritis | |
| DOID:10966 | lipoid nephrosis |
