SCF(Skp2)-mediated degradation of p27/p21
|
|
|
- ADRM1
- CCNA1
- CCNA2
- CCND1
- CCNE1
- CCNE2
- CDK2
- CDK4
- CDKN1A
- CDKN1B
- CDKN2
- CKS1
- CKS1B
- CUL1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- PTK6
- RPS27A
- SKP1
- SKP1A
- SKP2
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Autodegradation of the E3 ubiquitin ligase COP1
|
|
|
- ADRM1
- ATM
- COP1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TP53
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
|
|
|
- ADRM1
- AJUBA
- CUL2
- EGLN1
- EGLN2
- EGLN3
- ELOC
- EPAS1
- HIF1A
- HIF3A
- JUB
- LIMD1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TCEB1
- TCEB2
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBC4
- UBCEP1
- UBCEP2
- UBCH4
- UBCH5B
- UBE2D1
- UBE2D2
- UBE2D3
- WTIP
|
|
GLI3 is processed to GLI3R by the proteasome
|
|
|
- ADRM1
- CSNK1A1
- CUL1
- GLI3
- GSK3B
- PRKACA
- PRKACB
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SKP1
- SKP1A
- SUFU
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Regulation of PTEN stability and activity
|
|
|
- ADRM1
- CK2A1
- CK2N
- CSNK2A1
- CSNK2A2
- CSNK2B
- FRK
- MKRN1
- NEDD4
- OTUD3
- PREX2
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- PTEN
- RNF146B
- RPS27A
- STUB1
- SUG1
- TNKS
- TNKS2
- TRAP2
- TRIM27
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- USP13
- WWP2
- XIAP
|
|
Orc1 removal from chromatin
|
|
|
- ADRM1
- CCNA1
- CCNA2
- CDC6
- CDK2
- CDKN2
- CDT1
- CUL1
- MCM2
- MCM3
- MCM4
- MCM5
- MCM6
- MCM7
- MCM8
- ORC1
- ORC2
- ORC3
- ORC4
- ORC4L
- ORC5
- ORC5L
- ORC6
- ORC6L
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SKP1
- SKP1A
- SKP2
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Hedgehog 'on' state
|
|
|
- ADRM1
- CDC73
- CUL3
- DZIP1
- EVC
- EVC2
- GLI1
- GLI2
- GLI3
- GPR161
- ITCH
- KIF7
- NUMB
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- PTCH1
- RPS27A
- SMO
- SMURF1
- SMURF2
- SPOP
- SPOPL
- SUFU
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- ULK3
|
|
The role of GTSE1 in G2/M progression after G2 checkpoint
|
|
|
- ADRM1
- CCNB1
- CCNB2
- CDC2
- CDK1
- CDKN1
- GTSE1
- MAPRE1
- PLK1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TP53
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
G2/M Checkpoints
|
|
|
- ADRM1
- GTSE1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TP53
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
|
|
|
- ADRM1
- CDC25A
- CHEK2
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Regulation of RUNX3 expression and activity
|
|
|
- ADRM1
- CBFB
- EP300
- MDM2
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- RUNX3
- SMURF1
- SMURF2
- SRC
- SUG1
- TGFB1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Interleukin-1 signaling
|
|
|
- ADRM1
- CHUK
- CUL1
- IKBKB
- IKBKG
- IKKA
- IL1A
- IL1B
- IL1R1
- IL1R2
- IL1RN
- IRAK1
- IRAK2
- IRAK3
- IRAK4
- MAP2K6
- MAP3K3
- MAP3K7
- MYD88
- NEMO
- NFKB1
- NFKBIA
- PELI1
- PELI2
- PELI3
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RELA
- RPS27A
- SKP1
- SKP1A
- SQSTM1
- SUG1
- TAB1
- TAB2
- TAB3
- TOLLIP
- TRAF6
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBE2N
- bIkBa
|
|
Regulation of RUNX2 expression and activity
|
|
|
- ADRM1
- CUL1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- RUNX2
- SKP1
- SKP1A
- SKP2
- STUB1
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Degradation of GLI1 by the proteasome
|
|
|
- ADRM1
- CUL1
- GLI1
- ITCH
- NUMB
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SKP1
- SKP1A
- SUFU
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Dectin-1 mediated noncanonical NF-kB signaling
|
|
|
- ADRM1
- CHUK
- CUL1
- FBXW11
- IKKA
- MAP3K14
- NFKB2
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RELB
- RPS27A
- SKP1
- SKP1A
- SUG1
- TRAP2
- UBA3
- UBA52
- UBA80
- UBB
- UBC
- UBC12
- UBCEP1
- UBCEP2
- UBE2M
|
|
NIK-->noncanonical NF-kB signaling
|
|
|
- ADRM1
- CHUK
- CUL1
- FBXW11
- IKKA
- MAP3K14
- NFKB2
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RELB
- RPS27A
- SKP1
- SKP1A
- SUG1
- TRAP2
- UBA3
- UBA52
- UBA80
- UBB
- UBC
- UBC12
- UBCEP1
- UBCEP2
- UBE2M
|
|
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
|
|
|
- ADRM1
- CUL1
- GSK3B
- NFE2L2
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SKP1
- SKP1A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Degradation of DVL
|
|
|
- ADRM1
- CUL3
- DACT1
- DVL1
- DVL2
- DVL3
- HECW1
- KLHL12
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
KEAP1-NFE2L2 pathway
|
|
|
- ADRM1
- CUL3
- KEAP1
- MAP1ALC3
- MAP1LC3
- MAP1LC3B
- MUL1
- NFE2L2
- NPLOC4
- PRKCI
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SESN1
- SESN2
- SQSTM1
- SUG1
- TRAP2
- TRIM21
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- UBXN7
- UFD1
- VCP
|
|
Ubiquitin-dependent degradation of Cyclin D
|
|
|
- ADRM1
- CCND1
- CDK4
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
|
|
Hedgehog ligand biogenesis
|
|
|
- ADRM1
- DERL2
- DHH
- ERLEC1
- HHAT
- IHH
- OS9
- P4HB
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SEL1L
- SHH
- SUG1
- SYVN1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- VCP
|
|
Asymmetric localization of PCP proteins
|
|
|
- ADRM1
- DVL2
- FZD1
- FZD2
- FZD3
- FZD5
- FZD7
- FZD8
- PARD6A
- PRICKLE1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SMURF1
- SMURF2
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
- WNT5A
|
|
AUF1 (hnRNP D0) binds and destabilizes mRNA
|
|
|
- ADRM1
- EIF4G1
- HNRNPD
- HSC70
- HSP27
- HSP70-1
- HSPA1A
- HSPA8
- HSPB1
- PABP1
- PABPC1
- PSMA1
- PSMA2
- PSMA3
- PSMA4
- PSMA5
- PSMA6
- PSMA7
- PSMB1
- PSMB2
- PSMB3
- PSMB4
- PSMB5
- PSMB6
- PSMB7
- PSMC2
- PSMC3
- PSMC4
- PSMC5
- PSMC6
- PSMD1
- PSMD11
- PSMD12
- PSMD13
- PSMD14
- PSMD2
- PSMD3
- PSMD6
- PSMD7
- PSMD8
- RPS27A
- SUG1
- TRAP2
- UBA52
- UBA80
- UBB
- UBC
- UBCEP1
- UBCEP2
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|
Mineralocorticoid biosynthesis
|
|
|
- CGA
- CYP11B1
- CYP21
- CYP21A1
- CYP21A2
- HSD3B
- LHB
|
|
Cytosolic sulfonation of small molecules
|
|
|
- ABHD14B
- BPNT1
- BPNT2
- LOC100300896
- PODXL2
- STP
- SULT1A1
- SULT1B1
- SULT1C2
- SULT1E1
- SULT2A1
- SULT2B1
- SULT4A1
- SULT6B1
- TPST1
- TPST2
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|