Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Database Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB) June 1, 2016
Species Pathogen Adherence Molecule Ligand Name Ligand Feature Target Source Glycan Sequence Binding ▲ PubMed ID
PrsG (class III)
DSGG (Disialosyl galactosyl globoside, disialyl Gb5)
Disialoglycosphingolipids
Human kidney tissues
NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer
Binding
PapG (class I)
DSGG (Disialosyl galactosyl globoside, disialyl Gb5)
Disialoglycosphingolipids
Human kidney tissues
NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer
Binding
P-fimbriae
DSGG (Disialosyl galactosyl globoside, disialyl Gb5)
Disialoglycosphingolipids
Human kidney tissues
NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer
Binding
Botulinum neurotoxin (type C)
GD1b
Disialoglycosphingolipids
Presynaptic neuronal cells
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
Tetanus toxin
GD1b
Disialoglycosphingolipids
Brain membrane
Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer
Binding
S-fimbriae (SfaA)
Seminolipid (Sulfogalactosylglycerolipid)
Glycolipids
Brain endothelial cells
Gal(3SO4)(b1-1)-alkylacylglycerol
Binding
S-fimbriae
Sialyl galactoside units of cell surface glycoproteins
Glycoproteins
Vascular endothelial/epithelial cells of the choroid plexus, Ependyma cells lining the brain ventricles
NeuAc(a2-3)Gal(b1-4)Glc
Binding
S-fimbriae
NeuAcα3Galβ-containing glycoproteins
Glycoproteins
Lumenal surfaces of the vascular endothelium in the neonatal rat brain
NeuAc(a2-3)Gal(b
Binding
Unknown
Sialylated type 2 chain conjugates (S-type 2-HSA)
Glycoproteins
Human serum albumin
NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD
Binding
Unknown
Sialyl Lewis x (SLex-HSA)
Glycoproteins
Human serum albumin
NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD
Binding
Displaying entries 1 - 10 of 1840 in total

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01