Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Source Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB) June 1, 2016
Displaying entries 26 - 50 of 1840 in total
Species Pathogen Adherence Molecule Ligand Name Ligand Feature Target Source Glycan Sequence Binding PubMed ID
Polyoma virus Capsid protein VP1 Sialylated oligosaccharides Oligosaccharides Cell surface NeuAc(a2-3)Gal(b1-3)GalNAc Binding 8805524
Helicobacter pylori Unknown unnamed ligand Oligosaccharides Stomach NeuAc(a2-3)Gal(b1-4)GlcNAc Binding 16564136
Polyoma virus Unknown Sialylated oligosaccharides Oligosaccharides Erythrocytes NeuAc(a2-3)Gal(b1-3)GalNAc Binding 6316632
Escherichia coli K99 unnamed ligand Oligosaccharides Intestinal cells NeuAc(a2-3)Gal(b1-4)Glc Binding 16564136
Influenza virus Residues 226 (glutamine) and 228 (glycine) Sialic acid linked to α2,3Galβ1,3GalNAc Oligosaccharides Avian/equine isolates NeuAc(a2-3)Gal(b1-3)GalNAc Binding 7975212
Polyoma virus Unknown unnamed ligand Oligosaccharides Murine small plaque NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc Binding 8574698
Reovirus Unknown Sialic acid (α2,6) Saccharides Most organs including the central nervous system/heart/liver NeuAc(a2-6) Binding 18216114
Bordetella pertussis Adhesins terminal Gal(3SO4) β1- residues Sulfoglycosphingolipids Human lung, Human trachea Gal(3SO4)(b Binding 1918002
Bordetella pertussis FHA (filamentous hemagglutinin) Sulfatide (CSE) Sulfoglycosphingolipids Cell surface HSO3(-3)Gal(b1-1)Cer Binding 10341176
Mycoplasma pneumoniae Adhesins Sulfatide (CSE) Sulfoglycosphingolipids Erythrocytes HSO3(-3)Gal(b1-1)Cer Binding 2470754
Helicobacter pylori Adhesins Sulfatide (CSE) Sulfoglycosphingolipids Human gastric mucosa HSO3(-3)Gal(b1-1)Cer Binding 2037054
Mycoplasma pneumoniae Unknown Sulfo-lactosylceramide (SM3) Sulfoglycosphingolipids Human colon adenocarcinoma cells (WiDr ) HSO3(-3)Gal(b1-4)Glc(b1-1)Cer Binding 2470753
Human immunodeficiency virus gp120 Sulfatide (CSE) Sulfoglycosphingolipids Human U373-MG glioma and SK-N-MC neuroblastoma cells, Human colon epithelial HT29 cells HSO3(-3)Gal(b1-1)Cer Binding 15973004
Helicobacter pylori Neutrophil-activating proteins (150-kDa) Sulfatide (CSE) Sulfoglycosphingolipids Human meconium HSO3(-3)Gal(b1-1)Cer Binding 9228091
Human immunodeficiency virus Envelope glycoprotein gp120 Galactosyl sulfatide Sulfoglycosphingolipids Neural receptor HSO3(-3)Gal(b1-1)Cer Binding 1871126
Lactobacillus casei Unknown Sulfatide (CSE) Sulfoglycosphingolipids Intestinal tract HSO3(-3)Gal(b1-1)Cer Binding 8912650
Clostridium botulinum Botulinum neurotoxin (type C) GT1b Trisialoglycosphingolipids Presynaptic neuronal cells NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 18242046
Clostridium tetani Tetanus toxin GT1b Trisialoglycosphingolipids Brain membrane NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 6257717
Clostridium botulinum BoNT/C (located within amino acid residues 1122-1290) GT1b Trisialoglycosphingolipids Presynaptic neuronal cells NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 18242046
Influenza virus Hemagglutinin (HA) GT1b Trisialoglycosphingolipids Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 11030743
Clostridium tetani Unknown GT1b Trisialoglycosphingolipids Brain membrane NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 6257717
Actinomyces naeslundii Type-2 fimbrial lectins GD1a Disialoglycosphingolipids NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 3804448
Actinomyces naeslundii Type-2 fimbrial lectins GD1b Disialoglycosphingolipids Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 3804448
Escherichia coli K99 GD1a(NeuGc) Disialoglycosphingolipids NeuGc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuGc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 7849044
Vibrio cholerae Cholera toxin GD1b Disialoglycosphingolipids Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 8574698

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