Downstream TCR signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PIP3PIP2H2OPiPI3KPI3K bound to TRATPhospho TRATADPATPPI(3,4)P2PIP3, PI(3,4)P2PDK1:PIP2,PIP3PDK1PKC-theta (closed)PKC-theta (open): DAGDAGp-Y90-PKC-theta:DAGActive PKC theta bound to DAGCARD11CARMA1 bound to PDK1Activated CARMA1CARMA1 trimerp-S552-CARD11BCL10Bcl10 bound to CARMA1Phosphorylated Bcl10 bound to CARMA1 and RIP2p-BCL10Bcl10 trimer bound to CARMA1 trimerMALT1 trimerMALT1 trimer bound to Bcl10 and CARMA1 trimerTRAF6 trimer bound to CBM complexTRAF6K63polyUbTRIKA1Ub-TRAF6 trimer bound to CBM complexTAB2/TAK1 complexTAK1/TAB2 complex bound to TRAF6/CBM complexIKK complexp-S177,S181-IKKB:IKKA:NEMOp-S177,S181-IKKB:IKKA:pUb-NEMOIkB(alpha):NF-kB complexp-S32,36-IkB-alpha:NF-kB complexSCF-beta-TRCPUBE2D2,UBE2D1,(CDC34)K48-UbK48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complexNF-kB complexNF-kB complex
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 2 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_002758 P01911 HLA class II histocompatibility antigen, DRB1 beta chain view
GL_002832 P01903 HLA class II histocompatibility antigen, DR alpha chain view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025