Oncogene Induced Senescence

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
p14ARFp14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53TP53 Tetramerp14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4p16INK4A/p14ARF mRNAp16INK4A/p14ARF mRNA: miR-24 Nonendonucleolytic RISCmiR-24 Nonendonucleolytic RISCp16INK4A mRNAMTS1ETS1/ETS2ADPATPp-T38-ETS1/ p-T72-ETS2p-T38-ETS1p-T38-ETS1:CDKN2A geneCDKN2A genep-T72-ETS2:CDKN2A genep-T72-ETS2p-T72-ETS2:ID1ID1ETS2 GeneERF:ETS2 GeneERFETS2p-T526-ERFp-T526-ERFSP1DP1/2: E2F1/2/3: SP1: CDKN2A GeneE2F1/2/3:DP1/2p14ARF mRNAp14ARFp-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4UbPolyUb-TP53 TetramerINK4CDK4,CDK6:INK4CDK4,CDK6
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025