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Transcription factor E2F1

Summary

UniProt ID

Q01094

Gene Symbol

E2F1
RBBP3

Organism

Homo sapiens (human)

External Links

GlyGen: Q01094
PubChem: Q01094
The O-GlcNAc Database: Q01094

Annotation

Keyword

3D-structure
Acetylation
Activator
Apoptosis
Cell cycle
DNA-binding
Host-virus interaction
Methylation
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of gene expression
forebrain development
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation of fat cell differentiation
positive regulation of fibroblast proliferation
negative regulation of fat cell proliferation
lens fiber cell apoptotic process
anoikis
mRNA stabilization

Displaying **all 8** entries
GO Term
protein-containing complex
nucleoplasm
centrosome
RNA polymerase II transcription regulator complex
Rb-E2F complex
chromatin
nucleus
cytoplasm

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GO Term
DNA binding
molecular adaptor activity
DNA-binding transcription factor binding
protein dimerization activity
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity
DNA-binding transcription factor activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding

Annotation information from UniProt.

Sequence

MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
382			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Activation of NOXA and translocation to mitochondria	Homo sapiens
Activation of PUMA and translocation to mitochondria	Homo sapiens
Cyclin A:Cdk2-associated events at S phase entry	Homo sapiens
Cyclin D associated events in G1	Homo sapiens
Cyclin E associated events during G1/S transition	Homo sapiens
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Homo sapiens
G1/S-Specific Transcription	Homo sapiens
G2 Phase	Homo sapiens
Inhibition of replication initiation of damaged DNA by RB1/E2F1	Homo sapiens
Oncogene Induced Senescence	Homo sapiens