Ca2+ pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
IP3ITPR:I(1,4,5)P3 tetramerIP3 receptor homotetramerG-protein beta-gamma complexG-protein beta-gamma:PLC beta 1/2/3PLC-beta 1/2/3PIP2DAGWNT/Ca2+ FZDsWNT5A/11:FZDWNT5A/WNT11Heterotrimeric G-protein (o/t2) (inactive)WNT5A/11:FZD:G-protein (alpha o/t2) inactiveGDPGTPWNT5A/11:FZD:G-protein (alpha o/t2) activeG-protein alpha (o/t2)activated PKC alphaPSPKC-ACa2+PPP3R1:PPP3CA,BPPP3R1:PPP3CA,B:Calmodulin:Ca2+CALM1:4xCa2+NFATC1:CaN:CaMH2OPiNFATC1NFATC1:CaN:CaMCa2+PDE6GNAT2:PDE6GNAT2:GTPGMPcGMPCAMK2ACAMK2:CaMPRKG homodimer:cGMPPRKG dimerATPADPp-T286 CAMK2:CaMp-T286,T305,T306-CAMK2Ap-T286,305,306-CAMK2:MAP3K7TAK1Phospho TAK1NLKpT298-NLK dimerpT298-NLK dimerATPADPTCF/LEF:CTNNB1p-TCF/LEF:CTNNB1NLK mRNANLK mRNA:miR-92b RISCmiR-92b RISCTCF/LEF:CTNNB1'canonical' WNT target genes:TCF/LEF:CTNNB1'canonical' WNT target genes'canonical' WNT target gene transcripts
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025