Formation of the cornified envelope

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
EVPLEVPL:PPLPPLEVPL:PPL:Cell surfaceCell surfaceTGM1IVL:TGM1:Cell surfaceIVLEVPL:PPL:IVL:TGM1:Cell surfaceFILA_HUMANFLG(?-?)FLG(?-?):Keratin tonofilament:DesmosomeKeratin tonofilament:DesmosomeFLG-Keratin filament networkEarly cornified envelopeSPRsLORMinor CE proteinsLamellar bodyCornified envelopeCDSNCornified envelope:CDSNLate cornified envelopeLEPsMature cornified envelopeMature cornified envelopePERPDesmosome:PERPDesmosomeKAZN:PPLKAZNH2OKLK5(23-66)KLK5proKLK5LEKTI D8-D9KLK5:LEKTIproELA2AELA2AELA2A propeptideproKLK8KLK8 propeptideKLK8KLK12KLK12:SPINK6SPINK6KLK13KLK13:SPINK6KLK14:SPINK6KLK14KLK5:SPINK6KLK5:SPINK9SPINK9TAGsRCOOHDAG
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 37 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
A0A183 Late cornified envelope protein 6A
  • C1orf44
  • LCE6A
view
O43548 Protein-glutamine gamma-glutamyltransferase 5
  • TGM5
  • TGMX
view
O60259 Kallikrein-8
  • KLK8
  • NRPN
  • PRSS19
  • TADG14
view
O60437 Periplakin
  • KIAA0568
  • PPL
view
P04632 Calpain small subunit 1
  • CAPN4
  • CAPNS
  • CAPNS1
view
P07384 Calpain-1 catalytic subunit
  • CANPL1
  • CAPN1
view
P07476 Involucrin
  • IVL
view
P09958 Furin
  • FUR
  • FURIN
  • PACE
  • PCSK3
view
P14923 Junction plakoglobin
  • CTNNG
  • DP3
  • JUP
view
P15924 Desmoplakin
  • DSP
view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025