MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis

Summary
Species
Rattus norvegicus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
rPpargp-Y226,Y393-ABL1:PPARG2E9PT20ATPO88275ADPPPARG:RXRA:Adipogenesis genes:NucleosomesPPARG:RXRA:NCoR/SMRT:adipogenesis genes:NucleosomesNCoR/SMRT complexRXRA natural ligandsPPARG ligands:PPARG:RXRA ligands:RXRA:Corepressors:adipogenesis genes:NucleosomesPPARG ligands:PPARG:RXRA:Corepressors:adipogenesis genes:NucleosomesPPARG ligands:PPARG:RXRA ligands:RXRA:adipogenesis genes:NucleosomesTRAP coactivator complexActivated PPARG:RXRA:adipogenesis genes:NucleosomesNCOAs (PPARG,RXRA)PPARGC1A, PPARGC1BCBP/p300
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 4 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
A0A8I6APA0 Nuclear receptor coactivator
  • Ncoa1
view
O88275 Peroxisome proliferator-activated receptor gamma
  • Nr1c3
  • Pparg
view
Q03114 Cyclin-dependent kinase 5
  • Cdk5
  • Cdkn5
  • PSSALRE
view
Q9QYK2 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  • Pgc1
  • Pgc1a
  • Ppargc1
  • Ppargc1a
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025