GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **101 - 125** of **270** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism ▲	GlyTouCan ID
The canonical retinoid cycle in rods (twilight vision)	ATP binding cassette subfamily A member 4 Cytochrome P450 family 4 subfamily V member 2 Cytosolic fatty-acid binding proteins domain-containing protein Dehydrogenase/reductase 9 Hydroxysteroid 17-beta dehydrogenase 6 Lecithin retinol acyltransferase Myosin VIIA NADP-retinol dehydrogenase Plasma retinol-binding protein Receptor for retinol uptake STRA6 Retinaldehyde binding protein 1 Retinoid isomerohydrolase Retinol binding protein 3 Retinol dehydrogenase 12 Retinol dehydrogenase 16 Retinol dehydrogenase 5 Rhodopsin Short chain dehydrogenase/reductase family 9C member 7 Transthyretin	A0A8I3MJB9 A0A8I3MRK7 A0A8I3MTG2 A0A8I3N0K5 A0A8I3N0Y3 A0A8I3N2V4 A0A8I3N8N5 A0A8I3NEZ4 A0A8I3NFK0 A0A8I3NXV6 A0A8I3P9M8 A0A8I3PAT8 A0A8I3Q0S8 A0A8I3Q3P2 A0A8I3QE57 A0A8I3QHU9 A0A8I3RVK1 A0A8I3RWP2 A0A8I3S143	ABCA4 CYP4V2 DHRS9 HSD17B6 LRAT MYO7A RBP1 RBP3 RBP4 RDH10 RDH12 RDH16 RDH5 RHO RLBP1 RPE65 SDR9C7 STRA6 TTR	Canis familiaris (dog)
p130Cas linkage to MAPK signaling for integrins	Adapter molecule crk Amyloid beta A4 precursor protein-binding family B member 1-interacting protein BCAR1 scaffold protein, Cas family member Fibronectin Focal adhesion kinase 1 Integrin beta Integrin subunit alpha 2b Talin 1 Tyrosine-protein kinase small monomeric GTPase small monomeric GTPase von Willebrand factor von Willebrand factor	A0A8I3N6K0 A0A8I3N737 A0A8I3NGQ0 A0A8I3NMY1 A0A8I3NUL4 A0A8I3PED8 A0A8I3PMU9 A0A8I3RUF3 A0A8I3RVR5 A0A8I3S8J3 A0A8I3SBF9 A0A8I3SCK0 Q28295	APBB1IP BCAR1 CRK F8VWF FN1 ITGA2B ITGB3 PTK2 RAP1A RAP1B SRC TLN1 VWF	Canis familiaris (dog)
Orexin and neuropeptides FF and QRFP bind to their respective receptors	Hypocretin neuropeptide precursor Orexin receptor type 2 Orexin/Hypocretin receptor type 1 Pyroglutamylated RFamide peptide receptor Pyroglutamylated RFamide peptide	A0A8I3PCA6 A0A8I3PCK7 A0A8I3RSX8 Q9GLF6 Q9TUP7	HCRT HCRTR1 HCRTR2 OX PPOX QRFP QRFPR	Canis familiaris (dog)
Trafficking and processing of endosomal TLR	Canopy FGF signaling regulator 3 Cathepsin B Cathepsin S Endoplasmin Legumain Procathepsin L Toll like receptor 3 Toll like receptor 7 Toll like receptor 8 Toll-like receptor 9 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A8I3N2H5 A0A8I3NCE8 A0A8I3P6K4 A0A8I3P8U9 A0A8I3P903 A0A8I3PZY7 A0A8I3Q7B4 A0A8I3S0M3 A0A8I3SBE6 P41148 Q5I2M8 Q9GL24	CNPY3 CTSB CTSL CTSL1 CTSS GRP94 HSP90B1 HSPC4 LGMN TLR3 TLR7 TLR8 TLR9 TRA1 UNC93B1	Canis familiaris (dog)
GABA synthesis, release, reuptake and degradation	Complexin-1 DnaJ homolog subfamily C member 5 Glutamate decarboxylase 1 Glutamate decarboxylase 2 Heat shock cognate 71 kDa protein Multifunctional fusion protein Ras-related protein Rab-3 Regulating synaptic membrane exocytosis 1 Synaptotagmin Syntaxin-1A Syntaxin-binding protein 1 Vesicle-associated membrane protein 2 Vesicular inhibitory amino acid transporter	A0A8I3ME77 A0A8I3MLF8 A0A8I3MQ89 A0A8I3N2E5 A0A8I3N5Z9 A0A8I3NNW3 A0A8I3P737 A0A8I3PDP4 A0A8I3PNE3 A0A8I3Q823 A0A8I3S6J8 A0PA85 Q4PRC2	CPLX1 DNAJC5 GAD1 GAD2 GAD65 GAD67 LOC607182 RAB3A RIMS1 SLC32A1 SNAP25 STX1A STXBP1 SYT1 VAMP2	Canis familiaris (dog)
Class B/2 (Secretin family receptors)	Adhesion G protein-coupled receptor E1 Adhesion G protein-coupled receptor E3 Adhesion G protein-coupled receptor E5 Corticoliberin Corticotropin releasing hormone receptor 2 Corticotropin-releasing factor receptor 1 Corticotropin-releasing factor-binding protein Parathyroid hormone 2 receptor Parathyroid hormone-related protein Parathyroid hormone/parathyroid hormone-related peptide receptor Parathyroid hormone Sushi domain-containing protein Tuberoinfundibular peptide of 39 residues Uncharacterized protein Uncharacterized protein Urocortin	A0A8I3MZB5 A0A8I3P6W0 A0A8I3P7R9 A0A8I3PCJ2 A0A8I3PCP1 A0A8I3PHA9 A0A8I3PPK6 A0A8I3PPW2 A0A8I3RQ73 A0A8I3RSJ3 A0A8I3RVU2 A0A8I3RXL4 P52211 P52212 Q2Q423 Q9TU31	ADGRE1 ADGRE3 ADGRE5 CD55 CRH CRHBP CRHR1 CRHR2 LOC484897 PTH PTH1 PTH1R PTH2 PTH2R PTHLH PTHR1 UCN UCN3	Canis familiaris (dog)
Hyaluronan uptake and degradation	Beta-glucuronidase Beta-hexosaminidase Beta-hexosaminidase CD44 antigen Calcineurin B homologous protein 1 Hyaluronan mediated motility receptor Hyaluronidase Lymphatic vessel endothelial hyaluronan receptor 1 Sodium/hydrogen exchanger Stabilin 2	A0A8I3MHZ0 A0A8I3MY15 A0A8I3NBX1 A0A8I3NDU0 A0A8I3NYL9 A0A8I3PCF8 A0A8I3PI48 A0A8I3PNW9 A0A8I3Q0H4 A0A8I3RW87	CD44 CHP1 GUSB HEXA HEXB HMMR HYAL1 LYVE1 SLC9A1 STAB2	Canis familiaris (dog)	G35674CY
Interleukin-1 signaling	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ADRM1 26S proteasome ubiquitin receptor Cullin 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase pellino homolog E3 ubiquitin-protein ligase pellino homolog IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Interleukin 1 receptor accessory protein Interleukin 1 receptor associated kinase 3 Interleukin 1 receptor type 1 Interleukin 1 receptor type 2 Interleukin-1 receptor antagonist protein Interleukin-1 receptor-associated kinase 4 Interleukin-1 receptor-associated kinase-like 2 Interleukin-1 Mitogen-activated protein kinase kinase kinase 3 Mitogen-activated protein kinase kinase kinase 7 Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Pellino E3 ubiquitin protein ligase family member 3 Proteasome 20S subunit alpha 3 Proteasome 26S subunit, ATPase 1 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 12 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta RELA proto-oncogene, NF-kB subunit S-phase kinase-associated protein 1 Sequestosome 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor 6 Toll interacting protein Ubiquitin B Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein Uncharacterized protein Uncharacterized protein cullin-RING-type E3 NEDD8 transferase mitogen-activated protein kinase kinase non-specific serine/threonine protein kinase	A0A8I3MKL4 A0A8I3MMN5 A0A8I3MNI0 A0A8I3MR89 A0A8I3N0P1 A0A8I3N165 A0A8I3N2A1 A0A8I3N3S4 A0A8I3N4F2 A0A8I3N5F1 A0A8I3N5F6 A0A8I3N7L6 A0A8I3N9G3 A0A8I3NBF5 A0A8I3NFB9 A0A8I3NH42 A0A8I3NHA9 A0A8I3NJ31 A0A8I3NMB6 A0A8I3NN65 A0A8I3NNJ9 A0A8I3NP41 A0A8I3NP66 A0A8I3NPR4 A0A8I3NPT2 A0A8I3NPX1 A0A8I3NUC6 A0A8I3NVB6 A0A8I3NW81 A0A8I3NXK9 A0A8I3NXW3 A0A8I3NZN1 A0A8I3P046 A0A8I3P2V4 A0A8I3P3H3 A0A8I3P499 A0A8I3P4Z1 A0A8I3P6I7 A0A8I3PBB2 A0A8I3PCE5 A0A8I3PCT4 A0A8I3PDR8 A0A8I3PF55 A0A8I3PGC5 A0A8I3PJH9 A0A8I3PJW0 A0A8I3PKH4 A0A8I3PLL0 A0A8I3PN81 A0A8I3PV99 A0A8I3PZT2 A0A8I3Q059 A0A8I3Q209 A0A8I3QV78 A0A8I3QYD0 A0A8I3RRR7 A0A8I3RT39 A0A8I3RUU8 A0A8I3RXV3 A0A8I3RY59 A0A8I3RZD9 A0A8I3S1Z6 A0A8I3S6C6 A0A8I3S6Q5 A0A8I3S792 E2R2I5 P63050 Q6F3J0 Q9BEH0	ADRM1 CHUK CUL1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK2 IRAK3 IRAK4 LOC100686569 LOC100687259 LOC119881719 MAP2K6 MAP3K3 MAP3K7 MYD88 NFKB1 NFKBIA PELI1 PELI2 PELI3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA7 PSMB1 PSMB2 PSMB3 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RBX1 RELA RPS27A SKP1 SQSTM1 TAB1 TAB2 TAB3 TOLLIP TRAF6 UBA52 UBB UBC UBCEP2 UBE2N	Canis familiaris (dog)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Acyl-coenzyme A oxidase Bile acid-CoA Bile salt export pump Cytochrome P450 family 27 subfamily A member 1 Cytochrome P450 family 7 subfamily A member 1 Cytochrome P450 family 7 subfamily B member 1 Cytochrome P450 family 8 subfamily B member 1 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Hydroxysteroid 17-beta dehydrogenase 4 NADP-dependent oxidoreductase domain-containing protein Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor subfamily 1 group H member 4 Retinoic acid receptor RXR Sterol carrier protein 2 long-chain-fatty-acid--CoA ligase long-chain-fatty-acid--CoA ligase palmitoyl-CoA hydrolase	A0A8I3MAI7 A0A8I3N1E1 A0A8I3N2S7 A0A8I3N3X9 A0A8I3NIH7 A0A8I3NZF5 A0A8I3P4G5 A0A8I3P7P8 A0A8I3PDX5 A0A8I3PFY5 A0A8I3PRC4 A0A8I3PYI4 A0A8I3RWQ9 A0A8I3RZP4 A0A8I3S339 A0A8I3S6P6 A0A8I3SAZ3 B8K1W2	ACOT8 ACOX2 Abcb11e BAAT BSEP CYP27A1 CYP7A1 CYP7B1 CYP8B1 HSD17B4 HSD3B7 LOC119874618 NCOA1 NCOA2 NR1H4 RXRA SCP2 SLC27A2 SLC27A5	Canis familiaris (dog)
Sensory perception of sweet, bitter, and umami (glutamate) taste	Bitter taste receptor T2R43 G protein subunit alpha transducin 3 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Inositol 1,4,5-trisphosphate receptor Taste 1 receptor member 1 Taste receptor type 1 member 3 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2	A0A8I3NKU5 A0A8I3PJF2 A0A8I3PQY2 A0A8I3PRQ9 A0A8I3Q2P2 A0A8I3Q7L4 A0A8I3QV74 A0A8I3S925 A0A8I3S929 A0A8I3SCV7 P62872 P79147 Q2ABD0 Q2ABD1 Q2ABD4 Q2ABD5 Q2ABD6 Q2ABD8 Q2ABE0	CAFA-T2R43 GNAT3 GNB1 GNB3 GNG13 ITPR3 LOC100682759 TAS1R1 TAS1R3 TAS2R1 TAS2R10 TAS2R3 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R5 TAS2R7	Canis familiaris (dog)	G58161NS
Common Pathway of Fibrin Clot Formation	Antithrombin-III Coagulation factor V Coagulation factor X Coagulation factor XIII A chain Coagulation factor XIII B chain Protein C receptor Proteinase-activated receptor 1 Prothrombin Serpin domain-containing protein Serpin family A member 5 Serpin family D member 1 Thrombomodulin Vitamin K-dependent protein C Vitamin K-dependent protein S	A0A8I3MGM0 A0A8I3MLH1 A0A8I3MQ40 A0A8I3NE44 A0A8I3NHZ1 A0A8I3P760 A0A8I3P7K7 A0A8I3PPY1 A0A8I3PQV5 A0A8I3PUT1 A0A8I3Q092 A0A8I3QAV8 A0A8I3S1X8 Q28278	F10 F13A1 F13B F2 F2R F5 PROC PROCR PROS1 SERPINA5 SERPINC1 SERPIND1 SERPINE2 THBD	Canis familiaris (dog)
Synthesis of bile acids and bile salts	Cytochrome P450 family 7 subfamily A member 1 Cytochrome P450 family 7 subfamily B member 1 Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor subfamily 1 group H member 4 Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein Retinoic acid receptor RXR	A0A8I3N2S7 A0A8I3NA48 A0A8I3NIH7 A0A8I3NPK5 A0A8I3NS93 A0A8I3P033 A0A8I3P4G5 A0A8I3PNT4 A0A8I3PRC4 A0A8I3PYI4 A0A8I3S236 A0A8I3S5H8 A0A8I3SAZ3	CYP7A1 CYP7B1 NCOA1 NCOA2 NR1H4 OSBP OSBPL1A OSBPL2 OSBPL3 OSBPL6 OSBPL7 OSBPL9 RXRA	Canis familiaris (dog)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	78 kDa glucose-regulated protein ABC-type antigen peptide transporter Aminopeptidase Beta-2-microglobulin Calnexin Calreticulin Immunoglobulin C1-set domain-containing protein MHC class I DLA-12 MHC class I DLA-64 MHC class I DLA-88 MHC class Ib Protein SEC13 homolog Protein disulfide-isomerase Protein transport protein SEC23 Protein transport protein Sec31A SEC24 homolog A, COPII coat complex component SEC24 homolog B, COPII coat complex component SEC24 homolog C, COPII coat complex component SEC24 homolog D, COPII coat complex component Small COPII coat GTPase SAR1B Tapasin	A0A8I3MLY2 A0A8I3N796 A0A8I3N9C4 A0A8I3NCJ5 A0A8I3NCT5 A0A8I3NDA5 A0A8I3NM03 A0A8I3NPS2 A0A8I3NRG2 A0A8I3NSU2 A0A8I3NZH7 A0A8I3P4F9 A0A8I3P4Y2 A0A8I3PXH7 A0A8I3Q7H2 A0A8I3RR85 A0A8I3RUA9 A0A8I3S449 A0A8I3S5M8 A0A8I3SCF9 Q5TJE4	B2M CALR CANX DLA-12 DLA-79 DLA-DOB DLA88 ERAP1 HSPA5 LOC119876190 LOC119876868 PDIA3 SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A TAPBP	Canis familiaris (dog)
The activation of arylsulfatases	Arylsulfatase A Arylsulfatase B Arylsulfatase F Arylsulfatase G Arylsulfatase K Arylsulfatase L Arylsulfatase family member H Arylsulfatase family member I Arylsulfatase family member J Steroid sulfatase Sulfatase modifying factor 1 Sulfatase modifying factor 2	A0A8I3N2H8 A0A8I3NK85 A0A8I3NQ68 A0A8I3PN86 A0A8I3PP93 A0A8I3PPB0 A0A8I3PT92 A0A8I3Q0D0 A0A8I3Q695 A0A8I3S3Z3 Q32KH0 Q32KI4	ARSA ARSB ARSF ARSG ARSH ARSI ARSJ ARSK ARSL STS SUMF1 SUMF2 arsb	Canis familiaris (dog)
Generation of second messenger molecules	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma CD101 molecule Cytoplasmic protein FYN binding protein 1 GRB2 related adaptor protein 2 Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Lymphocyte cytosolic protein 2 MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Phosphoinositide phospholipase C T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MGV8 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MMK2 A0A8I3MMK3 A0A8I3MMZ1 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NMF7 A0A8I3NTK0 A0A8I3NZG2 A0A8I3P4A1 A0A8I3P564 A0A8I3P6Q8 A0A8I3P8U2 A0A8I3PAB8 A0A8I3PNN9 A0A8I3Q5D2 A0A8I3QD39 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 A0A8I3S602 A0A8I3SCI7 P27597 P33705	CD101 CD247 CD3D CD3E CD3G CD4 DLA-DQA1 DLA-DRA FYB1 GRAP2 HLA-DQB2 ITK LAT LCK LCP2 NCK1 PAK1 PAK2 PAK3 PLCG1 PLCG2 TRAV29DV5 ZAP70	Canis familiaris (dog)
Regulation of Complement cascade	C3a anaphylatoxin chemotactic receptor C4a anaphylatoxin C5a anaphylatoxin chemotactic receptor 1 CD19 molecule Carboxypeptidase B2 Carboxypeptidase N subunit 1 Carboxypeptidase N subunit 2 Clusterin Complement C1q B chain Complement C1q C chain Complement C1q subcomponent subunit A Complement C1s Complement C2 Complement C3 Complement C5 Complement C5a receptor 2 Complement C7 Complement C8 alpha chain Complement C8 gamma chain Complement component C6 Complement component C8 beta chain Complement component C9 Complement factor B Complement factor I Elastase, neutrophil expressed Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MAC-inhibitory protein Membrane cofactor protein Prothrombin Serpin family G member 1 Sushi domain-containing protein Sushi domain-containing protein Sushi domain-containing protein Sushi domain-containing protein Tetraspanin Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vitronectin complement subcomponent C1r	A0A8I3MAL2 A0A8I3MBH0 A0A8I3MDV8 A0A8I3MFV5 A0A8I3MKD7 A0A8I3MKJ7 A0A8I3MLF7 A0A8I3MPF4 A0A8I3MQ72 A0A8I3MQK6 A0A8I3MRL7 A0A8I3N180 A0A8I3N567 A0A8I3NC13 A0A8I3NH95 A0A8I3NLH3 A0A8I3NQA0 A0A8I3NQQ5 A0A8I3NT81 A0A8I3NVC1 A0A8I3NWR3 A0A8I3NYS7 A0A8I3P0T6 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P941 A0A8I3PD67 A0A8I3PDU9 A0A8I3PJQ7 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PTW0 A0A8I3PUA5 A0A8I3PUL5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PUT1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3Q044 A0A8I3Q2F2 A0A8I3Q318 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3RQ73 A0A8I3RQX0 A0A8I3RSI3 A0A8I3RSN2 A0A8I3RUJ7 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S1V7 A0A8I3S6H5 A0A8I3S7V8 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 P25473 Q8MJD1	C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C5 C5AR1 C5AR2 C6 C7 C8A C8B C8G C9 CD19 CD55 CD59 CD81 CFB CFH CFHR5 CFI CLU CPB2 CPN1 CPN2 ELA2 ELANE F2 LOC102156626 LOC481722 LOC490269 SEBOX SERPING1	Canis familiaris (dog)
Tie2 Signaling	Angiopoietin 4 Angiopoietin-1 Angiopoietin-2 Docking protein 2 GTPase HRas GTPase NRas Growth factor receptor bound protein 14 Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase small monomeric GTPase	A0A5F4C2B1 A0A8I3N971 A0A8I3NC50 A0A8I3NID0 A0A8I3NM36 A0A8I3NUU1 A0A8I3NZA4 A0A8I3PMT9 A0A8I3PSP7 A0A8I3PT69 A0A8I3PWT3 A0A8I3PZB5 A0A8I3Q1A9 A0A8I3Q1I3 A0A8I3S0B4 A0A8I3S3D9 A0A8I3S3N2 A0A8J8	ANGPT1 ANGPT2 ANGPT4 DOK2 GRB14 GRB2 GRB7 HRAS KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PTPN11 SHC1 SOS1 TEK	Canis familiaris (dog)
MET Receptor Activation	HGF activator Hepatocyte growth factor receptor Hepatocyte growth factor Hepsin Serine peptidase inhibitor, Kunitz type 1 Serine peptidase inhibitor, Kunitz type 2	A0A8I3MSC1 A0A8I3MW78 A0A8I3NGY1 A0A8I3NIY8 A0A8I3S6Z5 Q867B7	HGF HGFAC HPN MET SPINT1 SPINT2	Canis familiaris (dog)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Uncharacterized protein small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3NYK3 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 J9P8K0 P79150 Q20FD0	FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 GRB2 HRAS KGF KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
Phase 4 - resting membrane potential	Inward rectifier potassium channel 2 Inward rectifier potassium channel Potassium channel domain-containing protein Potassium channel subfamily K member 9 Potassium channel subfamily K member Potassium inwardly rectifying channel subfamily J member 14 Potassium two pore domain channel subfamily K member 10 Potassium two pore domain channel subfamily K member 12 Potassium two pore domain channel subfamily K member 13 Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17 Potassium two pore domain channel subfamily K member 18 Potassium two pore domain channel subfamily K member 4 Potassium two pore domain channel subfamily K member 5 Potassium two pore domain channel subfamily K member 6 Potassium two pore domain channel subfamily K member 7	A0A8I3MR75 A0A8I3MTD8 A0A8I3MV05 A0A8I3N317 A0A8I3NAZ8 A0A8I3NNF9 A0A8I3NSP8 A0A8I3NUT1 A0A8I3NUY1 A0A8I3P863 A0A8I3Q3Z0 A0A8I3Q644 A0A8I3RRG3 A0A8I3S0J2 A0A8I3S6X0 F6KIF6 Q9MYY9	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK18 KCNK3 KCNK4 KCNK5 KCNK6 KCNK7 KCNK9	Canis familiaris (dog)
Glycerophospholipid biosynthesis	Acylglycerol kinase, mitochondrial Copine 3 Copine 7	A0A8I3PCG6 A0A8I3Q635 F1P6M8	AGK CPNE3 CPNE7	Canis familiaris (dog)
Extra-nuclear estrogen signaling	72 kDa type IV collagenase Caveolin-1 Caveolin-2 EGF-like domain-containing protein Epiregulin Estrogen receptor beta Estrogen receptor Focal adhesion kinase 1 G protein subunit alpha transducin 3 G protein subunit beta 2 G protein subunit beta 4 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(i) subunit alpha-1 Guanine nucleotide-binding protein G(i) subunit alpha-2 Guanine nucleotide-binding protein G(i) subunit alpha-3 Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Matrix metallopeptidase 7 Matrix metalloproteinase-9 Palmitoyltransferase Palmitoyltransferase Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Pro-epidermal growth factor Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase SHC-transforming protein 1 Sphingosine kinase 1 Sphingosine-1-phosphate receptor 3 Striatin Stromelysin-1 Tyrosine-protein kinase receptor Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase type I protein arginine methyltransferase	A0A5F4C2B1 A0A8I3MAV6 A0A8I3MCQ8 A0A8I3ME07 A0A8I3MGS0 A0A8I3MHA7 A0A8I3MM75 A0A8I3MN99 A0A8I3MNZ2 A0A8I3MT80 A0A8I3MYE3 A0A8I3MZG1 A0A8I3N081 A0A8I3N0H9 A0A8I3N8T5 A0A8I3N971 A0A8I3NI71 A0A8I3NMY1 A0A8I3NPA7 A0A8I3NPM9 A0A8I3NUU1 A0A8I3P3M1 A0A8I3P478 A0A8I3P519 A0A8I3P7L3 A0A8I3PJF2 A0A8I3PQY2 A0A8I3PS34 A0A8I3PV05 A0A8I3Q314 A0A8I3Q5L9 A0A8I3RPS3 A0A8I3RQ77 A0A8I3RRT3 A0A8I3RSE4 A0A8I3RYJ5 A0A8I3RYN2 A0A8I3S0D0 A0A8I3S3N2 A0A8I3S583 A0A8I3SBF9 O46550 O97564 P33724 P38400 P62872 P63210 P79147 Q6Y4Q5	AREG BTC CAV CAV-2 CAV1 CAV2 EGF EGFR EPGN EREG ESR1 ESR2 GNAI1 GNAI2 GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG11 GNG13 GNG2 GNG3 GNG4 GNG8 GNGT1 GNGT2 HBEGF IGF1R LOC100856339 LOC119863873 MMP2 MMP3 MMP7 MMP9 PIK3CA PIK3R1 PIK3R2 PRMT1 PTK2 S1PR3 SHC1 SPHK1 SRC STRN TGFA ZDHHC21 ZDHHC7	Canis familiaris (dog)
Ion homeostasis	ATP binding cassette subfamily C member 9 ATP-sensitive inward rectifier potassium channel 11 ATPase Na+/K+ transporting subunit alpha 3 Adenosylhomocysteinase like 1 Aspartate beta-hydroxylase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Cardiac phospholamban Chloride intracellular channel protein EF-hand domain-containing protein FXYD domain-containing ion transport regulator FXYD domain-containing ion transport regulator FXYD domain-containing ion transport regulator FXYD domain-containing ion transport regulator FXYD domain-containing ion transport regulator FXYD domain-containing ion transport regulator Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Nitric oxide synthase 1 Ryanodine receptor 1 Ryanodine receptor 2 Ryanodine receptor 3 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Short transient receptor potential channel 1 Sodium/calcium exchanger 1 Sodium/potassium-transporting ATPase subunit alpha Sodium/potassium-transporting ATPase subunit alpha Sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit beta Sodium/potassium-transporting ATPase subunit beta Solute carrier family 8 member A2 Solute carrier family 8 member A3 Sorcin Stromal interaction molecule 1 Triadin Troponin I, cardiac muscle cAMP-dependent protein kinase catalytic subunit alpha calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase peptidylprolyl isomerase	A0A8I3M9N6 A0A8I3MFG9 A0A8I3MID3 A0A8I3MJQ7 A0A8I3MK29 A0A8I3MM26 A0A8I3MQA1 A0A8I3MRH3 A0A8I3MSQ7 A0A8I3MSS1 A0A8I3MT21 A0A8I3MTJ5 A0A8I3MXS3 A0A8I3NIS8 A0A8I3NKB2 A0A8I3NMP2 A0A8I3NNW7 A0A8I3NVA4 A0A8I3NYA8 A0A8I3P560 A0A8I3PCD4 A0A8I3PEN3 A0A8I3PJ46 A0A8I3PQA5 A0A8I3PRW9 A0A8I3PT17 A0A8I3PW88 A0A8I3PX80 A0A8I3Q281 A0A8I3Q2P2 A0A8I3Q886 A0A8I3Q8P6 A0A8I3QAS6 A0A8I3RSR2 A0A8I3RTF4 A0A8I3RVD4 A0A8I3RWC7 A0A8I3RWM0 A0A8I3RY81 A0A8I3S0A4 A0A8I3SBE1 A0A8I3SBK9 O46674 P23685 P61012 Q8MKD5	ABCC9 AHCYL1 ASPH ATP1A1 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM2 CAMK2A CAMK2B CAMK2G CLIC2 FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 ITPR1 ITPR2 ITPR3 KCNJ11 LOC119880472 NCX1 NOS1 PLN PRKACA RYR1 RYR2 RYR3 SLC8A1 SLC8A2 SLC8A3 SRI STIM1 TNNI3 TRDN TRPC1	Canis familiaris (dog)
COPII-mediated vesicle transport	Alpha 1 antitrypsin Ankyrin repeat domain 28 Bet1 golgi vesicular membrane trafficking protein Casein kinase I isoform delta Coagulation factor V Cornichon family AMPA receptor auxiliary protein 1 Cornichon family AMPA receptor auxiliary protein 3 Dipeptidyl peptidase 1 EF-hand domain-containing protein EGF-like domain-containing protein Folate receptor alpha Gamma-soluble NSF attachment protein General vesicular transport factor p115 Glutamate receptor Golgi SNAP receptor complex member 2 Lectin, mannose binding 1 like Lectin, mannose binding 1 Lectin, mannose binding 2 like MAC-inhibitory protein NSF attachment protein alpha NSF attachment protein beta Prolactin regulatory element-binding protein Protein SEC13 homolog Protein cornichon homolog 2 Protein phosphatase 6 regulatory subunit 1 Protein phosphatase 6 regulatory subunit 3 Protein transport protein SEC23 Protein transport protein Sec31A Protein transport protein sec16 Protein transport protein sec16 Ras-related protein Rab-1A SEC22 homolog A, vesicle trafficking protein SEC22 homolog B, vesicle trafficking protein SEC22 homolog C, vesicle trafficking protein SEC23 interacting protein SEC24 homolog A, COPII coat complex component SEC24 homolog B, COPII coat complex component SEC24 homolog C, COPII coat complex component SEC24 homolog D, COPII coat complex component SEC31 homolog B, COPII coat complex component Sec1 family domain containing 1 Serine/threonine-protein phosphatase Small COPII coat GTPase SAR1B Syntaxin 17 Syntaxin 5 TBC1 domain family member 20 Trafficking from ER to golgi regulator Trafficking protein particle complex subunit 10 Trafficking protein particle complex subunit 2-like protein Trafficking protein particle complex subunit 2 Trafficking protein particle complex subunit 6A Trafficking protein particle complex subunit 6B Trafficking protein particle complex subunit 9 Trafficking protein particle complex subunit Trafficking protein particle complex subunit Trafficking protein particle complex subunit Transmembrane emp24 domain-containing protein 10 Transmembrane p24 trafficking protein 2 Uncharacterized protein Uncharacterized protein Uncharacterized protein Vesicle-fusing ATPase Vesicular integral-membrane protein VIP36 YKT6 v-SNARE homolog cathepsin X small monomeric GTPase	A0A8I3MAV2 A0A8I3MJ74 A0A8I3MLH1 A0A8I3MLQ0 A0A8I3MT73 A0A8I3MT80 A0A8I3MUS5 A0A8I3MUT1 A0A8I3MY57 A0A8I3MYK4 A0A8I3MZY0 A0A8I3N2I9 A0A8I3N5A8 A0A8I3N5C1 A0A8I3N796 A0A8I3N7P4 A0A8I3N9C4 A0A8I3N9V0 A0A8I3NBA1 A0A8I3NCZ9 A0A8I3NFJ9 A0A8I3NKE3 A0A8I3NPG4 A0A8I3NPS2 A0A8I3NRF0 A0A8I3NT46 A0A8I3NX57 A0A8I3NYM5 A0A8I3NZH7 A0A8I3NZS8 A0A8I3P0W8 A0A8I3P2X8 A0A8I3P4I1 A0A8I3PAS9 A0A8I3PEN5 A0A8I3PNK8 A0A8I3PQR9 A0A8I3PTJ0 A0A8I3PTW0 A0A8I3PU34 A0A8I3PV59 A0A8I3PVF9 A0A8I3Q314 A0A8I3Q3Y7 A0A8I3Q4E7 A0A8I3Q5G1 A0A8I3Q7H2 A0A8I3QC45 A0A8I3QS42 A0A8I3RR85 A0A8I3RRF7 A0A8I3RSX1 A0A8I3RU45 A0A8I3RUA0 A0A8I3RVH6 A0A8I3RWZ7 A0A8I3RZB2 A0A8I3S3N8 A0A8I3S444 A0A8I3S449 A0A8I3S5V2 A0A8I3SCF9 A1ILJ0 E2QV03 P49256 P62822	ANKRD28 AREG BET1 CD59 CNIH1 CNIH2 CNIH3 CSNK1D CTSC CTSZ F5 GOLGA2 GORASP1 GOSR2 GRIA1 LMAN1 LMAN1L LMAN2 LMAN2L LOC119876190 LOC609612 MCFD2 NAPA NAPB NAPG NSF PPP6C PPP6R1 PPP6R3 PREB RAB1 RAB1A SCFD1 SEC13 SEC16A SEC16B SEC22A SEC22C SEC23A SEC23IP SEC24A SEC24B SEC24C SEC24D SEC31A SEC31B SERPINA1 STX17 STX5 TBC1D20 TFG TGFA TMED10 TMED2 TRAPPC1 TRAPPC10 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9 USO1 YKT6	Canis familiaris (dog)
MET receptor recycling	ADP-ribosylation factor 6 Adapter molecule crk CRK like proto-oncogene, adaptor protein GRB2 associated binding protein 1 Golgi associated, gamma adaptin ear containing, ARF binding protein 3 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Ras-related protein Rab-4 Ras-related protein Rab-4B	A0A8I3MGJ1 A0A8I3MPX3 A0A8I3NGQ0 A0A8I3NGY1 A0A8I3NXI8 A0A8I3PN08 A0A8I3PT69 A0A8I3S696 P61017 Q867B7	ARF6 CRK CRKL GAB1 GGA3 GRB2 HGF MET RAB4A RAB4B	Canis familiaris (dog)

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