GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **126 - 150** of **268** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Stimuli-sensing channels	Acid sensing ion channel subunit 1 Acid sensing ion channel subunit 2 Acid sensing ion channel subunit 3 Acid sensing ion channel subunit family member 4 Acid sensing ion channel subunit family member 5 Amiloride-sensitive sodium channel subunit alpha Amiloride-sensitive sodium channel subunit beta Amiloride-sensitive sodium channel subunit gamma Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Aspartate beta-hydroxylase Barttin CLCNK type accessory subunit beta Bestrophin Bestrophin Bestrophin Bestrophin Calcium-activated chloride channel regulator 1 Chloride channel accessory 2 Chloride channel accessory 4 Chloride channel protein 1 Chloride channel protein 2 Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Chloride intracellular channel protein E3 ubiquitin-protein ligase EF-hand domain-containing protein HECT-type E3 ubiquitin transferase Osteoclastogenesis associated transmembrane protein 1 Protein tweety homolog Protein tweety homolog Protein tweety homolog RAF proto-oncogene serine/threonine-protein kinase Ryanodine receptor 1 Ryanodine receptor 2 Ryanodine receptor 3 Serine/threonine-protein kinase Sgk1 Serum/glucocorticoid regulated kinase family, member 3 Sodium channel epithelial 1 subunit delta Sodium leak channel, non-selective Solute carrier family 17 member 3 Solute carrier family 9 member B1 Solute carrier family 9 member B2 Solute carrier family 9 member C2 (putative) Sorcin Stomatin like 3 Stomatin Triadin Two pore segment channel 1 Two pore segment channel 2 Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Unc-79 homolog, NALCN channel complex subunit Unc-80 homolog, NALCN channel complex subunit peptidylprolyl isomerase	A0A8I3M9N6 A0A8I3MIG8 A0A8I3MK25 A0A8I3MKE6 A0A8I3MKT6 A0A8I3MMN5 A0A8I3MSQ7 A0A8I3MT21 A0A8I3MUX4 A0A8I3MXS3 A0A8I3N0C5 A0A8I3N0E7 A0A8I3N106 A0A8I3N6S0 A0A8I3N726 A0A8I3NAC3 A0A8I3NFB9 A0A8I3NH80 A0A8I3NHZ8 A0A8I3NKC4 A0A8I3NSX7 A0A8I3NUI9 A0A8I3NXW9 A0A8I3NYL1 A0A8I3P370 A0A8I3P4T9 A0A8I3P560 A0A8I3P659 A0A8I3P6A5 A0A8I3P7M3 A0A8I3P948 A0A8I3PAS7 A0A8I3PCD4 A0A8I3PDN2 A0A8I3PET1 A0A8I3PGN5 A0A8I3PJ01 A0A8I3PJ21 A0A8I3PJD4 A0A8I3PNF9 A0A8I3PP54 A0A8I3PRH5 A0A8I3PSM5 A0A8I3PV66 A0A8I3PY43 A0A8I3PZA0 A0A8I3Q0B9 A0A8I3Q0M9 A0A8I3Q2P4 A0A8I3Q383 A0A8I3Q4Q6 A0A8I3Q679 A0A8I3Q886 A0A8I3Q8P6 A0A8I3Q8R4 A0A8I3QA03 A0A8I3QXX9 A0A8I3QYD0 A0A8I3RQJ2 A0A8I3RSF1 A0A8I3RW06 A0A8I3RY81 A0A8I3RZ58 A0A8I3S651 A0A8I3SA78 P63050 Q9MZT1	ANO1 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ASPH BEST1 BEST2 BEST3 BEST4 BSND CALM2 CLCA1 CLCA2 CLCA4 CLCN1 CLCN2 CLCN4 CLCN5 CLCN6 CLCN7 CLCNK CLCNKA CLIC2 LOC119880472 NALCN NEDD4L OSTM1 RAF1 RPS27A RYR1 RYR2 RYR3 SCNN1A SCNN1B SCNN1D SCNN1G SGK1 SGK3 SLC17A2 SLC9B1 SLC9B2 SLC9C2 SRI STOM STOML3 TPCN1 TPCN2 TRDN TTYH1 TTYH2 TTYH3 UBA52 UBB UBC UBCEP2 UNC79 UNC80 WWP1	Canis familiaris (dog)
Formation of the cornified envelope	Calpain small subunit 1 Calpain-1 catalytic subunit Caspase 14 Corneodesmosin Cystatin A Desmocollin 1 Desmoglein 1 Desmoglein 2 Desmoglein 3 Desmoglein 4 Desmoglein-3 Desmoplakin EF-hand domain-containing protein EF-hand domain-containing protein EF-hand domain-containing protein Junction plakoglobin Kallikrein related peptidase 12 Kallikrein related peptidase 13 Kallikrein related peptidase 14 Kazrin, periplakin interacting protein Lipase Lipase Lipase P53 apoptosis effector related to PMP22 Partial AB-hydrolase lipase domain-containing protein Peptidase inhibitor 3 Periplakin Plakophilin 1 Plakophilin 2 Plakophilin 3 Plakophilin 4 Proprotein convertase subtilisin/kexin type 6 Protein-glutamine gamma-glutamyltransferase K SH3 domain-containing protein Serine peptidase inhibitor Kazal type 6 Serine protease 8 Uncharacterized protein furin	A0A8I3MEZ7 A0A8I3MGG5 A0A8I3MMJ6 A0A8I3MP57 A0A8I3MV56 A0A8I3N1T9 A0A8I3N282 A0A8I3NHU5 A0A8I3NIB1 A0A8I3NJG7 A0A8I3NL10 A0A8I3NLL5 A0A8I3NRG5 A0A8I3NVV6 A0A8I3NXI7 A0A8I3NYR0 A0A8I3NZ03 A0A8I3P0I4 A0A8I3P212 A0A8I3PDW6 A0A8I3PMI7 A0A8I3PQU9 A0A8I3PW84 A0A8I3PYD8 A0A8I3Q1A4 A0A8I3Q2T7 A0A8I3Q6Y1 A0A8I3Q7P7 A0A8I3Q910 A0A8I3QKA9 A0A8I3RW47 A0A8I3RY38 A0A8I3RYD5 A0A8I3S0K7 A0A8I3S9F9 D3DMB4 F1PHB6 Q7YRU7	CAPN1 CAPNS1 CASP14 CSTA DSC1 DSC3 DSG1 DSG2 DSG3 DSG4 DSP EVPL FLG FURIN JUP KAZN KLK12 KLK13 KLK14 LIPJ LIPK LIPM LIPN LOC119876865 PCSK6 PERP PI3 PKP1 PKP2 PKP3 PKP4 PPL PRSS8 RPTN SPINK6 TCHH TGM1 cystatin A	Canis familiaris (dog)
Histamine receptors	Histamine H1 receptor Histamine H2 receptor Histamine receptor H3 Histamine receptor H4	A0A8I3MSX9 A0A8I3NPW0 A0A8I3P226 P17124	HRH1 HRH2 HRH3 HRH4	Canis familiaris (dog)
Transport of inorganic cations/anions and amino acids/oligopeptides	Amino acid transporter Amino acid transporter Amino acid transporter Amino acid transporter Amino acid transporter Cystinosin, lysosomal cystine transporter Mitochondrial S-adenosylmethionine carrier protein Vesicular inhibitory amino acid transporter	A0A8I3N947 A0A8I3NY92 A0A8I3P1B2 A0A8I3P4E1 A0A8I3PQ76 A0A8I3Q823 A0A8I3RSG2 Q9N280	CTNS GLAST SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC25A26 SLC32A1	Canis familiaris (dog)
Synthesis of Leukotrienes (LT) and Eoxins (EX)	Arachidonate 5-lipoxygenase-activating protein Arachidonate 5-lipoxygenase Cytochrome P450 4A37 Cytochrome P450 4A39 Cytochrome P450 family 4 subfamily B member 1 Cytochrome P450 family 4 subfamily F member 22 Dipeptidase 3 Dipeptidase Dipeptidase Glutathione hydrolase Leukotriene A(4) hydrolase Leukotriene C4 synthase Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Polyunsaturated fatty acid lipoxygenase ALOX15 Uncharacterized protein Uncharacterized protein	A0A8I3MKG9 A0A8I3MWD6 A0A8I3N1I8 A0A8I3NBG0 A0A8I3NUL1 A0A8I3NW02 A0A8I3NZI5 A0A8I3P4E2 A0A8I3P5X5 A0A8I3PDD9 A0A8I3PHP8 A0A8I3PP24 A0A8I3RZ66 A0A8I3S2G2 A0A8I3SA30 Q2VHZ7 Q6UR05	ABCC1 ALOX15 ALOX5 ALOX5AP CYP4A11 CYP4A37 CYP4A39 CYP4B1 CYP4F22 DPEP1 DPEP2 DPEP3 GGT1 LOC119863926 LTA4H LTC4S MRP1	Canis familiaris (dog)
Apoptotic execution phase	B-cell receptor-associated protein Caspase 8 Dynamin-1-like protein Dynamin-1-like protein non-specific serine/threonine protein kinase	A0A8I3NR52 A0A8I3PR10 A0A8I3Q0S5 A0A8I3S1Q3 Q38JA9	BCAP31 CASP8 DNM1L LOC119868890 STK24	Canis familiaris (dog)
Downstream signaling of activated FGFR1	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibronectin leucine rich transmembrane protein 1 Fibronectin leucine rich transmembrane protein 2 Fibronectin leucine rich transmembrane protein 3 Klotho Multifunctional fusion protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3PDH2 A0A8I3PJY6 A0A8I3RV97 A0A8I3SAY5 A0A8I3SCU1 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FLRT1 FLRT2 FLRT3 KL	Canis familiaris (dog)
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A2 Epidermal growth factor receptor pathway substrate 15 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine rich repeats and immunoglobulin like domains 1 SH3 domain containing GRB2 like 2, endophilin A1 SH3 domain containing kinase binding protein 1 Signal transducing adaptor molecule 2 Signal transducing adaptor molecule Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein protein-tyrosine-phosphatase ubiquitinyl hydrolase 1	A0A8I3MBU4 A0A8I3MMN5 A0A8I3MZ64 A0A8I3N2P0 A0A8I3N8H2 A0A8I3NFB9 A0A8I3NGD3 A0A8I3NGY1 A0A8I3NKR3 A0A8I3NRM5 A0A8I3NTR3 A0A8I3P598 A0A8I3PMU1 A0A8I3PNU1 A0A8I3PT69 A0A8I3PXV2 A0A8I3Q5C2 A0A8I3QYD0 P63050 Q867B7	CBL EPS15 GRB2 HGF HGS LRIG1 MET PTPN1 PTPN2 PTPRJ RPS27A SH3GL1 SH3GL2 SH3KBP1 STAM STAM2 UBA52 UBB UBC UBCEP2 USP8	Canis familiaris (dog)
Surfactant metabolism	ATP binding cassette subfamily A member 3 Adenosine receptor A2a Adhesion G protein-coupled receptor F5 Alpha-2A adrenergic receptor Alpha-2C adrenergic receptor C-type lectin domain-containing protein Coiled-coil domain containing 59 Colony stimulating factor 2 receptor subunit beta Cytoskeleton associated protein 4 Fibronectin type-III domain-containing protein GATA binding protein 6 LIM and cysteine rich domains 1 Napsin A aspartic peptidase P2Y purinoceptor 2 Palmitoyltransferase Pepsin A Pro-cathepsin H Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C SRCR domain-containing protein Sodium-dependent phosphate transport protein 2A Sodium-dependent phosphate transport protein 2B Transcription termination factor 1 Uncharacterized protein	A0A8I3MSD7 A0A8I3MZ62 A0A8I3NCW6 A0A8I3NFK5 A0A8I3NFY6 A0A8I3NHV8 A0A8I3NQ93 A0A8I3NR35 A0A8I3NUR4 A0A8I3NUT9 A0A8I3NWG1 A0A8I3NWJ3 A0A8I3NXR2 A0A8I3NZU4 A0A8I3P3J7 A0A8I3PBB4 A0A8I3PJM9 A0A8I3Q7S8 A0A8I3RTH9 A0A8I3RVV0 A0A8I3RW10 A0A8I3S9H9 P11617 Q9GMY6	ABCA3 ADGRF5 ADORA2A ADRA2A ADRA2C CCDC59 CKAP4 CSF2RA CSF2RB CTSH GATA6 LMCD1 LOC610540 NAPSA P2RY2 PGA PGNA RDC8 SFTPB SFTPC SFTPD SLC34A1 SLC34A2 TTF1 ZDHHC2	Canis familiaris (dog)
Na+/Cl- dependent neurotransmitter transporters	Sodium- and chloride-dependent betaine transporter Sodium- and chloride-dependent glycine transporter 1 Solute carrier family 18 member A1 Solute carrier family 18 member A2 Solute carrier family 22 member 1 Solute carrier family 22 member 2 Solute carrier family 6 member 13 Solute carrier family 6 member 6 Transporter Transporter Transporter Transporter Transporter Transporter Transporter Transporter Transporter Transporter Transporter	A0A8I3MBP6 A0A8I3MM56 A0A8I3MNK2 A0A8I3N6A1 A0A8I3N7M6 A0A8I3NCF6 A0A8I3NLL1 A0A8I3P2T9 A0A8I3PHP5 A0A8I3PME4 A0A8I3PQT8 A0A8I3PSN6 A0A8I3PV06 A0A8I3Q066 A0A8I3QQP1 A0A8I3QS48 A0A8I3RV00 A0A8I3S5V8 P27799	SLC18A1 SLC18A2 SLC22A1 SLC22A2 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A18 SLC6A19 SLC6A2 SLC6A20 SLC6A3 SLC6A5 SLC6A6 SLC6A7 SLC6A9	Canis familiaris (dog)
Post-translational protein phosphorylation	Albumin Alpha 1 antitrypsin Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-2-HS-glycoprotein Alpha-L-fucosidase Alpha-fetoprotein Ameloblastin Amelogenin X isoform Amelotin Amyloid beta precursor like protein 2 Amyloid-beta A4 protein Anoctamin Antithrombin-III Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-V Apolipoprotein B Apolipoprotein E Apolipoprotein L3 Apolipoprotein L3 BPI fold containing family B member 2 Bone morphogenetic protein 4 C4a anaphylatoxin CCN family member 1 Cadherin-2 Calumenin Chordin like 1 Coagulation factor V Complement C3 Cytoskeleton associated protein 4 Dentin matrix acidic phosphoprotein 1 Disintegrin and metalloproteinase domain-containing protein 10 DnaJ homolog subfamily C member 3 Enamelin Endoplasmin FAM20 C-terminal domain-containing protein FAM20A golgi associated secretory pathway pseudokinase Fibrillin 1 Fibrinogen alpha chain Fibroblast growth factor 23 Fibronectin Follistatin like 3 Follistatin-related protein 1 Galectin 1 Glypican-3 Golgi membrane protein 1 Growth arrest specific 6 Histidine rich calcium binding protein Insulin like growth factor binding protein 7 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 5 Inter-alpha-trypsin inhibitor heavy chain 2 Interleukin-6 Kinectin 1 Kininogen 1 Latent transforming growth factor beta binding protein 1 MIA SH3 domain ER export factor 3 Macrophage colony-stimulating factor 1 Matrilin 3 Matrix extracellular phosphoglycoprotein Matrix remodeling-associated protein 8 Melanotransferrin Membrane bound transcription factor peptidase, site 1 Menin Metalloproteinase inhibitor 1 Milk fat globule EGF and factor V/VIII domain containing Multiple EGF like domains 6 Nucleobindin-1 Patatin like phospholipase domain containing 2 Proenkephalin-A Protein disulfide-isomerase A6 Protein disulfide-isomerase Protein kinase C substrate 80K-H Reticulocalbin 1 SPARC like 1 Secreted phosphoprotein 1 Secreted phosphoprotein 24 Secretogranin-1 Secretogranin-2 Secretogranin-3 Serine protease Serpin family D member 1 Stanniocalcin-2 Sulfhydryl oxidase Tenascin C Trans-golgi network protein 2 Transmembrane protein 132A Uncharacterized protein Uncharacterized protein Uncharacterized protein VGF nerve growth factor inducible Versican core protein Vitamin K-dependent protein C [Wnt protein] O-palmitoleoyl-L-serine hydrolase ferroxidase von Willebrand factor A domain-containing protein 1	A0A0B4J199 A0A8I3MBU3 A0A8I3MBV3 A0A8I3MD84 A0A8I3MKS3 A0A8I3MKU0 A0A8I3MLH1 A0A8I3MRY5 A0A8I3MSG4 A0A8I3MSR8 A0A8I3MVA9 A0A8I3MY68 A0A8I3MZB7 A0A8I3N0D8 A0A8I3N1E6 A0A8I3N365 A0A8I3N3Q6 A0A8I3N5X9 A0A8I3N8F9 A0A8I3N8K1 A0A8I3N8X3 A0A8I3NA54 A0A8I3NAE2 A0A8I3NAG2 A0A8I3NBG6 A0A8I3NBI4 A0A8I3NBI7 A0A8I3NFV4 A0A8I3NH95 A0A8I3NHN1 A0A8I3NHZ1 A0A8I3NIA5 A0A8I3NLT2 A0A8I3NN59 A0A8I3NPQ9 A0A8I3NQA0 A0A8I3NR35 A0A8I3NSE7 A0A8I3NTU0 A0A8I3NXQ1 A0A8I3NY94 A0A8I3P0M4 A0A8I3P1E4 A0A8I3P1V2 A0A8I3P1W2 A0A8I3P261 A0A8I3P2Y2 A0A8I3P735 A0A8I3P7V0 A0A8I3P874 A0A8I3P9H6 A0A8I3PA47 A0A8I3PB34 A0A8I3PED8 A0A8I3PI20 A0A8I3PIK8 A0A8I3PM36 A0A8I3PMB5 A0A8I3PMF7 A0A8I3PPY1 A0A8I3PSD1 A0A8I3PTJ6 A0A8I3PTU8 A0A8I3PU47 A0A8I3PWU3 A0A8I3Q0F7 A0A8I3Q0M1 A0A8I3Q1K1 A0A8I3Q1Q3 A0A8I3Q2P4 A0A8I3Q2T3 A0A8I3Q4H4 A0A8I3Q662 A0A8I3QBE2 A0A8I3QN81 A0A8I3QNP3 A0A8I3RP80 A0A8I3RQL9 A0A8I3RRH5 A0A8I3RT41 A0A8I3RYZ7 A0A8I3S0I3 A0A8I3S0P1 A0A8I3S3D7 A0A8I3S4D1 A0A8I3S5B1 A0A8I3S6A4 A0A8I3S8V0 A0A8I3S915 A1ILJ0 A2SXS5 E2RAK7 F6PLF2 J9PBH8 P18649 P41148 Q28278	ADAM10 AFP AHSG ALB AMBN AMELX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APP BMP15 BMP4 BPIFB2 C3 CALU CCN1 CDH2 CHGB CHRDL1 CKAP4 COA5 CP CSF1 DMP1 DNAJC3 ENAM F5 FAM20A FAM20C FBN1 FGA FGF23 FGF8B FN1 FSTL1 FSTL3 FUCA2 GAS6 GOLM1 GPC3 GRP94 HRC HSP90B1 HSPC4 IGFBP3 IGFBP4 IGFBP5 IGFBP7 IL6 ITIH2 KNG1 KTN1 LGALS1 LOC102156332 LOC481722 LOC607874 LTBP1 MATN3 MBTPS1 MEGF6 MELTF MEN1 MEPE MFGE8 MIA3 MXRA8 NOTUM NUCB1 P4HB PDIA6 PENK PNPLA2 PRKCSH PROC PRSS23 QSOX1 RCN1 SCG2 SCG3 SERPINA1 SERPINC1 SERPIND1 SPARCL1 SPP1 SPP2 STC2 TGOLN2 TIMP1 TMEM132A TNC TRA1 VCAN VGF VWA1 WFS1	Canis familiaris (dog)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Klotho Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3NYK3 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 GRB2 HRAS KL KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
MHC class II antigen presentation	ADP-ribosylation factor AP complex subunit beta AP complex subunit sigma AP complex subunit sigma AP-1 complex subunit mu-1 AP-1 complex subunit mu-2 AP-2 complex subunit alpha AP-2 complex subunit alpha AP-2 complex subunit mu AP-2 complex subunit sigma Actin related protein 10 Actin related protein 1B Alpha-centractin CD74 molecule Calnexin Carboxypeptidase Cathepsin B Cathepsin D Cathepsin E Cathepsin F Cathepsin O Cathepsin S Centromere protein E Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain domain-containing protein Clathrin heavy chain Clathrin light chain Cytoplasmic dynein 1 intermediate chain 2 Dipeptidyl peptidase 1 Dynactin subunit 1 Dynactin subunit 2 Dynactin subunit 3 Dynactin subunit 4 Dynactin subunit 5 Dynactin subunit 6 Dynein cytoplasmic 1 heavy chain 1 Dynein cytoplasmic 1 intermediate chain 1 Dynein light chain Dynein light chain Dynein light intermediate chain Dynein light intermediate chain F-actin-capping protein subunit alpha-2 F-actin-capping protein subunit alpha F-actin-capping protein subunit alpha F-actin-capping protein subunit beta GTP-binding protein SAR1b Gamma-interferon-inducible lysosomal thiol reductase HLA class II histocompatibility antigen, DO alpha chain-like Kinesin associated protein 3 Kinesin family member 11 Kinesin family member 26A Kinesin family member 4A Kinesin family member 5A Kinesin light chain Kinesin light chain Kinesin light chain Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Legumain Lymphocyte activating 3 MHC class II DR alpha chain MHC class II antigen DM beta Major histocompatibility complex, class II, DM alpha Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Oxysterol-binding protein Pro-cathepsin H Procathepsin L Protein SEC13 homolog Protein transport protein SEC23 Protein transport protein Sec31A Queuine tRNA-ribosyltransferase catalytic subunit 1 Rab interacting lysosomal protein Rac GTPase activating protein 1 Ras-related protein Rab-7a SEC24 homolog A, COPII coat complex component SEC24 homolog B, COPII coat complex component SEC24 homolog C, COPII coat complex component SEC24 homolog D, COPII coat complex component SH3 domain containing GRB2 like 2, endophilin A1 Spectrin beta chain Uncharacterized protein Uncharacterized protein dynamin GTPase dynamin GTPase	A0A8I3MB83 A0A8I3MEF2 A0A8I3MGM6 A0A8I3MHS5 A0A8I3MQ01 A0A8I3MQ56 A0A8I3MSD7 A0A8I3MX81 A0A8I3MZR3 A0A8I3N2P7 A0A8I3N366 A0A8I3N413 A0A8I3N448 A0A8I3N536 A0A8I3N796 A0A8I3N7P9 A0A8I3N9C4 A0A8I3NBU3 A0A8I3NCI2 A0A8I3NCU8 A0A8I3NF50 A0A8I3NFH8 A0A8I3NH94 A0A8I3NHB2 A0A8I3NHV2 A0A8I3NIZ3 A0A8I3NMB7 A0A8I3NMT0 A0A8I3NPI1 A0A8I3NPK5 A0A8I3NPS2 A0A8I3NRM5 A0A8I3NTK0 A0A8I3NTV2 A0A8I3NUM0 A0A8I3NWA9 A0A8I3NX29 A0A8I3NYK0 A0A8I3NZH7 A0A8I3P2D4 A0A8I3P3K7 A0A8I3P4A1 A0A8I3P503 A0A8I3P5K8 A0A8I3P5S6 A0A8I3P8U9 A0A8I3P903 A0A8I3PA63 A0A8I3PC10 A0A8I3PDJ0 A0A8I3PFS2 A0A8I3PHA3 A0A8I3PK57 A0A8I3PQE6 A0A8I3PSF4 A0A8I3PSI0 A0A8I3PSI8 A0A8I3PSX7 A0A8I3PTU4 A0A8I3PVW4 A0A8I3PXL9 A0A8I3PZW5 A0A8I3Q2C8 A0A8I3Q4C7 A0A8I3Q5Y5 A0A8I3Q7H2 A0A8I3QA46 A0A8I3RR85 A0A8I3RSP2 A0A8I3RUA9 A0A8I3RZ95 A0A8I3S023 A0A8I3S0M3 A0A8I3S1I6 A0A8I3S2N1 A0A8I3S2X1 A0A8I3S449 A0A8I3S4X0 A0A8I3S565 A0A8I3S5V2 A0A8I3S7Q4 A0A8I3SB08 A0A8I3SB35 A0A8I3SCF9 A0A8I3SCQ9 P18067 P61162 Q4LAL9 Q5TJG5 Q5TJH0 Q9GL24	ACTR10 ACTR1A ACTR1B AP1B1 AP1M1 AP1M2 AP1S1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 CANX CAPZA2 CAPZA3 CAPZB CD74 CENPE CLTA CLTC CTRN1 CTSA CTSB CTSC CTSD CTSE CTSF CTSH CTSL CTSL1 CTSO CTSS DCTN1 DCTN3 DCTN4 DCTN5 DCTN6 DLA-DMA DLA-DMB DLA-DOA DLA-DQA1 DLA-DRA DNM1 DNM2 DNM3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 HLA-DQB2 IFI30 KIF11 KIF18A KIF20A KIF22 KIF23 KIF26A KIF2B KIF2C KIF3A KIF3C KIF4A KIF5A KIF5B KIFAP3 KLC1 KLC3 KLC4 LAG3 LGMN LOC100856399 LOC119868747 LOC119876190 LOC612266 OSBPL1A PHLPP2 QTRT1 RAB7 RAB7A RACGAP1 RILP SEC13 SEC23A SEC24A SEC24B SEC24C SEC24D SEC31A SH3GL2 SPTBN2	Canis familiaris (dog)
Vasopressin regulates renal water homeostasis via Aquaporins	Aquaporin-1 Aquaporin-2 Aquaporin-3 Aquaporin-4 Arginine vasopressin G protein subunit beta 2 G protein subunit beta 4 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Guanine nucleotide-binding protein G(T) subunit gamma-T1 Guanine nucleotide-binding protein G(s) subunit alpha Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Myosin VB Protein kinase cAMP-dependent type I regulatory subunit beta Protein kinase cAMP-dependent type II regulatory subunit beta RAB11 family interacting protein 2 Ras-related protein Rab-11A Vasopressin V2 receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit cAMP-dependent protein kinase	A0A8I3ME07 A0A8I3MHA7 A0A8I3MM75 A0A8I3MNZ2 A0A8I3MYE3 A0A8I3N081 A0A8I3N0M1 A0A8I3NCW7 A0A8I3NP65 A0A8I3NPA7 A0A8I3NPM9 A0A8I3NR61 A0A8I3NVA6 A0A8I3NZX3 A0A8I3P6A6 A0A8I3P7C5 A0A8I3PJF2 A0A8I3PRW9 A0A8I3PV05 A0A8I3PWA8 A0A8I3Q628 A0A8I3QJ88 A0A8I3QW96 A0A8I3RYN2 A0A8I3S5Y6 O97564 P62490 P62872 P63210 P79147 Q9N2J4	AQP1 AQP2 AQP3 AQP4 AVP AVPR2 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG11 GNG13 GNG2 GNG3 GNG4 GNG8 GNGT1 GNGT2 LOC119863873 MYO5B PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAB11 RAB11A RAB11FIP2	Canis familiaris (dog)
Negative regulation of FGFR1 signaling	Anosmin 1 E3 ubiquitin-protein ligase CBL Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor bound protein 2 Klotho Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MBU4 A0A8I3MMN5 A0A8I3MP09 A0A8I3NFB9 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3PZP0 A0A8I3QYD0 A0A8I3RQD0 A0A8I3S906 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 P63050 Q20FD0	ANOS1 CBL FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FRS2 GRB2 KL MAPK1 MAPK3 PTPN11 RPS27A UBA52 UBB UBC UBCEP2	Canis familiaris (dog)
Ub-specific processing proteases	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ADRM1 26S proteasome ubiquitin receptor Androgen receptor Ataxin 7 Axin 2 Axin-1 Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 Beclin-1 Beta-2 adrenergic receptor Beta-arrestin-1 Beta-arrestin-2 Cell division cycle 20 Cellular tumor antigen p53 Centriolar coiled-coil protein 110 Claspin Cyclin-A1 Cyclin-A2 Cystic fibrosis transmembrane conductance regulator Cystic fibrosis transmembrane conductance regulator DNA polymerase E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Farnesylated proteins-converting enzyme 2 Forkhead box O4 GATA binding protein 3 Hepatocyte growth factor-regulated tyrosine kinase substrate Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Hypoxia-inducible factor 1-alpha Insulin degrading enzyme Interleukin-33 Kelch-like ECH-associated protein 1 M-phase inducer phosphatase Methionine adenosyltransferase 2 subunit beta Mitochondrial Rho GTPase Mitochondrial import receptor subunit TOM20 homolog Mitogen-activated protein kinase kinase kinase 7 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Myc proto-oncogene protein NF-kappa-B essential modulator NF-kappa-B inhibitor alpha Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Proteasome 20S subunit alpha 3 Proteasome 26S subunit, ATPase 1 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 10 Proteasome 26S subunit, non-ATPase 12 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta type-8 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Protein Mdm4 RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RNA helicase Receptor interacting serine/threonine kinase 1 Ring finger protein 128 RuvB-like helicase SDS3 homolog, SIN3A corepressor complex component Signal transducing adaptor molecule 2 TATA-box binding protein associated factor 9b TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta receptor type-1 TNF receptor-associated factor 6 TNF receptor-associated factor Tankyrase 2 Transcription initiation factor TFIID subunit 10 Transcriptional adapter 3 Transcriptional adapter Transformation/transcription domain associated protein Translocase of outer mitochondrial membrane 70 USP domain-containing protein Ubiquitin B Ubiquitin carboxyl-terminal hydrolase 16 Ubiquitin carboxyl-terminal hydrolase 37 Ubiquitin carboxyl-terminal hydrolase 47 Ubiquitin carboxyl-terminal hydrolase 48 Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin specific peptidase 28 Ubiquitin specific peptidase 42 Ubiquitin thioesterase Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Voltage-dependent anion-selective channel protein 1 Voltage-dependent anion-selective channel protein 2 Voltage-dependent anion-selective channel protein 3 WD repeat domain 20 WD repeat-containing protein 48 histone acetyltransferase peptidyl-tRNA hydrolase peptidylprolyl isomerase ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A7R7V602 A0A8I3MC37 A0A8I3MCW5 A0A8I3MDM0 A0A8I3MDQ5 A0A8I3MFT9 A0A8I3MJQ1 A0A8I3MKL2 A0A8I3MKL4 A0A8I3MMN5 A0A8I3MNI0 A0A8I3MPG9 A0A8I3MQC7 A0A8I3MR89 A0A8I3MRP8 A0A8I3MSL4 A0A8I3MU16 A0A8I3MUE2 A0A8I3MWJ0 A0A8I3MWQ7 A0A8I3MZA5 A0A8I3N0P1 A0A8I3N165 A0A8I3N2P0 A0A8I3N371 A0A8I3N3A0 A0A8I3N3R0 A0A8I3N3S4 A0A8I3N5F1 A0A8I3N683 A0A8I3N6Q2 A0A8I3N7L6 A0A8I3N7R6 A0A8I3N952 A0A8I3N9G3 A0A8I3NA81 A0A8I3NAP2 A0A8I3NAV8 A0A8I3NBQ5 A0A8I3NDB6 A0A8I3NEM9 A0A8I3NFB9 A0A8I3NGD3 A0A8I3NGL0 A0A8I3NGV0 A0A8I3NH42 A0A8I3NH60 A0A8I3NHL8 A0A8I3NLI9 A0A8I3NM89 A0A8I3NMN1 A0A8I3NN65 A0A8I3NNJ9 A0A8I3NP66 A0A8I3NP69 A0A8I3NPX1 A0A8I3NR70 A0A8I3NRK8 A0A8I3NUC6 A0A8I3NUK8 A0A8I3NUT4 A0A8I3NV88 A0A8I3NW63 A0A8I3NW81 A0A8I3NWA6 A0A8I3NXK9 A0A8I3NY77 A0A8I3NYC7 A0A8I3NYE9 A0A8I3NYK2 A0A8I3NZ86 A0A8I3P0Y8 A0A8I3P135 A0A8I3P2V4 A0A8I3P616 A0A8I3P6B7 A0A8I3P6G1 A0A8I3P6J5 A0A8I3P6M2 A0A8I3P738 A0A8I3P7J9 A0A8I3P9V4 A0A8I3PB52 A0A8I3PB85 A0A8I3PBB2 A0A8I3PCC0 A0A8I3PCE5 A0A8I3PCI4 A0A8I3PCT4 A0A8I3PDR8 A0A8I3PE84 A0A8I3PF55 A0A8I3PF76 A0A8I3PFL3 A0A8I3PG60 A0A8I3PGG8 A0A8I3PHC7 A0A8I3PI05 A0A8I3PJL4 A0A8I3PJW0 A0A8I3PKH4 A0A8I3PLL0 A0A8I3PMA2 A0A8I3PMH0 A0A8I3PNU1 A0A8I3PQ44 A0A8I3PQ52 A0A8I3PQD9 A0A8I3PU69 A0A8I3PVR3 A0A8I3PW10 A0A8I3PWL6 A0A8I3PWM3 A0A8I3PWW2 A0A8I3PX43 A0A8I3PY49 A0A8I3PYV8 A0A8I3PZ26 A0A8I3PZ42 A0A8I3PZ96 A0A8I3PZT2 A0A8I3Q0K8 A0A8I3Q3S2 A0A8I3Q4M1 A0A8I3Q5J1 A0A8I3Q610 A0A8I3Q7Y0 A0A8I3Q883 A0A8I3QA55 A0A8I3QBV9 A0A8I3QCQ3 A0A8I3QV78 A0A8I3QYD0 A0A8I3RP35 A0A8I3RRR7 A0A8I3RS56 A0A8I3RSX0 A0A8I3RT18 A0A8I3RT39 A0A8I3RV68 A0A8I3RVA5 A0A8I3RWV3 A0A8I3RWY9 A0A8I3RXL5 A0A8I3RXS6 A0A8I3RXV3 A0A8I3RZ76 A0A8I3RZD9 A0A8I3RZF7 A0A8I3RZF8 A0A8I3RZP6 A0A8I3RZQ8 A0A8I3S1Z6 A0A8I3S2L7 A0A8I3S2R9 A0A8I3S3G6 A0A8I3S4J6 A0A8I3S4R5 A0A8I3S6C6 A0A8I3S6H8 A0A8I3S6Q5 A0A8I3S789 A0A8I3S792 A0A8I3S794 A0A8I3S7M5 A0A8I3S9E1 A0A8I3S9T4 A0A8I3SCL5 A1E2V0 D2YYC0 E2RK09 E7FIY6 H9GWB1 J9P6S8 O97863 P56950 P60483 P63050 Q5U820 Q5W412 Q5W416	ABCC7 ADRB2 ADRM1 AR ARRB1 ARRB2 ATXN7 AXIN1 AXIN2 BECN1 BIRC2 BIRC3 CCNA1 CCNA2 CCP110 CDC20 CDC25A CDK16 CFTR CLSPN CYLD FKBP8 FOXO4 GATA3 H2AC1 H2AC13 H2AC14 H2AC16 H2AC19 H2AC21 H2AC25 H2AC4 H2AC6 H2BC10 H2BC15 H2BC2 H2BC21 H2BC26 H2BC3 HGS HIF1A IDE IFIH1 IKBKG IL33 KAT2A KEAP1 LOC100686569 LOC100687259 LOC100688437 LOC119867694 LOC119867696 LOC119867718 LOC119868881 LOC119869165 LOC119869175 LOC119869178 LOC119869187 LOC119869258 LOC119874734 LOC482940 LOC610717 MAP3K7 MAT2B MDM2 MDM4 MMAC1 MUL1 MYC Madh3 NFKBIA OTUB1 POLB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 PTEN PTRH2 RCE1 RHOT1 RIPK1 RNF123 RNF128 RNF146 RPS27A RUVBL1 SIAH2 SMAD1 SMAD2 SMAD3 SMAD7 SMURF2 STAM2 SUDS3 TAB1 TADA2B TADA3 TAF10 TAF9B TGFBR1 TNKS TNKS2 TOMM20 TOMM70 TP53 TRAF2 TRAF6 TRRAP UBA52 UBB UBC UBCEP2 USP10 USP12 USP13 USP14 USP15 USP16 USP18 USP19 USP2 USP20 USP21 USP22 USP26 USP28 USP3 USP30 USP33 USP34 USP37 USP4 USP42 USP44 USP47 USP48 USP49 USP5 USP7 USP8 VDAC1 VDAC2 VDAC3 WDR20 WDR48 p53	Canis familiaris (dog)
Interleukin receptor SHC signaling	Colony stimulating factor 2 receptor subunit beta Fibronectin type-III domain-containing protein GRB2 associated binding protein 2 Granulocyte-macrophage colony-stimulating factor Growth factor receptor bound protein 2 Interleukin 5 receptor subunit alpha Interleukin-2 receptor subunit alpha Interleukin-2 receptor subunit beta Interleukin-2 Interleukin-3 Interleukin-5 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3MVN6 A0A8I3N971 A0A8I3N9M7 A0A8I3NFE2 A0A8I3NUU1 A0A8I3NVH4 A0A8I3P519 A0A8I3PAP4 A0A8I3PBB4 A0A8I3PT69 A0A8I3PWC6 A0A8I3PWT3 A0A8I3Q525 A0A8I3RRY0 A0A8I3RS40 A0A8I3RVV0 A0A8I3RX48 A0A8I3S3D9 A0A8I3S3N2 A0A8I3S4Z2 P48749 Q29416 Q95J76 Q9BDX4	CSF2 CSF2RA CSF2RB GAB2 GRB2 IL2 IL2RA IL2RB IL3 IL5 IL5RA INPP5D INPPL1 JAK1 JAK2 JAK3 LOC100856339 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PTPN6 SHC1 SHIP2 SOS1	Canis familiaris (dog)
EPH-Ephrin signaling	EPH receptor A10 EPH receptor B6 EPH-related receptor tyrosine kinase ligand 7 Ephrin A2 Ephrin A3 Ephrin A4 Ephrin B3 Ephrin type-B receptor 3 Ephrin-A1 Ephrin-B2 Uncharacterized protein receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A8I3MB23 A0A8I3MBN5 A0A8I3MD88 A0A8I3MVS4 A0A8I3N250 A0A8I3NEL5 A0A8I3NQ24 A0A8I3NR10 A0A8I3NS68 A0A8I3NYD1 A0A8I3PTE3 A0A8I3PZY2 A0A8I3Q5U0 A0A8I3QB00 A0A8I3RP21 A0A8I3RVX4 A0A8I3RZP3 A0A8I3S0G7 A0A8I3SCP8 B0LDS6	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 EPHA1 EPHA10 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB2 EPHB3 EPHB4 EPHB6 efnB2	Canis familiaris (dog)
ABC-family proteins mediated transport	26S proteasome non-ATPase regulatory subunit 11 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 9 26S proteasome regulatory subunit 6B 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ABC-type glutathione-S-conjugate transporter ABC-type glutathione-S-conjugate transporter ABC-type glutathione-S-conjugate transporter ATP binding cassette subfamily A member 4 ATP binding cassette subfamily A member 8 ATP binding cassette subfamily B member 1 ATP binding cassette subfamily B member 4 ATP binding cassette subfamily B member 5 ATP binding cassette subfamily B member 9 ATP binding cassette subfamily C member 10 ATP binding cassette subfamily C member 11 ATP binding cassette subfamily C member 4 ATP binding cassette subfamily C member 5 ATP binding cassette subfamily C member 9 ATP binding cassette subfamily F member 1 ATP-sensitive inward rectifier potassium channel 11 Cystic fibrosis transmembrane conductance regulator Cystic fibrosis transmembrane conductance regulator Derlin Derlin Derlin E3 ubiquitin-protein ligase RNF Endoplasmic reticulum lectin Endoplasmic reticulum lectin Erlin Erlin Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Proteasome 20S subunit alpha 3 Proteasome 26S subunit, ATPase 1 Proteasome 26S subunit, ATPase 6 Proteasome 26S subunit, non-ATPase 10 Proteasome 26S subunit, non-ATPase 12 Proteasome 26S subunit, non-ATPase 14 Proteasome 26S subunit, non-ATPase 3 Proteasome 26S subunit, non-ATPase 7 Proteasome activator complex subunit 1 Proteasome activator complex subunit 2 Proteasome activator subunit 4 Proteasome inhibitor PI31 subunit Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit alpha type Proteasome subunit beta type-8 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta SEL1L adaptor subunit of ERAD E3 ubiquitin ligase Transitional endoplasmic reticulum ATPase Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein Uncharacterized protein protein-synthesizing GTPase	A0A8I3MFR7 A0A8I3MMN5 A0A8I3MNI0 A0A8I3MR89 A0A8I3MU16 A0A8I3MUE2 A0A8I3MV19 A0A8I3N0P1 A0A8I3N153 A0A8I3N165 A0A8I3N1B7 A0A8I3N1I8 A0A8I3N222 A0A8I3N2I4 A0A8I3N3S4 A0A8I3N5F1 A0A8I3N6K4 A0A8I3N6T3 A0A8I3N6X7 A0A8I3N7G8 A0A8I3N952 A0A8I3N9B0 A0A8I3N9G3 A0A8I3NB03 A0A8I3NFB9 A0A8I3NH42 A0A8I3NKE8 A0A8I3NN65 A0A8I3NND5 A0A8I3NNJ9 A0A8I3NNW7 A0A8I3NP66 A0A8I3NPX1 A0A8I3NUC6 A0A8I3NUK8 A0A8I3NV30 A0A8I3NVA4 A0A8I3NW81 A0A8I3NXK9 A0A8I3NXV6 A0A8I3NZK9 A0A8I3P6M2 A0A8I3PB85 A0A8I3PBB2 A0A8I3PCE5 A0A8I3PCT4 A0A8I3PDR8 A0A8I3PF55 A0A8I3PF76 A0A8I3PGC3 A0A8I3PJW0 A0A8I3PKH4 A0A8I3PM01 A0A8I3PMA2 A0A8I3PME6 A0A8I3PVZ3 A0A8I3PZT2 A0A8I3Q3Z7 A0A8I3Q7I5 A0A8I3QV78 A0A8I3QYD0 A0A8I3RRR7 A0A8I3RT39 A0A8I3RU74 A0A8I3RV68 A0A8I3RXV3 A0A8I3RZF7 A0A8I3RZP6 A0A8I3S0X8 A0A8I3S1Z6 A0A8I3S6C6 A0A8I3S6Q5 A0A8I3SCV5 B8K1W7 P63050 Q5U820 Q5W412 Q5W416 Q6UR05	ABCA4 ABCA8 ABCB1 ABCB4 ABCB5 ABCB9 ABCC1 ABCC10 ABCC11 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC7 ABCC9 ABCF1 Abcc4 CFTR DERL1 DERL2 DERL3 EIF2S1 EIF2S2 EIF2S3 ERLEC1 ERLIN1 ERLIN2 KCNJ11 LOC100686569 LOC100687259 LOC610717 MRP1 OS9 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA7 PSMA8 PSMB1 PSMB10 PSMB2 PSMB3 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME4 PSMF1 RNF5 RPS27A SEL1L UBA52 UBB UBC UBCEP2 VCP	Canis familiaris (dog)
Drug-mediated inhibition of MET activation	Hepatocyte growth factor receptor Hepatocyte growth factor	A0A8I3NGY1 Q867B7	HGF MET	Canis familiaris (dog)
Macroautophagy	5'-AMP-activated protein kinase catalytic subunit alpha-2 5'-AMP-activated protein kinase subunit beta-1 5'-AMP-activated protein kinase subunit gamma-1 Association with the SNF1 complex (ASC) domain-containing protein Autophagy and beclin 1 regulator 1 Autophagy protein 5 Autophagy related 13 Autophagy related 14 Autophagy related 16 like 1 Autophagy-related protein 101 Autophagy-related protein 9 Autophagy-related protein 9 Beclin-1 Charged multivesicular body protein 2B Charged multivesicular body protein 2a Charged multivesicular body protein 3 Charged multivesicular body protein 4A Charged multivesicular body protein 4B Charged multivesicular body protein 4C Charged multivesicular body protein 7 Cysteine protease ATG4D Cysteine protease Cysteine protease Cysteine protease Dynein light chain Dynein light chain GABA type A receptor associated protein like 2 Gamma-aminobutyric acid receptor-associated protein Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Microtubule associated protein 1 light chain 3 gamma Myotubularin related protein 14 Neutral amino acid transporter 9 Phosphatidylinositol 3-kinase catalytic subunit type 3 Protein kinase AMP-activated non-catalytic subunit gamma 2 Protein kinase AMP-activated non-catalytic subunit gamma 3 RB1 inducible coiled-coil 1 Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras homolog, mTORC1 binding Ras-related GTP-binding protein Ras-related GTP-binding protein Ras-related GTP-binding protein Ras-related GTP-binding protein Regulatory associated protein of MTOR complex 1 Serine/threonine-protein kinase mTOR Serine/threonine-protein kinase TSC complex subunit 1 TSC complex subunit 2 Target of rapamycin complex subunit LST8 UV radiation resistance associated Ubiquitin-like modifier-activating enzyme ATG7 Ubiquitin-like protein ATG12 Ubiquitin-like-conjugating enzyme ATG10 Ubiquitin-like-conjugating enzyme ATG3 Uncharacterized protein WD repeat domain phosphoinositide-interacting protein 2 WD repeat domain phosphoinositide-interacting protein 3 WD repeat domain phosphoinositide-interacting protein 4 WD repeat domain, phosphoinositide interacting 1 non-specific serine/threonine protein kinase protein-tyrosine-phosphatase	A0A8I3MF29 A0A8I3MJG3 A0A8I3MPV7 A0A8I3MS83 A0A8I3MTF8 A0A8I3MUN9 A0A8I3MWD3 A0A8I3MX71 A0A8I3N241 A0A8I3N3R3 A0A8I3N683 A0A8I3N7J8 A0A8I3N8Z8 A0A8I3N9T9 A0A8I3NBC3 A0A8I3NDI3 A0A8I3NFM6 A0A8I3NIS5 A0A8I3NIZ5 A0A8I3NME4 A0A8I3NR33 A0A8I3NRH7 A0A8I3NTI1 A0A8I3NTN6 A0A8I3P1L5 A0A8I3P1V6 A0A8I3P1X3 A0A8I3P2D4 A0A8I3P766 A0A8I3PBL8 A0A8I3PFE0 A0A8I3PFM5 A0A8I3PK33 A0A8I3PLN8 A0A8I3PM06 A0A8I3PP92 A0A8I3PPE0 A0A8I3PS98 A0A8I3PT36 A0A8I3PTC5 A0A8I3PWP1 A0A8I3PY75 A0A8I3PYA9 A0A8I3PZS6 A0A8I3Q041 A0A8I3Q098 A0A8I3Q0F1 A0A8I3Q4C7 A0A8I3QAP4 A0A8I3QCJ3 A0A8I3QFN1 A0A8I3QXU8 A0A8I3QZ96 A0A8I3RS87 A0A8I3RU83 A0A8I3RW45 A0A8I3RWY6 A0A8I3RXW5 A0A8I3S4R4 A0A8I3S4Z7 A0A8I3S6E7 A0A8I3SA74 E2RDP2	AMBRA1 ATG10 ATG101 ATG12 ATG13 ATG14 ATG16L1 ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 ATG9A ATG9B BECN1 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP7 DYNLL1 DYNLL2 GABARAP GABARAPL2 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAP1LC3C MLST8 MTMR14 MTMR3 MTOR PIK3C3 PIK3R4 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RB1CC1 RHEB RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 TSC1 TSC2 ULK1 UVRAG WDR45 WDR45B WIPI1 WIPI2	Canis familiaris (dog)
Recycling of bile acids and salts	ABC-type glutathione-S-conjugate transporter Albumin Bile acid-CoA Bile salt export pump Ileal sodium/bile acid cotransporter Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor subfamily 1 group H member 4 Retinoic acid receptor RXR Solute carrier family 10 member 1 Solute carrier family 51 subunit alpha Solute carrier family 51 subunit beta Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member StAR related lipid transfer domain containing 5 long-chain-fatty-acid--CoA ligase	A0A8I3MAI7 A0A8I3MLS9 A0A8I3MY68 A0A8I3N1E1 A0A8I3N2S7 A0A8I3NIH7 A0A8I3NUI6 A0A8I3NXT1 A0A8I3PI53 A0A8I3PRC4 A0A8I3PYI4 A0A8I3Q2C1 A0A8I3RTD6 A0A8I3S0X8 B8K1W2 Q70HQ9	ABCC3 ALB Abcb11e BAAT BSEP NCOA1 NCOA2 NR1H4 RXRA SLC10A1 SLC10A2 SLC27A5 SLC51A SLC51B SLCO1A2 SLCO1B2 SLCO1B3 STARD5 slc10a2	Canis familiaris (dog)
Trafficking and processing of endosomal TLR	Canopy FGF signaling regulator 3 Cathepsin B Cathepsin S Endoplasmin Legumain Procathepsin L Toll like receptor 3 Toll like receptor 7 Toll like receptor 8 Toll-like receptor 9 Toll-like receptor 9 Unc-93 homolog B1, TLR signaling regulator	A0A8I3N2H5 A0A8I3NCE8 A0A8I3P6K4 A0A8I3P8U9 A0A8I3P903 A0A8I3PZY7 A0A8I3Q7B4 A0A8I3S0M3 A0A8I3SBE6 P41148 Q5I2M8 Q9GL24	CNPY3 CTSB CTSL CTSL1 CTSS GRP94 HSP90B1 HSPC4 LGMN TLR3 TLR7 TLR8 TLR9 TRA1 UNC93B1	Canis familiaris (dog)
Interferon gamma signaling	Fibronectin type-III domain-containing protein Interferon gamma Mitogen-activated protein kinase Mitogen-activated protein kinase Protein kinase C delta type Signal transducer and activator of transcription Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Y-box-binding protein 1 Y-box-binding protein 1 Y-box-binding protein 1 calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase	A0A8I3MY73 A0A8I3NIS8 A0A8I3NMP2 A0A8I3NPS8 A0A8I3NU62 A0A8I3NVH4 A0A8I3NXV5 A0A8I3PF62 A0A8I3PSA1 A0A8I3PWC6 A0A8I3PZJ7 A0A8I3PZP0 A0A8I3QCJ0 A0A8I3RQD0 A0A8I3RS40 A0A8I3RWC7 P42161	CAMK2A CAMK2B CAMK2G IFNG IFNGR1 IFNGR2 JAK1 JAK2 LOC479011 MAPK1 MAPK3 PRKCD PTPN6 SOCS3 STAT1 YBX1	Canis familiaris (dog)
GP1b-IX-V activation signalling	14-3-3 protein zeta/delta RAF proto-oncogene serine/threonine-protein kinase Tyrosine-protein kinase von Willebrand factor von Willebrand factor	A0A8I3PZA0 A0A8I3Q4Y8 A0A8I3SBF9 A0A8I3SCK0 Q28295	F8VWF RAF1 SRC VWF YWHAZ	Canis familiaris (dog)

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