GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **176 - 200** of **270** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Signaling by BMP	Bone morphogenetic protein 10 Bone morphogenetic protein 2 Cerberus 1, DAN family BMP antagonist Chordin like 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Follistatin-related protein 1 Gremlin Growth differentiation factor 2 Inhibin alpha chain Inhibin beta A chain Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Noggin Serine/threonine-protein kinase receptor Serine/threonine-protein kinase receptor Ski oncogene Transforming growth factor beta receptor 3 Ubiquitin conjugating enzyme E2 D3 Zinc finger FYVE domain-containing protein receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase	A0A7I8AUV5 A0A8I3MLM6 A0A8I3MRS8 A0A8I3MVJ8 A0A8I3N281 A0A8I3N723 A0A8I3N8R4 A0A8I3NCV3 A0A8I3NHH0 A0A8I3NM89 A0A8I3NU17 A0A8I3NW84 A0A8I3NYK2 A0A8I3NZI6 A0A8I3P2D1 A0A8I3P2Y0 A0A8I3P330 A0A8I3P4Q9 A0A8I3PB34 A0A8I3PG53 A0A8I3PG60 A0A8I3PPQ3 A0A8I3PZR5 A0A8I3Q270 A0A8I3QCM6 A0A8I3RR80 A0A8I3S5B1 A0A8I3S5W5 A0A8I3SCQ0	ACVR2A ACVR2B ACVRL1 BMP10 BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GDF2 GREM2 INHA INHBA NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 TGFBR3 UBE2D1 UBE2D3 ZFYVE16	Canis familiaris (dog)
Dermatan sulfate biosynthesis	Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 Decorin Dermatan sulfate epimerase like Dermatan sulfate epimerase Neurocan Uronyl 2-sulfotransferase Versican core protein	A0A8I3MK93 A0A8I3MZW8 A0A8I3N5J5 A0A8I3N8Z0 A0A8I3NUF9 A0A8I3NUZ7 A0A8I3P874 A0A8I3PDW3 A0A8I3PHY6 Q29393	BCAN BGN CSPG4 CSPG5 DCN DCN1C DSE DSEL NCAN UST VCAN	Canis familiaris (dog)
Phospholipase C-mediated cascade; FGFR2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Multifunctional fusion protein Uncharacterized protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P6D2 A0A8I3PJY6 A0A8I3SAY5 A0A8I3SCI7 E2REX2 J9P0B3 J9P3I7 J9P8K0 P79150 Q20FD0	FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 KGF PLCG1	Canis familiaris (dog)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	protein-ribulosamine 3-kinase protein-ribulosamine 3-kinase	A0A8I3PPB5 A0A8I3S5V4	FN3K FN3KRP	Canis familiaris (dog)
Regulation of Glucokinase by Glucokinase Regulatory Protein	Aladin WD repeat nucleoporin BIG2 domain-containing protein Glucokinase regulator Nuclear pore complex protein Nup85 Nuclear pore complex protein Nup93 Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex protein Nucleoporin 133 Nucleoporin 153 Nucleoporin 155 Nucleoporin 160 Nucleoporin 205 Nucleoporin 214 Nucleoporin 37 Nucleoporin 43 Nucleoporin 50 Nucleoporin 54 Nucleoporin 58 Nucleoporin 62 Nucleoporin 88 Nucleoporin NDC1 Nucleoporin NUP188 Nucleoporin NUP35 Nucleoporin NUP42 Nucleoprotein TPR POM121 transmembrane nucleoporin C Phosphotransferase Protein SEC13 homolog Uncharacterized protein	A0A8I3MJ67 A0A8I3MKP8 A0A8I3MMX0 A0A8I3MS44 A0A8I3MW92 A0A8I3MW93 A0A8I3MZ55 A0A8I3N5H9 A0A8I3N8Q5 A0A8I3N975 A0A8I3N9C4 A0A8I3NAH9 A0A8I3NAY7 A0A8I3NDG5 A0A8I3NIY6 A0A8I3NMR5 A0A8I3NQA4 A0A8I3NV53 A0A8I3NZW0 A0A8I3P0U9 A0A8I3P537 A0A8I3P769 A0A8I3PAE6 A0A8I3PBR9 A0A8I3PUC1 A0A8I3Q2U4 A0A8I3S484 A0A8I3S533 A0A8I3S9D7	AAAS GCK GCKR NDC1 NUP107 NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP42 NUP43 NUP50 NUP54 NUP58 NUP62 NUP85 NUP88 NUP93 NUP98 POM121C RANBP2 SEC13 TPR	Canis familiaris (dog)	G58161NS
VxPx cargo-targeting to cilium	ADP-ribosylation factor ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Cyclic nucleotide gated channel subunit alpha 4 Cyclic nucleotide gated channel subunit beta 1 Cyclic nucleotide-gated channel alpha-2 Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 5 Exocyst complex component 7 Exocyst complex component 8 Exocyst complex component Sec8 Exocyst complex component Golgi brefeldin A resistant guanine nucleotide exchange factor 1 Polycystin-2 RAB11 family interacting protein 3 RAB3A interacting protein Ras-related protein Rab-11A Ras-related protein Rab-8A Rhodopsin	A0A8I3MLB7 A0A8I3MLZ0 A0A8I3N510 A0A8I3NMX3 A0A8I3NS37 A0A8I3NTX3 A0A8I3NZH4 A0A8I3NZH6 A0A8I3P3F1 A0A8I3PAA1 A0A8I3PH62 A0A8I3PMI1 A0A8I3PN68 A0A8I3PQE3 A0A8I3PZW4 A0A8I3QBX3 A0A8I3QE57 A0A8I3S0B6 P61007 P62490	ARF4 ASAP1 CNGA2 CNGA4 CNGB1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 MEL PKD2 RAB11 RAB11A RAB11FIP3 RAB3IP RAB8 RAB8A RHO	Canis familiaris (dog)
Phase 0 - rapid depolarisation	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium voltage-gated channel auxiliary subunit gamma 4 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit	A0A8I3MK78 A0A8I3N7S8 A0A8I3NMX5 A0A8I3NPX9 A0A8I3P8U8 A0A8I3Q178 A0A8I3QY31 A0A8I3RTB9	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8	Canis familiaris (dog)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	B7-1 protein Brain-derived neurotrophic factor CD19 molecule CD86 molecule EGF-like domain-containing protein Epiregulin Estrogen receptor beta Estrogen receptor Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fms related receptor tyrosine kinase 3 ligand GRB2 associated binding protein 1 GRB2 associated binding protein 2 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Immediate early response 3 Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin Interleukin 1 receptor accessory protein Interleukin-1 receptor-associated kinase 4 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Kit Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 Neurotrophin-3 Neurotrophin-4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Phosphatidylinositol-4-phosphate 5-kinase type 1 beta Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Phosphatidylinositol-5-phosphate 4-kinase type 2 beta Phosphoinositide-3-kinase adaptor protein 1 Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Protein phosphatase 2 regulatory subunit B'beta Protein phosphatase 2 scaffold subunit Abeta Rac family small GTPase 2 Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase Serine/threonine-protein phosphatase Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Tyrosine-protein kinase receptor Tyrosine-protein kinase receptor Tyrosine-protein kinase receptor Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A0B4J199 A0A5F4C2B1 A0A7U3JWB8 A0A8I3MAV6 A0A8I3MIK6 A0A8I3MIK8 A0A8I3MIV9 A0A8I3MM61 A0A8I3MN72 A0A8I3MP09 A0A8I3MPF4 A0A8I3MQS1 A0A8I3MRL6 A0A8I3MS02 A0A8I3MT80 A0A8I3MU82 A0A8I3MVE7 A0A8I3MWU3 A0A8I3MZG1 A0A8I3N0H9 A0A8I3N488 A0A8I3N5M3 A0A8I3N821 A0A8I3N8J8 A0A8I3N8T5 A0A8I3N971 A0A8I3N9M7 A0A8I3NA65 A0A8I3NAC6 A0A8I3NAN8 A0A8I3NCP9 A0A8I3NEF4 A0A8I3NGY1 A0A8I3NH46 A0A8I3NH64 A0A8I3NHA2 A0A8I3NHF3 A0A8I3NIT3 A0A8I3NKX5 A0A8I3NLT7 A0A8I3NN81 A0A8I3NNZ2 A0A8I3NS74 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NU74 A0A8I3NV07 A0A8I3NVK5 A0A8I3NVV1 A0A8I3NVW9 A0A8I3NWK3 A0A8I3NXI8 A0A8I3NYK3 A0A8I3P2V4 A0A8I3P3M1 A0A8I3P3X1 A0A8I3P4L9 A0A8I3P519 A0A8I3P6D2 A0A8I3PB14 A0A8I3PJY6 A0A8I3PK39 A0A8I3PKX6 A0A8I3PMT9 A0A8I3PN81 A0A8I3PR42 A0A8I3PT69 A0A8I3PV99 A0A8I3PWD4 A0A8I3PWT3 A0A8I3PZJ3 A0A8I3PZP0 A0A8I3Q059 A0A8I3Q1C3 A0A8I3Q209 A0A8I3Q314 A0A8I3Q525 A0A8I3Q5L9 A0A8I3QXQ5 A0A8I3RPS3 A0A8I3RQD0 A0A8I3RRJ5 A0A8I3RRT3 A0A8I3RS70 A0A8I3RTN7 A0A8I3RXU6 A0A8I3RYJ5 A0A8I3S0I1 A0A8I3S0T0 A0A8I3S1W8 A0A8I3S333 A0A8I3S3N2 A0A8I3S8G3 A0A8I3SAY5 A0A8I3SBF9 E2REX2 J9P0B3 J9P3I7 J9P8K0 O97799 O97863 P01321 P62999 P79150 Q06220 Q20FD0 Q6Q7I7 Q7YR73 Q867B7 Q9TQX1	AILIM AREG BDNF BTC CD19 CD28 CD80 CD86 EGF EGFR EPGN ERBB2 ERBB3 ERBB4 EREG ESR1 ESR2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GRB2 HBEGF HGF ICOS IER3 IL1RAP IL33 INS INSR IRAK1 IRAK4 IRS1 IRS2 KGF KIT KITLG KL KLB LCK LOC100856339 MAPK1 MAPK3 MET MGF MYD88 NRG1 NRG2 NRG3 NTF3 NTF4 NTRK2 NTRK3 PDGFA PDGFB PDGFRA PDGFRB PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN11 RAC1 RAC2 RHOG SRC STRN TGFA TRAF6 TRAT1 VAV1	Canis familiaris (dog)
Assembly and cell surface presentation of NMDA receptors	Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Glutamate receptor Glutamate receptor Glutamate receptor Glutamate receptor	A0A8I3NNK2 A0A8I3NRD6 A0A8I3P9B8 A0A8I3RRH4 Q5R1P0 Q5R1P3	GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A NMDAR1	Canis familiaris (dog)
N-Glycan antennae elongation	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase MGAT4 family member C ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase beta-galactoside alpha-(2,6)-sialyltransferase	A0A8I3MKA0 A0A8I3N3C9 A0A8I3NB67 A0A8I3NFU6 A0A8I3NHI8 A0A8I3NXH0 A0A8I3P7V0 A0A8I3PUA8 A0A8I3Q3V7 A0A8I3Q406 A0A8I3RVK4 A0A8I3RVR8 A0A8I3RZ81 A0A8I3S1K5 A0A8I3S5C7	B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 COA5 MGAT4B MGAT4C MGAT5 ST3GAL4 ST6GAL1 ST8SIA2 ST8SIA3 ST8SIA6	Canis familiaris (dog)	G81533KY
Interleukin-3, Interleukin-5 and GM-CSF signaling	14-3-3 protein zeta/delta Colony stimulating factor 2 receptor subunit beta Fibronectin type-III domain-containing protein Granulocyte-macrophage colony-stimulating factor Interleukin 5 receptor subunit alpha Interleukin-3 Interleukin-5 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 SHC-transforming protein 1 Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Vav guanine nucleotide exchange factor 1 cAMP-dependent protein kinase catalytic subunit alpha phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3N971 A0A8I3N974 A0A8I3NA65 A0A8I3NBM3 A0A8I3NUU1 A0A8I3NVH4 A0A8I3P519 A0A8I3PBB4 A0A8I3PMT9 A0A8I3PRW9 A0A8I3PWC6 A0A8I3PWT3 A0A8I3Q4Y8 A0A8I3Q525 A0A8I3RVE7 A0A8I3RVV0 A0A8I3RX48 A0A8I3S3N2 P48749 Q95J76 Q9BDX4	CSF2 CSF2RA CSF2RB IL3 IL5 IL5RA JAK2 LOC100856339 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PRKACA PTPN11 PTPN6 SHC1 STAT5A STAT5B TEC VAV1 YWHAZ	Canis familiaris (dog)
Adenosine P1 receptors	Adenosine receptor A1 Adenosine receptor A2a Adenosine receptor A3	P11616 P11617 Q28309	ADORA1 ADORA2A ADORA3 RDC7 RDC8	Canis familiaris (dog)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho Multifunctional fusion protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3PJY6 A0A8I3SAY5 A0A8I3SCI7 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 KL PLCG1	Canis familiaris (dog)
Vitamin B5 (pantothenate) metabolism	4'-phosphopantetheine phosphatase Fatty acid synthase L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Mitochondrial coenzyme A transporter SLC25A42 PDZ domain-containing protein 11 Pantetheinase Solute carrier family 25 member 16 Solute carrier family 5 member 6	A0A8I3MUX5 A0A8I3MVX3 A0A8I3MY61 A0A8I3PCZ1 A0A8I3Q2U7 A0A8I3RQN4 A0A8I3S3J2 Q9TSX8	AASDHPPT FASN PANK4 PDZD11 SLC25A16 SLC25A42 SLC5A6 VNN1	Canis familiaris (dog)
O-glycosylation of TSR domain-containing proteins	A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAM metallopeptidase with thrombospondin type 1 motif 10 ADAM metallopeptidase with thrombospondin type 1 motif 12 ADAM metallopeptidase with thrombospondin type 1 motif 13 ADAM metallopeptidase with thrombospondin type 1 motif 14 ADAM metallopeptidase with thrombospondin type 1 motif 16 ADAM metallopeptidase with thrombospondin type 1 motif 17 ADAM metallopeptidase with thrombospondin type 1 motif 18 ADAM metallopeptidase with thrombospondin type 1 motif 19 ADAM metallopeptidase with thrombospondin type 1 motif 1 ADAM metallopeptidase with thrombospondin type 1 motif 20 ADAM metallopeptidase with thrombospondin type 1 motif 2 ADAM metallopeptidase with thrombospondin type 1 motif 3 ADAM metallopeptidase with thrombospondin type 1 motif 5 ADAM metallopeptidase with thrombospondin type 1 motif 6 ADAM metallopeptidase with thrombospondin type 1 motif 8 ADAM metallopeptidase with thrombospondin type 1 motif 9 ADAMTS like 1 ADAMTS like 2 ADAMTS like 4 Beta 3-glucosyltransferase Complement factor properdin GDP-fucose protein O-fucosyltransferase 2 NTR domain-containing protein SCO-spondin Semaphorin 5A Semaphorin 5B Somatomedin B and thrombospondin type 1 domain containing Spondin-1 Thrombospondin 1 Thrombospondin 2 Thrombospondin type 1 domain containing 7A Thrombospondin type 1 domain containing 7B Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein	A0A4D6CAB5 A0A8I3MD18 A0A8I3MIA8 A0A8I3MQ02 A0A8I3MRT7 A0A8I3MXQ6 A0A8I3MZ18 A0A8I3MZD5 A0A8I3N140 A0A8I3N1D3 A0A8I3N2T5 A0A8I3NA49 A0A8I3NAX6 A0A8I3NB75 A0A8I3NE19 A0A8I3NGS7 A0A8I3NK12 A0A8I3NKG0 A0A8I3NM21 A0A8I3NS78 A0A8I3P088 A0A8I3P1X0 A0A8I3P533 A0A8I3PA53 A0A8I3PBE9 A0A8I3PG52 A0A8I3PJ96 A0A8I3PJW2 A0A8I3PNR9 A0A8I3PPJ4 A0A8I3PPU8 A0A8I3PQZ5 A0A8I3PUQ0 A0A8I3Q3A2 A0A8I3Q4T9 A0A8I3Q9Y4 A0A8I3RTV1 A0A8I3S8L6	ADAMTS1 ADAMTS10 ADAMTS12 ADAMTS13 ADAMTS14 ADAMTS15 ADAMTS16 ADAMTS17 ADAMTS18 ADAMTS19 ADAMTS2 ADAMTS20 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS6 ADAMTS7 ADAMTS8 ADAMTS9 ADAMTSL1 ADAMTSL2 ADAMTSL4 ADAMTSL5 B3GLCT CFP POFUT2 SBSPON SEMA5A SEMA5B SH3GL3 SPON1 SPON2 SSPO THBS1 THBS2 THSD1 THSD7A THSD7B	Canis familiaris (dog)
The NLRP3 inflammasome	Heat shock protein HSP 90-beta MEFV innate immunity regulator, pyrin NACHT, LRR and PYD domains-containing protein 3 P2X purinoceptor PYD and CARD domain containing Pannexin Proline-serine-threonine phosphatase interacting protein 1 Thioredoxin-interacting protein Thioredoxin Uncharacterized protein	A0A8I3N9V3 A0A8I3ND03 A0A8I3NKV1 A0A8I3P020 A0A8I3PDQ2 A0A8I3PGK7 A0A8I3PV78 A0A8I3RQW6 A0A8I3RXE3 A0A8I3RYZ8	HSP90AB1 MEFV NLRP3 P2RX7 PANX PANX1 PSTPIP1 PYCARD SUGT1 TXN TXNIP	Canis familiaris (dog)
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cathepsin B Cathepsin D Collagen type XII alpha 1 chain Collagen type XIII alpha 1 chain Collagen type XIX alpha 1 chain Collagen type XV alpha 1 chain Collagen type XVIII alpha 1 chain Collagen type XXV alpha 1 chain Collagen type XXVI alpha 1 chain Collagenase 3 Matrix metallopeptidase 12 Matrix metallopeptidase 15 Matrix metallopeptidase 20 Matrix metallopeptidase 7 Matrix metallopeptidase 8 Matrix metalloproteinase-14 Matrix metalloproteinase-9 Stromelysin-1 Transmembrane serine protease 6 furin interstitial collagenase trypsin	A0A8I3MCQ8 A0A8I3MGS0 A0A8I3MJI6 A0A8I3MND9 A0A8I3MSY3 A0A8I3MWG8 A0A8I3MWY2 A0A8I3MX21 A0A8I3MXC2 A0A8I3N1T9 A0A8I3N1V6 A0A8I3N4V8 A0A8I3NL35 A0A8I3P478 A0A8I3PD99 A0A8I3PHE2 A0A8I3QKG6 A0A8I3RPH1 A0A8I3RPK2 A0A8I3RU13 A0A8I3RVF8 A0A8I3S0M3 Q4LAL9 Q6Y4Q5	COL12A1 COL13A1 COL15A1 COL18A1 COL19A1 COL25A1 COL26A1 CTSB CTSD FURIN MMP1 MMP12 MMP13 MMP14 MMP15 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 PHYKPL PRSS2 TMPRSS6	Canis familiaris (dog)
Sodium/Calcium exchangers	EF-hand domain-containing protein Sodium/calcium exchanger 1 Solute carrier family 24 member 2 Solute carrier family 24 member 3 Solute carrier family 24 member 4 Solute carrier family 24 member 5 Solute carrier family 8 member A2 Solute carrier family 8 member A3 Solute carrier family 8 member B1 Sorcin	A0A8I3MSQ7 A0A8I3MTJ5 A0A8I3NPM6 A0A8I3NX53 A0A8I3PDR2 A0A8I3PJY1 A0A8I3Q687 A0A8I3RTF4 A0A8I3RY81 P23685	CALM2 NCX1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI	Canis familiaris (dog)
MET activates PTPN11	GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Tyrosine-protein phosphatase non-receptor type	A0A8I3NGY1 A0A8I3NXI8 A0A8I3PMT9 A0A8I3PT69 Q867B7	GAB1 GRB2 HGF MET PTPN11	Canis familiaris (dog)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	B cell linker B-cell antigen receptor complex-associated protein alpha chain B-cell receptor CD22 CD19 molecule CD79a molecule CD79b molecule Cytoplasmic protein Dual adaptor of phosphotyrosine and 3-phosphoinositides 1 Growth factor receptor bound protein 2 Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Inositol 1,4,5-trisphosphate receptor Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide phospholipase C Phosphoinositide-3-kinase adaptor protein 1 SH3 domain containing kinase binding protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Short transient receptor potential channel 1 Stromal interaction molecule 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A8I3MIL9 A0A8I3MPF4 A0A8I3MUW4 A0A8I3N971 A0A8I3NA65 A0A8I3NKB2 A0A8I3NVL7 A0A8I3NWR3 A0A8I3NZG2 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P501 A0A8I3P6V2 A0A8I3P7Z3 A0A8I3P941 A0A8I3PD67 A0A8I3PDA6 A0A8I3PDU9 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PT69 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PW88 A0A8I3PWC6 A0A8I3PWK4 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PY14 A0A8I3PYF1 A0A8I3Q1C3 A0A8I3Q281 A0A8I3Q2P2 A0A8I3Q525 A0A8I3Q5C2 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3RWM0 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S3D9 A0A8I3S602 A0A8I3S6H5 A0A8I3S960 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 P0CAN6	BLNK BTK CD19 CD79A CD79B DAPP1 GRB2 IGHM ITPR1 ITPR2 ITPR3 MAG NCK1 PIK3AP1 PIK3CD PIK3R1 PLCG2 PTPN6 SH3KBP1 SOS1 STIM1 SYK TRPC1 VAV1	Canis familiaris (dog)
Gluconeogenesis	Beta-enolase Enolase 4 Fructose-1,6-bisphosphatase 1 Fructose-1,6-bisphosphatase isozyme 2 Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase Fructose-bisphosphate aldolase Glucose-6-phosphatase Glucose-6-phosphatase Glucose-6-phosphatase Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-phosphate dehydrogenase Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Phosphoglycerate kinase Phosphoglycerate kinase Phosphoglycerate mutase Phosphoglycerate mutase Pyruvate carboxylase Solute carrier family 37 member 1 Solute carrier family 37 member 2 Solute carrier family 37 member 4 Triosephosphate isomerase phosphoenolpyruvate carboxykinase (GTP) phosphopyruvate hydratase phosphopyruvate hydratase	A0A8I3MHK0 A0A8I3MJP4 A0A8I3MKD5 A0A8I3MKW3 A0A8I3MS60 A0A8I3MWF0 A0A8I3MZQ1 A0A8I3N1E7 A0A8I3N4J1 A0A8I3N504 A0A8I3ND17 A0A8I3NII5 A0A8I3NKZ1 A0A8I3NMJ6 A0A8I3P2U1 A0A8I3P9Y9 A0A8I3PK19 A0A8I3PRM7 A0A8I3PU48 A0A8I3PZE8 A0A8I3Q5N9 A0A8I3Q5Z0 A0A8I3QWQ0 A0A8I3RRW0 A0A8I3RTJ7 A0A8I3RYI2 A0A8I3S286 A0A8I3SC19	ALDOA ALDOB ALDOC ENO2 ENO3 ENO4 FBP1 FBP2 G6PC1 G6PC2 G6PC3 GAPDH GAPDHS GPI LOC106558132 PC PCK1 PCK2 PGAM1 PGAM2 PGK1 PGK2 SLC37A1 SLC37A2 SLC37A4 TPI1	Canis familiaris (dog)	G58161NS
RET signaling	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Docking protein 1 Docking protein 2 Docking protein 4 Docking protein 5 Docking protein 6 Fibroblast growth factor receptor substrate 2 GDNF family receptor alpha 4 GDNF family receptor alpha-1 GDNF family receptor alpha-2 GRB2 associated binding protein 1 GRB2 associated binding protein 2 Glial cell derived neurotrophic factor Growth factor receptor bound protein 10 Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Insulin receptor substrate 2 Mitogen-activated protein kinase Neurturin PDZ and LIM domain protein 7 Persephin Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Protein kinase C RAP1 GTPase activating protein Ret proto-onco SH3 and multiple ankyrin repeat domains 3 SHC adaptor protein 3 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A5F4C2B1 A0A8I3MGQ2 A0A8I3MHB6 A0A8I3MNH7 A0A8I3MVS5 A0A8I3N0M1 A0A8I3N7X4 A0A8I3N8L0 A0A8I3N971 A0A8I3N9M7 A0A8I3NBK6 A0A8I3NID0 A0A8I3NUU1 A0A8I3NXI8 A0A8I3P1P0 A0A8I3P4L9 A0A8I3P519 A0A8I3P721 A0A8I3PIF6 A0A8I3PMT9 A0A8I3PQ79 A0A8I3PRW9 A0A8I3PT69 A0A8I3PUQ8 A0A8I3PW06 A0A8I3PWT3 A0A8I3Q1A9 A0A8I3Q244 A0A8I3Q525 A0A8I3QCB4 A0A8I3QHK6 A0A8I3S0I1 A0A8I3S0X9 A0A8I3S3D9 A0A8I3S3N2 A0A8I3SBF9 A0A8I3SCI7 E2R534	DBN1 DOK1 DOK2 DOK4 DOK5 DOK6 FRS2 GAB1 GAB2 GDNF GFRA1 GFRA2 GFRA4 GRB10 GRB2 GRB7 IRS2 LOC100856339 MAPK7 NRTN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PLCG1 PRKACA PRKACB PRKCA PSPN PTPN11 RAP1GAP RET SHANK3 SHC1 SHC3 SOS1 SRC	Canis familiaris (dog)
Scavenging by Class A Receptors	Apolipoprotein A-I Apolipoprotein B Apolipoprotein E Calreticulin Endoplasmin Macrophage receptor with collagenous structure Macrophage scavenger receptor 1 Secretoglobin family 3A member 2	A0A8I3MSG4 A0A8I3NM03 A0A8I3NVT5 A0A8I3PTI1 A0A8I3QIL7 A0A8I3S4D1 P18649 P41148	APOA1 APOB APOE CALR GRP94 HSP90B1 HSPC4 MARCO MSR1 SCGB3A2 TRA1	Canis familiaris (dog)
PI-3K cascade:FGFR1	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Klotho Multifunctional fusion protein Phosphatidylinositol 3-kinase regulatory subunit alpha Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0B4J199 A0A5F4C2B1 A0A7U3JWB8 A0A8I3MP09 A0A8I3N971 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NXI8 A0A8I3NYK3 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FRS2 GAB1 GRB2 KL PIK3CA PIK3R1 PTPN11	Canis familiaris (dog)
Negative regulation of FGFR1 signaling	Anosmin 1 E3 ubiquitin-protein ligase CBL Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor bound protein 2 Klotho Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MBU4 A0A8I3MMN5 A0A8I3MP09 A0A8I3NFB9 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3PZP0 A0A8I3QYD0 A0A8I3RQD0 A0A8I3S906 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 P63050 Q20FD0	ANOS1 CBL FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FRS2 GRB2 KL MAPK1 MAPK3 PTPN11 RPS27A UBA52 UBB UBC UBCEP2	Canis familiaris (dog)

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