GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **201 - 225** of **268** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Regulation of expression of SLITs and ROBOs	Dystroglycan 1 Slit guidance ligand 2	A0A8I3NQC4 Q9TSZ6	DAG1 SLIT2	Canis familiaris (dog)
Regulation of insulin secretion	ATP binding cassette subfamily C member 8 ATP-sensitive inward rectifier potassium channel 11 Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Rap guanine nucleotide exchange factor 3 Rap guanine nucleotide exchange factor 4 Solute carrier family 2, facilitated glucose transporter member 1 Solute carrier family 2, facilitated glucose transporter member 2 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha Voltage-dependent R-type calcium channel subunit alpha cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase	A0A8I3MU54 A0A8I3N0M1 A0A8I3NPX9 A0A8I3NRK7 A0A8I3NVA4 A0A8I3P8U8 A0A8I3PMW4 A0A8I3PRW9 A0A8I3PW63 A0A8I3PZ28 A0A8I3Q2Z6 A0A8I3Q3U9 A0A8I3QY31 A0A8I3S0T4 A0A8I3S464	ABCC8 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 KCNJ11 PRKACA PRKACB RAPGEF3 RAPGEF4 SLC2A1 SLC2A2	Canis familiaris (dog)	G58161NS
Relaxin receptors	Insulin-like 3 Relaxin 2 Relaxin family peptide receptor 1 Relaxin family peptide receptor 3 Relaxin receptor 2 Relaxin-3	A0A8I3NLX3 A0A8I3PPP9 A0A8I3RPW6 A0A8I3RZ39 Q5XM32 Q6X7V3	INSL3 LGR8 RLF RLN2 RLN3 RXFP1 RXFP2 RXFP3	Canis familiaris (dog)
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Coagulation factor IX Coagulation factor VII Coagulation factor X Growth arrest specific 6 Osteocalcin Prothrombin Vitamin K-dependent protein C Vitamin K-dependent protein S furin	A0A8I3N1T9 A0A8I3N921 A0A8I3PQV5 A0A8I3PUT1 A0A8I3Q1K1 A0A8I3QAV8 A0A8I3S489 A0A8I3SCE7 Q28278	BGLAP F10 F2 F7 F9 FURIN GAS6 PROC PROS1	Canis familiaris (dog)
Response to elevated platelet cytosolic Ca2+	Protein kinase C Protein kinase C Protein kinase C	A0A8I3MI53 A0A8I3PUQ8 E2R2X3	PRKCA PRKCB PRKCG	Canis familiaris (dog)
Reuptake of GABA	Sodium- and chloride-dependent betaine transporter Solute carrier family 6 member 13 Transporter Transporter	A0A8I3N6A1 A0A8I3Q066 A0A8I3RV00 P27799	SLC6A1 SLC6A11 SLC6A12 SLC6A13	Canis familiaris (dog)
Rhesus glycoproteins mediate ammonium transport.	Ammonium transporter Rh type A Ammonium transporter Rh type B Ammonium transporter Rh type C	A0A8I3MHG4 A0A8I3MZM2 Q4VUI0	RHAG RHBG RHCG	Canis familiaris (dog)
Role of phospholipids in phagocytosis	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 5'-3' exonuclease PLD3 Fc fragment of IgG receptor Ia Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide phospholipase C Phosphoinositide-3-kinase regulatory subunit 2 Phospholipase Phospholipase Phospholipid phosphatase 4 Protein kinase C delta type Protein kinase C epsilon type T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phospholipase A2	A0A5F4C2B1 A0A8I3MFY1 A0A8I3MMY6 A0A8I3MQR0 A0A8I3MV98 A0A8I3N971 A0A8I3NEM6 A0A8I3NWR3 A0A8I3NYY2 A0A8I3NZG2 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P941 A0A8I3PAT0 A0A8I3PCM7 A0A8I3PD67 A0A8I3PDU9 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PWT0 A0A8I3PWT3 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3PZJ7 A0A8I3Q258 A0A8I3Q590 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3QHH1 A0A8I3QQ00 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S3N2 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 A0A8I3SCI7 E2RP87	CD247 CD3G FCGR1A FCGR2B FCGR3A LOC478984 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PLPP4 PLPP5 PRKCD PRKCE SYK	Canis familiaris (dog)
SHC-mediated cascade:FGFR1	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Klotho Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NKX5 A0A8I3NNZ2 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3NYK3 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 Q20FD0	FGF1 FGF10 FGF17 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF5 FGF6 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 GRB2 HRAS KL KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
SHC-mediated cascade:FGFR2	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Uncharacterized protein small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3MP09 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3NYK3 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 J9P8K0 P79150 Q20FD0	FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 GRB2 HRAS KGF KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor bound protein 2 Multifunctional fusion protein SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Uncharacterized protein small monomeric GTPase	A0A0B4J199 A0A7U3JWB8 A0A8I3MIK8 A0A8I3NHF3 A0A8I3NS74 A0A8I3NTD6 A0A8I3NUU1 A0A8I3NV07 A0A8I3PJY6 A0A8I3PSP7 A0A8I3PT69 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3S3D9 A0A8I3SAY5 J9P0B3 J9P3I7 J9P8K0 Q20FD0	FGF1 FGF16 FGF17 FGF18 FGF20 FGF23 FGF3A FGF4 FGF4B FGF4C FGF5 FGF7A FGF8 FGF8B FGF9 FGFR3 GRB2 HRAS KRAS NRAS SHC1 SOS1	Canis familiaris (dog)
Scavenging by Class A Receptors	Apolipoprotein A-I Apolipoprotein B Apolipoprotein E Calreticulin Endoplasmin Macrophage receptor with collagenous structure Macrophage scavenger receptor 1 Secretoglobin family 3A member 2	A0A8I3MSG4 A0A8I3NM03 A0A8I3NVT5 A0A8I3PTI1 A0A8I3QIL7 A0A8I3S4D1 P18649 P41148	APOA1 APOB APOE CALR GRP94 HSP90B1 HSPC4 MARCO MSR1 SCGB3A2 TRA1	Canis familiaris (dog)
Sensory perception of sweet, bitter, and umami (glutamate) taste	Bitter taste receptor T2R43 G protein subunit alpha transducin 3 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Inositol 1,4,5-trisphosphate receptor Taste 1 receptor member 1 Taste receptor type 1 member 3 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2	A0A8I3NKU5 A0A8I3PJF2 A0A8I3PQY2 A0A8I3PRQ9 A0A8I3Q2P2 A0A8I3Q7L4 A0A8I3QV74 A0A8I3S925 A0A8I3S929 A0A8I3SCV7 P62872 P79147 Q2ABD0 Q2ABD1 Q2ABD4 Q2ABD5 Q2ABD6 Q2ABD8 Q2ABE0	CAFA-T2R43 GNAT3 GNB1 GNB3 GNG13 ITPR3 LOC100682759 TAS1R1 TAS1R3 TAS2R1 TAS2R10 TAS2R3 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R5 TAS2R7	Canis familiaris (dog)	G58161NS
Serotonin receptors	5-hydroxytryptamine receptor 1A 5-hydroxytryptamine receptor 1B 5-hydroxytryptamine receptor 1D 5-hydroxytryptamine receptor 1E 5-hydroxytryptamine receptor 1F 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine receptor 2B 5-hydroxytryptamine receptor 2C 5-hydroxytryptamine receptor 4 5-hydroxytryptamine receptor 5A 5-hydroxytryptamine receptor 7 G-protein coupled receptors family 1 profile domain-containing protein	A0A8I3MN28 A0A8I3N6U6 A0A8I3NAA7 A0A8I3NLJ6 A0A8I3NMV4 A0A8I3PC67 A0A8I3RXP5 A0A8I3S1Q6 A0A8I3S5I1 A0A8I3S709 O46635 P79250	5-HTR2A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7	Canis familiaris (dog)
Sialic acid metabolism	Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Beta-galactosidase Beta-galactoside alpha-2,6-sialyltransferase 2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Carboxypeptidase Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Lactosylceramide alpha-2,3-sialyltransferase N-acetylneuraminate lyase N-acetylneuraminate synthase N-acylneuraminate cytidylyltransferase ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Sialidase-1 Solute carrier family 17 member 5 Solute carrier family 35 member A1 Type 2 lactosamine alpha-2,3-sialyltransferase Uncharacterized protein alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase beta-galactoside alpha-(2,6)-sialyltransferase exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase	A0A8I3MKA0 A0A8I3MMF0 A0A8I3MQ19 A0A8I3MQZ3 A0A8I3MRB4 A0A8I3MRS4 A0A8I3MSL1 A0A8I3MWM9 A0A8I3MZA8 A0A8I3N2X1 A0A8I3N3C9 A0A8I3N9F9 A0A8I3NB27 A0A8I3NB67 A0A8I3NFK8 A0A8I3NHI8 A0A8I3NN43 A0A8I3NNC5 A0A8I3NR40 A0A8I3NVQ5 A0A8I3P0Y9 A0A8I3P9I7 A0A8I3PBB8 A0A8I3PGV9 A0A8I3Q6S3 A0A8I3RSF2 A0A8I3RV22 A0A8I3RWY3 A0A8I3RZ95 A0A8I3S0P4 A0A8I3S2B0 A0A8I3S5C7 Q9TRY9	CMAS CTSA GLB1 GNE NANP NANS NEU1 NEU2 NEU3 NEU4 NPL SLC17A5 SLC35A1 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6	Canis familiaris (dog)
Signaling by BMP	Bone morphogenetic protein 10 Bone morphogenetic protein 2 Cerberus 1, DAN family BMP antagonist Chordin like 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Follistatin-related protein 1 Gremlin Growth differentiation factor 2 Inhibin alpha chain Inhibin beta A chain Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Noggin Serine/threonine-protein kinase receptor Serine/threonine-protein kinase receptor Ski oncogene Transforming growth factor beta receptor 3 Ubiquitin conjugating enzyme E2 D3 Zinc finger FYVE domain-containing protein receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase	A0A7I8AUV5 A0A8I3MLM6 A0A8I3MRS8 A0A8I3MVJ8 A0A8I3N281 A0A8I3N723 A0A8I3N8R4 A0A8I3NCV3 A0A8I3NHH0 A0A8I3NM89 A0A8I3NU17 A0A8I3NW84 A0A8I3NYK2 A0A8I3NZI6 A0A8I3P2D1 A0A8I3P2Y0 A0A8I3P330 A0A8I3P4Q9 A0A8I3PB34 A0A8I3PG53 A0A8I3PG60 A0A8I3PPQ3 A0A8I3PZR5 A0A8I3Q270 A0A8I3QCM6 A0A8I3RR80 A0A8I3S5B1 A0A8I3S5W5 A0A8I3SCQ0	ACVR2A ACVR2B ACVRL1 BMP10 BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GDF2 GREM2 INHA INHBA NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 TGFBR3 UBE2D1 UBE2D3 ZFYVE16	Canis familiaris (dog)
Signaling by Insulin receptor	Insulin Tyrosine-protein kinase receptor	A0A8I3PWD4 P01321	INS INSR	Canis familiaris (dog)
Signaling by PDGF	Collagen type IV alpha 1 chain Collagen type IV alpha 2 chain Collagen type IV alpha 3 chain Collagen type IV alpha 4 chain Collagen type IV alpha 5 chain Collagen type IX alpha 1 chain Collagen type IX alpha 2 Collagen type IX alpha 3 chain Plasminogen Platelet-derived growth factor C Platelet-derived growth factor D Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Secreted phosphoprotein 1 Thrombospondin 1 Thrombospondin 2 Thrombospondin 3 Thrombospondin 4 furin protein-tyrosine-phosphatase t-plasminogen activator	A0A8I3MF27 A0A8I3MGR1 A0A8I3MW94 A0A8I3N1T9 A0A8I3N488 A0A8I3NAN8 A0A8I3NB75 A0A8I3NC04 A0A8I3NEF4 A0A8I3NEX5 A0A8I3NL86 A0A8I3NM06 A0A8I3NMW4 A0A8I3NXU0 A0A8I3P1W2 A0A8I3P613 A0A8I3P8B9 A0A8I3PDX7 A0A8I3PJI8 A0A8I3PPU8 A0A8I3S0U4 E2DP67 Q6Q7I7	COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL9A1 COL9A2 COL9A3 FURIN PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PLAT PLG PTPN12 SPP1 THBS1 THBS2 THBS3 THBS4	Canis familiaris (dog)
Signaling by ROBO receptors	Glypican-1 Slit guidance ligand 2 Slit guidance ligand 3	A0A8I3MRE2 A0A8I3NQC4 A0A8I3Q4U0	GPC1 SLIT2 SLIT3	Canis familiaris (dog)
Signaling by SCF-KIT	Chymase GRB2 associated binding protein 2 GRB2 related adaptor protein 2 GRB2 related adaptor protein GTPase HRas GTPase NRas Growth factor receptor bound protein 10 Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Kit ligand Mast/stem cell growth factor receptor Kit Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Protein kinase C Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Vav guanine nucleotide exchange factor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase protein-tyrosine-phosphatase small monomeric GTPase	A0A5F4C2B1 A0A8I3MAK5 A0A8I3MKV4 A0A8I3ML64 A0A8I3MW46 A0A8I3N971 A0A8I3N974 A0A8I3N9M7 A0A8I3NA65 A0A8I3NAC6 A0A8I3NB92 A0A8I3NBK6 A0A8I3NBM3 A0A8I3NH46 A0A8I3NID0 A0A8I3NVH4 A0A8I3P3X1 A0A8I3P478 A0A8I3P519 A0A8I3P5U0 A0A8I3P6Q8 A0A8I3PMT9 A0A8I3PSA1 A0A8I3PSP7 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3RV66 A0A8I3RVE7 A0A8I3S3D9 A0A8I3S3N2 A0A8I3SBF9 O97799 P21842 P62999 Q06220	CHEK1 CMA1 FER FES FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 HRAS JAK2 KIT KITLG KRAS LCK LOC100856339 LYN MGF MMP9 NRAS PIK3CA PIK3R1 PIK3R2 PRKCA PTPN11 PTPRU RAC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 YES1	Canis familiaris (dog)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Cartilage intermediate layer protein Insulin-like growth factor I Insulin-like growth factor II Tyrosine-protein kinase receptor	A0A8I3NI15 A0A8I3RQ77 A0A8I3S512 P33712	CILP IGF1 IGF1R IGF2 IGFIA	Canis familiaris (dog)
Sodium/Calcium exchangers	EF-hand domain-containing protein Sodium/calcium exchanger 1 Solute carrier family 24 member 2 Solute carrier family 24 member 3 Solute carrier family 24 member 4 Solute carrier family 24 member 5 Solute carrier family 8 member A2 Solute carrier family 8 member A3 Solute carrier family 8 member B1 Sorcin	A0A8I3MSQ7 A0A8I3MTJ5 A0A8I3NPM6 A0A8I3NX53 A0A8I3PDR2 A0A8I3PJY1 A0A8I3Q687 A0A8I3RTF4 A0A8I3RY81 P23685	CALM2 NCX1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI	Canis familiaris (dog)
Sphingolipid de novo biosynthesis	3-dehydrosphinganine reductase Broad substrate specificity ATP-binding cassette transporter ABCG2 Ceramide synthase 1 Ceramide synthase 2 Ceramide synthase 3 Ceramide synthase 4 Ceramide synthase 5 Ceramide synthase 6 Cytochrome b5 heme-binding domain-containing protein Delta 4-desaturase, sphingolipid 2 Fatty acid 2-hydroxylase Major facilitator superfamily domain containing 2B Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 ORM1-like protein ORM1-like protein ORM1-like protein SPNS lysolipid transporter 2, sphingosine-1-phosphate Serine palmitoyltransferase 1 Serine palmitoyltransferase long chain base subunit 2 Serine palmitoyltransferase long chain base subunit 3 Sphingolipid delta(4)-desaturase DES1 Sphingomyelin synthase 2 Sphingosine kinase 1 Sphingosine kinase 2 Sterile alpha motif domain containing 8 Uncharacterized protein Uncharacterized protein	A0A8I3MDB1 A0A8I3MDX2 A0A8I3MH69 A0A8I3MTG4 A0A8I3MVV0 A0A8I3MZT5 A0A8I3N0C8 A0A8I3N1I8 A0A8I3N6A8 A0A8I3N8H8 A0A8I3NCL9 A0A8I3NE51 A0A8I3NF48 A0A8I3P1Y0 A0A8I3P1Z6 A0A8I3P4B7 A0A8I3PAM7 A0A8I3PG24 A0A8I3PM33 A0A8I3PMG7 A0A8I3PQ53 A0A8I3Q2P7 A0A8I3S0D0 A0A8I3S194 A0A8I3S6X3 A0A8I3S790 B3RFJ1 Q6UR05	ABCC1 ABCG2 Abcg2 CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CYB5B DEGS1 DEGS2 FA2H KDSR MFSD2B MRP1 ORMDL1 ORMDL2 ORMDL3 SAMD8 SGMS1 SGMS2 SPHK1 SPHK2 SPNS2 SPTLC1 SPTLC2 SPTLC3 SPTSSA	Canis familiaris (dog)
Stimuli-sensing channels	Acid sensing ion channel subunit 1 Acid sensing ion channel subunit 2 Acid sensing ion channel subunit 3 Acid sensing ion channel subunit family member 4 Acid sensing ion channel subunit family member 5 Amiloride-sensitive sodium channel subunit alpha Amiloride-sensitive sodium channel subunit beta Amiloride-sensitive sodium channel subunit gamma Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Anoctamin Aspartate beta-hydroxylase Barttin CLCNK type accessory subunit beta Bestrophin Bestrophin Bestrophin Bestrophin Calcium-activated chloride channel regulator 1 Chloride channel accessory 2 Chloride channel accessory 4 Chloride channel protein 1 Chloride channel protein 2 Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Chloride channel protein Chloride intracellular channel protein E3 ubiquitin-protein ligase EF-hand domain-containing protein HECT-type E3 ubiquitin transferase Osteoclastogenesis associated transmembrane protein 1 Protein tweety homolog Protein tweety homolog Protein tweety homolog RAF proto-oncogene serine/threonine-protein kinase Ryanodine receptor 1 Ryanodine receptor 2 Ryanodine receptor 3 Serine/threonine-protein kinase Sgk1 Serum/glucocorticoid regulated kinase family, member 3 Sodium channel epithelial 1 subunit delta Sodium leak channel, non-selective Solute carrier family 17 member 3 Solute carrier family 9 member B1 Solute carrier family 9 member B2 Solute carrier family 9 member C2 (putative) Sorcin Stomatin like 3 Stomatin Triadin Two pore segment channel 1 Two pore segment channel 2 Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Unc-79 homolog, NALCN channel complex subunit Unc-80 homolog, NALCN channel complex subunit peptidylprolyl isomerase	A0A8I3M9N6 A0A8I3MIG8 A0A8I3MK25 A0A8I3MKE6 A0A8I3MKT6 A0A8I3MMN5 A0A8I3MSQ7 A0A8I3MT21 A0A8I3MUX4 A0A8I3MXS3 A0A8I3N0C5 A0A8I3N0E7 A0A8I3N106 A0A8I3N6S0 A0A8I3N726 A0A8I3NAC3 A0A8I3NFB9 A0A8I3NH80 A0A8I3NHZ8 A0A8I3NKC4 A0A8I3NSX7 A0A8I3NUI9 A0A8I3NXW9 A0A8I3NYL1 A0A8I3P370 A0A8I3P4T9 A0A8I3P560 A0A8I3P659 A0A8I3P6A5 A0A8I3P7M3 A0A8I3P948 A0A8I3PAS7 A0A8I3PCD4 A0A8I3PDN2 A0A8I3PET1 A0A8I3PGN5 A0A8I3PJ01 A0A8I3PJ21 A0A8I3PJD4 A0A8I3PNF9 A0A8I3PP54 A0A8I3PRH5 A0A8I3PSM5 A0A8I3PV66 A0A8I3PY43 A0A8I3PZA0 A0A8I3Q0B9 A0A8I3Q0M9 A0A8I3Q2P4 A0A8I3Q383 A0A8I3Q4Q6 A0A8I3Q679 A0A8I3Q886 A0A8I3Q8P6 A0A8I3Q8R4 A0A8I3QA03 A0A8I3QXX9 A0A8I3QYD0 A0A8I3RQJ2 A0A8I3RSF1 A0A8I3RW06 A0A8I3RY81 A0A8I3RZ58 A0A8I3S651 A0A8I3SA78 P63050 Q9MZT1	ANO1 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ASPH BEST1 BEST2 BEST3 BEST4 BSND CALM2 CLCA1 CLCA2 CLCA4 CLCN1 CLCN2 CLCN4 CLCN5 CLCN6 CLCN7 CLCNK CLCNKA CLIC2 LOC119880472 NALCN NEDD4L OSTM1 RAF1 RPS27A RYR1 RYR2 RYR3 SCNN1A SCNN1B SCNN1D SCNN1G SGK1 SGK3 SLC17A2 SLC9B1 SLC9B2 SLC9C2 SRI STOM STOML3 TPCN1 TPCN2 TRDN TTYH1 TTYH2 TTYH3 UBA52 UBB UBC UBCEP2 UNC79 UNC80 WWP1	Canis familiaris (dog)
Surfactant metabolism	ATP binding cassette subfamily A member 3 Adenosine receptor A2a Adhesion G protein-coupled receptor F5 Alpha-2A adrenergic receptor Alpha-2C adrenergic receptor C-type lectin domain-containing protein Coiled-coil domain containing 59 Colony stimulating factor 2 receptor subunit beta Cytoskeleton associated protein 4 Fibronectin type-III domain-containing protein GATA binding protein 6 LIM and cysteine rich domains 1 Napsin A aspartic peptidase P2Y purinoceptor 2 Palmitoyltransferase Pepsin A Pro-cathepsin H Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C SRCR domain-containing protein Sodium-dependent phosphate transport protein 2A Sodium-dependent phosphate transport protein 2B Transcription termination factor 1 Uncharacterized protein	A0A8I3MSD7 A0A8I3MZ62 A0A8I3NCW6 A0A8I3NFK5 A0A8I3NFY6 A0A8I3NHV8 A0A8I3NQ93 A0A8I3NR35 A0A8I3NUR4 A0A8I3NUT9 A0A8I3NWG1 A0A8I3NWJ3 A0A8I3NXR2 A0A8I3NZU4 A0A8I3P3J7 A0A8I3PBB4 A0A8I3PJM9 A0A8I3Q7S8 A0A8I3RTH9 A0A8I3RVV0 A0A8I3RW10 A0A8I3S9H9 P11617 Q9GMY6	ABCA3 ADGRF5 ADORA2A ADRA2A ADRA2C CCDC59 CKAP4 CSF2RA CSF2RB CTSH GATA6 LMCD1 LOC610540 NAPSA P2RY2 PGA PGNA RDC8 SFTPB SFTPC SFTPD SLC34A1 SLC34A2 TTF1 ZDHHC2	Canis familiaris (dog)

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