GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **126 - 150** of **360** in total

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Pathway Name ▼	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Platelet Aggregation (Plug Formation)	Glycoprotein IX platelet Glycoprotein Ib platelet subunit beta Glycoprotein V platelet Prothrombin von Willebrand factor	B7TY21 B7TY22 F1SIB1 F1SL22 K7GN20	F2 GP1BB GP5 GP9 GPIX GPIbB VWF	Sus scrofa (pig)
Phosphorylation of CD3 and TCR zeta chains	Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II DR-alpha MHC class II antigen MHC class II histocompatibility antigen SLA-DRB1 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 SLA class II histocompatibility antigen, DQ haplotype D alpha chain SLA-DQ beta1 domain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A286ZKB7 A0A286ZUJ9 A0A287AC24 A0A287AT33 A0A287B968 A0A287BD80 A0A287BF11 A0A287BQ31 A0A5G2QCN4 A0A8W4F9V5 A0A8W4FBN9 A0A8W4FJW4 A0A8W4FNK4 A0A8W4FP49 A0A8X9AEU9 F1RXA1 F1S5F1 F1S6S1 F1S975 F1SJ27 F1SV94 I3L556 I3LAQ5 K7GS60 P15981 Q5PXD3 Q764N2 Q7YQ94 Q85ZW4	CD247 CD3D CD3E CD3G CD4 CSK DRA HLA-DRA LCK LOC100153139 PAG1 PTPN22 PTPRC SLA-DQA SLA-DQA1 SLA-DQB1 SLA-DR SLA-DRA SLA-DRA1 SLA-DRB1	Sus scrofa (pig)
Phospholipase C-mediated cascade; FGFR4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho beta Multifunctional fusion protein	A0A287AFX3 A0A287AXR0 A0A287B3V5 A0A287BGK8 A0A5G2QUY7 A0A5G2R7G2 F1RM38 F1RY80 F1S3B8 F1SDV6 F1SET9 I3L560 I3LR27 Q95L12	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 Fgf4 KLB PLCG1	Sus scrofa (pig)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho Multifunctional fusion protein	A0A287AAE4 A0A287AFX3 A0A287AXR0 A0A287BG34 A0A287BGK8 A0A5G2R7G2 F1RM38 F1RSR6 F1RY78 F1RY80 F1SDV6 F1SET9 F1SMG2 K7GQJ1 Q95L12	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 Fgf4 KL PLCG1	Sus scrofa (pig)
Phase I - Functionalization of compounds	Aldehyde dehydrogenase Amine oxidase Amine oxidase Amine oxidase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor repressor Aryl hydrocarbon receptor Arylacetamide deacetylase Biphenyl hydrolase like Carbonyl reductase (NADPH) Carboxylesterase 1 Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxymethylenebutenolidase homolog Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 family 2 subfamily B member 6B Cytochrome b5 type B Diamine oxidase [copper-containing] Epoxide hydrolase 1 Epoxide hydrolase Mitochondrial amidoxime reducing component 2 Mitochondrial amidoxime-reducing component 1 N-ribosyldihydronicotinamide NADH-cytochrome b5 reductase	A0A286ZIQ2 A0A286ZKL1 A0A286ZPA0 A0A287A6V9 A0A287A8N2 A0A287ALY1 A0A287AXR4 A0A287B6R1 A0A287B7I8 A0A2C9F385 A0A480K1W5 A0A5G2QPB6 A0A5G2QRH6 A0A5G2QSC0 A0A5G2QWJ0 A0A5G2RD43 A0A5G2REZ9 F1RF16 F1RWY7 F1S1G7 F1S9I9 F1SDC4 F1SGX4 I3LA57 I3LEX8 I3LF82 P79381 Q9TRC7	AADAC ABP AHR AHRR ALDH3A1 AOC1 AOC2 ARNT ARNT2 BPHL CBR3 CES1 CES3 CMBL CYB5B CYB5R3 CYP2B6B CYP3A22 CYP3A227 CYP3A29 DAO EPHX1 LOC100520329 LOC100736962 LOC110256000 MTARC1 MTARC2 NQO2	Sus scrofa (pig)
Phase 4 - resting membrane potential	ATP-sensitive inward rectifier potassium channel 12 isoform X1 ATP-sensitive inward rectifier potassium channel 14 Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 Potassium channel subfamily K member 10 isoform 2 Potassium channel subfamily K member 12 Potassium channel subfamily K member 13 Potassium channel subfamily K member 5 Potassium channel subfamily K member Potassium channel subfamily K member Potassium channel subfamily K member Potassium channel subfamily K member Potassium channel subfamily K member Potassium two pore domain channel subfamily K member 15 Potassium two pore domain channel subfamily K member 16 Potassium two pore domain channel subfamily K member 17 Potassium two pore domain channel subfamily K member 4	A0A286ZMZ4 A0A287A5K0 A0A287A685 A0A287AIG4 A0A287AWU0 A0A287B0A6 F1RGV1 F1RL84 F1RQN9 F1RRI8 F1RVQ8 F1RVQ9 F1SDA6 F1SDS1 F1SKP8 F1SQH8 O18839	IRK1 KCNJ12 KCNJ14 KCNJ2 KCNJ4 KCNK1 KCNK10 KCNK12 KCNK13 KCNK15 KCNK16 KCNK17 KCNK3 KCNK4 KCNK5 KCNK6 KCNK7 KCNK9	Sus scrofa (pig)
Peptide ligand-binding receptors	Adrenocorticotropic hormone receptor Angiotensinogen Apelin Atypical chemokine receptor 1 C5a anaphylatoxin chemotactic receptor 1 Cholecystokinin receptor type A Cholecystokinin Coagulation factor II thrombin receptor like 2 Complement C3 Complement C5 Complement C5a receptor 2 Endothelin receptor type B Endothelin-1 receptor Endothelin-1 Endothelin-2 Endothelin-3 Endothelin-converting enzyme 1 F2R like thrombin or trypsin receptor 3 F2R like trypsin receptor 1 G protein-coupled receptor 37 like 1 G protein-coupled receptor 37 G-protein coupled estrogen receptor 1 Galanin receptor 2 Galanin receptor 3 Gastrin-releasing peptide receptor Gastrin-releasing peptide Interleukin-8 Kappa-type opioid receptor Kell metallo-endopeptidase Melanin concentrating hormone receptor 2 Melanocortin receptor 4 Melanocortin receptor 5 Melanocortin-3 receptor Melanocyte-stimulating hormone receptor Motilin receptor Mu-type opioid receptor Neurolysin, mitochondrial Neurolysin, mitochondrial Neuromedin B receptor Neuromedin U receptor 1 Neuromedin U Neuromedin-B receptor Neuromedin-B Neuropeptide B Neuropeptide S receptor 1 Neuropeptide S Neuropeptide W Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5 Neuropeptide Y Neuropeptides B and W receptor 1 Neuropeptides B and W receptor 2 Neurotensin receptor 1 Neurotensin receptor 2 Neurotensin/neuromedin N Nociceptin receptor Opioid receptor delta 1 Peptide YY Prepronociceptin Pro-MCH Pro-opiomelanocortin Pro-thyrotropin-releasing hormone Proenkephalin-B Prokineticin 1 Prokineticin 2 Prokineticin receptor 1 Prokineticin receptor 2 Prolactin releasing hormone receptor Prolactin releasing hormone Promotilin Prosaposin Proteinase-activated receptor 1 Prothrombin Somatostatin receptor 3 Somatostatin receptor 5 Somatostatin receptor type 2 Somatostatin Thyrotropin-releasing hormone receptor Type-1 angiotensin II receptor Urotensin-2 receptor Urotensin-2 XK-related protein endothelin-converting enzyme 1	A0A140TAJ7 A0A286ZHZ6 A0A286ZK57 A0A286ZKL8 A0A286ZRE5 A0A286ZU96 A0A286ZX16 A0A287A2W4 A0A287A5D3 A0A287A6C0 A0A287ABF9 A0A287AHA8 A0A287AIM8 A0A287AJ51 A0A287AS48 A0A287AYV0 A0A287B139 A0A287B165 A0A287B5V5 A0A287B834 A0A287BA96 A0A287BCE8 A0A287BEQ0 A0A287BN94 A0A287BRG4 A0A5G2QHE8 A0A5G2R3H1 A0A5G2R3Z5 A0A5G2R7J7 A0A5G2RMY7 A0A5K1UZ28 A0A8W4F7A0 A0A8W4FDT9 A0A900QTH5 A5A752 A5GFS7 B2ZI34 D3K5J9 F1RS70 F1RSG5 F1RXX8 F1RYR8 F1S2H4 F1S4P9 F1S7X7 F1SCR5 F1SDK8 F1SIB1 F1SIK6 F1SKN3 F1SPI7 F1SPX3 F1SRJ6 F1SRT7 H2DHJ9 I3L946 I3LFK5 I3LHJ5 I3LHX2 I3LKG8 I3LKQ0 I3LL93 I3LS26 I3LSZ2 I3LTJ3 I3LTQ7 I3LUE7 K7GMP1 K7GR81 O97504 O97505 O97969 P01168 P01297 P01356 P26894 P30555 P34994 P35463 P63153 Q02038 Q1ELV2 Q8HYN8 Q8MI35	ACKR1 AGT AGTR1 APLN C3 C5 C5AR1 C5AR2 CCK CCKAR CXCL8 ECE1 ECE2 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 GALR2 GALR3 GPER1 GPR37 GPR37L1 GRP GRPR IL8 KEL MC1R MC2R MC3R MC4R MC5R MCHR2 MLN MLNR NLN NMB NMBR NMU NMUR1 NPB NPBWR1 NPBWR2 NPS NPSR1 NPW NPY NPY Y4 NPY2R NPY4R NPY5R NPYR5 NTS NTSR1 NTSR2 OPRD1 OPRK1 OPRL1 OPRM1 PDYN PMCH PNOC POMC PPL8 PPYR1 PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PYY SST SSTR2 SSTR3 SSTR5 TRH TRHR UTS2 UTS2R XK	Sus scrofa (pig)
Peptide hormone biosynthesis	Pro-opiomelanocortin	I3LKG8	POMC	Sus scrofa (pig)
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating 6-phosphogluconolactonase Glucose-6-phosphate 1-dehydrogenase Phosphoglucomutase 2 Ribokinase Ribulose-phosphate 3-epimerase Sedoheptulokinase Transaldolase Transketolase deoxyribose-phosphate aldolase ribose-5-phosphate isomerase	A0A286ZQY9 A0A286ZS31 A0A287A7K4 A0A287BSL9 A0A5G2QMT1 A0A5G2QR34 A8U4R4 F1RLI9 F1S4K7 F1STC1 Q29593	DERA G6PD PGD PGLS PGM2 RBKS RPE RPIA SHPK TALDO1 TKT tkt	Sus scrofa (pig)	G31080DL
Passive transport by Aquaporins	Aquaporin 7 Aquaporin 9 Aquaporin-10 Aquaporin-1 Aquaporin-2 Aquaporin-3 Aquaporin-4 Aquaporin-5 Aquaporin-8 Aquaporin	A0A286ZI15 A0A287AT23 A0A287AVV4 A0A287BD05 A8W649 A8WCF7 A9Y007 B2D2K0 F1DQZ7 I3LH92	AQP1 AQP10 AQP12 AQP2 AQP3 AQP4 AQP5 AQP7 AQP8 AQP9	Sus scrofa (pig)
PTK6 promotes HIF1A stabilization	Glycoprotein nmb Hypoxia-inducible factor 1-alpha Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase Tyrosine-protein kinase non-specific serine/threonine protein kinase	A0A286ZJF6 A0A286ZYS4 A0A287B2Q0 A0A5G2QBP1 F1SHN7 Q01580	DTR EGFR GPNMB HBEGF HEGFL HIF1A LRRK2 PTK6	Sus scrofa (pig)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amphiregulin Betacellulin CD80 molecule CD86 molecule Epiregulin Estrogen receptor beta Estrogen receptor Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fms related receptor tyrosine kinase 3 ligand GRB2 associated binding protein 1 GRB2 associated binding protein 2 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Immediate early response 3 Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin Interleukin 1 receptor like 1 Interleukin-1 receptor-associated kinase 4 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X5 Phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphoinositide-3-kinase adaptor protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Protein phosphatase 2 regulatory subunit B'gamma Protein phosphatase 2 scaffold subunit Abeta Proto-oncogene vav Rac family small GTPase 2 Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase Striatin T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Transforming growth factor alpha Tyrosine-protein kinase Fyn Tyrosine-protein kinase receptor Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A140TAK4 A0A286ZJM1 A0A286ZQX2 A0A286ZSM8 A0A287A231 A0A287A4F0 A0A287A6I2 A0A287A9P4 A0A287AAE4 A0A287ADF0 A0A287AFX3 A0A287APB4 A0A287AU44 A0A287AXR0 A0A287AYB4 A0A287AZM9 A0A287B3V5 A0A287B510 A0A287B5E0 A0A287B630 A0A287B726 A0A287B929 A0A287BCW9 A0A287BG34 A0A287BGB1 A0A287BGK8 A0A287BK67 A0A480ECT1 A0A480I421 A0A480J4F4 A0A480LMF4 A0A480NH74 A0A5G2QBP1 A0A5G2QNL8 A0A5G2QUY7 A0A5G2R1H6 A0A5G2R1K1 A0A5G2R7G2 A0A5G2RG05 A0A5K1UB41 A0A5K1UPW2 A0A8W4FI56 A0A8W4FMH5 A0A8X9AEI7 A1Y2K1 A7XUJ6 B6E241 F1RL75 F1RM38 F1RQR5 F1RSR6 F1RVI6 F1RWM5 F1RX68 F1RY78 F1RY80 F1RZU1 F1S2V7 F1S3B8 F1S4P0 F1S916 F1SB93 F1SCL0 F1SET9 F1SKR9 F1SLD3 F1SMG2 F1SRR6 F1SSQ9 F1SV94 F6Q7E6 I3L560 I3LG49 I3LKR6 I3LLF1 I3LR27 K7GMQ2 K7GMT0 K7GMU1 K7GPR7 K7GQJ1 P01315 P54612 P67776 Q01580 Q29040 Q2QLE0 Q95L12 Q9BDH4 Q9BE99	AREG BTC CD28 CD80 CD80/B7-1 CD86 DTR EGF EGFR ERBB2 ERBB3 ERBB4 EREG ESR ESR1 ESR2 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR4 FLT3 FLT3LG FYN Fgf4 GAB1 GAB2 GRB2 HBEGF HEGFL HGF IER3 IL1RL1 INS INSR IRAK1 IRAK4 IRS1 IRS2 KIT KITLG KL KLB LCK MAPK1 MAPK3 MET MYD88 NR3A1 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIP4K2A PIP4K2B PIP5K1A PIP5K1B PIP5K1C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PTPN11 RAC1 RAC2 RHOG SRC STRN TGFA TRAF6 VAV1	Sus scrofa (pig)
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Amphiregulin Betacellulin CD80 molecule CD86 molecule Epiregulin Estrogen receptor beta Estrogen receptor Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fms related receptor tyrosine kinase 3 ligand GRB2 associated binding protein 1 GRB2 associated binding protein 2 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin 1 receptor like 1 Interleukin-1 receptor-associated kinase 4 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Phosphatidylinositol 3-kinase regulatory subunit beta Phosphoinositide-3-kinase adaptor protein 1 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Proline rich 5 Proto-oncogene vav RPTOR independent companion of MTOR complex 2 Rac family small GTPase 2 Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein kinase mTOR Striatin T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Target of rapamycin complex subunit LST8 Transforming growth factor alpha Tyrosine-protein kinase Fyn Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A140TAK4 A0A286ZJM1 A0A286ZQX2 A0A286ZSM8 A0A286ZV67 A0A287A231 A0A287A6I2 A0A287A8R7 A0A287AAE4 A0A287ADF0 A0A287AFX3 A0A287AXR0 A0A287AYB4 A0A287AZM9 A0A287B3V5 A0A287B510 A0A287B5E0 A0A287B630 A0A287B726 A0A287B929 A0A287BCW9 A0A287BG34 A0A287BGK8 A0A287BK67 A0A480ECT1 A0A480J4F4 A0A480LMF4 A0A5G2QBP1 A0A5G2QNL8 A0A5G2QUY7 A0A5G2R1H6 A0A5G2R1K1 A0A5G2R7G2 A0A5K1UB41 A0A5K1UPW2 A0A8W4FI56 A0A8W4FMH5 A0A8X9AEI7 A1Y2K1 A7XUJ6 B6E241 F1RFA8 F1RHR8 F1RL75 F1RM38 F1RSR6 F1RWM5 F1RY78 F1RY80 F1RZU1 F1S3B8 F1S4P0 F1S916 F1SB93 F1SET9 F1SKR9 F1SLD3 F1SMG2 F1SRR6 F1SSQ9 F1SV94 F6Q7E6 I3L560 I3LEK8 I3LKR6 I3LLF1 I3LR27 K7GMT0 K7GMU1 K7GPR7 K7GQJ1 Q01580 Q29040 Q2QLE0 Q95L12 Q9BDH4 Q9BE99	AREG BTC CD28 CD80 CD80/B7-1 CD86 DTR EGF EGFR ERBB2 ERBB3 ERBB4 EREG ESR ESR1 ESR2 FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR4 FLT3 FLT3LG FYN Fgf4 GAB1 GAB2 GRB2 HBEGF HEGFL HGF IL1RL1 IRAK1 IRAK4 IRS1 IRS2 KIT KITLG KL KLB LCK MET MLST8 MTOR MYD88 NR3A1 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PRR5 PTPN11 RAC1 RAC2 RHOG RICTOR SRC STRN TGFA TRAF6 VAV1	Sus scrofa (pig)
PI3K events in ERBB4 signaling	Betacellulin Epiregulin Neuregulin 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A286ZJM1 A0A287A6I2 A0A287AZM9 A0A287BCW9 A0A5G2R1H6 A0A5K1UB41 F1SKR9 F1SSQ9 Q01580	BTC DTR ERBB4 EREG HBEGF HEGFL NRG1 NRG2 NRG3 PIK3CA PIK3R1	Sus scrofa (pig)
PI3K events in ERBB2 signaling	Betacellulin Epiregulin GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Neuregulin 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A286ZJM1 A0A287A231 A0A287A6I2 A0A287AZM9 A0A287BCW9 A0A480J4F4 A0A5G2QBP1 A0A5G2R1H6 A0A5K1UB41 B6E241 F1RWM5 F1SKR9 F1SSQ9 K7GMT0 Q01580	BTC DTR EGF EGFR ERBB2 ERBB3 ERBB4 EREG GAB1 GRB2 HBEGF HEGFL NRG1 NRG2 NRG3 PIK3CA PIK3R1	Sus scrofa (pig)
PI3K Cascade	Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fms related receptor tyrosine kinase 3 ligand GRB2 associated binding protein 1 GRB2 associated binding protein 2 Growth factor receptor bound protein 2 Insulin receptor substrate 1 Insulin receptor substrate 2 Klotho beta Klotho Multifunctional fusion protein Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Phosphatidylinositol 3-kinase regulatory subunit beta Toll-like receptor 9 Tyrosine-protein phosphatase non-receptor type non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A287AAE4 A0A287AFX3 A0A287AXR0 A0A287B3V5 A0A287B630 A0A287B726 A0A287B929 A0A287BG34 A0A287BGK8 A0A287BHR8 A0A480ECT1 A0A480LMF4 A0A5G2QUY7 A0A5G2R7G2 A0A5K1UB41 A0A8X9AEI7 B6E241 F1RM38 F1RSR6 F1RY78 F1RY80 F1S3B8 F1S916 F1SAI0 F1SET9 F1SKR9 F1SMG2 I3L560 I3LLF1 I3LR27 K7GMT0 K7GQJ1 Q5I2M3 Q95L12	FGF1 FGF10 FGF16 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR4 FLT3 FLT3LG Fgf4 GAB1 GAB2 GRB2 IRS1 IRS2 KL KLB PIK3C3 PIK3CA PIK3CB PIK3R1 PIK3R2 PIK3R4 PTPN11 TLR9	Sus scrofa (pig)
PI-3K cascade:FGFR4	Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Klotho beta Multifunctional fusion protein Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A287AFX3 A0A287AXR0 A0A287B3V5 A0A287BGK8 A0A480LMF4 A0A5G2QUY7 A0A5G2R7G2 A0A5K1UB41 B6E241 F1RM38 F1RY80 F1S3B8 F1SET9 F1SKR9 I3L560 I3LR27 K7GMT0 Q95L12	FGF1 FGF16 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 Fgf4 GAB1 GRB2 KLB PIK3CA PIK3R1 PTPN11	Sus scrofa (pig)
PI-3K cascade:FGFR1	Fibroblast growth factor 23 Fibroblast growth factor 9 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 1 Growth factor receptor bound protein 2 Klotho Multifunctional fusion protein Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2 Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A287AAE4 A0A287AFX3 A0A287AXR0 A0A287BG34 A0A287BGK8 A0A480LMF4 A0A5G2R7G2 A0A5K1UB41 B6E241 F1RM38 F1RSR6 F1RY78 F1RY80 F1SET9 F1SKR9 F1SMG2 K7GMT0 K7GQJ1 Q95L12	FGF1 FGF10 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 Fgf4 GAB1 GRB2 KL PIK3CA PIK3R1 PTPN11	Sus scrofa (pig)
PI Metabolism	Tumor necrosis factor alpha-induced protein 8-like protein 2	F1SSY0	TNFAIP8L2	Sus scrofa (pig)
PECAM1 interactions	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Integrin beta Integrin subunit alpha V Platelet and endothelial cell adhesion molecule 1 Platelet endothelial cell adhesion molecule Tyrosine-protein kinase Fyn Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase	A0A287ABR0 A0A480LMF4 A0A5G2QU81 A0A5G2R7K7 A0A5K1V6L8 A1Y2K1 F1RT53 F1SDV6 F1SV94 K7GPR7 K7GS31 Q95242	FYN INPP5D ITGAV ITGB3 LCK LYN PECAM1 PLCG1 PTPN11 SRC YES1	Sus scrofa (pig)
PD-1 signaling	Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein MHC class II DR-alpha MHC class II antigen MHC class II histocompatibility antigen SLA-DRB1 Programmed cell death 1 ligand 2 Programmed cell death 1 SLA class II histocompatibility antigen, DQ haplotype D alpha chain SLA-DQ beta1 domain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein	A0A286ZKB7 A0A286ZUJ9 A0A287A1C3 A0A287AC24 A0A287AT33 A0A287B968 A0A287BF11 A0A287BQ31 A0A480LMF4 A0A5G2QCN4 A0A5G2QPQ3 A0A8W4F9V5 A0A8W4FBN9 A0A8W4FJW4 A0A8W4FNK4 A0A8W4FP49 A0A8X9AEU9 F1S6S1 F1S975 F1SJ27 F1SV94 I3L556 I3LAQ5 K7GS60 P15981 Q5PXD3 Q764N2 Q7YQ94 Q85ZW4	CD247 CD3D CD3E CD3G CD4 CSK DRA HLA-DRA LCK LOC100153139 PDCD1 PDCD1LG2 PTPN11 SLA-DQA SLA-DQA1 SLA-DQB1 SLA-DR SLA-DRA SLA-DRA1 SLA-DRB1	Sus scrofa (pig)
Ovarian tumor domain proteases	APC regulator of WNT signaling pathway Cellular tumor antigen p53 Cyclin dependent kinase 1 E2 ubiquitin-conjugating enzyme Estrogen receptor Phosphatase and tensin homolog Polyubiquitin-C Receptor interacting serine/threonine kinase 1 Ring finger protein 128 TNF receptor-associated factor 6 TNF receptor-associated factor TNFAIP3 interacting protein 1 TNFAIP3 interacting protein 2 TNFAIP3 interacting protein 3 Transforming protein RhoA Ubiquitin B Ubiquitin C Ubiquitin thioesterase OTU Ubiquitin thioesterase Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A287ABN4 A0A287AKB2 A0A287AZA7 A0A287B1C5 A0A287BI48 A0A287BRT1 A0A2C9F3G2 A0A480EGF6 A0A8W4FAU5 A0A8W4FK46 A7U5U2 A7XUJ6 C5H0C6 F1RTZ5 F1RXM2 F1S1T3 F1S6A4 F1S8Q0 F1S911 F1SCG8 F1SDG3 F1SNR5 F2Z5H1 I3LVS7 P0CG68 Q06AA8 Q29040 Q9TUB2	APC CDK1 ESR ESR1 NR3A1 OTUB1 OTUB2 OTUD3 OTUD7A OTUD7B P53 PTEN RHOA RIPK1 RNF128 RPS27A TNFAIP3 TNIP1 TNIP2 TNIP3 TP53 TRAF3 TRAF6 UBA52 UBB UBC UBE2D1 VCPIP1 YOD1 ZRANB1	Sus scrofa (pig)
Other interleukin signaling	Colony stimulating factor 3 receptor Granulocyte colony-stimulating factor Granulocyte colony-stimulating factor Interferon lambda receptor 1 Interferon lambda-1 Interleukin 34 Interleukin-10 receptor subunit beta Macrophage colony-stimulating factor 1 Pro-interleukin-16 Syndecan Syntaxin 3 Syntaxin 4 Syntaxin-1A Syntaxin-binding protein 2 T-cell surface glycoprotein CD4 Taxilin alpha Tyrosine-protein kinase Tyrosine-protein kinase Vesicle-associated membrane protein 2 protein-tyrosine-phosphatase receptor protein-tyrosine kinase	A0A286ZLI2 A0A286ZQU5 A0A286ZTU8 A0A286ZYA3 A0A287A6Q8 A0A287A948 A0A287BPE2 A0A287BQK7 A0A288CFU1 A0A5G2QA44 A0A5G2QIU0 A0A5G2QVW3 A0A5G2QXL6 A0A5G2R276 A0A8W4FDM0 F1RGA3 F1RIR2 F1S3L9 I3L556 K7GNF5 O02837	CD4 CSF1 CSF1R CSF3 CSF3R IFNLR1 IL10RB IL16 IL29 IL34 JAK1 PTPRZ1 SDC1 STX1A STX3 STX4 STXBP2 TXLNA TYK2 VAMP2	Sus scrofa (pig)
Organic cation transport	Runt-related transcription factor Solute carrier family 22 member 15 Solute carrier family 22 member 16 Solute carrier family 22 member 18 Solute carrier family 22 member 1 Solute carrier family 22 member 2 Solute carrier family 22 member 3 Solute carrier family 22 member 4 Solute carrier family 22 member 5	A0A286ZXK3 A0A287A9U9 A0A287ABQ9 F1RT02 F1RYX1 F1SAX0 F1SB80 F8SIP5 O02713	OCT2 RUNX1 SLC22A1 SLC22A15 SLC22A16 SLC22A18 SLC22A2 SLC22A3 SLC22A4 SLC22A5	Sus scrofa (pig)
Organic anion transport	Organic anion transporter 3 Solute carrier family 22 member 11 Solute carrier family 22 member 12 Solute carrier family 22 member 6 Solute carrier family 22 member 7	A0A8W4FD67 I3L7D2 I3LKR0 Q1RPP5 Q70BM6	OAT2 OAT3 SLC22A11 SLC22A12 SLC22A6 SLC22A7 SLC22A8	Sus scrofa (pig)

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