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MIRAGE
Signaling by PDGF

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
PDGF precursor dimers (AA, BB, A/B, CC, DD)PDGF precursor dimers (AA, BB, A/B, CC, DD)proPDGF-AA dimeractive PDGF-AA dimerN-ter PDGF-A fragmentproPDGF-BB dimeractive PDGF-BB dimerCleaved PDGF-B peptidesproPDGF-AB dimerPDGF A/B heterodimerPDGFA_HUMANNovel PDGF precursor dimers (CC, DD)Novel PDGF precursor dimers (CC, DD)Cleaved novel PDGF fragmentsActive PDGF dimers (CC, DD)Extracellular matrix ligandsPDGF A and B chains:ECM complexPDGF A and B chains with retention motifPDGFRA, PDGFRBPDGF:PDGF receptor dimerActive PDGF dimers (AA, AB, BB)PDGF beta receptor:PDGF chain B homodimerADPATPPhospho PDGF beta receptor: PDGF chain B homodimerPhospho PDGF alpha receptor:PDGF dimersPDGF alpha receptor: PDGF dimersPhospho PDGF alpha-beta dimer:PDGF AB or BB dimersPDGF alpha/beta:PDGF AB and BB dimersH2OPip-PDGFRB homo and heterodimersp-PDGFRB homo and heterodimers dephosphorylated at Y1021PDGFRAPDGFRA:olaratumabIMC-3G3type I PDGFR-binding tyrosine kinase inhibitorsPDGFR:type I PDGFR-binding TKIstype II PDGFR-binding tyrosine kinase inhibitorsPDGFR:type II PDGFR-binding TKIs
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 1 - 10 of 26 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
A6NMZ7 Collagen alpha-6(VI) chain
  • COL6A6
 view
A8TX70 Collagen alpha-5(VI) chain
  • COL29A1
  • COL6A5
  • VWA4
 view
P00747 Plasminogen
  • PLG
 view
P00750 Tissue-type plasminogen activator
  • PLAT
 view
P01127 Platelet-derived growth factor subunit B
  • PDGF2
  • PDGFB
  • SIS
 view
P02462 Collagen alpha-1(IV) chain
  • COL4A1
 view
P07996 Thrombospondin-1
  • THBS1
  • TSP
  • TSP1
 view
P08572 Collagen alpha-2(IV) chain
  • COL4A2
 view
P09619 Platelet-derived growth factor receptor beta
  • PDGFR
  • PDGFR1
  • PDGFRB
 view
P09958 Furin
  • FUR
  • FURIN
  • PACE
  • PCSK3
 view
Displaying 1 entry
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_001410 P20849 Collagen alpha-1(IX) chain view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025