Signaling by ALK

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ligand-bound ALK dimerActive ALK dimerATPADPIRS1Active ALK:IRS1SHC1 p46,p52Active ALK:SHC1Active ALK:FRS2FRS2Active ALK:PI3KPI3KActive ALK:SRCSRC1JAK3Active ALK:JAK3H2OPiActive ALK:p-Y980 JAK3STAT3p-Y705,S727-STAT3 dimerALK geneALKALKAL2:(ALKAL1)ALK dimer:ALKAL2:(ALKAL1)ALK dimer:ligand:type I ALK binding TKItype I ALK-binding TKIsActive ALK:pY-IRS1Active ALK:p-3Y SHC1Active ALK:p-6Y FRS2PIP2PIP3Active ALK:PLCG1PLC1Active ALK:p-4Y PLCG1Active ALK:p-Y419 SRCSTAT3p-Y705,S727-STAT3 dimerMYC/MYCN:ALK geneMYC,MYCNMYCN geneMYCN
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025