Ca2+ pathway

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
G-protein beta-gamma complexG-protein beta-gamma:PLC beta 1/2/3PLC-beta 1/2/3PIP2IP3DAGWNT5A/WNT11WNT5A/11:FZDWNT/Ca2+ FZDsHeterotrimeric G-protein (o/t2) (inactive)WNT5A/11:FZD:G-protein (alpha o/t2) inactiveGTPGDPWNT5A/11:FZD:G-protein (alpha o/t2) activeG-protein alpha (o/t2)Ca2+activated PKC alphaPKC-APSCALM1:4xCa2+PPP3R1:PPP3CA,B:Calmodulin:Ca2+PPP3R1:PPP3CA,BH2OPiNFATC1NFATC1:CaN:CaMNFATC1:CaN:CaMCa2+GNAT2:GTPGNAT2:PDE6PDE6cGMPGMPCAMK2:CaMCAMK2APRKG homodimer:cGMPPRKG dimerADPATPp-T286 CAMK2:CaMp-T286,T305,T306-CAMK2ATAK1p-T286,305,306-CAMK2:MAP3K7Phospho TAK1NLKpT298-NLK dimerpT298-NLK dimerATPp-TCF/LEF:CTNNB1TCF/LEF:CTNNB1ADPNLK mRNANLK mRNA:miR-92b RISCmiR-92b RISC'canonical' WNT target genes'canonical' WNT target genes:TCF/LEF:CTNNB1TCF/LEF:CTNNB1'canonical' WNT target gene transcriptsITPR:I(1,4,5)P3 tetramerIP3 receptor homotetramer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025