SARS-CoV-2 activates/modulates innate and adaptive immune responses

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
LARP1LARP1:SARS-CoV-2 gRNA:RTCSARS-CoV-2 gRNA:RTCviral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3dsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:TBK1/IKKiTBK1/IKKi:SIKE1SIKE1N dimerN:TAK1complexTAK1 complexH2ONAL12_HUMANNLRP12NAL12_HUMANNAL12_HUMANNAL12_HUMAN9b homodimerTOMM70:9bTOMM70C-ter TLR7 dimerTLR7 dimer:SARS-CoV-2 ssRNASARS-CoV-2 GU-rich ssRNAMDA5:DAKSARS-CoV-2 dsRNA intermediates:IFIH1SARS-CoV-2 dsRNA intermediates:RTCDAKTLR1:TLR2TLR2:TLR1:E pentamer within mature SARS-CoV-2 virionS3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramerISGylated IRF3ISG15IRF3TBK1TBK1:pp1ab-nsp6nsp6MM:MAVSMAVSdsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:2xTBK1/IKKidsRNA:RIG-1/MDA5:IPS-1:Ub-TRAF3:2x(TBK1/IKBKE)ADPATPN:MAVSDDX58:NDDX58RNF135,TRIM25,TRIM42xviral dsRNA:2xK63polyUb-DDX58:2xRNF135,TRIM25:2xATPdsRNA bound to RIG-IK63polyUbIKK complexp-S177,S181-IKKB:IKKA:NEMOIFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2STAT1MBL2 dodecamer:MASP1 dimer:MASP2-1 dimerN:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimerN dimerTAB1(1-132)TAB1TAB1(133-504)TAB1(1-444)TAB1(445-504)3CLp dimerSTING:3CLpro dimerMITAK+K+66:NPCNuclear Pore Complex (NPC)9b:IKK complexBeclin-1 complex8:class I MHC:BECN1 complex8:antigen peptide bound class I MHC8 homodimer8:IL17RAIL17RSFTPD 12merSFTPD:S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramerTLR8 dimer:SARS-CoV-2 ssRNATLR8 dimerSARS-CoV-2 gRNA:RTC:nascent RNA minus strandSARS-CoV-2 dsRNA intermediates:DDX58CNBPCNBP:SARS-CoV-2 G-rich RNA:RTCSARS-CoV-2 G-rich RNA:RTCISGylated IFIH1IRF3(272-427)IRF3(2-271)HelicaseTBK1:pp1ab-nsp13MM:TBK1Ac-CoACoA-SHN dimerTRIM25TRIM25:NG3BP1,G3BP2:NG3BP1,G3BP2N:CHUK:IKBKB:IKBKGN:NLRP3NLRP3Ca2+Ca2+O-glycosyl 3a tetramerSTING:O-glycosyl 3a tetramer6KPNA2:6IMA2phosphorylated IRF3 and/or IRF7 dimerphosphorylated IRF3 and/or IRF7 dimerMAVS:TOMM70MAVS:TOMM70:HSP90:TBK1:IRF3HSP90:TBK1:IRF38 homodimerAntigen peptide bound class I MHCSar1p:GTP:Sec23p:Sec24p:Ag bound MHC class ISAR1B:GTP:SEC23:SEC24IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17FIL17RCIL17RA:IL17RC ligandsSTAT1,STAT2STAT1,STAT2:N
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 3 entries
GlyCosmos Lectin UniProt ID Lectin Name Pathway Viewer
GL_001022 P35247 Pulmonary surfactant-associated protein D view
GL_002337 P0DTC2 Spike glycoprotein view
GL_002341 P11226 Mannose-binding protein C view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025