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MIRAGE
tissue factor pathway inhibitor
Summary
- Gene Symbol
-
- TFPI
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Blood coagulation
- Direct protein sequencing
- Disulfide bond
- GPI-anchor
- Microsome
- Reference proteome
- Repeat
- Secreted
- Serine protease inhibitor
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P10646 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| blood coagulation | ||
| negative regulation of peptidase activity |
|
|
| negative regulation of blood coagulation | ||
| cellular response to steroid hormone stimulus |
GO Hierarchy
biological process
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| endoplasmic reticulum | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| endopeptidase inhibitor activity | ||
| serine-type endopeptidase inhibitor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- kunitz-type serine protease inhibitor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| peptidase inhibitor activity |
| serine-type endopeptidase inhibitor activity |
| InterPro |
|---|
| Pancreatic trypsin inhibitor Kunitz domain superfamily |
| Pancreatic trypsin inhibitor Kunitz domain |
| Proteinase inhibitor I2, Kunitz, conserved site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080630 | B-lymphoblastic leukemia/lymphoma | |
| DOID:10159 | osteonecrosis | |
| DOID:11247 | disseminated intravascular coagulation | |
| DOID:12134 | factor VIII deficiency | |
| DOID:14115 | toxic shock syndrome | |
| DOID:224 | transient cerebral ischemia | |
| DOID:2451 | protein S deficiency | |
| DOID:3770 | pulmonary fibrosis | |
| DOID:5082 | liver cirrhosis | |
| DOID:5844 | myocardial infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 470603 | PANTR29340 | ||
| 508763 | BOVIN23916 | ||
| 613026 | MACMU06487 | ||
| 100009401 | RABIT11842 | ||
| 100028266 | MONDO21418 | ||
| 100068873 | HORSE13449 | ||
| 100086245 | ORNAN26734 | ||
| 100155068 | PIGXX09627 | ||
| 100171528 | PONAB24487 | ||
| 100228168 | TAEGU28532 |
