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ceramide synthase 2

Summary

Gene Symbol

Cers2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

76893

PubChem

76893

Alliance of Genome Resources

MGI:1924143

Annotation

Keyword

Acetylation
Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Phosphoprotein
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q924Z4	LAG1 longevity assurance homolog 2 Sphingosine N-acyltransferase CERS2 Translocating chain-associating membrane protein homolog 3 Tumor metastasis-suppressor gene 1 protein Very-long-chain ceramide synthase CERS2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
negative regulation of Schwann cell proliferation	ISO
regulation of lipid metabolic process	IMP	32279995
sphingolipid biosynthetic process	IDA	15823095
response to immobilization stress	IEA
ceramide biosynthetic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process

ceramide biosynthetic process

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

regulation of glial cell migration [inference]

regulation of Schwann cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to wounding [inference]

negative regulation of axon regeneration

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to wounding [inference]

negative regulation of axon regeneration

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of response to wounding [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of response to wounding [inference]

negative regulation of axon regeneration

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of glial cell proliferation [inference]

regulation of Schwann cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of Schwann cell proliferation involved in axon regeneration [inference]

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

negative regulation of axon regeneration

negative regulation of neuron projection regeneration [inference]

negative regulation of axon regeneration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

regulation of glial cell migration [inference]

regulation of Schwann cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of glial cell migration [inference]

negative regulation of Schwann cell migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell proliferation [inference]

negative regulation of Schwann cell proliferation

negative regulation of Schwann cell proliferation involved in axon regeneration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
protein binding	IPI	26620563 32279995
N-acyltransferase activity	IMP	19801672
sphingosine N-acyltransferase activity	ISO
sphingosine N-acyltransferase activity	IDA	15823095 23275342 38961186

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity

sphingosine N-acyltransferase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ceramide synthase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ceramide biosynthetic process
sphingosine N-acyltransferase activity

Displaying **all 2** entries
InterPro
Sphingosine N-acyltransferase Lag1/Lac1-like
TRAM/LAG1/CLN8 homology domain

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	10715	SGD:S000001491
Homo sapiens	29956	Xenbase:XB-GENE-852703	HUMAN51971
Saccharomyces cerevisiae S288C	67260	SGD:S000001491
Saccharomyces cerevisiae S288C	71949	SGD:S000001491
Xenopus tropicalis	76893	Xenbase:XB-GENE-852703
Saccharomyces cerevisiae S288C	79603	SGD:S000001491
Saccharomyces cerevisiae S288C	91012	SGD:S000001491
Xenopus tropicalis	180743	Xenbase:XB-GENE-852703
Saccharomyces cerevisiae S288C	204219	SGD:S000001491
Saccharomyces cerevisiae S288C	241447	SGD:S000001491

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements