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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
C-X-C motif chemokine receptor 4
Summary
- Gene Symbol
-
- CXCR4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell junction
- Cell membrane
- Disease variant
- Disulfide bond
- Endosome
- G-protein coupled receptor
- Host cell receptor for virus entry
- Host-virus interaction
- Isopeptide bond
- Lysosome
- Phosphoprotein
- Proteoglycan
- Proteomics identification
- Reference proteome
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0U3FJG0 |
|
| A0A0U3GXA9 |
|
| A0A8Q3WLL1 |
|
| P61073 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| epithelial cell development | ||
| regulation of programmed cell death | ||
| endothelial cell differentiation | ||
| positive regulation of chemotaxis | ||
| regulation of cell adhesion |
GO Hierarchy
- regulation of viral process
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| cytoplasmic vesicle | ||
| early endosome | ||
| anchoring junction | ||
| late endosome |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| actin binding | ||
| coreceptor activity | ||
| C-X-C motif chemokine 12 receptor activity | ||
| small molecule binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| C-C chemokine binding |
| C-C chemokine receptor activity |
| brain development |
| calcium-mediated signaling |
| cell chemotaxis |
| chemokine receptor activity |
| chemokine-mediated signaling pathway |
| chemotaxis |
| immune response |
| neurogenesis |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050700 | cardiomyopathy | |
| DOID:0050909 | extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue | |
| DOID:0060284 | paroxysmal nocturnal hemoglobinuria | |
| DOID:0060591 | WHIM syndrome | |
| DOID:0060901 | lymphoplasmacytic lymphoma | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:10283 | prostate cancer | |
| DOID:10534 | stomach cancer | |
| DOID:11476 | osteoporosis | |
| DOID:1993 | rectum cancer |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12767 | MGI:109563 | MOUSE28321 | ||
| 60628 | RGD:620465 | RATNO06450 | ||
| 114447 | ZFIN:ZDB-GENE-010614-1 | DANRE45348 | ||
| 140747 | ZFIN:ZDB-GENE-020102-1 | DANRE38061 | ||
| 188226 | WB:WBGene00011578 | |||
| 281736 | BOVIN24353 | |||
| 380373 | Xenbase:XB-GENE-6256540 | |||
| 396659 | PIGXX08843 | |||
| 443532 | SHEEP09537 | |||
| 450130 | 9598_0:000ce1 | PANTR28757 |
