GlyCosmos Portal

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GlyCosmos Genes

Integrated list of glycan-related genes extracted KEGG GENES Database, UniProt, GlycoGene Database (GGDB), Plant GARDEN and FlyGlycoDB. Glycan-related genes including glycosyltransferase, hydrolase activity (acting on glycosyl bonds), carbohydrate metabolic process, etc .

Source	Last Updated
FlyGlycoDB	March 25, 2024
GlycoGene Database (GGDB)	January 26, 2018
KEGG GENES Database	September 20, 2023
Plant GARDEN	May 28, 2020
UniProt	July 8, 2024

Selecting the function you want to look up from the categories displays a list narrowed down to glycan-related genes with that function (Gene Ontology).

Catalytic activity

glycosyltransferase activity

hydrolase activity, acting on glycosyl bonds

Binding

carbohydrate binding

Response to carbohydrate

Primary metabolic process

Search results for "hydrolase activity, hydrolyzing O-glycosyl compounds"

Displaying entries **26 - 50** of **15431** in total

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Gene ID ▲	Gene Name	Gene Symbol	Organism	Disease Ontology
3425	alpha-L-iduronidase	IDUA Aliases: MPS1 MPSI mucopolysaccharidosis type I	Homo sapiens (human)	Alzheimer's disease Balo concentric sclerosis Creutzfeldt-Jakob disease Fabry disease Gaucher's disease Hartnup disease Huntington's disease-like 1 Huntington's disease-like 2 Huntington's disease Klippel-Feil syndrome Krabbe disease Laron syndrome Loeys-Dietz syndrome Niemann-Pick disease Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease Patau syndrome Richter's syndrome Scheie syndrome Sly syndrome T-cell acute lymphoblastic leukemia Weissenbacher-Zweymuller syndrome achondroplasia acute biphenotypic leukemia acute leukemia acute lymphoblastic leukemia acute myeloid leukemia adrenoleukodystrophy adult medulloblastoma agranulocytosis anemia anogenital venereal wart aortic valve disease 2 aortic valve insufficiency aortic valve stenosis autosomal recessive hypophosphatemic rickets benign mesothelioma blindness bone disease brain cancer breast cancer breast carcinoma cancer cardiomyopathy cartilage disease central nervous system disease cerebral palsy childhood medulloblastoma chromophobe renal cell carcinoma chronic lymphocytic leukemia chylomicron retention disease clear cell renal cell carcinoma collecting duct carcinoma colon cancer colon carcinoma colonic benign neoplasm colorectal cancer colorectal carcinoma common wart communicating hydrocephalus congenital heart disease connective tissue disease deficiency anemia dental caries dentin caries depressive disorder disease of mental health disease of metabolism dysthymic disorder embryoma endomyocardial fibrosis essential hypertension gastric ulcer giant cell glioblastoma gingival hypertrophy gingival overgrowth glaucoma glioblastoma glycogen storage disease II glycoproteinosis head and neck squamous cell carcinoma hemiplegia hepatocellular carcinoma high grade glioma hydrocephalus hypertension hypertrophic cardiomyopathy hypochromic anemia inflammatory bowel disease 1 inflammatory bowel disease inguinal hernia inherited metabolic disorder intellectual disability intracranial hypotension large intestine cancer learning disability leukopenia lipid storage disease liver cancer liver carcinoma lung benign neoplasm lung carcinoma lymphoblastic lymphoma lysosomal storage disease macrocytic anemia major depressive disorder malignant mesothelioma medulloblastoma medullomyoblastoma melancholic depression melanoma melanotic medulloblastoma microcytic anemia mitral valve insufficiency mitral valve prolapse mucolipidosis II alpha/beta mucopolysaccharidosis I mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis IVA mucopolysaccharidosis Ih/s mucopolysaccharidosis Ih mucopolysaccharidosis VI mucopolysaccharidosis type IIIA mucopolysaccharidosis type IIIB mucopolysaccharidosis type IVB mucopolysaccharidosis multiple epiphyseal dysplasia multiple myeloma narcolepsy nervous system disease neurotic disorder neutropenia nonpapillary renal cell carcinoma obsolete melancholia obsolete ymphosarcoma obstructive hydrocephalus obstructive sleep apnea osteochondrodysplasia osteoporosis otitis media pancreatic ductal adenocarcinoma papillary renal cell carcinoma primary pulmonary hypertension psychotic disorder recurrent corneal erosion renal carcinoma renal cell carcinoma retinal disease retinitis sarcomatoid renal cell carcinoma scoliosis senile degeneration of brain sensorineural hearing loss severe congenital neutropenia skin melanoma spastic diplegia spastic monoplegia spastic quadriplegic cerebral palsy sphingolipidosis spinal cord disease spondylolisthesis stomach cancer stomach carcinoma thyroid adenoma thyroid cancer thyroid gland carcinoma tracheal stenosis tyrosinemia type I tyrosinemia ulcerative colitis
3906	lactalbumin alpha	LALBA Aliases: HAMLET LYZG LYZL7 lactose synthase B lysozyme G	Homo sapiens (human)	breast cancer breast carcinoma cancer deficiency anemia embryoma eosinophilic esophagitis fibromyalgia gastroenteritis hypochromic anemia liver cirrhosis microcytic anemia milk allergy mitral valve stenosis multiple sclerosis myositis obesity polycystic ovary syndrome steatotic liver disease
3938	lactase	LCT	Homo sapiens (human)	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Clostridium difficile colitis Crohn's colitis Crohn's disease EEC syndrome Gilles de la Tourette syndrome Leydig cell tumor Pick's disease Reye syndrome Sertoli cell-only syndrome T-cell acute lymphoblastic leukemia Y-linked spermatogenic failure 1 abdominal obesity-metabolic syndrome 1 acute myocardial infarction acute retinal necrosis syndrome adult T-cell leukemia/lymphoma adult respiratory distress syndrome allergic asthma antiphospholipid syndrome antithrombin III deficiency asthma autoimmune polyendocrine syndrome bullous congenital ichthyosiform erythroderma cancer celiac disease cerebral degeneration colitis colorectal cancer colorectal carcinoma congenital lactase deficiency coronary artery disease coronary thrombosis cystic fibrosis diarrhea dysentery ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1 ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 embryoma eosinophilic esophagitis essential hypertension extraosseous Ewing sarcoma extraosseous Ewings sarcoma-primitive neuroepithelial tumor familial adenomatous polyposis 1 familial adenomatous polyposis gastritis gastroenteritis gastrointestinal system disease gestational diabetes gingival recession hypertension ileitis ileocolitis immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome inflammatory bowel disease 1 inflammatory bowel disease intestinal disease intestinal infectious disease intrinsic asthma irritable bowel syndrome islet cell tumor kidney disease kwashiorkor lactic acidosis lactose intolerance large intestine cancer lupus erythematosus marasmus myocardial infarction neurocirculatory asthenia newborn respiratory distress syndrome nutrition disease obesity obsessive-compulsive disorder oligospermia osteomyelitis osteoporosis pneumonia polycystic ovary syndrome prostate cancer prostate carcinoma protein C deficiency protein S deficiency protein-energy malnutrition schizophrenia silent myocardial infarction systemic lupus erythematosus testicular cancer thrombophilia transthyretin amyloidosis tropical sprue ulcerative colitis
4069	lysozyme	LYZ Aliases: renal amyloidosis	Homo sapiens (human)	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Behcet's disease Burkitt lymphoma Crohn's colitis Crohn's disease Graves' disease Langerhans-cell histiocytosis Meier-Gorlin syndrome 1 Meier-Gorlin syndrome Pick's disease Reye syndrome Shwachman-Diamond syndrome Sjogren's syndrome abdominal obesity-metabolic syndrome 1 acinar cell carcinoma acne acquired immunodeficiency syndrome actinic keratosis acute myeloid leukemia adenocarcinoma adenoid cystic carcinoma adenoma alcohol dependence alcohol use disorder allergic rhinitis alternating hemiplegia of childhood amyloidosis anorexia nervosa aphthous stomatitis arachnoiditis arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease arthritis arthropathy atherosclerosis autism spectrum disorder autistic disorder autoimmune disease autoimmune lymphoproliferative syndrome autoimmune polyendocrine syndrome type 1 autoimmune polyendocrine syndrome autonomic neuropathy bacterial infectious disease bacterial vaginosis biliary tract disease breast cancer breast carcinoma cancer candidiasis celiac disease central nervous system cancer central nervous system disease cerebral degeneration childhood leukemia cholestasis chronic ethmoiditis chronic monocytic leukemia chronic myelomonocytic leukemia chronic sphenoidal sinusitis colitis common cold complement deficiency congestive heart failure coronary artery disease craniosynostosis cribriform carcinoma dacryoadenitis dacryocystitis diabetes mellitus diabetic ketoacidosis diarrhea dysentery egg allergy endocrine exophthalmos essential hypertension exanthem familial hyperlipidemia familial mediterranean fever familial nephrotic syndrome familial visceral amyloidosis follicular adenoma gallbladder disease gastritis gastroduodenal Crohn's disease gastroenteritis gastrointestinal stromal tumor gastrointestinal system disease gingivitis gliosarcoma glomerulonephritis granular cell carcinoma hepatocellular carcinoma high grade glioma human immunodeficiency virus infectious disease hypertension hyperthyroidism hypohidrotic ectodermal dysplasia ileitis ileocolitis immune system disease inflammatory bowel disease 1 inflammatory bowel disease interstitial lung disease intestinal disease intestinal infectious disease jejunoileitis juvenile myelomonocytic leukemia juvenile rheumatoid arthritis keratoconjunctivitis sicca kidney disease kidney failure leukemia lipoid nephrosis liver cancer liver disease malignant fibrous histiocytoma mastitis meningitis mevalonic aciduria microcystic adenoma mixed glioma myeloid sarcoma nephritis nephrosis nephrotic syndrome nervous system disease neuropathy nodular prostate non-Langerhans-cell histiocytosis obsolete malignant histiocytosis obsolete ymphosarcoma obstructive jaundice oral candidiasis oral mucosa leukoplakia papillary adenoma parapsoriasis periodontal disease peripheral nervous system disease polyneuropathy post-traumatic stress disorder proctitis prostatic adenoma proteinuria psoriasis pulmonary tuberculosis purpura pustulosis of palm and sole pyoureter reticulohistiocytic granuloma rheumatoid arthritis salivary gland adenoid cystic carcinoma sarcoidosis seborrheic keratosis shigellosis sickle cell anemia skin disease spiradenoma stomach cancer stomach carcinoma systemic lupus erythematosus thyrotoxicosis tuberculosis tuberculous pneumothorax tubular adenocarcinoma type 2 diabetes mellitus ulcerative colitis uremia ureteral obstruction uveoparotid fever vaginitis vasomotor rhinitis vulvitis vulvovaginitis white sponge nevus
4121	mannosidase alpha class 1A member 1	MAN1A1	Homo sapiens (human)	Gaucher's disease acquired immunodeficiency syndrome breast cancer cancer congenital disorder of glycosylation Ih congenital disorder of glycosylation type I congenital disorder of glycosylation diabetes mellitus human immunodeficiency virus infectious disease ovarian cancer ovarian carcinoma type 2 diabetes mellitus
4122	mannosidase alpha class 2A member 2	MAN2A2 Aliases: HsT19662 MANA2X	Homo sapiens (human)	attention deficit hyperactivity disorder schizophrenia
4123	mannosidase alpha class 2C member 1	MAN2C1	Homo sapiens (human)	alpha-mannosidosis breast cancer breast carcinoma carcinoma esophageal cancer esophageal carcinoma intellectual disability learning disability post-traumatic stress disorder prostate cancer prostate carcinoma sarcomatoid carcinoma
4124	mannosidase alpha class 2A member 1	MAN2A1 Aliases: GOLIM7 golgi integral membrane protein 7	Homo sapiens (human)	autoimmune disease autoimmune lymphoproliferative syndrome cancer childhood acute lymphocytic leukemia congenital dyserythropoietic anemia type II congenital dyserythropoietic anemia diabetes mellitus embryoma giant cell glioblastoma glioblastoma hepatocellular carcinoma high grade glioma immune system disease liver cancer prostate cancer prostate carcinoma schizophrenia systemic lupus erythematosus type 2 diabetes mellitus
4125	mannosidase alpha class 2B member 1	MAN2B1 Aliases: LAMAN lysosomal alpha-mannosidase	Homo sapiens (human)	IgA glomerulonephritis Klippel-Feil syndrome age related macular degeneration alpha-mannosidosis aspartylglucosaminuria cerebral degeneration congenital nystagmus degeneration of macula and posterior pole dissociated nystagmus fucosidosis gingival hypertrophy gingival overgrowth glycogen storage disease II hypertrichosis inguinal hernia intellectual disability learning disability lingual-facial-buccal dyskinesia lysosomal storage disease macular degeneration methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency movement disease mucopolysaccharidosis I mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis Ih mucopolysaccharidosis VI mucopolysaccharidosis pathologic nystagmus retinal degeneration sensorineural hearing loss spondylolisthesis spontaneous ocular nystagmus
4126	mannosidase beta	MANBA Aliases: beta-mannosidase A	Homo sapiens (human)	Fabry disease allergic asthma allergic disease alternating hemiplegia of childhood angiokeratoma ascending cholangitis asthma attention deficit hyperactivity disorder autonomic neuropathy beta-mannosidosis central nervous system disease cholangitis chronic kidney disease chylomicron retention disease colorectal cancer colorectal carcinoma complement deficiency congenital nystagmus dissociated nystagmus epilepsy intellectual disability intrinsic asthma large intestine cancer learning disability lipid storage disease lysosomal storage disease multiple sclerosis nervous system disease obsolete constipation pathologic nystagmus primary biliary cholangitis primary sclerosing cholangitis sarcoidosis sclerosing cholangitis sensorineural hearing loss speech disorder spontaneous ocular nystagmus suppurative cholangitis uveoparotid fever visual epilepsy
4668	alpha-N-acetylgalactosaminidase	NAGA Aliases: D22S674 alpha-galactosidase B	Homo sapiens (human)	Clouston syndrome Fabry disease Kanzaki disease Schindler disease type 1 Unverricht-Lundborg syndrome acquired hyperkeratosis alternating hemiplegia of childhood angiokeratoma autistic disorder autonomic neuropathy blepharospasm cancer cardiomyopathy cataract central nervous system disease central nervous system origin vertigo cerebral degeneration chylomicron retention disease congenital nystagmus dissociated nystagmus early myoclonic encephalopathy elephantiasis embryoma endomyocardial fibrosis epilepsy familial hypertrophic cardiomyopathy focal hand dystonia gallbladder disease hypertrophic cardiomyopathy hypertropia influenza intellectual disability learning disability lipid storage disease liver disease lymphedema mechanical strabismus nervous system disease neuroaxonal dystrophy neurodegeneration with brain iron accumulation 2a neuropathy ophthalmoplegia optic atrophy pathologic nystagmus peripheral nervous system disease sensorineural hearing loss spontaneous ocular nystagmus strabismus syndromic X-linked intellectual disability 94 trichomoniasis visual epilepsy
4669	N-acetyl-alpha-glucosaminidase	NAGLU Aliases: NAG Sanfilippo disease IIIB	Homo sapiens (human)	Alzheimer's disease Burkitt lymphoma Charcot-Marie-Tooth disease axonal type 2V Clouston syndrome Dent disease Fanconi syndrome Glanzmann's thrombasthenia Kluver-Bucy syndrome Legg-Calve-Perthes disease Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease adenocarcinoma adenoma adrenal carcinoma adrenal cortex cancer adrenocortical carcinoma amnestic disorder amyloidosis appendicitis arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease atherosclerosis atrophic gastritis autistic disorder cancer cardiovascular system disease cholera chronic kidney disease chronic pyelonephritis cone-rod dystrophy congestive heart failure coronary artery disease cribriform carcinoma cystinosis cystitis dementia dentatorubral-pallidoluysian atrophy diabetes mellitus diabetic ketoacidosis diarrhea embryoma epilepsy essential thrombocythemia focal segmental glomerulosclerosis follicular adenoma fundus albipunctatus glomerulonephritis granular cell carcinoma gray platelet syndrome heart disease hydronephrosis hypertrichosis hypertrophic cardiomyopathy 1 intellectual disability kidney disease kidney failure learning disability lipoid nephrosis liver cirrhosis lysosomal storage disease malignant pleural mesothelioma microcystic adenoma mucopolysaccharidosis I mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis IVA mucopolysaccharidosis Ih mucopolysaccharidosis VI mucopolysaccharidosis type IIIA mucopolysaccharidosis type IIIB mucopolysaccharidosis type IIIC mucopolysaccharidosis type IIID mucopolysaccharidosis multiple epiphyseal dysplasia multiple myeloma myelodysplastic syndrome nephritis nephrosis neuroblastoma neurodegenerative disease oculocerebrorenal syndrome oculocutaneous albinism type IA osteochondrodysplasia otitis media panic disorder papillary adenoma parapsoriasis platelet-type bleeding disorder 17 platelet-type bleeding disorder 18 progressive familial intrahepatic cholestasis 1 progressive myoclonus epilepsy prostate cancer prostate carcinoma psoriasis pustulosis of palm and sole pyoureter qualitative platelet defect renal osteodystrophy retinitis pigmentosa retrograde amnesia sensorineural hearing loss spondyloepimetaphyseal dysplasia, Sponastrime type stomach cancer stomach carcinoma syndromic X-linked intellectual disability 94 trigonitis tubular adenocarcinoma type 2 diabetes mellitus viral infectious disease visual epilepsy
4758	neuraminidase 1	NEU1 Aliases: sialidase-1	Homo sapiens (human)	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Crohn's colitis Crohn's disease Ewing sarcoma of bone GM1 gangliosidosis type 1 GM1 gangliosidosis IgA glomerulonephritis Laron syndrome Marfan syndrome Paget's disease of bone Pick's disease Reye syndrome Unverricht-Lundborg syndrome achondroplasia acquired hyperkeratosis adenocarcinoma adenoma allergic rhinitis anaplastic astrocytoma arachnoiditis arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease aspartylglucosaminuria atherosclerosis autoimmune disease autoimmune lymphoproliferative syndrome basal cell carcinoma bile duct adenocarcinoma bile duct carcinoma biliary tract cancer bladder urothelial carcinoma blepharospasm bone osteosarcoma breast cancer breast carcinoma breast ductal carcinoma bronchus cancer bronchus carcinoma cancer carcinoma cardiomyopathy cataract cerebral degeneration childhood cerebral astrocytoma childhood osteosarcoma cholangiocarcinoma chondrodysplasia punctata chromophobe renal cell carcinoma clear cell renal cell carcinoma collecting duct carcinoma colorectal cancer colorectal carcinoma congenital nystagmus coronary artery disease cribriform carcinoma cutaneous Paget's disease dentatorubral-pallidoluysian atrophy dermoid cyst of ovary dissociated nystagmus early myoclonic encephalopathy embryoma endometrial adenocarcinoma endometrial cancer endometrial carcinoma endometrial serous adenocarcinoma endomyocardial fibrosis enterocele epilepsy fibrillary astrocytoma focal hand dystonia fucosidosis galactosialidosis gastroesophageal junction adenocarcinoma gemistocytic astrocytoma giant cell glioblastoma glioblastoma glomerulonephritis glucose intolerance glycoproteinosis granular cell carcinoma head and neck squamous cell carcinoma hepatocellular carcinoma high grade glioma hyperglycemia hypertrophic cardiomyopathy idiopathic interstitial pneumonia idiopathic pulmonary fibrosis immune system disease inflammatory bowel disease 1 inflammatory bowel disease influenza inguinal hernia intellectual disability intrahepatic cholangiocarcinoma invasive ductal carcinoma juvenile pilocytic astrocytoma kidney disease large intestine cancer learning disability livedoid vasculitis liver cancer lung benign neoplasm lung cancer lung carcinoma lung non-small cell carcinoma lysosomal storage disease malignant astrocytoma mammary Paget's disease melanoma meningitis microphthalmia mucolipidosis mucopolysaccharidosis I mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis Ih mucopolysaccharidosis VI mucopolysaccharidosis type IVB mucopolysaccharidosis multiple epiphyseal dysplasia nephritis nervous system cancer nonpapillary renal cell carcinoma osteochondrodysplasia osteosarcoma ovarian cancer ovarian carcinoma ovary adenocarcinoma papillary carcinoma papillary renal cell carcinoma pathologic nystagmus pilocytic astrocytoma postinflammatory pulmonary fibrosis prediabetes syndrome progressive myoclonus epilepsy 1A progressive myoclonus epilepsy 4 progressive myoclonus epilepsy prostate cancer prostate carcinoma proteinuria protoplasmic astrocytoma pulmonary fibrosis recurrent corneal erosion renal carcinoma renal cell carcinoma retinal disease retinitis rheumatoid arthritis sarcomatoid carcinoma sarcomatoid renal cell carcinoma schizophrenia scoliosis sebaceous carcinoma sensorineural hearing loss serous cystadenocarcinoma situs inversus skin melanoma speech disorder spontaneous ocular nystagmus steatotic liver disease stomach cancer stomach carcinoma subependymal giant cell astrocytoma sweat gland cancer systemic lupus erythematosus tarsal-carpal coalition syndrome transitional cell carcinoma tuberous sclerosis tubular adenocarcinoma ulcerative colitis uterine corpus cancer vascular skin disease vasomotor rhinitis visual epilepsy vitiligo
4759	neuraminidase 2	NEU2 Aliases: N-acetyl-alpha-neuraminidase 2 SIAL2	Homo sapiens (human)	allergic rhinitis cancer pancreatic cancer pancreatic carcinoma pancreatic ductal adenocarcinoma prostate cancer prostate carcinoma rhabdomyosarcoma stomach cancer stomach carcinoma vasomotor rhinitis
5016	oviductal glycoprotein 1	OVGP1 Aliases: CHIT5 oviductin	Homo sapiens (human)	bagassosis cancer centronuclear myopathy ciliary body disease colorectal cancer colorectal carcinoma congenital structural myopathy embryoma endometrial carcinoma endosalpingiosis iris disease large intestine cancer laryngitis ovarian cancer ovarian carcinoma panuveitis transient myeloproliferative syndrome tubular aggregate myopathy 1 uveitis
6476	sucrase-isomaltase	SI Aliases: Alpha-methylglucosidase Oligo-1,6-glucosidase Oligosaccharide alpha-1,6-glucosidase alpha-glucosidase	Homo sapiens (human)	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease Barrett's esophagus Clostridium difficile colitis Duchenne muscular dystrophy Fabry disease Gaucher's disease Gerstmann-Straussler-Scheinker syndrome Gorham's disease Japanese encephalitis Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease Pick's disease Reye syndrome Richter's syndrome adenocarcinoma adenoma amyotrophic lateral sclerosis arteriosclerotic cardiovascular disease atherosclerosis autosomal dominant Emery-Dreifuss muscular dystrophy 2 autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 1H autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2S autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy brachydactyly type C brachydactyly cancer cardiomyopathy cardiovascular system disease cerebral degeneration chronic lymphocytic leukemia chylomicron retention disease colitis colorectal cancer colorectal carcinoma congenital disorder of glycosylation congenital muscular dystrophy congenital sucrase-isomaltase deficiency coronary artery disease cribriform carcinoma cystic fibrosis cystinuria dengue disease depressive disorder diabetes mellitus diabetic ketoacidosis diarrhea disease of metabolism distal myopathy embryoma endomyocardial fibrosis facioscapulohumeral muscular dystrophy familial hypertrophic cardiomyopathy familial periodic paralysis galactosemia gastric cardia adenocarcinoma gastroenteritis gastrointestinal system disease glucose intolerance glucosephosphate dehydrogenase deficiency glycogen storage disease II glycogen storage disease IXa glycogen storage disease IXb glycogen storage disease IXc glycogen storage disease IXd glycogen storage disease Ia glycogen storage disease granular cell carcinoma heart disease hyperglycemia hypertrophic cardiomyopathy hypoglycemia ileitis ileocolitis intestinal disease irritable bowel syndrome kwashiorkor lactose intolerance large intestine cancer limb-girdle muscular dystrophy lipid storage disease lysosomal storage disease major depressive disorder marasmus melancholic depression muscular dystrophy myofibrillar myopathy 1 myofibrillar myopathy 3 myopathy myotonic dystrophy type 1 myotonic dystrophy type 2 nephrolithiasis neurocirculatory asthenia neurodegenerative disease nutmeg liver nutrition disease obesity obsolete autosomal dominant limb-girdle muscular dystrophy type 1A obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal recessive limb-girdle muscular dystrophy type 2R obsolete melancholia oculopharyngeal muscular dystrophy peptic ulcer disease prediabetes syndrome progressive muscular atrophy prolactinoma protein-energy malnutrition punctate palmoplantar keratoderma type III rippling muscle disease 2 sudden infant death syndrome tropical sprue tubular adenocarcinoma type 2 diabetes mellitus uric acid nephrolithiasis viral infectious disease yellow fever
6519	solute carrier family 3 member 1	SLC3A1 Aliases: ATR1 CSNU1 D2H NBAT RBAT amino acid transporter 1 neutral and basic amino acid transport protein rBAT	Homo sapiens (human)	IgA glomerulonephritis Marfan syndrome abdominal obesity-metabolic syndrome 1 acute myocardial infarction autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 1H autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2S autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy breast cancer breast carcinoma bulimia nervosa calcinosis calcium metabolism disease cancer chronic kidney disease colon carcinoma colorectal cancer congenital myasthenic syndrome 22 congenital ptosis coronary thrombosis cystinuria diabetes mellitus diabetic ketoacidosis distal myopathy epilepsy essential hypertension facioscapulohumeral muscular dystrophy galactosemia giant cell glioblastoma glioblastoma glucosephosphate dehydrogenase deficiency glycogen storage disease Ia glycogen storage disease high grade glioma hypercalcemia hypertension hypoglycemia hypogonadism hypotonia-cystinuria syndrome interstitial nephritis kidney failure lactic acidosis limb-girdle muscular dystrophy muscular dystrophy myocardial infarction nephrocalcinosis nephrolithiasis nephrosclerosis obsolete autosomal dominant limb-girdle muscular dystrophy type 1A obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal recessive limb-girdle muscular dystrophy type 2R oculopharyngeal muscular dystrophy panic disorder phosphorus metabolism disease primary pulmonary hypertension prostate cancer prostate carcinoma ptosis pyelitis pyelonephritis renal hypertension renal infectious disease silent myocardial infarction situs inversus synovial sarcoma tuberous sclerosis type 2 diabetes mellitus uric acid nephrolithiasis urinary tract obstruction vesicoureteral reflux visual epilepsy
6677	sperm adhesion molecule 1	SPAM1 Aliases: HYAL5 PH-20 PH-20 hyaluronidase SPAG15	Homo sapiens (human)	bladder carcinoma breast cancer breast carcinoma cancer carcinoma chronic obstructive pulmonary disease embryoma endocrine exophthalmos endometrial cancer endometrial carcinoma melanoma mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis VI mucopolysaccharidosis osteochondrodysplasia ovarian carcinoma prostate cancer prostate carcinoma skin melanoma squamous cell carcinoma thromboangiitis obliterans tongue squamous cell carcinoma urinary bladder cancer uterine corpus cancer
7841	mannosyl-oligosaccharide glucosidase	MOGS Aliases: CWH41 DER7 GCS1 glucosidase I processing A-glucosidase I	Homo sapiens (human)	Japanese encephalitis Turner syndrome Zika fever acquired hyperkeratosis actinic keratosis acute lymphoblastic leukemia acute myeloid leukemia adamantinoma agammaglobulinemia ameloblastoma blepharophimosis bronchus cancer bronchus carcinoma cancer cerebral degeneration chronic monocytic leukemia chronic myelomonocytic leukemia congenital disorder of glycosylation In congenital disorder of glycosylation Iq congenital disorder of glycosylation type I congenital disorder of glycosylation type II congenital disorder of glycosylation type IIb congenital disorder of glycosylation cystic fibrosis dengue disease epilepsy gonadal dysgenesis holoprosencephaly 1 holoprosencephaly juvenile myelomonocytic leukemia keratoacanthoma lung benign neoplasm lung cancer lung carcinoma lymphoblastic lymphoma malaria melanoma obesity optic atrophy pleomorphic xanthoastrocytoma sensorineural hearing loss skin melanoma viral infectious disease visual epilepsy yellow fever
8372	hyaluronidase 3	HYAL3 Aliases: LUCA-3 LUCA14 Minna14	Homo sapiens (human)	basal cell carcinoma cancer carcinoma central nervous system cancer embryoma endometrial cancer endometrial carcinoma glaucoma gliosarcoma high grade glioma lung squamous cell carcinoma mixed glioma sarcomatoid carcinoma uterine corpus cancer
8505	poly(ADP-ribose) glycohydrolase	PARG	Homo sapiens (human)	acute myeloid leukemia autoimmune disease autoimmune lymphoproliferative syndrome bone osteosarcoma borna disease brain infarction breast cancer breast carcinoma bronchus cancer bronchus carcinoma cancer childhood leukemia childhood osteosarcoma colon carcinoma colorectal cancer embryoma esophagus squamous cell carcinoma giant cell glioblastoma glioblastoma hepatocellular carcinoma herpes simplex high grade glioma immune system disease leukemia liver cancer liver carcinoma lung adenocarcinoma lung benign neoplasm lung cancer lung carcinoma microphthalmia obsolete Matthew-Wood syndrome osteosarcoma ovarian cancer ovarian carcinoma pancreatic cancer pancreatic carcinoma papillary adenocarcinoma papillary renal cell carcinoma stress-induced childhood-onset neurodegeneration with variable ataxia and seizures thyroid gland papillary carcinoma
8692	hyaluronidase 2	HYAL2 Aliases: LUCA2 LuCa-2 PH-20 homolog lysosomal hyaluronidase	Homo sapiens (human)	B-cell lymphoma acute chest syndrome adenocarcinoma adenoma adult lymphoma arthritis arthropathy breast cancer breast carcinoma bronchiolo-alveolar adenocarcinoma bronchus cancer bronchus carcinoma cancer carcinoma central nervous system cancer central nervous system lymphoma childhood lymphoma colitis colon cancer colon carcinoma colonic benign neoplasm colorectal cancer colorectal carcinoma congenital heart disease cribriform carcinoma dysplastic nevus syndrome embryoma endometrial cancer endometrial carcinoma endometriosis of uterus endometriosis gastroenteritis gliosarcoma granular cell carcinoma high grade glioma ileitis ileocolitis inflammatory bowel disease large intestine cancer lung benign neoplasm lung cancer lung carcinoma lung small cell carcinoma lymphoma melanoma microphthalmia mixed glioma mucopolysaccharidosis II mucopolysaccharidosis III mucopolysaccharidosis IV mucopolysaccharidosis IX mucopolysaccharidosis VI mucopolysaccharidosis obsolete Matthew-Wood syndrome obsolete ymphosarcoma osteoarthritis primary pulmonary hypertension pulmonary hypertension reticulosarcoma rheumatoid arthritis sarcomatoid carcinoma skin melanoma squamous cell carcinoma tongue squamous cell carcinoma tubular adenocarcinoma uterine corpus cancer
8972	maltase-glucoamylase	MGAM Aliases: MGA alpha-glucosidase	Homo sapiens (human)	Duchenne muscular dystrophy Fabry disease Gaucher's disease Gerstmann-Straussler-Scheinker syndrome Gorham's disease Japanese encephalitis adenocarcinoma adenoma amyotrophic lateral sclerosis arteriosclerotic cardiovascular disease atherosclerosis autosomal dominant Emery-Dreifuss muscular dystrophy 2 autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 1H autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2S autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy brachydactyly type C brachydactyly breast cancer breast carcinoma cancer cardiomyopathy cardiovascular system disease chylomicron retention disease congenital disorder of glycosylation congenital muscular dystrophy coronary artery disease cribriform carcinoma cystic fibrosis cystinuria dengue disease depressive disorder diabetes mellitus diabetic ketoacidosis dilated cardiomyopathy 1A dilated cardiomyopathy distal myopathy embryoma endomyocardial fibrosis facioscapulohumeral muscular dystrophy familial hypertrophic cardiomyopathy familial periodic paralysis galactosemia glucosephosphate dehydrogenase deficiency glycogen storage disease II glycogen storage disease IXa glycogen storage disease IXb glycogen storage disease IXc glycogen storage disease IXd glycogen storage disease Ia glycogen storage disease granular cell carcinoma heart disease hyperglycemia hypertrophic cardiomyopathy hypoglycemia limb-girdle muscular dystrophy lipid storage disease lysosomal storage disease major depressive disorder melancholic depression muscular dystrophy myofibrillar myopathy 1 myofibrillar myopathy 3 myopathy myotonic dystrophy type 1 myotonic dystrophy type 2 neuromuscular disease nutmeg liver obesity obsolete autosomal dominant limb-girdle muscular dystrophy type 1A obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal recessive limb-girdle muscular dystrophy type 2R obsolete constipation obsolete melancholia oculopharyngeal muscular dystrophy progressive muscular atrophy prolactinoma punctate palmoplantar keratoderma type III rippling muscle disease 2 squamous cell carcinoma tongue squamous cell carcinoma tubular adenocarcinoma type 2 diabetes mellitus viral infectious disease yellow fever
9365	klotho	KL Aliases: KLA alpha-klotho	Homo sapiens (human)	Alzheimer's disease 10 Alzheimer's disease 11 Alzheimer's disease 12 Alzheimer's disease 13 Alzheimer's disease 14 Alzheimer's disease 15 Alzheimer's disease 1 Alzheimer's disease 2 Alzheimer's disease 5 Alzheimer's disease 6 Alzheimer's disease 7 Alzheimer's disease 8 Alzheimer's disease B-cell lymphoma Burkitt lymphoma Cockayne syndrome Cornelia de Lange syndrome Dubowitz syndrome Duchenne muscular dystrophy Hodgkin's granuloma Hodgkin's lymphoma, lymphocytic depletion Hodgkin's lymphoma, lymphocytic-histiocytic predominance Hodgkin's lymphoma, mixed cellularity Hodgkin's lymphoma Huntington's disease-like 1 Huntington's disease-like 2 Huntington's disease IgA glomerulonephritis Kummell's disease Noonan syndrome 10 Noonan syndrome 1 Noonan syndrome 2 Noonan syndrome 3 Noonan syndrome 4 Noonan syndrome 5 Noonan syndrome 6 Noonan syndrome 7 Noonan syndrome 8 Noonan syndrome 9 Noonan syndrome Parkinson's disease 19A Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease Pick's disease Prader-Willi syndrome Prinzmetal angina Reye syndrome Robinow syndrome Seckel syndrome Silver-Russell syndrome Smith-McCort dysplasia Werner syndrome X-linked Aarskog syndrome X-linked dominant hypophosphatemic rickets Zollinger-Ellison syndrome abdominal obesity-metabolic syndrome 1 acromegaly actinic keratosis acute myocardial infarction acute pancreatitis adenocarcinoma adenoma adult respiratory distress syndrome alcohol dependence alcohol use disorder alternating hemiplegia of childhood amnestic disorder amyotrophic lateral sclerosis androgen insensitivity syndrome anemia aortic valve disease 1 aortic valve disease aortic valve stenosis arteriolosclerosis arteriosclerosis arteriosclerotic cardiovascular disease arthritis arthropathy atherosclerosis atrial fibrillation autonomic neuropathy autosomal dominant Robinow syndrome 1 autosomal dominant Robinow syndrome 2 autosomal dominant Robinow syndrome 3 autosomal dominant polycystic kidney disease autosomal recessive Robinow syndrome bacterial infectious disease bacterial sepsis beta thalassemia bicuspid aortic valve disease bipolar disorder bladder carcinoma bone disease breast cancer breast carcinoma bronchus cancer bronchus carcinoma calcinosis calcium metabolism disease cancer cardiomyopathy cardiovascular system disease carotid artery disease carotid artery thrombosis carotid stenosis cartilage disease central nervous system disease cerebral degeneration cerebral infarction cerebrovascular disease cervical adenocarcinoma cervical cancer cervix carcinoma chondrocalcinosis chondrodysplasia-pseudohermaphroditism syndrome chromophobe renal cell carcinoma chronic fatigue syndrome chronic kidney disease chronic obstructive pulmonary disease clear cell renal cell carcinoma colitis collecting duct carcinoma colon cancer colon carcinoma colonic benign neoplasm colorectal cancer colorectal carcinoma cone-rod dystrophy congestive heart failure connective tissue disease coronary artery disease coronary stenosis coronary thrombosis cribriform carcinoma dedifferentiated liposarcoma dementia demyelinating disease depressive disorder diabetes mellitus diabetic ketoacidosis diffuse large B-cell lymphoma dilated cardiomyopathy 1A dilated cardiomyopathy disease of metabolism dysthymic disorder embryoma encephalitis encephalomyelitis end stage renal disease endomyocardial fibrosis enthesopathy epilepsy essential hypertension exostosis familial adenomatous polyposis familial hyperlipidemia familial nephrotic syndrome follicular adenoma fundus albipunctatus gastroenteritis giant cell glioblastoma glioblastoma glomerulonephritis granular cell carcinoma growth hormone secreting pituitary adenoma head and neck squamous cell carcinoma heart disease hematologic cancer hepatocellular carcinoma high grade glioma hypercalcemia hyperglycemia hyperinsulinism hyperparathyroidism hyperphosphatemia hyperphosphatemic familial tumoral calcinosis hyperpituitarism hypertension hypertrophic cardiomyopathy hypoglycemia hypophosphatemia idiopathic interstitial pneumonia idiopathic pulmonary fibrosis ileitis ileocolitis infertility insulinoma intellectual disability intracranial embolism invasive ductal carcinoma kidney cancer kidney disease kidney failure kidney hypertrophy kwashiorkor large intestine cancer late onset Parkinson's disease learning disability lipoid nephrosis liposarcoma liver cancer liver cirrhosis localized scleroderma lung benign neoplasm lung cancer lung carcinoma lung large cell carcinoma lung non-small cell carcinoma lung small cell carcinoma lung squamous cell carcinoma macrocytic anemia major depressive disorder marasmus melancholic depression melanoma microcephalic osteodysplastic primordial dwarfism type I microcephalic osteodysplastic primordial dwarfism type II microcystic adenoma microphthalmia middle cerebral artery infarction monoclonal gammopathy of uncertain significance mood disorder multiple myeloma multiple sclerosis muscular dystrophy musculoskeletal system disease myelitis myocardial infarction myositis nephritis nephrocalcinosis nephrolithiasis nephrosis nephrotic syndrome nervous system disease neurodegenerative disease neurotic disorder newborn respiratory distress syndrome nonpapillary renal cell carcinoma nutmeg liver nutrition disease obesity obsolete Matthew-Wood syndrome obsolete melancholia obsolete type 1 diabetes mellitus 9 obsolete ymphosarcoma obstructive sleep apnea osteitis fibrosa osteoarthritis osteomalacia osteonecrosis osteoporosis ovarian cancer ovarian carcinoma pancreatic adenocarcinoma pancreatic cancer pancreatic carcinoma pancreatitis papillary adenoma papillary renal cell carcinoma parathyroid adenoma parathyroid carcinoma parathyroid gland disease periarthritis phosphorus metabolism disease placental insufficiency pleomorphic liposarcoma polycystic kidney disease 1 porphyria cutanea tarda postinflammatory pulmonary fibrosis premature menopause priapism primary hyperparathyroidism primary ovarian insufficiency primary pulmonary hypertension progeria progressive muscular atrophy prostate cancer prostate carcinoma protein-energy malnutrition pulmonary emphysema pulmonary fibrosis pulmonary large cell neuroendocrine carcinoma pyoureter reflex sympathetic dystrophy relapsing-remitting multiple sclerosis renal carcinoma renal cell carcinoma renal osteodystrophy retinal disease retinitis pigmentosa 1 retinitis pigmentosa retinitis retrograde amnesia rheumatoid arthritis rickets sarcomatoid renal cell carcinoma schizophrenia scleroderma seborrheic keratosis secondary hyperparathyroidism sickle cell anemia silent myocardial infarction skin disease skin melanoma spondyloarthropathy spondylosis squamous cell carcinoma systemic scleroderma tendinitis thyroid adenoma thyroid cancer thyroid gland carcinoma thyroid gland follicular carcinoma tongue squamous cell carcinoma tubular adenocarcinoma type 1 diabetes mellitus 10 type 1 diabetes mellitus 11 type 1 diabetes mellitus 12 type 1 diabetes mellitus 13 type 1 diabetes mellitus 15 type 1 diabetes mellitus 17 type 1 diabetes mellitus 18 type 1 diabetes mellitus 19 type 1 diabetes mellitus 20 type 1 diabetes mellitus 21 type 1 diabetes mellitus 22 type 1 diabetes mellitus 23 type 1 diabetes mellitus 24 type 1 diabetes mellitus 2 type 1 diabetes mellitus 3 type 1 diabetes mellitus 4 type 1 diabetes mellitus 5 type 1 diabetes mellitus 6 type 1 diabetes mellitus 7 type 1 diabetes mellitus 8 type 1 diabetes mellitus type 2 diabetes mellitus uremia ureteral obstruction uric acid nephrolithiasis urinary bladder cancer vascular dementia vascular disease
9695	ER degradation enhancing alpha-mannosidase like protein 1	EDEM1 Aliases: EDEM KIAA0212	Homo sapiens (human)	cystic fibrosis depressive disorder hepatitis C major depressive disorder melancholic depression melanoma neurotic disorder obsolete melancholia skin melanoma

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