Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / OrganismsTools
SugarDrawer
GlycanBuilder
Glycan Converters
GlycoMaple
GlycomeAtlas
LM-GlycomeAtlas
GALAXY
MCAW
GlycoSim
GRable
Guidelines
MIRAGE
Epidermal growth factor receptor
Summary
- UniProt ID
- P00533
- Gene Symbol
-
- EGFR
- ERBB
- ERBB1
- HER1
- Gene ID
- 1956
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011271
- GlyConnect
- GlyGen
- P00533
- PubChem
- P00533
- The Human Metabolome Database
- HMDBP01456
- The O-GlcNAc Database
- P00533
- RaftProt
- P00533
- O-GlcNAcAtlas
- P00533
- Re-Glyco
- P00533
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Developmental protein
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Golgi apparatus
- Host cell receptor for virus entry
- Host-virus interaction
- Hydroxylation
- Isopeptide bond
- Methylation
- Nucleus
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| basolateral plasma membrane |
| apical plasma membrane |
| perinuclear region of cytoplasm |
| focal adhesion |
| endosome membrane |
| early endosome membrane |
| ruffle membrane |
| membrane raft |
| GO Term |
|---|
| positive regulation of cell population proliferation |
| diterpenoid metabolic process |
| neurogenesis |
| positive regulation of cell growth |
| lung development |
| positive regulation of cell migration |
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 384 |
|
|||
| 413 | N-linked (GlcNAc...) asparagine | |||
| 430 |
|
|||
| 437 |
|
|||
| 442 |
|
|||
| 444 | N-linked (GlcNAc...) asparagine | |||
| 468 |
|
|||
| 474 |
|
|||
| 528 | N-linked (GlcNAc...) asparagine | |||
| 568 | N-linked (GlcNAc...) asparagine; partial |
G49108TO
G15127JD
G45395BF
G14972EH
G43223CG
G60177UT
G08918WF
G75983OB
G70441OD
G87661QW
G83646BJ
G04657PL
G25451PN
G27058EU
G83461WR
G41071NU
G70619PT
G42124LM
G90659AW
G62765YT
G95177YH
G80920RR
G33791AF
G48414YA
G84452RH
G40926MX
G27915IV
G59626AS
G37399XV
G31852PQ
G80479JV
G79666IR
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Homo sapiens |
| Clathrin-mediated endocytosis | Homo sapiens |
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| Constitutive Signaling by EGFRvIII | Homo sapiens |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Homo sapiens |
| Downregulation of ERBB2 signaling | Homo sapiens |
| EGFR Transactivation by Gastrin | Homo sapiens |
| EGFR downregulation | Homo sapiens |
| EGFR interacts with phospholipase C-gamma | Homo sapiens |
| ERBB2 Activates PTK6 Signaling | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050589 | inflammatory bowel disease | |
| DOID:10283 | prostate cancer | |
| DOID:1324 | lung cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:2957 | pulmonary tuberculosis | |
| DOID:3459 | breast carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3910 | lung adenocarcinoma | |
| DOID:4926 | bronchiolo-alveolar adenocarcinoma | |
| DOID:9256 | colorectal cancer |
