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Prothrombin

Summary
UniProt ID
P00734
Gene Symbol
  • F2
Gene ID
2147
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011275
GlyConnect
GlyGen
P00734
PubChem
P00734
The Human Metabolome Database
HMDBP13521
RaftProt
P00734
Re-Glyco
P00734
Annotation
Keyword
  • 3D-structure
  • Acute phase
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Kringle
  • Pharmaceutical
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Thrombophilia
  • Zymogen
Gene Ontology (GO)
Displaying all 8 entries
GO Term
extracellular region
extracellular space
plasma membrane
collagen-containing extracellular matrix
endoplasmic reticulum lumen
Golgi lumen
extracellular exosome
blood microparticle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 13 in total
Position Description PubMed ID GlyTouCan ID Source
78
121 N-linked (GlcNAc...) (complex) asparagine
143 N-linked (GlcNAc...) (complex) asparagine
145
192
199
205
207
260
315
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 14 in total
Pathway Name Organism
Cell surface interactions at the vascular wall Homo sapiens
Common Pathway of Fibrin Clot Formation Homo sapiens
Defective F8 cleavage by thrombin Homo sapiens
Defective factor XII causes hereditary angioedema Homo sapiens
G alpha (q) signalling events Homo sapiens
Gamma-carboxylation of protein precursors Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Peptide ligand-binding receptors Homo sapiens
Platelet Aggregation (Plug Formation) Homo sapiens
Regulation of Complement cascade Homo sapiens
Disease
Displaying entries 11 - 20 of 22 in total
DO ID Disease Name Source
DOID:1727 retinal vein occlusion
DOID:2048 autoimmune hepatitis
DOID:2235 prothrombin deficiency
DOID:2921 glomerulonephritis
DOID:3393 coronary artery disease
DOID:3526 cerebral infarction
DOID:5614 eye disease
DOID:5844 myocardial infarction
DOID:8337 appendicitis
DOID:8536 herpes zoster
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025