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Prothrombin

Summary
UniProt ID
P00734
Gene Symbol
  • F2
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011275
GlyConnect
GlyGen
P00734
PubChem
P00734
The Human Metabolome Database
HMDBP13521
RaftProt
P00734
Annotation
Keyword
  • 3D-structure
  • Acute phase
  • Calcium
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Gamma-carboxyglutamic acid
  • Glycoprotein
  • Kringle
  • Pharmaceutical
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Thrombophilia
  • Zymogen
Gene Ontology (GO)
Annotation information from UniProt.
Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 11 - 13 of 13 in total
Position Description PubMed ID GlyTouCan ID Source
317
416 N-linked (GlcNAc...) (complex) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 14 in total
Pathway Name Organism
Cell surface interactions at the vascular wall Homo sapiens
Common Pathway of Fibrin Clot Formation Homo sapiens
Defective F8 cleavage by thrombin Homo sapiens
Defective factor XII causes hereditary angioedema Homo sapiens
G alpha (q) signalling events Homo sapiens
Gamma-carboxylation of protein precursors Homo sapiens
Intrinsic Pathway of Fibrin Clot Formation Homo sapiens
Peptide ligand-binding receptors Homo sapiens
Platelet Aggregation (Plug Formation) Homo sapiens
Regulation of Complement cascade Homo sapiens
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024