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MIRAGE
Immunoglobulin heavy constant gamma 3

Summary
UniProt ID
P01860
Gene Symbol
  • IGHG3
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01860
PubChem
P01860
The O-GlcNAc Database
P01860
RaftProt
P01860
Re-Glyco
P01860
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Immunoglobulin
  • Immunoglobulin domain
  • Reference proteome
  • Repeat
  • Secreted
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 7 entries
GO Term
extracellular region
extracellular space
plasma membrane
immunoglobulin complex, circulating
IgG immunoglobulin complex
extracellular exosome
blood microparticle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
antigen binding
immunoglobulin receptor binding
Annotation information from UniProt.
Sequence
ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPREEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 9 entries
Position Description PubMed ID GlyTouCan ID Source
15
114
119
122 O-linked (GalNAc...) threonine
137 O-linked (GalNAc...) threonine
152 O-linked (GalNAc...) threonine
227 N-linked (GlcNAc...) asparagine
322 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 8 entries
Pathway Name Organism
Classical antibody-mediated complement activation Homo sapiens
FCGR activation Homo sapiens
FCGR3A-mediated IL10 synthesis Homo sapiens
FCGR3A-mediated phagocytosis Homo sapiens
Initial triggering of complement Homo sapiens
Regulation of Complement cascade Homo sapiens
Regulation of actin dynamics for phagocytic cup formation Homo sapiens
Role of phospholipids in phagocytosis Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025