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Lactotransferrin

Summary

UniProt ID

P02788

Gene Symbol

LTF
GIG12
LF

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0015589

GlyConnect

2842
320

GlyGen

P02788

PubChem

P02788

The Human Metabolome Database

HMDBP02010

The O-GlcNAc Database

P02788

RaftProt

P02788

Annotation

Keyword

3D-structure
Alternative promoter usage
Antibiotic
Cytoplasm
DNA-binding
Direct protein sequencing
Disulfide bond
Glycoprotein
Heparin-binding
Immunity
Iron transport
Isopeptide bond
Metal-binding
Nucleus
Osteogenesis
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 31 in total

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GO Term
negative regulation by host of viral process
negative regulation of viral genome replication
negative regulation of cysteine-type endopeptidase activity
negative regulation of ATP-dependent activity
positive regulation of canonical NF-kappaB signal transduction
positive regulation of NF-kappaB transcription factor activity
antibacterial humoral response
antifungal humoral response
killing of cells of another organism
defense response to Gram-negative bacterium

Displaying entries **11 - 15** of 15 in total

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GO Term
plasma membrane
secretory granule
protein-containing complex
extracellular exosome
tertiary granule lumen

Displaying **all 8** entries
GO Term
serine-type endopeptidase activity
lipopolysaccharide binding
cysteine-type endopeptidase inhibitor activity
membrane destabilizing activity
DNA binding
iron ion binding
heparin binding
protein serine/threonine kinase activator activity

Annotation information from UniProt.

Sequence

MKLVFLVLLFLGALGLCLAGRRRSVQWCAVSQPEATKCFQWQRNMRKVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
10	O-linked (GlcNAc) serine; alternate	20404350		UniProt
156	N-linked (GlcNAc...) asparagine	15299444 15299793 1581307 16201406 18780401 8069634	G26377UA G01521EA G12745LE G15127JD G67164EE G81637OR G70894RY G50856PC G99679NM G82443XX G32788FZ G52890YB G80669SJ G39471UU G05962QB G15169WU G70232NH G55132BD G79286RS G37818NZ G93656SY G03644CB G31544HA G06247RL G47518TP G35541EV G34617SM G75568BH G77582RK G20312EM G80075MS G11629QQ G57776ZS G75418YA G60834IK G07162IJ G33608TH G86795LJ G86880BF G27947YN G28622IK G90382BL G91473PK G81375TC G87123QX G96577RX G79666IR G81263BG G92135MA G34989PA G81198YO G40834TG G47012YE G51413EV G08146BT G17689DH G22310AV G45395BF G56749GV G88374WZ G91255CS G27516OE G02628JF G66163OV G74264KM G59536GA G77459ND G65540UB G02030ZB G43223CG G58954YZ G95977AE G31986NC G86226EA G10846ZT G60177UT G40574BA G82830MN G93683YO G00273SJ G83229XP G08918WF G71146HJ G75983OB G90348RI G00912UN G42358LZ G48414YA G77252PU G84467IZ G08110WX G61256FT G72797UR G17208MA G63381RX G76295SF G80223IX G25418HZ G66766XF G04657PL G25451PN G87051GH G11041DA G27058EU G44444MB G45495MK G84452RH G32332VU G46524LG G39619TI G75051CY G83460ZZ G76613WN G35253PZ G42962KI G44215PV G70619PT G06356OH G37868ZX G59626AS G93284HQ G72398FA G08290VR G14994KB G70101JE G80920RR G65092SV G23863VK G57818FI G78059CC G83555HU G64409MC G62765YT G47950XN G47644PP G23432EQ G10256JP G46687AB G61937QU G29880MM G23453IV G27993JQ G92275SC	GlycoProtDB UniProt GlyGen GlyConnect
436			G27945LI G63628AV	GlyGen GlyConnect
497	N-linked (GlcNAc...) asparagine	15299793 1581307 16201406 18780401 19159218	G64751KD G12745LE G15127JD G67164EE G07810QS G50856PC G95046LV G39471UU G05962QB G64394MX G55132BD G37818NZ G34105RF G51806IG G35541EV G34617SM G93718GY G75568BH G20312EM G80075MS G11629QQ G57776ZS G86408JD G99668VU G60834IK G07162IJ G33608TH G86795LJ G86880BF G27947YN G52527GH G90382BL G90093AU G37692EO G33416PL G04854VP G87123QX G96577RX G79666IR G81263BG G65019XG G92135MA G26403SG G98611JV G34989PA G81198YO G40834TG G47012YE G51413EV G08146BT G17689DH G22310AV G45395BF G56749GV G59324HL G20706XG G10819WX G66163OV G74264KM G40926MX G59536GA G77459ND G14972EH G02030ZB G43223CG G58954YZ G95977AE G37412TK G54612UD G31986NC G86226EA G26330YA G10846ZT G60177UT G40574BA G82830MN G00273SJ G83229XP G08918WF G71146HJ G75983OB G90348RI G00912UN G42358LZ G48414YA G77252PU G84467IZ G61256FT G72797UR G70822IO G87661QW G66760KM G83646BJ G63381RX G72667IM G76295SF G15664MX G66621EA G46691LC G80223IX G25418HZ G27126ED G04657PL G25451PN G11041DA G27058EU G44444MB G45495MK G84452RH G10773YW G51640FO G20425TQ G62837OZ G41071NU G91636VS G24835MQ G35253PZ G85228QD G46902YN G72747WU G42962KI G44215PV G70619PT G06356OH G37868ZX G59626AS G93284HQ G84862VB G08290VR G14994KB G92406TI G20210JR G23294PN G25079LO G63041LO G79568CQ G03382KH G65092SV G23863VK G57818FI G78059CC G90659AW G74430RZ G77547TA G31916IQ G64409MC G80333GO G59924QI G84820NF G29299MO G37399XV G82463GQ G62765YT G64527OM G66676MI G47950XN G11870QZ G47644PP G23432EQ G10256JP G22140GZ G50045TK G46687AB G61937QU G72735IY G82119TF G55383ZG G72291OX G05724UK G82020ZR G90575OW G81295CK G49874UX G33609NS G89319AW G29880MM G68698AP G39188ZX G80966KZ G23453IV G03127AL G94854LT G02815KT G06110VR G55220VL G27251WT G60145BJ G74724QE G92275SC G14669DU G22768VO	UniProt GlyGen GlyConnect
642	N-linked (GlcNAc...) asparagine	18780401	G20312EM G11629QQ G86795LJ G81263BG G51413EV G08146BT G22310AV G66163OV G71146HJ G75983OB G66760KM G45495MK G84452RH G46524LG G04909DG G06356OH G23863VK G57818FI G12313PD G26421QW	UniProt GlyGen GlyConnect
			G07162IJ G33608TH G86795LJ G90974PL G96577RX G17689DH G22310AV G56749GV G96921ZU G66163OV G68283NG G74264KM G75983OB G90348RI G14047PA G48414YA G77252PU G84467IZ G07392QY G11041DA G44444MB G84452RH G44215PV G76478FT G06356OH G93284HQ G23863VK G78059CC G50045TK G89241QS G75927AR G74587YW G26295XE G57449OF G90544QC G49108TO	GlyGen The O-GlcNAc Database GlyConnect GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Amyloid fiber formation	Homo sapiens
Antimicrobial peptides	Homo sapiens
Metal sequestration by antimicrobial proteins	Homo sapiens
Mtb iron assimilation by chelation	Homo sapiens
Neutrophil degranulation	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements