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MIRAGE
Receptor tyrosine-protein kinase erbB-2

Summary
UniProt ID
P04626
Gene Symbol
  • ERBB2
  • HER2
  • MLN19
  • NEU
  • NGL
Gene ID
2064
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011368
GlyConnect
GlyGen
P04626
PubChem
P04626
The Human Metabolome Database
HMDBP01473
RaftProt
P04626
Re-Glyco
P04626
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Activator
  • Alternative initiation
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Chromosomal rearrangement
  • Cytoplasm
  • Disease variant
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Nucleus
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Signal
  • Transcription regulation
  • Transmembrane helix
  • Tyrosine-protein kinase
Gene Ontology (GO)
Displaying entries 1 - 10 of 18 in total
GO Term
nucleus
plasma membrane
membrane
neuromuscular junction
myelin sheath
receptor complex
nucleoplasm
early endosome
cytosol
basal plasma membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 10 entries
Position Description PubMed ID GlyTouCan ID Source
68 N-linked (GlcNAc...) asparagine
124 N-linked (GlcNAc...) asparagine
127
187 N-linked (GlcNAc...) asparagine
259 N-linked (GlcNAc...) asparagine
526
530 N-linked (GlcNAc...) asparagine
571 N-linked (GlcNAc...) asparagine
629 N-linked (GlcNAc...) asparagine
998
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 21 - 30 of 30 in total
Pathway Name Organism
Resistance of ERBB2 KD mutants to sapitinib Homo sapiens
Resistance of ERBB2 KD mutants to tesevatinib Homo sapiens
Resistance of ERBB2 KD mutants to trastuzumab Homo sapiens
SHC1 events in ERBB2 signaling Homo sapiens
Sema4D induced cell migration and growth-cone collapse Homo sapiens
Signaling by ERBB2 Homo sapiens
Signaling by ERBB2 ECD mutants Homo sapiens
Signaling by ERBB2 KD Mutants Homo sapiens
Signaling by ERBB2 TMD/JMD mutants Homo sapiens
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Homo sapiens
Disease
Displaying all 9 entries
DO ID Disease Name Source
DOID:10283 prostate cancer
DOID:10534 stomach cancer
DOID:11054 urinary bladder cancer
DOID:1324 lung cancer
DOID:2394 ovarian cancer
DOID:3070 high grade glioma
DOID:3443 mammary Paget's disease
DOID:3910 lung adenocarcinoma
DOID:4450 renal cell carcinoma
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025