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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Neutrophil elastase
Summary
- UniProt ID
- P08246
- Gene Symbol
-
- ELANE
- ELA2
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P08246
- PubChem
- P08246
- The Human Metabolome Database
- HMDBP13378
Annotation
- Keyword
-
- 3D-structure
- Cytoplasmic vesicle
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Reference proteome
- Serine protease
- Signal
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| cell surface |
| extracellular region |
| extracellular space |
| cytoplasm |
| secretory granule |
| collagen-containing extracellular matrix |
| azurophil granule lumen |
| specific granule lumen |
| transcription repressor complex |
| GO Term |
|---|
| serine-type endopeptidase activity |
| heparin binding |
| protease binding |
| transcription corepressor activity |
| endopeptidase activity |
| peptidase activity |
| cytokine binding |
Sequence
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 88 | N-linked (GlcNAc...) asparagine | |||
| 124 | N-linked (GlcNAc...) asparagine |
|
||
| 173 | N-linked (GlcNAc...) asparagine | |||
| 185 |
|
|
G00912UN
G27058EU
G59626AS
G72291OX
G95865ZB
G11314AS
G25637MV
G36379GD
G08290VR
G29299MO
G47950XN
G11870QZ
G47644PP
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of Matrix Metalloproteinases | Homo sapiens |
| Antimicrobial peptides | Homo sapiens |
| Collagen degradation | Homo sapiens |
| Degradation of the extracellular matrix | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Pyroptosis | Homo sapiens |
| Regulation of Complement cascade | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
