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MIRAGE
HLA class I histocompatibility antigen, C alpha chain
Summary
- UniProt ID
- P10321
- Gene Symbol
-
- HLA-C
- HLAC
- Gene ID
- 3107
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Cell membrane
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Innate immunity
- MHC I
- Phosphoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| endoplasmic reticulum |
| Golgi apparatus |
| external side of plasma membrane |
| cell surface |
| ER to Golgi transport vesicle membrane |
| early endosome membrane |
| recycling endosome membrane |
| extracellular exosome |
| phagocytic vesicle membrane |
| GO Term |
|---|
| signaling receptor binding |
| TAP binding |
| peptide antigen binding |
Sequence
MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 110 | N-linked (GlcNAc...) asparagine | |||
| 112 |
|
|||
| 211 |
|
|||
| 214 |
|
|||
| 224 |
|
G39619TI
G08290VR
G48584BU
G70101JE
G64527OM
G49108TO
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Antigen Presentation: Folding, assembly and peptide loading of class I MHC | Homo sapiens |
| DAP12 interactions | Homo sapiens |
| ER-Phagosome pathway | Homo sapiens |
| Endosomal/Vacuolar pathway | Homo sapiens |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
| Interferon alpha/beta signaling | Homo sapiens |
| Interferon gamma signaling | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080600 | COVID-19 | |
| DOID:0111286 | psoriasis 1 | |
| DOID:526 | human immunodeficiency virus infectious disease | |
| DOID:9415 | allergic asthma |
