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HLA class I histocompatibility antigen, C alpha chain

Summary

UniProt ID

P10321

Gene Symbol

HLA-C
HLAC

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011467

GlyConnect

1363

GlyGen

P10321

PubChem

P10321

The O-GlcNAc Database

P10321

RaftProt

P10321

O-GlcNAcAtlas

P10321

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Host-virus interaction
Innate immunity
MHC I
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
adaptive immune response
immune response
innate immune response

Displaying entries **1 - 10** of 16 in total

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GO Term
ER to Golgi transport vesicle membrane
phagocytic vesicle membrane
early endosome membrane
recycling endosome membrane
extracellular exosome
lumenal side of endoplasmic reticulum membrane
MHC class I protein complex
Golgi membrane
endoplasmic reticulum
Golgi apparatus

Displaying **all 3** entries
GO Term
signaling receptor binding
TAP binding
peptide antigen binding

Annotation information from UniProt.

Sequence

MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
110	N-linked (GlcNAc...) asparagine	19159218	G39619TI G08290VR G48584BU G70101JE G64527OM	GlycoProtDB UniProt GlyGen GlyConnect
112			G49108TO	GlyGen The O-GlcNAc Database
211			G57321FI	GlyGen
214			G57321FI	GlyGen
224			G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Homo sapiens
DAP12 interactions	Homo sapiens
ER-Phagosome pathway	Homo sapiens
Endosomal/Vacuolar pathway	Homo sapiens
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Homo sapiens
Interferon alpha/beta signaling	Homo sapiens
Interferon gamma signaling	Homo sapiens
Neutrophil degranulation	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens