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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Summary
- UniProt ID
- P16885
- Gene Symbol
-
- PLCG2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P16885
- PubChem
- P16885
- SwissLipids
- The Human Metabolome Database
- HMDBP00230
- The O-GlcNAc Database
- P16885
- RaftProt
- P16885
Annotation
- Keyword
-
- 3D-structure
- Calcium
- Disease variant
- Hydrolase
- Lipid degradation
- Membrane
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- SH3 domain
- Transducer
- Gene Ontology (GO)
| GO Term |
|---|
| inositol trisphosphate biosynthetic process |
| positive regulation of NLRP3 inflammasome complex assembly |
| positive regulation of cell cycle G1/S phase transition |
| positive regulation of I-kappaB phosphorylation |
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| extracellular exosome |
| intracellular vesicle |
| cytosol |
| membrane raft |
| ruffle membrane |
| perinuclear region of cytoplasm |
Sequence
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSNSKFYS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | Homo sapiens |
| CLEC7A (Dectin-1) signaling | Homo sapiens |
| DAP12 signaling | Homo sapiens |
| Dectin-2 family | Homo sapiens |
| Erythropoietin activates Phospholipase C gamma (PLCG) | Homo sapiens |
| FCERI mediated Ca+2 mobilization | Homo sapiens |
| FCERI mediated MAPK activation | Homo sapiens |
| FCGR3A-mediated IL10 synthesis | Homo sapiens |
| GPVI-mediated activation cascade | Homo sapiens |
| Generation of second messenger molecules | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060901 | lymphoplasmacytic lymphoma | |
| DOID:0070129 | autosomal recessive cutis laxa type IID | |
| DOID:0070130 | autosomal dominant cutis laxa 1 | |
| DOID:0070131 | autosomal dominant cutis laxa 3 | |
| DOID:0070132 | autosomal recessive cutis laxa type IIIA | |
| DOID:0070133 | autosomal recessive cutis laxa type IB | |
| DOID:0070134 | autosomal recessive cutis laxa type IIA | |
| DOID:0070135 | autosomal recessive cutis laxa type IA | |
| DOID:0070136 | autosomal dominant cutis laxa 2 | |
| DOID:0070137 | autosomal recessive cutis laxa type IIB |
