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HLA class I histocompatibility antigen, alpha chain F

Summary

UniProt ID

P30511

Gene Symbol

HLA-F
HLA-5.4
HLAF

Organism

Homo sapiens (human)

External Links

GlyGen: P30511
The O-GlcNAc Database: P30511
RaftProt: P30511
O-GlcNAcAtlas: P30511

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Endosome
Glycoprotein
Lysosome
MHC I
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

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GO Term
immune response
positive regulation of natural killer cell cytokine production
antigen processing and presentation of exogenous peptide antigen via MHC class Ib
negative regulation of T cell cytokine production
negative regulation of natural killer cell degranulation
positive regulation of natural killer cell degranulation
negative regulation of natural killer cell cytokine production
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

Displaying entries **1 - 10** of 15 in total

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GO Term
Golgi membrane
endoplasmic reticulum
external side of plasma membrane
cell surface
extracellular space
plasma membrane
membrane
lumenal side of endoplasmic reticulum membrane
MHC class I protein complex
MHC class Ib protein complex

Displaying **all 6** entries
GO Term
signaling receptor binding
14-3-3 protein binding
TAP1 binding
TAP2 binding
beta-2-microglobulin binding
peptide antigen binding

Annotation information from UniProt.

Sequence

MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQRDGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
31			G49108TO	GlyGen The O-GlcNAc Database
107	N-linked (GlcNAc...) asparagine		G05962QB G79666IR G36442WJ G15664MX G72747WU G80920RR G54010QB	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Homo sapiens
ER-Phagosome pathway	Homo sapiens
Endosomal/Vacuolar pathway	Homo sapiens
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Homo sapiens
Interferon alpha/beta signaling	Homo sapiens
Interferon gamma signaling	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens