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Nuclear factor erythroid 2-related factor 2
Summary
- UniProt ID
- Q16236
- Gene Symbol
-
- NFE2L2
- NRF2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative splicing
- Cytoplasm
- DNA-binding
- Disease variant
- Glycation
- Host-virus interaction
- Nucleus
- Phosphoprotein
- Reference proteome
- Transcription regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| protein-DNA complex |
| RNA polymerase II transcription regulator complex |
Sequence
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 462 | N-linked (Glc) (glycation) lysine |
|
||
| 472 | N-linked (Glc) (glycation) lysine |
|
||
| 487 | N-linked (Glc) (glycation) lysine |
|
||
| 499 | N-linked (Glc) (glycation) arginine |
|
||
| 569 | N-linked (Glc) (glycation) arginine |
|
||
| 574 | N-linked (Glc) (glycation) lysine |
|
||
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 | Homo sapiens |
| Heme signaling | Homo sapiens |
| KEAP1-NFE2L2 pathway | Homo sapiens |
| NFE2L2 regulates pentose phosphate pathway genes | Homo sapiens |
| NFE2L2 regulating ER-stress associated genes | Homo sapiens |
| NFE2L2 regulating MDR associated enzymes | Homo sapiens |
| NFE2L2 regulating TCA cycle genes | Homo sapiens |
| NFE2L2 regulating anti-oxidant/detoxification enzymes | Homo sapiens |
| NFE2L2 regulating inflammation associated genes | Homo sapiens |
| NFE2L2 regulating tumorigenic genes | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
