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Histone-lysine N-methyltransferase EZH2

Summary

UniProt ID

Q61188

Gene Symbol

Ezh2
Enx1h

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q61188
PubChem: Q61188
The O-GlcNAc Database: Q61188

Annotation

Keyword

3D-structure
Alternative splicing
Biological rhythms
Chromatin regulator
Chromosome
Glycoprotein
Isopeptide bond
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repressor
S-adenosyl-L-methionine
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 54 in total

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GO Term
regulation of protein phosphorylation
positive regulation of cell population proliferation
epidermal cell differentiation
regulation of gene expression
negative regulation of gene expression
hemopoiesis
B cell differentiation
keratinocyte differentiation
protein modification process
regulation of cell population proliferation

Displaying **all 8** entries
GO Term
nucleus
pronucleus
synapse
chromosome, telomeric region
nucleoplasm
pericentric heterochromatin
chromatin silencing complex
ESC/E(Z) complex

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GO Term
DNA binding
chromatin binding
RNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription corepressor binding
transcription corepressor activity
protein-lysine N-methyltransferase activity
histone methyltransferase activity
primary miRNA binding

Annotation information from UniProt.

Sequence

MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
75	O-linked (GlcNAc) serine			UniProt GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Oxidative Stress Induced Senescence	Mus musculus
PKMTs methylate histone lysines	Mus musculus
PRC2 methylates histones and DNA	Mus musculus
Transcriptional Regulation by E2F6	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements