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Histone-lysine N-methyltransferase EZH2

Summary

UniProt ID

Q61188

Gene Symbol

Ezh2
Enx1h

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q61188
PubChem: Q61188

Annotation

Keyword

3D-structure
Alternative splicing
Biological rhythms
Chromatin regulator
Chromosome
Glycoprotein
Isopeptide bond
Methyltransferase
Nucleus
Phosphoprotein
Reference proteome
Repressor
S-adenosyl-L-methionine
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **31 - 40** of 54 in total

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GO Term
regulation of cell population proliferation
regulation of circadian rhythm
negative regulation of epidermal cell differentiation
negative regulation of keratinocyte differentiation
rhythmic process
regulation of neurogenesis
synaptic transmission, GABAergic
immunoglobulin heavy chain V-D-J recombination
negative regulation of cytokine production involved in inflammatory response
DNA methylation-dependent heterochromatin formation

Displaying **all 8** entries
GO Term
nucleoplasm
nucleus
synapse
chromosome, telomeric region
chromatin silencing complex
ESC/E(Z) complex
pericentric heterochromatin
pronucleus

Displaying entries **1 - 10** of 18 in total

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GO Term
chromatin binding
histone H3K27 methyltransferase activity
histone H3K27 trimethyltransferase activity
transcription cis-regulatory region binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
transcription corepressor binding
DNA binding
transcription corepressor activity
RNA binding
chromatin DNA binding

Annotation information from UniProt.

Sequence

MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
75	O-linked (GlcNAc) serine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Oxidative Stress Induced Senescence	Mus musculus
PKMTs methylate histone lysines	Mus musculus
PRC2 methylates histones and DNA	Mus musculus
Transcriptional Regulation by E2F6	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements