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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Prothrombin
Summary
- UniProt ID
- P00734
- Gene Symbol
-
- F2
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011275
- GlyConnect
- GlyGen
- P00734
- PubChem
- P00734
- The Human Metabolome Database
- HMDBP13521
- RaftProt
- P00734
Annotation
- Keyword
-
- 3D-structure
- Acute phase
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Gamma-carboxyglutamic acid
- Glycoprotein
- Kringle
- Pharmaceutical
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Thrombophilia
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| fibrinolysis |
| neutrophil-mediated killing of gram-negative bacterium |
| positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
Sequence
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cell surface interactions at the vascular wall | Homo sapiens |
| Common Pathway of Fibrin Clot Formation | Homo sapiens |
| Defective F8 cleavage by thrombin | Homo sapiens |
| Defective factor XII causes hereditary angioedema | Homo sapiens |
| G alpha (q) signalling events | Homo sapiens |
| Gamma-carboxylation of protein precursors | Homo sapiens |
| Intrinsic Pathway of Fibrin Clot Formation | Homo sapiens |
| Peptide ligand-binding receptors | Homo sapiens |
| Platelet Aggregation (Plug Formation) | Homo sapiens |
| Regulation of Complement cascade | Homo sapiens |
