FGFR4 mutant receptor activation
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Signaling by FGFR4 in disease
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- FGFR4
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- JTK2
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
- TKF
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Signaling by FGFR3 fusions in cancer
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t(4;14) translocations of FGFR3
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FGFR1c and Klotho ligand binding and activation
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Cellular hexose transport
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- Fibroblast growth factor 21
- Probable glucose sensor protein SLC5A4
- Sodium-dependent glucose transporter 1
- Sodium/glucose cotransporter 1
- Sodium/glucose cotransporter 2
- Sodium/glucose cotransporter 4
- Sodium/mannose cotransporter SLC5A10
- Solute carrier family 2, facilitated glucose transporter member 10
- Solute carrier family 2, facilitated glucose transporter member 11
- Solute carrier family 2, facilitated glucose transporter member 12
- Solute carrier family 2, facilitated glucose transporter member 14
- Solute carrier family 2, facilitated glucose transporter member 1
- Solute carrier family 2, facilitated glucose transporter member 2
- Solute carrier family 2, facilitated glucose transporter member 3
- Solute carrier family 2, facilitated glucose transporter member 4
- Solute carrier family 2, facilitated glucose transporter member 6
- Solute carrier family 2, facilitated glucose transporter member 7
- Solute carrier family 2, facilitated glucose transporter member 8
- Solute carrier family 2, facilitated glucose transporter member 9
- Solute carrier family 45 member 3
- Sugar transporter SWEET1
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- FGF21
- GLUT1
- GLUT10
- GLUT11
- GLUT12
- GLUT14
- GLUT2
- GLUT3
- GLUT4
- GLUT6
- GLUT7
- GLUT8
- GLUT9
- GLUTX1
- KIAA1919
- MFSD4B
- NAGLT1
- NAGT
- PCANAP6
- PRST
- RAG1AP1
- SAAT1
- SCP
- SGLT1
- SGLT2
- SGLT3
- SGLT4
- SGLT5
- SLC2A1
- SLC2A10
- SLC2A11
- SLC2A12
- SLC2A14
- SLC2A2
- SLC2A3
- SLC2A4
- SLC2A6
- SLC2A7
- SLC2A8
- SLC2A9
- SLC45A3
- SLC50A1
- SLC5A1
- SLC5A10
- SLC5A2
- SLC5A4
- SLC5A9
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betaKlotho-mediated ligand binding
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FGFRL1 modulation of FGFR1 signaling
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- FGF10
- FGF18
- FGF2
- FGF22
- FGF23
- FGF3
- FGF4
- FGFB
- FGFR5
- FGFRL1
- FHFR
- HST
- HSTF1
- HYPF
- INT2
- KS3
- SPRED1
- SPRED2
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FGFR3b ligand binding and activation
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- FGF1
- FGF18
- FGF20
- FGF9
- FGFA
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Phospholipase C-mediated cascade; FGFR3
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- HST
- HSTF1
- HYPF
- KS3
- PLC1
- PLCG1
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SHC-mediated cascade:FGFR3
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- HRAS
- HRAS1
- HST
- HSTF1
- HYPF
- KS3
- NRAS
- SOS1
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FGFR3c ligand binding and activation
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- GALNT3
- HST
- HSTF1
- HYPF
- KS3
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PI-3K cascade:FGFR3
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FRS2
- GAB1
- GRB1
- HST
- HSTF1
- HYPF
- KS3
- PIK3CA
- PIK3R1
- PTP2C
- PTPN11
- SHPTP2
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FRS-mediated FGFR3 signaling
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FRS2
- FRS3
- HRAS
- HRAS1
- HST
- HSTF1
- HYPF
- KS3
- NRAS
- PTP2C
- PTPN11
- SHPTP2
- SOS1
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Signaling by activated point mutants of FGFR3
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FGFR3
- HST
- HSTF1
- HYPF
- JTK4
- KS3
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Signaling by FGFR3 in disease
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF9
- FGFA
- FGFB
- FGFR3
- FRS2
- GAB1
- GRB1
- HRAS
- HRAS1
- HST
- HSTF1
- HYPF
- JTK4
- KS3
- NRAS
- PIK3CA
- PIK3R1
- PLC1
- PLCG1
- SOS1
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FGFR2c ligand binding and activation
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- FGF1
- FGF16
- FGF18
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- KS3
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FGFR4 ligand binding and activation
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- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KS3
- TKF
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Phospholipase C-mediated cascade; FGFR4
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- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- PLC1
- PLCG1
- TKF
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SHC-mediated cascade:FGFR4
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- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- HRAS
- HRAS1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- NRAS
- SOS1
- TKF
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PI-3K cascade:FGFR4
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- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- FRS2
- GAB1
- GRB1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- PIK3CA
- PIK3R1
- PTP2C
- PTPN11
- SHPTP2
- TKF
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FRS-mediated FGFR4 signaling
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- FGF1
- FGF16
- FGF18
- FGF19
- FGF2
- FGF20
- FGF23
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FGFR4
- FRS2
- FRS3
- HRAS
- HRAS1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- JTK2
- KLB
- KS3
- NRAS
- PTP2C
- PTPN11
- SHPTP2
- SOS1
- TKF
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Phospholipase C-mediated cascade: FGFR1
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- FGF1
- FGF10
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KS3
- PLC1
- PLCG1
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SHC-mediated cascade:FGFR1
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- FGF1
- FGF10
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- HRAS
- HRAS1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KS3
- NRAS
- SOS1
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PI-3K cascade:FGFR1
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- FGF1
- FGF10
- FGF2
- FGF20
- FGF22
- FGF23
- FGF3
- FGF4
- FGF6
- FGF9
- FGFA
- FGFB
- FRS2
- GAB1
- GRB1
- HST
- HST2
- HSTF1
- HSTF2
- HYPF
- INT2
- KS3
- PIK3CA
- PIK3R1
- PTP2C
- PTPN11
- SHPTP2
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