VEGFR2 mediated vascular permeability
|
|
|
- CALM3
- CAV1
- CDH5
- CTNNA1
- CTNNB1
- CTNND1
- HSP90A
- HSP90AA1
- HSPCA
- JUP
- Jup
- NOS3
- PAK1
- PAK2
- PDPK1
- RAC1
- VAV1
- VAV2
|
|
Basigin interactions
|
|
|
- ATP1B1
- ATP1B2
- ATP1B3
- BSG
- CAV1
- ITGA3
- ITGA6
- ITGB1
- MAG
- MMP1
- PPIA
- PPIL2
- SLC16A3
- SLC16A8
- SLC3A2
- SLC7A10
- SLC7A11
- SLC7A5
- SLC7A7
- SLC7A8
- SLC7A9
- SPN
|
|
RND2 GTPase cycle
|
|
|
- ALDH3A2
- ARHGAP1
- ARHGAP35
- ARHGAP5
- BLTP3B
- CAV1
- CKAP4
- DEPDC1B
- DLG5
- DSG1
- DST
- EPHA2
- FAM83B
- FNBP1
- FRS3
- GOLGA3
- KCTD13
- KIDINS220
- KTN1
- LOC100516390
- LRRC1
- MUC13
- NISCH
- NUDC
- PIK3R1
- PIK3R2
- PKP4
- PLXND1
- PTPN13
- RBM39
- RND2
- SCRIB
- TFRC
- TNFAIP1
- TXNL1
- UBXN11
- VANGL1
- VANGL2
- WDR6
|
|
RND3 GTPase cycle
|
|
|
- ARHGAP21
- ARHGAP35
- ARHGAP5
- CAV1
- CCDC88A
- CKAP4
- CKB
- CPD
- DEPDC1B
- DLG5
- DSG1
- DSP
- DST
- EPHA2
- FAM83B
- FLOT2
- KCTD13
- KTN1
- LOC100516390
- MUC13
- NISCH
- PICALM
- PIK3R1
- PIK3R2
- PKP4
- PLEKHG5
- PTPN13
- RASAL2
- RBM39
- RND3
- ROCK1
- SCRIB
- SEMA4F
- TMOD3
- TNFAIP1
- TXNL1
- UBXN11
- VANGL1
- VANGL2
- WDR6
|
|
RND1 GTPase cycle
|
|
|
- ALDH3A2
- ARHGAP35
- ARHGAP5
- CAV1
- CCDC88A
- CPD
- DEPDC1B
- DLG5
- DSP
- DST
- EPHA2
- EPSTI1
- FAM135A
- FAM83B
- FLOT2
- FRS3
- GRB7
- KIDINS220
- LOC100516390
- MUC13
- PIK3R1
- PIK3R2
- PKP4
- PLEKHG5
- PLXNA1
- PTPN13
- RASAL2
- RBM39
- RRAS2
- TFRC
- TMEM59
- TXNL1
- UBXN11
- VANGL1
- VANGL2
- WDR6
|
|
Extra-nuclear estrogen signaling
|
|
|
- CALM3
- CAV1
- CAV2
- DTR
- ESR
- ESR1
- ESR2
- GNAI1
- GNAI2
- GNAI3
- GNB1
- GNB2
- GNB3
- GNB5
- GNG10
- GNG11
- GNG12
- GNG3
- GNG4
- GNG5
- GNG7
- GNG8
- HBEGF
- HEGFL
- HSP90A
- HSP90AA1
- HSPCA
- IGF1R
- LOC100621431
- LOC110255211
- MMP3
- MMP7
- MMP9
- NOS3
- NR3A1
- PIK3CA
- PIK3R1
- PIK3R2
- PRMT1
- S1PR3
- SHC1
- SPHK1
- SRC
- STRN
|
|
RHOB GTPase cycle
|
|
|
- ABR
- ACTC1
- AKAP13
- ANLN
- ARHGAP1
- ARHGAP21
- ARHGAP26
- ARHGAP35
- ARHGAP39
- ARHGAP5
- ARHGDIG
- ARHGEF1
- ARHGEF10
- ARHGEF10L
- ARHGEF11
- ARHGEF12
- ARHGEF17
- ARHGEF2
- ARHGEF25
- ARHGEF28
- ARHGEF3
- ARHGEF5
- BCR
- CAV1
- CAVIN1
- CIT
- DAAM1
- DEPDC1B
- DIAPH1
- DIAPH3
- DLC1
- ECT2
- FLOT1
- FLOT2
- IQGAP3
- JUP
- Jup
- MCAM
- MCF2
- MCF2L
- MYO9A
- MYO9B
- NET1
- OPHN1
- PCDH7
- PIK3R1
- PIK3R2
- PKN1
- PKN2
- PKN3
- PREX1
- RACGAP1
- RHOB
- RHPN2
- ROCK1
- ROCK2
- RTKN
- SLK
- SNAP23
- STARD8
- STOM
- TFRC
- TJP2
- VAMP3
- VANGL1
- VAV2
|
|
Estrogen-dependent gene expression
|
|
|
- CARM1
- CBFB
- CCNT1
- CDK9
- CITED1
- CREBBP
- DDX5
- EP300
- ERBB4
- ESR
- ESR1
- FKBP4
- FOS
- FOXA1
- GATA3
- GREB1
- GTF2A1
- GTF2A2
- GTF2F1
- H1-2
- H2AB1
- H2AB2
- H2AB3
- H2AC10
- H2AC11
- H2AC17
- H2AC18
- H2AC19
- H2AC20
- H2AC4
- H2AC6
- H2AC7
- H2AC8
- H2AX
- H2AZ2
- H2BC11
- H2BC12
- H2BC19
- H2BC20
- H2BC21
- H2BC5
- H3-3A
- H3C12
- H3C14
- H3C15
- H3C4
- H3C6
- H3F3A
- HDAC1
- HIST1H2BD
- HIST1H3E
- HSP90A
- HSP90AA1
- HSP90AB1
- HSPCA
- JUN
- KAT2B
- KAT5
- KDM1A
- KDM4B
- LOC110261482
- MED1
- NCOA1
- NCOA2
- NCOA3
- NR3A1
- NR5A2
- NRIP1
- PGR
- POLR2A
- POLR2B
- POLR2D
- POLR2E
- POLR2G
- POLR2H
- POLR2I
- POLR2J
- POLR2L
- POU2F1
- PRMT1
- PTGES3
- RUNX1
- SP1
- TLE3
- USF1
- USF2
- YY1
- ZNF217
|
|
PI3K events in ERBB4 signaling
|
|
|
- BTC
- DTR
- ERBB4
- EREG
- HBEGF
- HEGFL
- NRG1
- NRG2
- NRG3
- PIK3CA
- PIK3R1
|
|
Signaling by ERBB4
|
|
|
- BTC
- DTR
- EGF
- EGFR
- ERBB3
- ERBB4
- EREG
- HBEGF
- HEGFL
- NRG1
- NRG2
- NRG3
|
|
PI3K events in ERBB2 signaling
|
|
|
- BTC
- DTR
- EGF
- EGFR
- ERBB2
- ERBB3
- ERBB4
- EREG
- GAB1
- GRB2
- HBEGF
- HEGFL
- NRG1
- NRG2
- NRG3
- PIK3CA
- PIK3R1
|
|
Signaling by ERBB2
|
|
|
- BTC
- CDC37
- DTR
- EGF
- EGFR
- ERBB2
- ERBB3
- ERBB4
- EREG
- FYN
- HBEGF
- HEGFL
- HSP90A
- HSP90AA1
- HSPCA
- NRG1
- NRG2
- NRG3
- SRC
- YES1
|
|
ERBB2 Regulates Cell Motility
|
|
|
- BTC
- DIAPH1
- DTR
- EGF
- EGFR
- ERBB2
- ERBB3
- ERBB4
- EREG
- HBEGF
- HEGFL
- MEMO1
- NRG1
- NRG2
- NRG3
- RHOA
|
|
SHC1 events in ERBB2 signaling
|
|
|
- BTC
- DTR
- EGF
- EGFR
- ERBB2
- ERBB3
- ERBB4
- EREG
- HBEGF
- HEGFL
- NRG1
- NRG2
- NRG3
- PRKCA
- PRKCD
- PRKCE
- PTPN12
- SHC1
|
|
Downregulation of ERBB2 signaling
|
|
|
- BTC
- CDC37
- CUL5
- DTR
- EGF
- EGFR
- ERBB2
- ERBB3
- ERBB4
- EREG
- HBEGF
- HEGFL
- HSP90A
- HSP90AA1
- HSPCA
- MATK
- NRG1
- NRG2
- NRG3
- PTPN12
- PTPN18
- RPS27A
- STUB1
- UBA52
- UBB
- UBC
|
|
ERBB2 Activates PTK6 Signaling
|
|
|
- BTC
- DTR
- EGF
- EGFR
- ERBB2
- ERBB3
- ERBB4
- EREG
- HBEGF
- HEGFL
- NRG1
- NRG2
- NRG3
- PTK6
|
|
GRB2 events in ERBB2 signaling
|
|
|
- BTC
- DTR
- ERBB2
- ERBB4
- EREG
- GRB2
- HBEGF
- HEGFL
- HRAS
- KRAS
- NRAS
- NRG1
- NRG2
- NRG3
- SOS1
|
|
SHC1 events in ERBB4 signaling
|
|
|
- BTC
- DTR
- ERBB4
- EREG
- GRB2
- HBEGF
- HEGFL
- HRAS
- KRAS
- NRAS
- NRG1
- NRG2
- NRG3
- SHC1
- SOS1
|
|
MET activates RAP1 and RAC1
|
|
|
- CRK
- DOCK7
- GAB1
- GRB2
- HGF
- MET
- RAC1
- RAP1B
- RAPGEF1
|
|
CDC42 GTPase cycle
|
- ADP-ribosylation factor GTPase-activating protein 2
- ADP-ribosylation factor GTPase-activating protein 3
- Active breakpoint cluster region-related protein
- Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
- ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
- ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
- BCR activator of RhoGEF and GTPase
- Brain-specific angiogenesis inhibitor 1-associated protein 2
- CDC42 effector protein 1
- CDC42 effector protein 3
- CDC42 effector protein 4
- CDC42 effector protein 5
- CDC42 small effector protein 2
- Caveolin
- Cdc42 effector protein 2
- Cell division control protein 42 homolog
- Chimaerin
- Copine-8
- DEF6 guanine nucleotide exchange factor
- DEP domain containing 1B
- Dedicator of cytokinesis 10
- Dedicator of cytokinesis 11
- Dedicator of cytokinesis 6
- Dedicator of cytokinesis 7
- Dedicator of cytokinesis 8
- Dedicator of cytokinesis 9
- Delta(14)-sterol reductase LBR
- Diaphanous related formin 3
- Dishevelled associated activator of morphosis 1
- Dynamin-binding protein
- Epithelial cell transforming 2
- FERM, ARHGEF and pleckstrin domain-containing protein 1
- FYVE, RhoGEF and PH domain containing 1
- FYVE, RhoGEF and PH domain containing 2
- FYVE, RhoGEF and PH domain containing 3
- FYVE, RhoGEF and PH domain containing 4
- Family with sequence similarity 13 member B
- Formin binding protein 1
- Formin like 1
- Formin like 2
- Formin like 3
- Formin-binding protein 1-like
- G protein subunit alpha 13
- GEM interacting protein
- GIT ArfGAP 1
- GIT ArfGAP 2
- Golgin subfamily A conserved domain-containing protein
- Guanine nucleotide exchange factor DBS isoform X2
- IQ motif containing GTPase activating protein 2
- IQ motif containing GTPase activating protein 3
- Intersectin 1
- Junction plakoglobin
- Junction plakoglobin
- Kinectin 1
- MCF.2 cell line derived transforming sequence
- Mitogen-activated protein kinase kinase kinase
- Myosin IXB
- Neuronal guanine nucleotide exchange factor
- Oligophrenin-1
- Par-6 family cell polarity regulator alpha
- Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
- Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
- Phospholipase
- Pleckstrin homology and RhoGEF domain containing G1
- Pleckstrin homology and RhoGEF domain containing G2
- Pleckstrin homology and RhoGEF domain containing G3
- Potassium channel tetramerization domain containing 3
- Rac GTPase activating protein 1
- Rac/Cdc42 guanine nucleotide exchange factor 6
- Ragulator complex protein LAMTOR1
- Ras protein specific guanine nucleotide releasing factor 2
- Ras-related protein Rab-7a
- Rho GDP dissociation inhibitor gamma
- Rho GDP-dissociation inhibitor 1
- Rho GTPase activating protein 17
- Rho GTPase activating protein 1
- Rho GTPase activating protein 20
- Rho GTPase activating protein 21
- Rho GTPase activating protein 22
- Rho GTPase activating protein 24
- Rho GTPase activating protein 27
- Rho GTPase activating protein 30
- Rho GTPase activating protein 31
- Rho GTPase activating protein 33
- Rho GTPase activating protein 39
- Rho GTPase activating protein 44
- Rho GTPase activating protein 45
- Rho GTPase activating protein 4
- Rho GTPase activating protein 5
- Rho GTPase activating protein 9
- Rho GTPase-activating protein 10
- Rho GTPase-activating protein 26
- Rho GTPase-activating protein 29
- Rho GTPase-activating protein 35
- Rho GTPase-activating protein 7
- Rho guanine nucleotide exchange factor 10
- Rho guanine nucleotide exchange factor 11
- Rho guanine nucleotide exchange factor 12
- Rho guanine nucleotide exchange factor 15
- Rho guanine nucleotide exchange factor 16
- Rho guanine nucleotide exchange factor 19
- Rho guanine nucleotide exchange factor 25
- Rho guanine nucleotide exchange factor 26
- Rho guanine nucleotide exchange factor 5
- Rho guanine nucleotide exchange factor 7
- Rho guanine nucleotide exchange factor 9
- SH3 and PX domain-containing protein 2A
- SH3KBP1 binding protein 1
- SLIT-ROBO Rho GTPase activating protein 1
- SLIT-ROBO Rho GTPase activating protein 2
- SLIT-ROBO Rho GTPase activating protein 3
- STEAP3 metalloreductase
- Scribble planar cell polarity protein
- StAR related lipid transfer domain containing 8
- Stomatin
- Synapse defective Rho GTPase homolog 1
- Synaptosomal-associated protein
- T cell activation RhoGTPase activating protein
- TIAM Rac1 associated GEF 1
- Transferrin receptor protein 1
- Transferrin receptor protein 1
- Vang-like protein
- Vav guanine nucleotide exchange factor 2
- Vesicle-associated membrane protein 3
- WASP like actin nucleation promoting factor
- WD repeat domain 81
- WD repeat-containing protein 91
- WH2 domain-containing protein
- YKT6 v-SNARE homolog
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
|
|
- ABR
- ARAP1
- ARAP2
- ARAP3
- ARFGAP2
- ARFGAP3
- ARHGAP1
- ARHGAP10
- ARHGAP17
- ARHGAP20
- ARHGAP21
- ARHGAP22
- ARHGAP24
- ARHGAP26
- ARHGAP27
- ARHGAP29
- ARHGAP30
- ARHGAP31
- ARHGAP33
- ARHGAP35
- ARHGAP39
- ARHGAP4
- ARHGAP44
- ARHGAP45
- ARHGAP5
- ARHGAP9
- ARHGDIA
- ARHGDIG
- ARHGEF10
- ARHGEF11
- ARHGEF12
- ARHGEF15
- ARHGEF16
- ARHGEF19
- ARHGEF25
- ARHGEF26
- ARHGEF5
- ARHGEF6
- ARHGEF7
- ARHGEF9
- BAIAP2
- BCR
- CAV1
- CDC42
- CDC42BPA
- CDC42BPB
- CDC42EP1
- CDC42EP2
- CDC42EP3
- CDC42EP4
- CDC42EP5
- CDC42SE2
- CHN1
- CPNE8
- DAAM1
- DEF6
- DEPDC1B
- DIAPH3
- DLC1
- DNMBP
- DOCK10
- DOCK11
- DOCK6
- DOCK7
- DOCK8
- DOCK9
- ECT2
- FAM13B
- FARP1
- FGD1
- FGD2
- FGD3
- FGD4
- FMNL1
- FMNL2
- FMNL3
- FNBP1
- FNBP1L
- GIT1
- GIT2
- GMIP
- GNA13
- GOLGA2
- IQGAP2
- IQGAP3
- ITSN1
- JUP
- Jup
- KCTD3
- KTN1
- LAMTOR1
- LBR
- MAP3K11
- MCF2
- MCF2L
- MYO9B
- NGEF
- OPHN1
- PAK1
- PAK2
- PAK5
- PAK6
- PARD6A
- PIK3R1
- PIK3R2
- PLD1
- PLEKHG1
- PLEKHG2
- PLEKHG3
- PREX1
- PREX2
- RAB7A
- RACGAP1
- RASGRF2
- SCRIB
- SH3PXD2A
- SHKBP1
- SNAP23
- SRGAP1
- SRGAP2
- SRGAP3
- STARD8
- STEAP3
- STOM
- SYDE1
- TAGAP
- TFRC
- TIAM1
- TRIO
- VAMP3
- VANGL1
- VAV2
- WASL
- WDR81
- WDR91
- WIPF1
- YKT6
|
|
PTK6 promotes HIF1A stabilization
|
|
|
- DTR
- EGFR
- GPNMB
- HBEGF
- HEGFL
- HIF1A
- LRRK2
- PTK6
|
|
Keratinization
|
|
|
- DSC1
- DSC2
- DSC3
- DSG1
- DSG2
- DSG3
- DSG4
- DSP
- JUP
- Jup
- KRT1
- KRT10
- KRT12
- KRT15
- KRT17
- KRT18
- KRT19
- KRT2
- KRT20
- KRT23
- KRT24
- KRT25
- KRT26
- KRT27
- KRT28
- KRT3
- KRT31
- KRT32
- KRT33A
- KRT34
- KRT35
- KRT36
- KRT39
- KRT4
- KRT40
- KRT5
- KRT6A
- KRT7
- KRT71
- KRT72
- KRT73
- KRT74
- KRT75
- KRT77
- KRT78
- KRT79
- KRT80
- KRT82
- KRT84
- KRT85
- KRTAP11-1
- KRTAP24-1
- KRTAP8-1
- LOC100515166
- LOC100516036
- LOC100517674
- LOC100518807
- LOC100523123
- LOC100523275
- LOC100523670
- LOC100621639
- LOC100621844
- LOC100622826
- LOC100623393
- LOC100625168
- LOC100625858
- LOC100737483
- LOC102160031
- LOC102164863
- LOC106504189
- LOC106507258
- LOC106508044
- LOC110255272
- LOC110255312
- LOC110256008
- LOC110256282
- LOC110260665
- PKP1
- PKP2
- PKP3
- PKP4
|
|
Caspase-mediated cleavage of cytoskeletal proteins
|
|
|
- ADD1
- CASP6
- CASP7
- CASP8
- GAS2
- GSN
- MAPT
- PLEC
- SORBS2
- SPTAN1
- VIM
|
|
SUMOylation of DNA replication proteins
|
|
|
- AURKB
- BIRC5
- CDCA8
- CEP192
- INCENP
- LOC100627016
- LOC110258677
- MRNP41
- NDC1
- NUP107
- NUP133
- NUP153
- NUP155
- NUP160
- NUP188
- NUP205
- NUP210
- NUP214
- NUP35
- NUP37
- NUP42
- NUP43
- NUP50
- NUP58
- NUP62
- NUP85
- NUP88
- NUP93
- NUP98
- PCNA
- PIAS3
- PIAS4
- POM121C
- RAE1
- RANBP2
- RANGAP1
- SEH1L
- SMT3A
- SMT3H2
- SUMO1
- SUMO2
- SUMO3
- TOP1
- TOP2A
- TOP2B
- TPR
- UBE2I
|
|
Generic Transcription Pathway
|
|
|
- CCNC
- CDK8
- CRSP8
- CRSP9
- KRBA1
- LOC100513362
- LOC100513741
- LOC100516085
- LOC100516355
- LOC100517149
- LOC100517161
- LOC100517751
- LOC100519853
- LOC100520720
- LOC100520903
- LOC100521069
- LOC100525433
- LOC100620238
- LOC100626048
- LOC100627241
- LOC100737756
- LOC100737823
- LOC100738050
- LOC100739480
- LOC102164547
- LOC102167305
- LOC102167351
- LOC110259370
- LOC110261311
- LOC110261312
- LOC110261313
- LOC110261321
- MED1
- MED10
- MED12
- MED13
- MED14
- MED15
- MED16
- MED17
- MED20
- MED23
- MED24
- MED25
- MED26
- MED27
- MED30
- MED4
- MED6
- MED7
- MED8
- PRDM7
- TRIM28
- ZBTB41
- ZBTB48
- ZFP1
- ZFP14
- ZFP2
- ZFP28
- ZFP37
- ZFP69B
- ZKSCAN1
- ZKSCAN4
- ZKSCAN5
- ZKSCAN7
- ZKSCAN8
- ZNF10
- ZNF112
- ZNF114
- ZNF133
- ZNF140
- ZNF16
- ZNF175
- ZNF18
- ZNF180
- ZNF181
- ZNF184
- ZNF189
- ZNF200
- ZNF202
- ZNF205
- ZNF213
- ZNF23
- ZNF235
- ZNF248
- ZNF25
- ZNF26
- ZNF263
- ZNF274
- ZNF282
- ZNF286A
- ZNF3
- ZNF300
- ZNF311
- ZNF317
- ZNF333
- ZNF33B
- ZNF34
- ZNF354B
- ZNF354C
- ZNF383
- ZNF394
- ZNF397
- ZNF445
- ZNF446
- ZNF45
- ZNF471
- ZNF483
- ZNF484
- ZNF496
- ZNF529
- ZNF546
- ZNF550
- ZNF555
- ZNF558
- ZNF565
- ZNF566
- ZNF567
- ZNF568
- ZNF569
- ZNF577
- ZNF582
- ZNF583
- ZNF594
- ZNF596
- ZNF599
- ZNF606
- ZNF614
- ZNF619
- ZNF621
- ZNF624
- ZNF658
- ZNF662
- ZNF664
- ZNF668
- ZNF672
- ZNF684
- ZNF688
- ZNF689
- ZNF697
- ZNF70
- ZNF703
- ZNF704
- ZNF706
- ZNF71
- ZNF713
- ZNF74
- ZNF75D
- ZNF770
- ZNF772
- ZNF782
- ZNF786
- ZNF79
- ZNF791
- ZNF792
- ZNF793
- ZNF804B
- ZNF839
- ZNF883
- ZSCAN25
|
|