Integrin signaling

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
GTPRAP1:GTPRAP1:GDPGDPPIP2Rap1-GTP:PIP2:RIAMRIAMTLN1Talin:RIAM complexIntegrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complexIntegrin alphaIIb beta3:p-Y530-SRC:CSKFocal complexTalin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK)CSKTalin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC)H2OPiTalin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC)FAKTalin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC)Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2ATPADPIntegrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHCSHCIntegrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHCp-Y427-SHC1Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYKTalin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYKIntegrin alphaIIb beta3 ECM ligandsIntegrin binding divalent cationsIntegrin alpha2bbeta3Integrin alpha IIb p(T779)-beta 3SYK
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 4, 2025