Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
G-alpha(s):GTP:G-beta:G-gammaG-beta:G-gamma (candidates)Gs:GTPmature GLP1GLP1:GLP1R:Heterotrimeric G(s):GDPGLP1R:Heterotrimeric G(s):GDPGLP1R:GLP1R agonistsGLP1R agonistsGTPGDPGLP-1:GLP-1R:Heterotrimeric G(s):GTPADCY5,6,8:G-alpha(s):GTPAdenylyl cyclase (pancreatic beta cell)ATPPPicAMPPKA:AKAP79:IQGAP1 ComplexcAMP:PKA:AKAP79:IQGAP1 ComplexPRKACA,PRKACB,PRKACGPotassium voltage-gated channels (beta cell, open)Potassium voltage-gated channels (beta cell, closed)Ca-channel (closed)Ca-channel (open)EPAC1Epac1:cAMP ComplexRAPGEF4RAPGEF4:cAMP ComplexRAP1A:GTPRAP1A:GDP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025