Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Ca2+Ca2+Calpain1,Calpain2Calpain1, Calpain2:Ca2+H2OMyrG-CDK5R1(2-98)MyrG-p35p25CASTCalpain1,Calpain2:Ca2+:CASTCDK5:p25CDK5CDC25Ap-S40,S116,S261-CDC25AADPATPCDC25Bp-S50,T69,S160,S321,S470-CDC25BATPADPp-T48,T67,S122,T130,S168,S214-CDC25CCDC25CYWHAECDC25C:YWHAEp-S37-GM130GM130CDK5:p25LMNA-1p-S22, S392-LMNA-1LMNB1p-S23,S393-LMNB1PRDX1p-T90-PRDX1PRDX2p-T89-PRDX2JUNp-S63,S73-JUNFOXO3p-S43,S173,S294,S325-FOXO3p-S43,S173,S294,S325-FOXO3BIM geneBIMFASLG geneFASLMnSODSOD2APP geneAPP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying entries 1 - 10 of 16 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O43524 Forkhead box protein O3
  • FKHRL1
  • FOXO3
  • FOXO3A
view
P04179 Superoxide dismutase [Mn], mitochondrial
  • SOD2
view
P04632 Calpain small subunit 1
  • CAPN4
  • CAPNS
  • CAPNS1
view
P05067 Amyloid-beta precursor protein
  • A4
  • AD1
  • APP
view
P05412 Transcription factor Jun
  • JUN
view
P07384 Calpain-1 catalytic subunit
  • CANPL1
  • CAPN1
view
P20700 Lamin-B1
  • LMN2
  • LMNB
  • LMNB1
view
P20810 Calpastatin
  • CAST
view
P30304 M-phase inducer phosphatase 1
  • CDC25A
view
P30305 M-phase inducer phosphatase 2
  • CDC25B
  • CDC25HU2
view
a simple tooltip

About Release Notes Help Feedback

Click here to visit the beta site.


International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.2.1

Last updated: April 7, 2025