GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **326 - 350** of **557** in total

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Pathway Name	Protein Name ▼	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Lewis blood group biosynthesis	Alpha-(1,3)-fucosyltransferase 7 Alpha-(1,3)-fucosyltransferase Alpha-(1,3)-fucosyltransferase Beta-1,4-N-acetyl-galactosaminyltransferase 2 Fucosyltransferase Fucosyltransferase Fucosyltransferase Hexosyltransferase Hexosyltransferase L-Fucosyltransferase ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Type 2 lactosamine alpha-2,3-sialyltransferase	A0A3Q1LUC6 A0A3Q1MGH3 A0A452DJH9 E1BIT9 F1MBS8 F1MDG4 F1MUS1 F1MWE7 F1N557 F1N751 G3MZR2 Q2HJA3 Q3T0R9 Q6H8M7	B3GALT2 B3GALT4 B4GALNT2 FUT10 FUT11 FUT2 FUT4 FUT6 FUT7 FUT9 SIAT10 ST3GAL3 ST3GAL4 ST3GAL6 ST6GALNAC6	Bos taurus (cattle)	G39211DH G81971FM G83633HB G90387AM G98173LG
CTLA4 inhibitory signaling	Alpha isoform of regulatory subunit A, protein phosphatase 2 CD80 molecule CD86 molecule Cytotoxic T-lymphocyte protein 4 Protein phosphatase 2 scaffold subunit Abeta Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Tyrosine-protein kinase Fyn Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A3Q1MLL9 A0A3S5ZP81 A0JNB0 A2VDZ0 A4FV68 A5D973 A7MB57 E1BIM8 F1MQN0 F1N1S8 F1N261 F1N339 P67774 Q08DP7 Q0P594 Q28090 Q3ZCM0	CD152 CD80 CD86 CTLA-4 CTLA4 FYN LCK LYN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5D PPP2R5E PTPN11 SRC YES1	Bos taurus (cattle)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Alpha isoform of regulatory subunit A, protein phosphatase 2 Amphiregulin Betacellulin CD19 molecule CD80 molecule CD86 molecule Epiregulin Epithelial mitogen Estrogen receptor beta Estrogen receptor FLT3LG protein Fibroblast growth factor 1 Fibroblast growth factor 23 Fibroblast growth factor 2 Fibroblast growth factor 5 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2 associated binding protein 2 GRB2-associated-binding protein 1 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Immediate early response 3 Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Insulin Interleukin 1 receptor like 1 Interleukin-1 receptor-associated kinase 1 Interleukin-1 receptor-associated kinase 4 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Mitogen-activated protein kinase 1 Mitogen-activated protein kinase Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 PIP5K1A protein Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Phosphatidylinositol-4-phosphate 5-kinase type 1 beta Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma Phosphatidylinositol-5-phosphate 4-kinase type 2 beta Phosphoinositide-3-kinase adaptor protein 1 Phosphoinositide-3-kinase regulatory subunit 3 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Protein phosphatase 2 scaffold subunit Abeta Proto-oncogene vav Ras homolog family member G Ras-related C3 botulinum toxin substrate 2 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Transforming growth factor alpha Tyrosine-protein kinase Fyn Tyrosine-protein kinase receptor Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A3Q1LRU7 A0A3Q1LUE0 A0A3Q1M3Q3 A0A3Q1M535 A0A3Q1M7J4 A0A3Q1M864 A0A3Q1MBL1 A0A3Q1MCW9 A0A3Q1ME99 A0A3Q1MGW7 A0A3Q1MHB0 A0A3Q1MKB4 A0A3Q1MLL9 A0A3Q1MPT9 A0A3Q1N3Z8 A0A3Q1NAV6 A0A3Q1ND77 A0A3S5ZP81 A0A452DHW6 A0A452DHX3 A0JNB0 A0MTF4 A2VDZ0 A2VE24 A2VE27 A4FV68 A5D973 A5PJB2 A6QLC5 A6QLU3 A6QR62 B1H0W5 D8KXU9 E1B7I9 E1B8P9 E1BAI2 E1BBE2 E1BDM2 E1BE66 E1BFL8 E1BFP8 E1BGY3 E1BHC1 E1BIM8 E1BIN8 E1BJU2 E1BP37 F1MCQ7 F1MDQ5 F1MEV4 F1MHC6 F1MHR4 F1MHT2 F1MJE0 F1MN51 F1MPD0 F1MQN0 F1MRU0 F1MRU1 F1MS28 F1MV64 F1MYE0 F1MYM3 F1MZD6 F1N1S8 F1N339 F1N4S9 F1N586 F1N6G8 F1N7M1 F2Z4J0 G3MXR4 G3N104 G3XGD3 P03968 P03969 P23726 P23727 P32871 P46196 P49884 P67774 Q08DN7 Q08DP7 Q08DU3 Q0P594 Q0P5F7 Q0P5G7 Q1RMI2 Q1RMT8 Q28132 Q2KJ15 Q2LGB3 Q3T0F9 Q3ZCC3 Q3ZCM0 Q58DF9 Q9TU25 Q9XSB5 Z4YHD9	AFGF AREG BTC CD19 CD28 CD80 CD86 EGFR EPGN ERBB2 ERBB3 ERBB4 EREG ERK2 ESR ESR1 ESR2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF3 FGF4 FGF4A FGF4C FGF5 FGF5B FGF5C FGF6 FGF6A FGF7 FGF7B FGF8 FGF8A FGF9 FGFA FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FYN Fgf4 GAB1 GAB2 GRB2 HBEGF HBGF-1 HGF ICOS IER3 IL1RL1 IL33 INS INSR IRAK1 IRAK4 IRS1 IRS2 KIT KITLG KL KLB LCK MAPK1 MAPK3 MET MYD88 NR3A1 NR3A2 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5K2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5D PPP2R5E PRKM1 PTPN11 RAC2 RHOG SCF SRC STRN TGFA TRAF6 TRAT1 VAV1	Bos taurus (cattle)
Aflatoxin activation and detoxification	Aldo-keto reductase family 7 member A2 Aldo-keto reductase family 7 member A2 Cytochrome P450 1A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 Dipeptidase 1 Dipeptidase 3 Dipeptidase Glutathione S-transferase 3, mitochondrial Glutathione hydrolase 7 Glutathione hydrolase Glutathione hydrolase Microsomal glutathione S-transferase 1 Microsomal glutathione S-transferase 2 N-acyl-aliphatic-L-amino acid amidohydrolase	A0A3Q1LZ03 E1BDI1 E1BIR2 F1MHN9 F1MR63 F1MXY2 F1MYJ3 F1MZC0 F1N6I4 G3MYH2 G3N2D8 G3X6I4 Q0V8L2 Q29RV2 Q2KJG4 Q3SZM7 Q3T047 Q3T100	ACY1 AKR7A2 CYP1A2 CYP2A13 CYP3A28 CYP3A4 CYP3A5 CYP3A74 CYP3A76 DPEP1 DPEP2 DPEP3 GGT1 GGT5 GGT7 GGTL3 MGST1 MGST2 MGST3	Bos taurus (cattle)
Fructose biosynthesis	Aldo-keto reductase family 1 member B1 Sorbitol dehydrogenase	A0A493UA87 Q58D31	AKR1B1 SORD	Bos taurus (cattle)	G58161NS
Glutathione conjugation	Aldo-keto reductase family 1 member A1 Glutathione S-transferase 3, mitochondrial Glutathione S-transferase A2 Glutathione S-transferase A4 Glutathione S-transferase kappa Glutathione S-transferase omega Glutathione S-transferase theta-1 Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Glutathione S-transferase Glutathione-dependent dehydroascorbate reductase Microsomal glutathione S-transferase 1 Microsomal glutathione S-transferase 2 S-formylglutathione hydrolase glutathione transferase glutathione transferase	A0A3Q1LMV5 A0A3Q1LSN6 A0A3Q1LY34 A0A3Q1MEC8 A0A452DHY4 A1A4L7 E1BED9 E1BJ08 E1BKD8 F1MGZ9 F1MRG0 F1MUX5 F1MX44 F1MXY2 O18879 Q08E20 Q2KJG4 Q2NL00 Q3T100 Q3ZCJ2 Q5E9G0	AKR1A1 ESD GSTA1 GSTA2 GSTA4 GSTA5 GSTK1 GSTM1 GSTM3 GSTM4 GSTO2 GSTP1 GSTT1 HPGDS LOC100295687 MGST1 MGST2 MGST3	Bos taurus (cattle)
Phase I - Functionalization of compounds	Aldehyde dehydrogenase Alpha/beta hydrolase fold-3 domain-containing protein Amine oxidase [copper-containing] 3 Amine oxidase Amine oxidase Amine oxidase Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor Arylacetamide deacetylase Biphenyl hydrolase like CYB5B protein Carbonyl reductase (NADPH) Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxymethylenebutenolidase homolog Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 3A Cytochrome P450 family 2 subfamily B member 6 Epoxide hydrolase Mitochondrial amidoxime reducing component 1 Mitochondrial amidoxime reducing component 2 NAD(P)H dehydrogenase, quinone 2 NADH-cytochrome b5 reductase 3 Primary amine oxidase, liver isozyme	A0A3Q1LGS8 A0A3Q1LKX3 A0A3Q1LZ03 A0A3Q1M7J3 A0A3Q1MQJ1 A0A3Q1MU42 A0A452DHX8 E1BC09 F1MFG7 F1MI11 F1ML85 F1MU22 F1MYL2 F1N015 G3X6I4 G3X6X4 G5E6I5 P07514 Q0P5F6 Q0VC97 Q1LZH1 Q29437 Q29RV2 Q3MHQ1 Q3SZT2 Q3T047 Q3ZCJ6 Q9TTK6	AADAC ABP1 AHR ALDH3A1 AOC1 AOC2 AOC3 ARNT ARNT2 BPHL CBR3 CES1 CES2 CES3 CMBL CYB5B CYB5R3 CYP2B6 CYP3A28 CYP3A4 CYP3A5 CYP3A74 CYP3A76 DIA1 EPHX1 LOC100138645 MARC2 MOSC2 MTARC1 MTARC2 NQO2	Bos taurus (cattle)
RND1 GTPase cycle	Aldehyde dehydrogenase family 3 member A2 Ankyrin repeat domain containing 26 Carboxypeptidase D Caveolin-1 Coiled-coil domain containing 88A DEP domain containing 1B Desmoplakin Discs large MAGUK scaffold protein 5 Dystonin Epithelial stromal interaction 1 FRS3 protein Family with sequence similarity 135 member A Family with sequence similarity 83 member B Fibroblast growth factor receptor substrate 2 Flotillin-2 Growth factor receptor-bound protein 7 Kinase D interacting substrate 220 Kinesin family member 14 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plakophilin 4 Pleckstrin homology and RhoGEF domain containing G5 Plexin A1 Protein tyrosine phosphatase non-receptor type 13 RAS protein activator like 2 RNA binding motif protein 39 RNA binding motif protein X-linked Rho GTPase activating protein 5 Rho GTPase-activating protein 35 Rho-related GTP-binding protein Rho6 Stathmin Stress-induced-phosphoprotein 1 Thioredoxin like 1 Transferrin receptor protein 1 Transmembrane protein 59 UBX domain protein 11 Vang-like protein Vang-like protein receptor protein-tyrosine kinase tRNA (34-2'-O)-methyltransferase regulator WDR6	A0A3Q1LJ52 A0A3Q1LNS9 A0A3Q1LRJ9 A0A3Q1LTK4 A0A3Q1LWZ4 A0A3Q1M6F8 A0A3Q1M8V3 A0A3Q1ME81 A0A3Q1MNK3 A0A452DIX7 A6H792 A6QLR4 D3JUI8 E1B7I9 E1B801 E1BFR4 E1BIG6 E1BJ31 E1BKT4 E1BKT9 E1BLB3 E1BLC3 E1BLR9 E1BM23 E1BMF4 E1BNR7 F1MFE8 F1MI76 F1MJ11 F1MPJ6 F1MPT5 F1N5P7 G5E5S3 P23726 P23727 P79132 Q1RMW5 Q2HJ68 Q3T0Q2 Q3ZBZ8	ALDH3A2 ANKRD26 ARHGAP35 ARHGAP5 CAV1 CCDC88A CPD DEPDC1B DLG5 DSP DST EPHA2 EPSTI1 FAM135A FAM83B FLOT2 FRS2 FRS3 GRB7 KIDINS220 KIF14 PIK3R1 PIK3R2 PKP4 PLEKHG5 PLXNA1 PTPN13 RASAL2 RBM39 RBMX RHO6 RND1 STIP1 STMN2 TFRC TMEM59 TXNL1 UBXN11 VANGL1 VANGL2 WDR6	Bos taurus (cattle)
Sphingolipid catabolism	Aldehyde dehydrogenase family 3 member A2 Aldehyde dehydrogenase family 3 member B1 Alkaline ceramidase Alkaline ceramidase Alkaline ceramidase Phospholipid phosphatase 1 Phospholipid phosphatase 2 Phospholipid phosphatase 3 Sphingosine-1-phosphate phosphatase 1 sphinganine-1-phosphate aldolase	A0A3Q1LJ52 A0A3Q1LM94 A0A3Q1MIK4 A0JNA1 A7MBH7 E1B8N2 F1MGH9 Q1JPA0 Q2HJ61 Q3SZE3	ACER1 ACER2 ACER3 ALDH3A2 ALDH3B1 PLPP1 PLPP2 PLPP3 PPAP2B PPAP2C SGPL1 SGPP1	Bos taurus (cattle)
Scavenging of heme from plasma	Albumin Hemoglobin subunit alpha Hemoglobin subunit beta Hemopexin LDL receptor related protein 1 Scavenger receptor cysteine-rich type 1 protein M130	A0A140T897 A0A452DI25 E1BGJ0 P01966 P02070 P85521	ALB CD163 HBA HBB HPX LRP1 M130	Bos taurus (cattle)
Ciprofloxacin ADME	Albumin Broad substrate specificity ATP-binding cassette transporter ABCG2 Solute carrier family 22 member 1 Solute carrier organic anion transporter family member	A0A140T897 A2VDW7 A7MBE0 B2D1N9	ABCG2 ALB OCT1 SLC22A1 SLCO1A2	Bos taurus (cattle)
Cytoprotection by HMOX1	Albumin Biliverdin reductase A Cytochrome c oxidase assembly factor COX18 Cytochrome c oxidase assembly protein COX11, mitochondrial Cytochrome c oxidase assembly protein COX14 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Cytochrome c oxidase assembly protein COX19 Cytochrome c oxidase assembly protein COX20, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A-related protein, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8 Cytochrome c oxidase subunit NDUFA4 Cytochrome c oxidase subunit NDUFA4 Cytochrome c DNA helicase Fatty acid-binding protein, liver Flavin reductase (NADPH) Heme oxygenase 1 Hemoglobin subunit alpha Hemoglobin subunit beta Histone deacetylase 3 Leucine rich pentatricopeptide repeat containing Mediator of RNA polymerase II transcription subunit 1 Multidrug resistance-associated protein 1 Nuclear receptor coactivator 6 Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor corepressor 1 Nuclear receptor corepressor 2 Peroxisome proliferator-activated receptor alpha Protein SCO1 homolog, mitochondrial Protein SCO2 homolog, mitochondrial Retinoic acid receptor RXR SIN3 transcription regulator family member A SIN3 transcription regulator family member B SURF1-like protein SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Transducin beta like 1 X-linked Translational activator of cytochrome c oxidase I Trimethylguanosine synthase Uncharacterized protein heme oxygenase (biliverdin-producing) histone acetyltransferase	A0A0N4STN2 A0A140T897 A0A3Q1LKB8 A0A3Q1LTU9 A0A3Q1M6L2 A0A3Q1MMW4 A0A3Q1MQ83 A0A3Q1MQS6 A0A3Q1MY21 A1A4J8 A3KMZ6 A6H784 A8E4L1 B7TCI5 E1B7Q6 E1BDZ3 E1BGW5 E1BH77 E1BJK7 E1BND5 E1BPX9 E1BPY4 F1MD32 F1MGM4 F1MTR3 F1MTY9 F1MX52 F1N0W0 F1N1K9 F1N5P2 G3N0C2 P00423 P00426 P00430 P01966 P02070 P04038 P13182 P52556 P62894 P68530 P80425 Q01321 Q0II51 Q1RMH3 Q2NKS2 Q3T061 Q5E9F2 Q5EA13 Q6QTG5 Q6QTG9 Q8HXQ5	ABCC1 ALB BLVRA BLVRB CHD9 COII COX1 COX11 COX14 COX16 COX18 COX19 COX2 COX20 COX3 COX4 COX4I1 COX5A COX6A1 COX6C COX7A2L COX7B COX7C COX7CP1 COXII CREBBP CYC CYCS FABP1 HBA HBB HDAC3 HMOX1 HMOX2 LOC100296227 LOC783202 LRPPRC MED1 MRP1 MT-CO2 MTCO2 NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NDUFA4 PPARA RXRA SCAN SCO1 SCO2 SCOD1 SIN3A SIN3B SMARCD3 SURF1 TACO1 TBL1X TGS1	Bos taurus (cattle)
HDL remodeling	Albumin Apolipoprotein A-I Apolipoprotein C-II Apolipoprotein C-III Apolipoprotein E Lipase G, endothelial type Phosphatidylcholine-sterol acyltransferase Phospholipid transfer protein	A0A140T881 A0A140T897 A0A3Q1LR40 P15497 P19034 P19035 Q2KIW4 Q58DL9	ALB APOA1 APOC2 APOC3 APOE LCAT LIPG PLTP	Bos taurus (cattle)
HS-GAG biosynthesis	Agrin Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Exostosin glycosyltransferase 2 Exostosin-1 Glypican 2 Glypican 4 Glypican 5 Glypican-1 Glypican-3 Heparan sulfate 2-O-sulfotransferase 1 Heparan-sulfate 6-O-sulfotransferase Heparan-sulfate 6-O-sulfotransferase Solute carrier family 35 member D2 Sulfotransferase Sulfotransferase Sulfotransferase Sulfotransferase Sulfotransferase Sulfotransferase Syndecan-1 Syndecan-2 Syndecan [heparan sulfate]-glucosamine N-sulfotransferase [heparan sulfate]-glucosamine N-sulfotransferase	A0A3Q1LS54 A0A3Q1LTY7 A0A3Q1LZ29 A0A3Q1M8D2 A0A3S5ZPA0 A5D7I4 A8E4L2 E1B729 E1BCG5 E1BJP5 E1BKJ2 E1BKQ1 E1BKS1 E1BM02 E1BNJ7 E1BP03 F1MCX1 F1MMN3 F1MZX8 Q08DZ5 Q0VCB5 Q0VD21 Q3ZBZ6 Q58DD4	AGRN EXT1 EXT2 GPC1 GPC2 GPC3 GPC4 GPC5 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST5 HS3ST6 HS6ST2 HS6ST3 NDST1 NDST2 NDST4 SDC1 SDC2 SDC4 SLC35D2	Bos taurus (cattle)
A tetrasaccharide linker sequence is required for GAG synthesis	Agrin Beta-1,4-galactosyltransferase Biglycan Brevican core protein Chondroitin sulfate proteoglycan 4 Chondroitin sulfate proteoglycan 5 (Neuroglycan C) Decorin Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Glypican 2 Glypican 4 Glypican 5 Glypican-1 Glypican-3 Hexosyltransferase Neurocan Syndecan-1 Syndecan-2 Syndecan Versican core protein Xylosyltransferase 1 Xylosyltransferase 2	A0A3Q1LG25 A0A3Q1LSF3 A0A3Q1LTY7 A0A3Q1LZ29 E1BKJ2 E1BKS1 F1MCX1 F1MQ31 F1MQ60 F1MVH6 F1MY84 F1MZX8 F1N211 F1N2Y8 F6Q1U8 P21793 P21809 P81282 Q08DZ5 Q0VCM1 Q3ZBZ6 Q58DD4	AGRN B3GALT6 B3GAT1 B3GAT3 B4GALT7 BCAN BGN CSPG2 CSPG4 CSPG5 DCN GPC1 GPC2 GPC3 GPC4 GPC5 NCAN SDC1 SDC2 SDC4 VCAN XYLT1 XYLT2	Bos taurus (cattle)
HS-GAG degradation	Agrin Alpha-L-iduronidase Beta-galactosidase Beta-galactosidase Beta-glucuronidase Galactosidase beta 1 like Glypican 2 Glypican 4 Glypican 5 Glypican-1 Glypican-3 Heparanase 2 (inactive) Heparanase Iduronate 2-sulfatase N-acetyl-alpha-glucosaminidase N-sulfoglucosamine sulfohydrolase Syndecan-1 Syndecan-2 Syndecan	A0A3Q1LN81 A0A3Q1LRF3 A0A3Q1LTY7 A0A3Q1LZ29 A0A3Q1NAQ3 A0A3Q1NDQ7 A3KMY8 E1BCP9 E1BFX4 E1BKJ2 E1BKS1 F1MCX1 F1MY73 F1MZX8 F1N1G1 F1N2D5 Q08DZ5 Q3ZBZ6 Q58DD4	AGRN GLB1 GLB1L GLB1L2 GPC1 GPC2 GPC3 GPC4 GPC5 GUSB HPSE HPSE2 IDS IDUA NAGLU SDC1 SDC2 SDC4 SGSH	Bos taurus (cattle)	G01550VL G09546QO
Keratan sulfate degradation	Aggrecan core protein Beta-galactosidase Beta-galactosidase Beta-hexosaminidase subunit alpha Beta-hexosaminidase Fibromodulin Galactosidase beta 1 like Keratocan Lumican N-acetylglucosamine-6-sulfatase Osteomodulin Proline and arginine rich end leucine rich repeat protein	A0A140T890 A0A3Q1NDQ7 A6QQQ3 E1BCP9 F1MXZ0 F1MY73 F1N368 G3X6Y4 H7BWW2 P13605 Q05443 Q0V8R6	ACAN FMOD GLB1 GLB1L GLB1L2 GNS HEXA HEXB KERA LDC LUM OMD PRELP	Bos taurus (cattle)	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB G85384LV
Keratan sulfate biosynthesis	Aggrecan core protein Beta-1,4-galactosyltransferase 1 Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-galactosyltransferase Beta-1,4-glucuronyltransferase 1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 Fibromodulin Gal-NAc6S Hexosyltransferase Hexosyltransferase Keratocan Lumican Osteomodulin Proline and arginine rich end leucine rich repeat protein ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Solute carrier family 35 member D2 Sulfotransferase Sulfotransferase Type 2 lactosamine alpha-2,3-sialyltransferase	A0A140T890 A0A3Q1LUC6 A0A3Q1MGH3 A4IFE8 A5D960 A6QQQ3 A7YY64 E1BCQ2 E1BM02 E1BMN6 F1MSS4 F1MUJ7 F1N368 F6RH18 F6RJ53 G3X6Y4 P08037 P13605 Q05443 Q5EA01 Q6H8M7 Q6H8M9	ACAN B3GNT1 B3GNT2 B3GNT4 B3GNT6 B4GALT1 B4GALT2 B4GALT4 B4GALT5 B4GALT6 B4GAT1 CHST1 CHST2 FMOD GALT GGTB2 KERA LDC LUM OMD PRELP SIAT10 SLC35D2 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 siat4B	Bos taurus (cattle)
ECM proteoglycans	Aggrecan core protein Agrin Biglycan Brevican core protein Cartilage oligomeric matrix protein Decorin Dentin matrix acidic phosphoprotein 1 Dentin sialophosphoprotein Hyaluronan and proteoglycan link protein 1 Integrin beta-6 Integrin beta Integrin beta Integrin beta Integrin subunit alpha 2 Integrin subunit alpha 2b Integrin subunit alpha 7 Integrin subunit alpha 9 Integrin subunit alpha V Matrilin 1 Matrilin 3 Matrilin 4 Neurocan Plasminogen activator inhibitor 1 SPARC Tenascin C Tenascin N Tenascin R Tenascin XB VWFA domain-containing protein Versican core protein Vitronectin	A0A140T8D2 A0A3Q1LTY7 A0A3Q1LZT3 A0A3Q1MXS2 A0A452DIJ9 E1BB79 E1BDF3 E1BGA0 E1BKN2 E1BMV3 F1MBA3 F1MD94 F1MGZ4 F1MJM1 F1MMH2 F1MPK6 F1MQ31 F1MRZ6 F1MTN1 F1N2Y8 F1N368 G3MZB1 P13213 P21793 P21809 P35445 P55252 P81282 Q3ZBS7 Q8SQB8 Q8SQB9	ACAN AGRN BCAN BGN COMP CRTL1 CSPG2 DCN DMP1 DSPP HAPLN1 ITGA2 ITGA2B ITGA7 ITGA9 ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 MATN1 MATN3 MATN4 NCAN SERPINE1 SPARC TNC TNN TNR TNXB VCAN VTN	Bos taurus (cattle)
TRAF6 mediated NF-kB activation	Advanced glycosylation end-product specific receptor Amyloid-beta A4 protein High mobility group protein B1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappa-B inhibitor-interacting Ras-like protein 2 NF-kappaB transcription factor p65 subunit NFKB inhibitor interacting Ras like 1 NFKB2 protein Nuclear factor NF-kappa-B p105 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Protein S100-A12 Protein S100-B	A0A3Q1LUG2 A0A3Q1LZM4 A1XG22 A7MBB7 F1MKW9 F1N306 P02638 P10103 P79105 Q0IIB2 Q1JPF1 Q8WNW7 Q95KU9 Q95KV0 Q95KV1	AGER APP CAAF1 CHUK HMG1 HMGB1 IKBKB IKBKG IKKA NEMO NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA S100A12 S100B bIkBa	Bos taurus (cattle)
TAK1-dependent IKK and NF-kappa-B activation	Advanced glycosylation end-product specific receptor Amyloid-beta A4 protein High mobility group protein B1 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator NF-kappa-B inhibitor alpha (Fragment) NF-kappa-B inhibitor-interacting Ras-like protein 2 NF-kappaB transcription factor p65 subunit NFKB inhibitor interacting Ras like 1 NFKB2 protein Nuclear factor NF-kappa-B p105 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Protein S100-A12 Protein S100-B	A0A3Q1LUG2 A0A3Q1LZM4 A1XG22 A7MBB7 F1MKW9 F1N306 P02638 P10103 P79105 Q0IIB2 Q1JPF1 Q8WNW7 Q95KU9 Q95KV0 Q95KV1	AGER APP CAAF1 CHUK HMG1 HMGB1 IKBKB IKBKG IKKA NEMO NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 RELA S100A12 S100B bIkBa	Bos taurus (cattle)
Endogenous sterols	Adrenodoxin, mitochondrial Aryl hydrocarbon receptor nuclear translocator 2 Aryl hydrocarbon receptor nuclear translocator Aryl hydrocarbon receptor CYP39A1 protein Cholesterol 7-alpha-monooxygenase Cholesterol side-chain cleavage enzyme, mitochondrial Cytochrome P450 family 1 subfamily B member 1 Cytochrome P450 family 27 subfamily A member 1 Cytochrome P450 family 4 subfamily V member 2 Cytochrome P450, family 46, subfamily A, polypeptide 1 Ferredoxin-2, mitochondrial Lanosterol 14-alpha demethylase NADPH Nuclear receptor coactivator Nuclear receptor coactivator Nuclear receptor subfamily 1 group H member 4 Pro-opiomelanocortin Retinoic acid receptor RXR Steroid 21-hydroxylase aromatase steroid 11beta-monooxygenase steroid 11beta-monooxygenase steroid 11beta-monooxygenase	A0A3Q1LKX3 A3KMX9 A6H722 E1BM29 E1BPY4 F1MG97 F1ML85 F1MNG1 F1MTT1 F1MU47 F1MWH3 F1MX52 F1MYL2 F1N3Z7 F2Z4F2 F6QQE8 G3N0C2 P00191 P00257 P01190 Q05B51 Q08DD0 Q148K8 Q4PJW3	ADX AHR ARNT ARNT2 CYP11A1 CYP11B1 CYP19A1 CYP1B1 CYP21 CYP21A1 CYP21A2 CYP27A1 CYP39A1 CYP46A1 CYP4V2 CYP51A1 CYP7A1 FDX1 FDX1L FDX2 FDXR LOC112449566 NCOA1 NCOA2 NR1H4 POMC RXRA	Bos taurus (cattle)
Classical antibody-mediated complement activation	Adiponectin B Complement C1q subcomponent subunit A Complement C1q subcomponent subunit B Complement C1s Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Pentraxin family member complement subcomponent C1r	A0A3B0IZF8 A0A3Q1LKV0 A0A3Q1LPG0 A0A3Q1M3L6 A0A3Q1M7Q5 A0A3Q1MGP1 C4T8B4 G3N0V0 Q2KIV9 Q5E9E3	ADIB C1QA C1QB C1QC C1R C1S CRP	Bos taurus (cattle)
Initial triggering of complement	Adiponectin B Collectin subfamily member 10 Collectin-11 Complement C1q subcomponent subunit A Complement C1q subcomponent subunit B Complement C1s Complement C2 Complement component 4A Ficolin-2 Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MBL associated serine protease 1 MBL associated serine protease 2 Mannose-binding protein C Uncharacterized protein complement subcomponent C1r	A0A3B0IZF8 A0A3Q1LKV0 A0A3Q1LPG0 A0A3Q1M3L6 A0A3Q1M7Q5 A0A3Q1MGP1 A0A3Q1MLF4 E1BH06 E1BJ49 F1MVK1 F1MVS9 G3N0V0 O02659 Q17QH6 Q2KIV9 Q3SYW2 Q5E9E3 Q5I2E5	ADIB C1QA C1QB C1QC C1R C1S C2 C4A COLEC10 COLEC11 FCN2 LOC107131209 MASP1 MASP2 MBL	Bos taurus (cattle)	G49108TO G57321FI
Regulation of Complement cascade	Adiponectin B C3a anaphylatoxin chemotactic receptor C5L2 C5a anaphylatoxin chemotactic receptor 1 CD19 molecule CD55 molecule (Cromer blood group) CD59 glycoprotein CD81 antigen CPN2 protein Carboxypeptidase B2 Carboxypeptidase N subunit 1 Clusterin Complement C1q subcomponent subunit A Complement C1q subcomponent subunit B Complement C1s Complement C2 Complement C3 Complement C5 Complement C7 Complement C8 alpha chain Complement component 4A Complement component C8 beta chain Complement component C9 Complement factor B Complement factor H related 5 Complement factor H Complement factor I Elastase, neutrophil expressed Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Prothrombin Serpin family G member 1 Sushi domain-containing protein Sushi domain-containing protein Sushi domain-containing protein Uncharacterized protein Vitronectin complement subcomponent C1r	A0A3B0IZF8 A0A3Q1LI40 A0A3Q1LKV0 A0A3Q1LPG0 A0A3Q1LQX2 A0A3Q1LSC6 A0A3Q1M3I2 A0A3Q1M3L6 A0A3Q1M7Q5 A0A3Q1MF14 A0A3Q1MGP1 A0A3Q1MP45 A0A452DI66 A4IFF5 A6QP30 E1BH06 E1BMJ0 F1MC45 F1MLR1 F1MVK1 F1MX87 F1MY85 F1N102 F1N586 G3MWP1 G3N0V0 G5E5V0 P17697 P81187 Q08DZ7 Q2KIG3 Q2KIV9 Q2UVX4 Q32PA1 Q3MHN2 Q3SYW2 Q3ZBS7 Q3ZCD0 Q5E9E3 Q673L2	ADIB BF C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C5 C5AR1 C5AR2 C5L2 C7 C8A C8B C9 CD19 CD55 CD59 CD81 CFB CFH CFHR5 CFI CLU CPB2 CPN1 CPN2 ELANE F2 GPR77 LOC100336868 LOC107131209 LOC519737 LOC616002 SERPING1 VTN	Bos taurus (cattle)

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