GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **126 - 150** of **268** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism	GlyTouCan ID
Terminal pathway of complement	Clusterin Complement C5 Complement C7 Complement C8 alpha chain Complement C8 gamma chain Complement component C6 Complement component C8 beta chain Complement component C9	A0A8I3MKJ7 A0A8I3MQ72 A0A8I3MRL7 A0A8I3NT81 A0A8I3NVC1 A0A8I3P0T6 A0A8I3RSI3 P25473	C5 C6 C7 C8A C8B C8G C9 CLU	Canis familiaris (dog)
Presynaptic depolarization and calcium channel opening	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium voltage-gated channel auxiliary subunit alpha2delta 3 Calcium voltage-gated channel auxiliary subunit beta 4 Calcium voltage-gated channel auxiliary subunit gamma 4 Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 Voltage-dependent P/Q-type calcium channel subunit alpha Voltage-dependent R-type calcium channel subunit alpha Voltage-dependent calcium channel gamma-2 subunit	A0A8I3MU54 A0A8I3MZA1 A0A8I3N5F4 A0A8I3NMX5 A0A8I3NPX9 A0A8I3P8U8 A0A8I3PWX4 A0A8I3Q178 A0A8I3Q3U9 A0A8I3S464	CACNA1A CACNA1E CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4	Canis familiaris (dog)
Phase 2 - plateau phase	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium voltage-gated channel auxiliary subunit gamma 4 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit	A0A8I3MK78 A0A8I3N7S8 A0A8I3NMX5 A0A8I3NPX9 A0A8I3P8U8 A0A8I3Q178 A0A8I3QY31 A0A8I3RTB9	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8	Canis familiaris (dog)
Phase 0 - rapid depolarisation	Calcium voltage-gated channel auxiliary subunit alpha2delta 2 Calcium voltage-gated channel auxiliary subunit gamma 4 Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent L-type calcium channel subunit beta-1 Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent calcium channel gamma-6 subunit Voltage-dependent calcium channel gamma-7 subunit Voltage-dependent calcium channel gamma-8 subunit	A0A8I3MK78 A0A8I3N7S8 A0A8I3NMX5 A0A8I3NPX9 A0A8I3P8U8 A0A8I3Q178 A0A8I3QY31 A0A8I3RTB9	CACNA1C CACNA2D2 CACNB1 CACNB2 CACNG4 CACNG6 CACNG7 CACNG8	Canis familiaris (dog)
Sensory perception of sweet, bitter, and umami (glutamate) taste	Bitter taste receptor T2R43 G protein subunit alpha transducin 3 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Inositol 1,4,5-trisphosphate receptor Taste 1 receptor member 1 Taste receptor type 1 member 3 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2 Taste receptor type 2	A0A8I3NKU5 A0A8I3PJF2 A0A8I3PQY2 A0A8I3PRQ9 A0A8I3Q2P2 A0A8I3Q7L4 A0A8I3QV74 A0A8I3S925 A0A8I3S929 A0A8I3SCV7 P62872 P79147 Q2ABD0 Q2ABD1 Q2ABD4 Q2ABD5 Q2ABD6 Q2ABD8 Q2ABE0	CAFA-T2R43 GNAT3 GNB1 GNB3 GNG13 ITPR3 LOC100682759 TAS1R1 TAS1R3 TAS2R1 TAS2R10 TAS2R3 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R5 TAS2R7	Canis familiaris (dog)	G58161NS
Inactivation, recovery and regulation of the phototransduction cascade	Calmodulin-lysine N-methyltransferase Cyclic nucleotide gated channel subunit beta 1 EF-hand domain-containing protein G protein-coupled receptor kinase G protein-coupled receptor kinase G protein-coupled receptor kinase Glycylpeptide N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase Guanine nucleotide-binding protein G(t) subunit alpha-1 Guanine nucleotide-binding protein subunit beta-5 Guanylate cyclase activator 1C Guanylate cyclase Guanylate cyclase Guanylyl cyclase-activating protein 1 Methionine aminopeptidase 2 Methionine aminopeptidase Phosphodiesterase Recoverin Regulator of G protein signaling 9 binding protein Regulator of G-protein signaling 9 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Rhodopsin Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta S-arrestin Serine/threonine-protein phosphatase with EF-hands cGMP-gated cation channel alpha-1	A0A8I3MKZ0 A0A8I3MLZ0 A0A8I3MQ38 A0A8I3MR23 A0A8I3MSQ7 A0A8I3NB80 A0A8I3NDY5 A0A8I3NJ95 A0A8I3NUA6 A0A8I3P9Q1 A0A8I3PF51 A0A8I3PM46 A0A8I3PRB5 A0A8I3PV05 A0A8I3PV39 A0A8I3PWQ2 A0A8I3Q053 A0A8I3Q0S6 A0A8I3Q144 A0A8I3QE57 A0A8I3S5I9 A0A8I3S6V0 P33726 P54827 Q28263 Q28300 Q8MIH6	CALM2 CAMKMT CNGA1 CNGB1 GNAT1 GNB5 GRK1 GRK4 GRK7 GUCA1A GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT1 NMT2 PDBS PDE6A PDE6B PDE6G PDEA PDEB PDEG PPEF1 RCV1 RCVRN RGS9 RGS9BP RHO SAG	Canis familiaris (dog)
Synthesis of IP3 and IP4 in the cytosol	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase EF-hand domain-containing protein Inositol polyphosphate-5-phosphatase J Inositol-tetrakisphosphate 1-kinase Kinase Kinase Kinase Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phosphoinositide phospholipase C Phospholipase C delta 4 Phospholipase C zeta 1 Uncharacterized protein phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase phosphoinositide 5-phosphatase phosphoinositide 5-phosphatase phosphoinositide 5-phosphatase	A0A8I3MH68 A0A8I3MSQ7 A0A8I3MYA9 A0A8I3N810 A0A8I3NFE2 A0A8I3NWQ5 A0A8I3NY96 A0A8I3NZG2 A0A8I3PAP4 A0A8I3PAT0 A0A8I3PB87 A0A8I3PC05 A0A8I3PFD9 A0A8I3PLP7 A0A8I3PN52 A0A8I3PQK7 A0A8I3Q2Q7 A0A8I3Q4W3 A0A8I3Q7I7 A0A8I3Q9F2 A0A8I3QSE4 A0A8I3S2X3 A0A8I3S6D4 A0A8I3S7X1 A0A8I3SCI7 P60483	CALM2 INPP5B INPP5D INPP5J INPPL1 ITPK1 ITPKA ITPKB ITPKC MMAC1 OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PTEN SHIP2 SYNJ1	Canis familiaris (dog)
Sodium/Calcium exchangers	EF-hand domain-containing protein Sodium/calcium exchanger 1 Solute carrier family 24 member 2 Solute carrier family 24 member 3 Solute carrier family 24 member 4 Solute carrier family 24 member 5 Solute carrier family 8 member A2 Solute carrier family 8 member A3 Solute carrier family 8 member B1 Sorcin	A0A8I3MSQ7 A0A8I3MTJ5 A0A8I3NPM6 A0A8I3NX53 A0A8I3PDR2 A0A8I3PJY1 A0A8I3Q687 A0A8I3RTF4 A0A8I3RY81 P23685	CALM2 NCX1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI	Canis familiaris (dog)
Interferon gamma signaling	Fibronectin type-III domain-containing protein Interferon gamma Mitogen-activated protein kinase Mitogen-activated protein kinase Protein kinase C delta type Signal transducer and activator of transcription Suppressor of cytokine signaling 3 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Y-box-binding protein 1 Y-box-binding protein 1 Y-box-binding protein 1 calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase calcium/calmodulin-dependent protein kinase	A0A8I3MY73 A0A8I3NIS8 A0A8I3NMP2 A0A8I3NPS8 A0A8I3NU62 A0A8I3NVH4 A0A8I3NXV5 A0A8I3PF62 A0A8I3PSA1 A0A8I3PWC6 A0A8I3PZJ7 A0A8I3PZP0 A0A8I3QCJ0 A0A8I3RQD0 A0A8I3RS40 A0A8I3RWC7 P42161	CAMK2A CAMK2B CAMK2G IFNG IFNGR1 IFNGR2 JAK1 JAK2 LOC479011 MAPK1 MAPK3 PRKCD PTPN6 SOCS3 STAT1 YBX1	Canis familiaris (dog)
Formation of the cornified envelope	Calpain small subunit 1 Calpain-1 catalytic subunit Caspase 14 Corneodesmosin Cystatin A Desmocollin 1 Desmoglein 1 Desmoglein 2 Desmoglein 3 Desmoglein 4 Desmoglein-3 Desmoplakin EF-hand domain-containing protein EF-hand domain-containing protein EF-hand domain-containing protein Junction plakoglobin Kallikrein related peptidase 12 Kallikrein related peptidase 13 Kallikrein related peptidase 14 Kazrin, periplakin interacting protein Lipase Lipase Lipase P53 apoptosis effector related to PMP22 Partial AB-hydrolase lipase domain-containing protein Peptidase inhibitor 3 Periplakin Plakophilin 1 Plakophilin 2 Plakophilin 3 Plakophilin 4 Proprotein convertase subtilisin/kexin type 6 Protein-glutamine gamma-glutamyltransferase K SH3 domain-containing protein Serine peptidase inhibitor Kazal type 6 Serine protease 8 Uncharacterized protein furin	A0A8I3MEZ7 A0A8I3MGG5 A0A8I3MMJ6 A0A8I3MP57 A0A8I3MV56 A0A8I3N1T9 A0A8I3N282 A0A8I3NHU5 A0A8I3NIB1 A0A8I3NJG7 A0A8I3NL10 A0A8I3NLL5 A0A8I3NRG5 A0A8I3NVV6 A0A8I3NXI7 A0A8I3NYR0 A0A8I3NZ03 A0A8I3P0I4 A0A8I3P212 A0A8I3PDW6 A0A8I3PMI7 A0A8I3PQU9 A0A8I3PW84 A0A8I3PYD8 A0A8I3Q1A4 A0A8I3Q2T7 A0A8I3Q6Y1 A0A8I3Q7P7 A0A8I3Q910 A0A8I3QKA9 A0A8I3RW47 A0A8I3RY38 A0A8I3RYD5 A0A8I3S0K7 A0A8I3S9F9 D3DMB4 F1PHB6 Q7YRU7	CAPN1 CAPNS1 CASP14 CSTA DSC1 DSC3 DSG1 DSG2 DSG3 DSG4 DSP EVPL FLG FURIN JUP KAZN KLK12 KLK13 KLK14 LIPJ LIPK LIPM LIPN LOC119876865 PCSK6 PERP PI3 PKP1 PKP2 PKP3 PKP4 PPL PRSS8 RPTN SPINK6 TCHH TGM1 cystatin A	Canis familiaris (dog)
Other interleukin signaling	Caspase-3 Colony stimulating factor 3 receptor Granulocyte colony-stimulating factor Interferon lambda receptor 1 Interleukin 29-like Interleukin 34 Macrophage colony-stimulating factor 1 Multifunctional fusion protein Pro-interleukin-16 Syndecan Syntaxin 4 Syntaxin-1A Syntaxin-binding protein 2 T-cell surface glycoprotein CD4 Taxilin alpha Tissue factor Tyrosine-protein kinase Tyrosine-protein kinase Vesicle-associated membrane protein 2 protein-tyrosine-phosphatase receptor protein-tyrosine kinase t-SNARE coiled-coil homology domain-containing protein	A0A8I3MKU0 A0A8I3MLF8 A0A8I3MP33 A0A8I3MU79 A0A8I3MWJ5 A0A8I3MXT5 A0A8I3NFS8 A0A8I3NN34 A0A8I3NNE2 A0A8I3NRN4 A0A8I3P3C6 A0A8I3P4F5 A0A8I3PNE3 A0A8I3PUZ4 A0A8I3Q7V8 A0A8I3QCQ2 A0A8I3RS40 A0A8I3S0X5 A0A8I3S6B0 A0A8I3S6J8 F1PS12 P33705	CASP3 CD4 CSF1 CSF1R CSF3 CSF3R IFNLR1 IL10RB IL16 IL29L IL34 JAK1 PTPRZ1 SDC1 SNAP25 STX1A STX3 STX4 STXBP2 TXLNA TYK2 VAMP2	Canis familiaris (dog)
Apoptotic cleavage of cell adhesion proteins	Cadherin-1 Cadherin-1 Caspase-3 Catenin beta-1 Desmoglein 1 Desmoglein 2 Desmoglein 3 Desmoglein-3 Desmoplakin Occludin Plakophilin 1 Tight junction protein 1 Tight junction protein 2	A0A8I3MAQ1 A0A8I3NBM1 A0A8I3NIB1 A0A8I3NPT4 A0A8I3NRN4 A0A8I3NUM7 A0A8I3P212 A0A8I3RRA2 A0A8I3RW47 A0A8I3RY38 A0A8I3S0K7 F1PAA9 Q7YRU7	CASP3 CDH1 CTNNB1 DSG1 DSG2 DSG3 DSP OCLN PKP1 TJP1 TJP2	Canis familiaris (dog)
Class A/1 (Rhodopsin-like receptors)	Cannabinod receptor Chemerin-like receptor 1 G protein-coupled receptor 183 G protein-coupled receptor 35 G protein-coupled receptor 55 G protein-coupled receptor 68 G-protein coupled bile acid receptor 1 Melatonin receptor 1B Melatonin receptor type 1A N-arachidonyl glycine receptor Oxoglutarate receptor 1 Platelet-activating factor receptor Succinate receptor 1 Uncharacterized protein Uncharacterized protein Uncharacterized protein	A0A8I3NKP7 A0A8I3P831 A0A8I3P8G7 A0A8I3PBK9 A0A8I3PDW8 A0A8I3PE74 A0A8I3PH14 A0A8I3PIK0 A0A8I3PZA6 A0A8I3Q1X3 A0A8I3Q2D1 A0A8I3QYW7 A0A8I3RTK7 A0A8I3RY80 A0A8I3S3R7 E2RKA3	CB2 CMKLR1 CNR2 GPBAR1 GPR132 GPR18 GPR183 GPR35 GPR39 GPR55 GPR68 HCAR2 MTNR1A MTNR1B OXGR1 PTAFR SUCNR1	Canis familiaris (dog)
Negative regulation of MET activity	E3 ubiquitin-protein ligase CBL Endophilin-A2 Epidermal growth factor receptor pathway substrate 15 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor-regulated tyrosine kinase substrate Hepatocyte growth factor Leucine rich repeats and immunoglobulin like domains 1 SH3 domain containing GRB2 like 2, endophilin A1 SH3 domain containing kinase binding protein 1 Signal transducing adaptor molecule 2 Signal transducing adaptor molecule Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein protein-tyrosine-phosphatase ubiquitinyl hydrolase 1	A0A8I3MBU4 A0A8I3MMN5 A0A8I3MZ64 A0A8I3N2P0 A0A8I3N8H2 A0A8I3NFB9 A0A8I3NGD3 A0A8I3NGY1 A0A8I3NKR3 A0A8I3NRM5 A0A8I3NTR3 A0A8I3P598 A0A8I3PMU1 A0A8I3PNU1 A0A8I3PT69 A0A8I3PXV2 A0A8I3Q5C2 A0A8I3QYD0 P63050 Q867B7	CBL EPS15 GRB2 HGF HGS LRIG1 MET PTPN1 PTPN2 PTPRJ RPS27A SH3GL1 SH3GL2 SH3KBP1 STAM STAM2 UBA52 UBB UBC UBCEP2 USP8	Canis familiaris (dog)
Negative regulation of FGFR2 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor bound protein 2 Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MBU4 A0A8I3MIK8 A0A8I3MMN5 A0A8I3MP09 A0A8I3NFB9 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P4L9 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3PZP0 A0A8I3QYD0 A0A8I3RQD0 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 J9P8K0 P63050 P79150 Q20FD0	CBL FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 FRS2 GRB2 KGF MAPK1 MAPK3 PTPN11 RPS27A UBA52 UBB UBC UBCEP2	Canis familiaris (dog)
Negative regulation of FGFR3 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor bound protein 2 Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MBU4 A0A8I3MIK8 A0A8I3MMN5 A0A8I3NFB9 A0A8I3NHF3 A0A8I3NS74 A0A8I3NTD6 A0A8I3NV07 A0A8I3P4L9 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3PZP0 A0A8I3QYD0 A0A8I3RQD0 A0A8I3SAY5 J9P0B3 J9P3I7 J9P8K0 P63050 Q20FD0	CBL FGF1 FGF16 FGF17 FGF18 FGF20 FGF23 FGF3A FGF4 FGF4B FGF4C FGF5 FGF7A FGF8 FGF8B FGF9 FGFR3 FRS2 GRB2 MAPK1 MAPK3 PTPN11 RPS27A UBA52 UBB UBC UBCEP2	Canis familiaris (dog)
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Growth factor receptor bound protein 2 Kit ligand Mast/stem cell growth factor receptor Kit Protein kinase C SH2B adaptor protein 2 SH2B adaptor protein 3 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type	A0A8I3MBU4 A0A8I3ML64 A0A8I3MTK2 A0A8I3NAC6 A0A8I3P3X1 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PWC6 A0A8I3QRG3 A0A8I3S3D9 A0A8I3SBF9 O97799 Q06220	CBL FYN GRB2 KIT KITLG LCK LYN MGF PRKCA PTPN6 SH2B2 SH2B3 SOS1 SRC YES1	Canis familiaris (dog)
Uptake of dietary cobalamins into enterocytes	ATP binding cassette subfamily D member 4 Chymotrypsinogen 2 Cobalamin binding intrinsic factor Lysosomal cobalamin transport escort protein LMBD1 Transcobalamin-like C-terminal domain-containing protein trypsin	A0A8I3N584 A0A8I3P9U6 A0A8I3PD99 A0A8I3S4Z0 P04813 Q5XWD5	CBLIF CTRB CTRB1 GIF LMBRD1 LOC119869278 PRSS2 TCN1	Canis familiaris (dog)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Cytochrome P450 family 8 subfamily B member 1 Prostacyclin synthase Prostaglandin E synthase 2 Prostaglandin E synthase Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin-H2 D-isomerase Thromboxane-A synthase carbonyl reductase (NADPH) glutathione transferase	A0A8I3MUQ9 A0A8I3PFY5 A0A8I3PJM8 A0A8I3PV18 A0A8I3Q8L4 A0SYQ0 B4YY03 E5RQH2 Q8HZR1 Q8SPQ9	CBR1 COX-2 COX1 CYP8B1 H-PGDS HPGDS PGES PTGDS PTGES PTGES2 PTGIS PTGS1 PTGS2 TBXAS1	Canis familiaris (dog)
Gastrin-CREB signalling pathway via PKC and MAPK	Gastrin/cholecystokinin type B receptor Gastrin Mitogen-activated protein kinase Mitogen-activated protein kinase Mitogen-activated protein kinase Ribosomal protein S6 kinase Ribosomal protein S6 kinase cAMP responsive element binding protein 1 non-specific serine/threonine protein kinase	A0A8I3MV42 A0A8I3NAU2 A0A8I3P721 A0A8I3PZN8 A0A8I3PZP0 A0A8I3RQD0 A0A8I3S2U7 P01353 P30552	CCKBR CREB1 GAS GAST MAPK1 MAPK3 MAPK7 RPS6KA1 RPS6KA2 RPS6KA3	Canis familiaris (dog)
Generation of second messenger molecules	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma CD101 molecule Cytoplasmic protein FYN binding protein 1 GRB2 related adaptor protein 2 Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Lymphocyte cytosolic protein 2 MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 P21 (RAC1) activated kinase 3 Phosphoinositide phospholipase C T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MGV8 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MMK2 A0A8I3MMK3 A0A8I3MMZ1 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NMF7 A0A8I3NTK0 A0A8I3NZG2 A0A8I3P4A1 A0A8I3P564 A0A8I3P6Q8 A0A8I3P8U2 A0A8I3PAB8 A0A8I3PNN9 A0A8I3Q5D2 A0A8I3QD39 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 A0A8I3S602 A0A8I3SCI7 P27597 P33705	CD101 CD247 CD3D CD3E CD3G CD4 DLA-DQA1 DLA-DRA FYB1 GRAP2 HLA-DQB2 ITK LAT LCK LCP2 NCK1 PAK1 PAK2 PAK3 PLCG1 PLCG2 TRAV29DV5 ZAP70	Canis familiaris (dog)
PD-1 signaling	CD274 molecule Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Programmed cell death 1 ligand 2 Programmed cell death 1 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NNV6 A0A8I3NTK0 A0A8I3P4A1 A0A8I3P4Z0 A0A8I3P564 A0A8I3PAB8 A0A8I3PMT9 A0A8I3PR61 A0A8I3PWC6 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 E2RKZ5 P27597 P33705	CD247 CD274 CD3D CD3E CD3G CD4 CSK DLA-DQA1 DLA-DRA HLA-DQB2 LCK PD-L1 PDCD1 PDCD1LG2 PDL1 PTPN11 PTPN6 TRAV29DV5	Canis familiaris (dog)
Phosphorylation of CD3 and TCR zeta chains	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3NYA3 A0A8I3P4A1 A0A8I3P4Z0 A0A8I3P564 A0A8I3P598 A0A8I3PAB8 A0A8I3PC26 A0A8I3PV90 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 CSK DLA-DQA1 DLA-DRA HLA-DQB2 LCK PAG1 PTPN22 PTPRC PTPRJ TRAV29DV5	Canis familiaris (dog)
Translocation of ZAP-70 to Immunological synapse	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3P4A1 A0A8I3P564 A0A8I3P8U2 A0A8I3PAB8 A0A8I3PC26 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 DLA-DQA1 DLA-DRA HLA-DQB2 LCK PTPN22 TRAV29DV5 ZAP70	Canis familiaris (dog)
FCGR activation	Fc fragment of IgG receptor Ia Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein	A0A8I3MFY1 A0A8I3ML64 A0A8I3MV98 A0A8I3NEM6 A0A8I3NQX3 A0A8I3NWR3 A0A8I3P1N5 A0A8I3P2M2 A0A8I3P2N6 A0A8I3P3G0 A0A8I3P3T7 A0A8I3P3X1 A0A8I3P4X4 A0A8I3P4Y5 A0A8I3P6V2 A0A8I3P941 A0A8I3PD67 A0A8I3PDU9 A0A8I3PL11 A0A8I3PQA6 A0A8I3PT15 A0A8I3PTN6 A0A8I3PUA5 A0A8I3PUN0 A0A8I3PUN5 A0A8I3PUP2 A0A8I3PUS1 A0A8I3PV91 A0A8I3PVB5 A0A8I3PVC4 A0A8I3PVG3 A0A8I3PWK4 A0A8I3PXN9 A0A8I3PXQ9 A0A8I3PYF1 A0A8I3Q5E2 A0A8I3QCV8 A0A8I3QD99 A0A8I3QE86 A0A8I3QF04 A0A8I3QHH1 A0A8I3QQ00 A0A8I3S0G9 A0A8I3S0K3 A0A8I3S4F9 A0A8I3S6H5 A0A8I3S9C3 A0A8I3SAS3 A0A8I3SAS7 A0A8I3SBF9 E2RP87	CD247 CD3G FCGR1A FCGR2B FCGR3A FGR FYN HCK LOC478984 LYN SRC SYK YES1	Canis familiaris (dog)

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