GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **268** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
Sphingolipid de novo biosynthesis	3-dehydrosphinganine reductase Broad substrate specificity ATP-binding cassette transporter ABCG2 Ceramide synthase 1 Ceramide synthase 2 Ceramide synthase 3 Ceramide synthase 4 Ceramide synthase 5 Ceramide synthase 6 Cytochrome b5 heme-binding domain-containing protein Delta 4-desaturase, sphingolipid 2 Fatty acid 2-hydroxylase Major facilitator superfamily domain containing 2B Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 ORM1-like protein ORM1-like protein ORM1-like protein SPNS lysolipid transporter 2, sphingosine-1-phosphate Serine palmitoyltransferase 1 Serine palmitoyltransferase long chain base subunit 2 Serine palmitoyltransferase long chain base subunit 3 Sphingolipid delta(4)-desaturase DES1 Sphingomyelin synthase 2 Sphingosine kinase 1 Sphingosine kinase 2 Sterile alpha motif domain containing 8 Uncharacterized protein Uncharacterized protein	A0A8I3MDB1 A0A8I3MDX2 A0A8I3MH69 A0A8I3MTG4 A0A8I3MVV0 A0A8I3MZT5 A0A8I3N0C8 A0A8I3N1I8 A0A8I3N6A8 A0A8I3N8H8 A0A8I3NCL9 A0A8I3NE51 A0A8I3NF48 A0A8I3P1Y0 A0A8I3P1Z6 A0A8I3P4B7 A0A8I3PAM7 A0A8I3PG24 A0A8I3PM33 A0A8I3PMG7 A0A8I3PQ53 A0A8I3Q2P7 A0A8I3S0D0 A0A8I3S194 A0A8I3S6X3 A0A8I3S790 B3RFJ1 Q6UR05	ABCC1 ABCG2 Abcg2 CERS1 CERS2 CERS3 CERS4 CERS5 CERS6 CYB5B DEGS1 DEGS2 FA2H KDSR MFSD2B MRP1 ORMDL1 ORMDL2 ORMDL3 SAMD8 SGMS1 SGMS2 SPHK1 SPHK2 SPNS2 SPTLC1 SPTLC2 SPTLC3 SPTSSA	Canis familiaris (dog)
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Coagulation factor IX Coagulation factor VII Coagulation factor X Growth arrest specific 6 Osteocalcin Prothrombin Vitamin K-dependent protein C Vitamin K-dependent protein S furin	A0A8I3N1T9 A0A8I3N921 A0A8I3PQV5 A0A8I3PUT1 A0A8I3Q1K1 A0A8I3QAV8 A0A8I3S489 A0A8I3SCE7 Q28278	BGLAP F10 F2 F7 F9 FURIN GAS6 PROC PROS1	Canis familiaris (dog)
Inositol transporters	Sodium/myo-inositol cotransporter 2 Sodium/myo-inositol cotransporter Solute carrier family 2 member 13	A0A8I3RR05 A0A8I3S7S0 P31637	SLC2A13 SLC5A11 SLC5A3 SMIT	Canis familiaris (dog)
Post-translational modification: synthesis of GPI-anchored proteins	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Alkaline phosphatase Alkaline phosphatase CAMPATH-1 antigen CD109 molecule CEA cell adhesion molecule 1 CEA cell adhesion molecule 20 Carboxypeptidase M Contactin-5 Glycoprotein 2 Hemicentin 2 IZUMO1 receptor, JUNO Ig-like domain-containing protein LY6/PLAUR domain containing 1 LY6/PLAUR domain containing 3 LY6/PLAUR domain containing 4 LY6/PLAUR domain containing 5 LY6/PLAUR domain containing 6B Limbic system associated membrane protein Low affinity immunoglobulin gamma Fc region receptor III-A Low affinity immunoglobulin gamma Fc region receptor III-A Lymphocyte antigen 6 family member G6C Lymphocyte antigen 6 family member G6D Melanotransferrin NAD(P)(+)--arginine ADP-ribosyltransferase NAD(P)(+)--arginine ADP-ribosyltransferase Neuritin 1 like Neuritin 1 Neuronal growth regulator 1 Neurotrimin Opioid binding protein/cell adhesion molecule like Otoancorin Pantetheinase Peptidase S1 domain-containing protein Phosphatidylinositol-glycan-specific phospholipase D Placenta-expressed transcript 1 protein Prion like protein doppel Prostate stem cell antigen Reticulon 4 receptor like 1 Reticulon 4 receptor like 2 Retinoic acid early-inducible protein 1 domain-containing protein Reversion inducing cysteine rich protein with kazal motifs Shadow of prion protein Sperm acrosome associated 4 Tectorin alpha Tectorin beta Testis expressed 101 Thy-1 membrane glycoprotein UPAR/Ly6 domain-containing protein UPAR/Ly6 domain-containing protein UPAR/Ly6 domain-containing protein UPAR/Ly6 domain-containing protein UPAR/Ly6 domain-containing protein Uncharacterized protein Uncharacterized protein X-prolyl aminopeptidase 2	A0A5F4D8V4 A0A8I3MAT6 A0A8I3MB16 A0A8I3MC73 A0A8I3MEX4 A0A8I3MFF6 A0A8I3MGB5 A0A8I3MHK2 A0A8I3MI32 A0A8I3MK32 A0A8I3MP74 A0A8I3MTL7 A0A8I3MTQ6 A0A8I3MTU9 A0A8I3MZC0 A0A8I3N367 A0A8I3N3V2 A0A8I3N6F5 A0A8I3NAY9 A0A8I3NFT9 A0A8I3NGU2 A0A8I3NH91 A0A8I3NIQ2 A0A8I3NJB5 A0A8I3NMI6 A0A8I3NNX5 A0A8I3NQP0 A0A8I3NTH0 A0A8I3NZ50 A0A8I3P0V6 A0A8I3P2N1 A0A8I3P2X9 A0A8I3P9X8 A0A8I3PBG0 A0A8I3PFN4 A0A8I3PK10 A0A8I3PNW6 A0A8I3PYZ3 A0A8I3Q1D0 A0A8I3Q7C6 A0A8I3Q8E3 A0A8I3QHH1 A0A8I3QN81 A0A8I3RRI7 A0A8I3RUJ8 A0A8I3RVF3 A0A8I3RW46 A0A8I3RXK7 A0A8I3RXW9 A0A8I3RYC5 A0A8I3RYX0 A0A8I3S2E0 A0A8I3S779 E2RP87 Q28896 Q9TSX8	ALPI ALPL ART3 ART4 BST1 CD109 CD52 CDW52 CE5 CEACAM1 CEACAM20 CNTN5 CPM FCGR3A GLIPR2 GP2 GPIHBP1 GPLD1 HMCN2 IZUMO1R LOC100683099 LOC119875695 LOC476816 LOC478984 LSAMP LY6D LY6E LY6G6C LY6G6D LY6H LYPD1 LYPD3 LYPD4 LYPD5 LYPD6B LYPD8 MELTF NEGR1 NRN1 NRN1L NTM OPCML OTOA PLET1 PRND PSCA RTN4RL1 RTN4RL2 SPACA4 SPRN TECTA TECTB TEX101 THY1 VNN1 XPNPEP2	Canis familiaris (dog)
Metal ion SLC transporters	Copper transport protein Hephaestin Natural resistance-associated macrophage protein 1 Solute carrier family 11 member 2 Solute carrier family 30 member 10 Solute carrier family 40 protein member 1 Solute carrier family 41 member Solute carrier family 41 member ferroxidase	A0A8I3N3B2 A0A8I3N4Y2 A0A8I3PMF7 A0A8I3PWM1 A0A8I3PXW9 A0A8I3Q213 A0A8I3QCU8 A0A8I3RZ10 E2RFJ3	CP HEPH SLC11A1 SLC11A2 SLC30A10 SLC31A1 SLC40A1 SLC41A1 SLC41A2	Canis familiaris (dog)
Reduction of cytosolic Ca++ levels	Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase EF-hand domain-containing protein Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 Solute carrier family 8 member A2 Solute carrier family 8 member A3 Sorcin	A0A8I3MJQ7 A0A8I3MSQ7 A0A8I3MTJ5 A0A8I3NYA8 A0A8I3PEN3 A0A8I3PJ46 A0A8I3RTF4 A0A8I3RVD4 A0A8I3RY81 A0A8I3S0A4 O46674 P23685	ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM2 NCX1 SLC8A1 SLC8A2 SLC8A3 SRI	Canis familiaris (dog)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	protein-ribulosamine 3-kinase protein-ribulosamine 3-kinase	A0A8I3PPB5 A0A8I3S5V4	FN3K FN3KRP	Canis familiaris (dog)
Vitamin B2 (riboflavin) metabolism	FAD synthase Riboflavin transporter Riboflavin transporter Tartrate-resistant acid phosphatase type 5 Uncharacterized protein riboflavin kinase	A0A8I3NBD2 A0A8I3NDY6 A0A8I3P1H5 A0A8I3RQK2 A0A8I3S1B1 E2RBY6	ACP5 ENPP1 FLAD1 RFK SLC52A2 SLC52A3	Canis familiaris (dog)
Negative regulation of FGFR2 signaling	E3 ubiquitin-protein ligase CBL Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor bound protein 2 Mitogen-activated protein kinase Mitogen-activated protein kinase Multifunctional fusion protein Tyrosine-protein phosphatase non-receptor type Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein	A0A0B4J199 A0A7U3JWB8 A0A8I3MBU4 A0A8I3MIK8 A0A8I3MMN5 A0A8I3MP09 A0A8I3NFB9 A0A8I3NHF3 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NYK3 A0A8I3P4L9 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PMT9 A0A8I3PT69 A0A8I3PZP0 A0A8I3QYD0 A0A8I3RQD0 A0A8I3SAY5 E2REX2 J9P0B3 J9P3I7 J9P8K0 P63050 P79150 Q20FD0	CBL FGF1 FGF10 FGF16 FGF17 FGF18 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR2 FRS2 GRB2 KGF MAPK1 MAPK3 PTPN11 RPS27A UBA52 UBB UBC UBCEP2	Canis familiaris (dog)
Signaling by SCF-KIT	Chymase GRB2 associated binding protein 2 GRB2 related adaptor protein 2 GRB2 related adaptor protein GTPase HRas GTPase NRas Growth factor receptor bound protein 10 Growth factor receptor bound protein 2 Growth factor receptor bound protein 7 Kit ligand Mast/stem cell growth factor receptor Kit Matrix metalloproteinase-9 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Protein kinase C Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Serine/threonine-protein kinase Chk1 Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Vav guanine nucleotide exchange factor 1 phosphatidylinositol-4,5-bisphosphate 3-kinase protein-tyrosine-phosphatase small monomeric GTPase	A0A5F4C2B1 A0A8I3MAK5 A0A8I3MKV4 A0A8I3ML64 A0A8I3MW46 A0A8I3N971 A0A8I3N974 A0A8I3N9M7 A0A8I3NA65 A0A8I3NAC6 A0A8I3NB92 A0A8I3NBK6 A0A8I3NBM3 A0A8I3NH46 A0A8I3NID0 A0A8I3NVH4 A0A8I3P3X1 A0A8I3P478 A0A8I3P519 A0A8I3P5U0 A0A8I3P6Q8 A0A8I3PMT9 A0A8I3PSA1 A0A8I3PSP7 A0A8I3PT69 A0A8I3PUN0 A0A8I3PUQ8 A0A8I3PZB5 A0A8I3Q1I3 A0A8I3RV66 A0A8I3RVE7 A0A8I3S3D9 A0A8I3S3N2 A0A8I3SBF9 O97799 P21842 P62999 Q06220	CHEK1 CMA1 FER FES FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 HRAS JAK2 KIT KITLG KRAS LCK LOC100856339 LYN MGF MMP9 NRAS PIK3CA PIK3R1 PIK3R2 PRKCA PTPN11 PTPRU RAC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 YES1	Canis familiaris (dog)
DAP12 interactions	Beta-2-microglobulin C-type lectin domain-containing protein C-type lectin domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein Immunoglobulin subtype domain-containing protein Natural killer cells antigen CD94 Sialic acid binding Ig like lectin 15 TYRO protein tyrosine kinase-binding protein Triggering receptor expressed on myeloid cells 1 Uncharacterized protein Uncharacterized protein	A0A8I3MDD5 A0A8I3MMC4 A0A8I3MNY2 A0A8I3MVN4 A0A8I3MYW9 A0A8I3NKZ7 A0A8I3NMD0 A0A8I3NVH5 A0A8I3PNS2 A0A8I3PWV8 A0A8I3PXH7 A0A8I3QBX8 A0A8I3S091 A0A8I3S0A6 A0A8I3S2M3 A0A8I3S2Y6 Q38HS3	B2M CD300E CD94 CLEC5A KLRD1 LOC119863908 LOC119866326 LOC119873404 LOC476396 LOC484343 SIGLEC15 SIRPA TREM1 TYROBP	Canis familiaris (dog)
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 B7-1 protein CD19 molecule CD86 molecule EGF-like domain-containing protein Epiregulin Estrogen receptor beta Estrogen receptor Fibroblast growth factor 23 Fibroblast growth factor 5 Fibroblast growth factor 7 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor 4 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fms related receptor tyrosine kinase 3 ligand GRB2 associated binding protein 1 GRB2 associated binding protein 2 Growth factor receptor bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Interleukin 1 receptor accessory protein Interleukin-1 receptor-associated kinase 4 Interleukin-33 Kit ligand Klotho beta Klotho Mast/stem cell growth factor receptor Kit Multifunctional fusion protein Myeloid differentiation primary response protein MyD88 Neuregulin 2 Neuregulin 3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase adaptor protein 1 Phosphoinositide-3-kinase regulatory subunit 2 Phosphoinositide-3-kinase regulatory subunit 3 Platelet-derived growth factor receptor alpha Platelet-derived growth factor receptor beta Platelet-derived growth factor subunit A Platelet-derived growth factor subunit B Pro-epidermal growth factor Pro-neuregulin-1, membrane-bound isoform Proheparin-binding EGF-like growth factor Proline rich 5 RPTOR independent companion of MTOR complex 2 Rac family small GTPase 2 Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Serine/threonine-protein kinase Sgk1 Serine/threonine-protein kinase mTOR Striatin T cell receptor associated transmembrane adaptor 1 T-cell-specific surface glycoprotein CD28 TNF receptor-associated factor 6 Target of rapamycin complex 2 subunit MAPKAP1 Target of rapamycin complex subunit LST8 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein Vav guanine nucleotide exchange factor 1 non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase	A0A0B4J199 A0A5F4C2B1 A0A7U3JWB8 A0A8I3MAV6 A0A8I3MIK8 A0A8I3MJG3 A0A8I3MN72 A0A8I3MP09 A0A8I3MPF4 A0A8I3MQX7 A0A8I3MRL6 A0A8I3MT80 A0A8I3MX71 A0A8I3MZ71 A0A8I3MZG1 A0A8I3N0H9 A0A8I3N488 A0A8I3N5M3 A0A8I3N8T5 A0A8I3N971 A0A8I3N9M7 A0A8I3NA65 A0A8I3NAC6 A0A8I3NAN8 A0A8I3NEF4 A0A8I3NFQ7 A0A8I3NGY1 A0A8I3NH46 A0A8I3NHA2 A0A8I3NHF3 A0A8I3NIT3 A0A8I3NKX5 A0A8I3NLT7 A0A8I3NNZ2 A0A8I3NS74 A0A8I3NSU7 A0A8I3NTD6 A0A8I3NV07 A0A8I3NVK5 A0A8I3NVV1 A0A8I3NVW9 A0A8I3NWK3 A0A8I3NXI8 A0A8I3NYK3 A0A8I3P2V4 A0A8I3P3M1 A0A8I3P3X1 A0A8I3P4L9 A0A8I3P519 A0A8I3P6D2 A0A8I3PJY6 A0A8I3PK39 A0A8I3PKX6 A0A8I3PMT9 A0A8I3PN81 A0A8I3PR42 A0A8I3PT69 A0A8I3PV99 A0A8I3PWT3 A0A8I3Q059 A0A8I3Q1C3 A0A8I3Q209 A0A8I3Q314 A0A8I3Q525 A0A8I3Q5L9 A0A8I3RPS3 A0A8I3RR99 A0A8I3RRT3 A0A8I3RSF1 A0A8I3RTN7 A0A8I3RYJ5 A0A8I3S0I1 A0A8I3S0T0 A0A8I3S333 A0A8I3S3N2 A0A8I3S8G3 A0A8I3SAY5 A0A8I3SBF9 E2REX2 J9P0B3 J9P3I7 J9P8K0 O97799 O97863 P62999 P79150 Q06220 Q20FD0 Q6Q7I7 Q7YR73 Q867B7 Q9TQX1	AILIM AREG BTC CD19 CD28 CD80 CD86 EGF EGFR EPGN ERBB2 ERBB3 ERBB4 EREG ESR1 ESR2 FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF20 FGF22 FGF23 FGF3 FGF3A FGF4 FGF4B FGF4C FGF5 FGF6 FGF7 FGF7A FGF7B FGF8 FGF8B FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FYN GAB1 GAB2 GRB2 HBEGF HGF ICOS IL1RAP IL33 IRAK1 IRAK4 IRS1 IRS2 KGF KIT KITLG KL KLB LCK LOC100856339 MAPKAP1 MET MGF MLST8 MTOR MYD88 NRG1 NRG2 NRG3 PDGFA PDGFB PDGFRA PDGFRB PDPK1 PIK3AP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PRR5 PTPN11 RAC1 RAC2 RHOG RICTOR SGK1 SRC STRN TGFA TRAF6 TRAT1 VAV1	Canis familiaris (dog)
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cathepsin B Cathepsin D Collagen type XII alpha 1 chain Collagen type XIII alpha 1 chain Collagen type XIX alpha 1 chain Collagen type XV alpha 1 chain Collagen type XVIII alpha 1 chain Collagen type XXV alpha 1 chain Collagen type XXVI alpha 1 chain Collagenase 3 Matrix metallopeptidase 12 Matrix metallopeptidase 15 Matrix metallopeptidase 20 Matrix metallopeptidase 7 Matrix metallopeptidase 8 Matrix metalloproteinase-14 Matrix metalloproteinase-9 Stromelysin-1 Transmembrane serine protease 6 furin interstitial collagenase trypsin	A0A8I3MCQ8 A0A8I3MGS0 A0A8I3MJI6 A0A8I3MND9 A0A8I3MSY3 A0A8I3MWG8 A0A8I3MWY2 A0A8I3MX21 A0A8I3MXC2 A0A8I3N1T9 A0A8I3N1V6 A0A8I3N4V8 A0A8I3NL35 A0A8I3P478 A0A8I3PD99 A0A8I3PHE2 A0A8I3QKG6 A0A8I3RPH1 A0A8I3RPK2 A0A8I3RU13 A0A8I3RVF8 A0A8I3S0M3 Q4LAL9 Q6Y4Q5	COL12A1 COL13A1 COL15A1 COL18A1 COL19A1 COL25A1 COL26A1 CTSB CTSD FURIN MMP1 MMP12 MMP13 MMP14 MMP15 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 PHYKPL PRSS2 TMPRSS6	Canis familiaris (dog)
Regulation of IGF Activity by IGFBP	Albumin Alpha 1 antitrypsin Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Alpha-2-HS-glycoprotein Alpha-L-fucosidase Alpha-fetoprotein Ameloblastin Amelogenin X isoform Amelotin Amyloid beta precursor like protein 2 Amyloid-beta A4 protein Anoctamin Antithrombin-III Apolipoprotein A-I Apolipoprotein A-II Apolipoprotein A-V Apolipoprotein B Apolipoprotein E Apolipoprotein L3 Apolipoprotein L3 BPI fold containing family B member 2 Bone morphogenetic protein 4 C4a anaphylatoxin CCN family member 1 Cadherin-2 Calumenin Chordin like 1 Coagulation factor V Complement C3 Cytoskeleton associated protein 4 Dentin matrix acidic phosphoprotein 1 Disintegrin and metalloproteinase domain-containing protein 10 DnaJ homolog subfamily C member 3 Enamelin Endoplasmin FAM20 C-terminal domain-containing protein FAM20A golgi associated secretory pathway pseudokinase Fibrillin 1 Fibrinogen alpha chain Fibroblast growth factor 23 Fibronectin Follistatin like 3 Follistatin-related protein 1 Galectin 1 Glypican-3 Golgi membrane protein 1 Growth arrest specific 6 Histidine rich calcium binding protein Insulin like growth factor binding protein 6 Insulin like growth factor binding protein 7 Insulin-like growth factor I Insulin-like growth factor II Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 5 Inter-alpha-trypsin inhibitor heavy chain 2 Interleukin-6 Kinectin 1 Kininogen 1 Latent transforming growth factor beta binding protein 1 MIA SH3 domain ER export factor 3 Macrophage colony-stimulating factor 1 Matrilin 3 Matrix extracellular phosphoglycoprotein Matrix remodeling-associated protein 8 Melanotransferrin Membrane bound transcription factor peptidase, site 1 Menin Metalloproteinase inhibitor 1 Milk fat globule EGF and factor V/VIII domain containing Multiple EGF like domains 6 Nucleobindin-1 Pappalysin 1 Pappalysin 2 Patatin like phospholipase domain containing 2 Proenkephalin-A Protein disulfide-isomerase A6 Protein disulfide-isomerase Protein kinase C substrate 80K-H Reticulocalbin 1 SPARC like 1 Secreted phosphoprotein 1 Secreted phosphoprotein 24 Secretogranin-1 Secretogranin-2 Secretogranin-3 Serine protease Serpin family D member 1 Stanniocalcin-2 Sulfhydryl oxidase Tenascin C Trans-golgi network protein 2 Transmembrane protein 132A Uncharacterized protein Uncharacterized protein Uncharacterized protein VGF nerve growth factor inducible Versican core protein Vitamin K-dependent protein C [Wnt protein] O-palmitoleoyl-L-serine hydrolase ferroxidase von Willebrand factor A domain-containing protein 1	A0A0B4J199 A0A8I3MBU3 A0A8I3MBV3 A0A8I3MD84 A0A8I3MKS3 A0A8I3MKU0 A0A8I3MLH1 A0A8I3MRY5 A0A8I3MSG4 A0A8I3MSR8 A0A8I3MVA9 A0A8I3MY68 A0A8I3MZB7 A0A8I3N0D8 A0A8I3N1E6 A0A8I3N365 A0A8I3N3Q6 A0A8I3N5X9 A0A8I3N8F9 A0A8I3N8K1 A0A8I3N8X3 A0A8I3N9A4 A0A8I3NA54 A0A8I3NAE2 A0A8I3NAG2 A0A8I3NBG6 A0A8I3NBI4 A0A8I3NBI7 A0A8I3NFV4 A0A8I3NH95 A0A8I3NHN1 A0A8I3NHZ1 A0A8I3NI15 A0A8I3NIA5 A0A8I3NLM1 A0A8I3NLT2 A0A8I3NN59 A0A8I3NPQ9 A0A8I3NQA0 A0A8I3NR35 A0A8I3NSE7 A0A8I3NTU0 A0A8I3NXQ1 A0A8I3NY94 A0A8I3P0M4 A0A8I3P1E4 A0A8I3P1V2 A0A8I3P1W2 A0A8I3P261 A0A8I3P2Y2 A0A8I3P735 A0A8I3P7V0 A0A8I3P874 A0A8I3P9H6 A0A8I3PA47 A0A8I3PB34 A0A8I3PED8 A0A8I3PEI1 A0A8I3PI20 A0A8I3PIK8 A0A8I3PM36 A0A8I3PMB5 A0A8I3PMF7 A0A8I3PPY1 A0A8I3PSD1 A0A8I3PTJ6 A0A8I3PTU8 A0A8I3PU47 A0A8I3PWU3 A0A8I3PX33 A0A8I3Q0F7 A0A8I3Q0M1 A0A8I3Q1K1 A0A8I3Q1Q3 A0A8I3Q2P4 A0A8I3Q2T3 A0A8I3Q4H4 A0A8I3Q662 A0A8I3QBE2 A0A8I3QN81 A0A8I3QNP3 A0A8I3RP80 A0A8I3RQL9 A0A8I3RRH5 A0A8I3RT41 A0A8I3RYZ7 A0A8I3S0I3 A0A8I3S0P1 A0A8I3S3D7 A0A8I3S4D1 A0A8I3S5B1 A0A8I3S6A4 A0A8I3S8V0 A0A8I3S915 A1ILJ0 A2SXS5 E2RAK7 F6PLF2 J9PBH8 P18649 P33712 P41148 Q28278	ADAM10 AFP AHSG ALB AMBN AMELX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APP BMP15 BMP4 BPIFB2 C3 CALU CCN1 CDH2 CHGB CHRDL1 CKAP4 COA5 CP CSF1 DMP1 DNAJC3 ENAM F5 FAM20A FAM20C FBN1 FGA FGF23 FGF8B FN1 FSTL1 FSTL3 FUCA2 GAS6 GOLM1 GPC3 GRP94 HRC HSP90B1 HSPC4 IGF1 IGF2 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGFIA IL6 ITIH2 KNG1 KTN1 LGALS1 LOC102156332 LOC481722 LOC607874 LTBP1 MATN3 MBTPS1 MEGF6 MELTF MEN1 MEPE MFGE8 MIA3 MXRA8 NOTUM NUCB1 P4HB PAPPA PAPPA2 PDIA6 PENK PNPLA2 PRKCSH PROC PRSS23 QSOX1 RCN1 SCG2 SCG3 SERPINA1 SERPINC1 SERPIND1 SPARCL1 SPP1 SPP2 STC2 TGOLN2 TIMP1 TMEM132A TNC TRA1 VCAN VGF VWA1 WFS1	Canis familiaris (dog)
Gastrin-CREB signalling pathway via PKC and MAPK	Gastrin/cholecystokinin type B receptor Gastrin Mitogen-activated protein kinase Mitogen-activated protein kinase Mitogen-activated protein kinase Ribosomal protein S6 kinase Ribosomal protein S6 kinase cAMP responsive element binding protein 1 non-specific serine/threonine protein kinase	A0A8I3MV42 A0A8I3NAU2 A0A8I3P721 A0A8I3PZN8 A0A8I3PZP0 A0A8I3RQD0 A0A8I3S2U7 P01353 P30552	CCKBR CREB1 GAS GAST MAPK1 MAPK3 MAPK7 RPS6KA1 RPS6KA2 RPS6KA3	Canis familiaris (dog)
Signaling by BMP	Bone morphogenetic protein 10 Bone morphogenetic protein 2 Cerberus 1, DAN family BMP antagonist Chordin like 1 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Follistatin-related protein 1 Gremlin Growth differentiation factor 2 Inhibin alpha chain Inhibin beta A chain Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Noggin Serine/threonine-protein kinase receptor Serine/threonine-protein kinase receptor Ski oncogene Transforming growth factor beta receptor 3 Ubiquitin conjugating enzyme E2 D3 Zinc finger FYVE domain-containing protein receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase receptor protein serine/threonine kinase	A0A7I8AUV5 A0A8I3MLM6 A0A8I3MRS8 A0A8I3MVJ8 A0A8I3N281 A0A8I3N723 A0A8I3N8R4 A0A8I3NCV3 A0A8I3NHH0 A0A8I3NM89 A0A8I3NU17 A0A8I3NW84 A0A8I3NYK2 A0A8I3NZI6 A0A8I3P2D1 A0A8I3P2Y0 A0A8I3P330 A0A8I3P4Q9 A0A8I3PB34 A0A8I3PG53 A0A8I3PG60 A0A8I3PPQ3 A0A8I3PZR5 A0A8I3Q270 A0A8I3QCM6 A0A8I3RR80 A0A8I3S5B1 A0A8I3S5W5 A0A8I3SCQ0	ACVR2A ACVR2B ACVRL1 BMP10 BMP2 BMPR1A BMPR1B BMPR2 CER1 CHRDL1 FSTL1 GDF2 GREM2 INHA INHBA NOG SKI SMAD1 SMAD4 SMAD5 SMAD6 SMAD7 SMAD9 SMURF1 SMURF2 TGFBR3 UBE2D1 UBE2D3 ZFYVE16	Canis familiaris (dog)
Iron uptake and transport	Broad substrate specificity ATP-binding cassette transporter ABCG2 Cullin 1 Cullin-associated NEDD8-dissociated protein 1 Cytoplasmic aconitate hydratase F-box/LRR-repeat protein 5 FLVCR heme transporter 1 Ferritin heavy chain Ferritin light chain Ferritin Ferritin Ferritin Heme oxygenase 1 Hephaestin Iron-responsive element-binding protein 2 Lipocalin 2 NEDD8 Plasma membrane ascorbate-dependent reductase CYBRD1 Proton-coupled folate transporter S-phase kinase-associated protein 1 Solute carrier family 11 member 2 Solute carrier family 22 member 17 Solute carrier family 40 protein member 1 Ubiquitin B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein ferroxidase heme oxygenase (biliverdin-producing)	A0A8I3ME81 A0A8I3MH42 A0A8I3MHS3 A0A8I3MKF8 A0A8I3MMN5 A0A8I3N1L5 A0A8I3N2C0 A0A8I3N2D2 A0A8I3N4B0 A0A8I3N8Y0 A0A8I3NAI4 A0A8I3NFB9 A0A8I3NP41 A0A8I3NPT2 A0A8I3NT24 A0A8I3NZI4 A0A8I3PMF7 A0A8I3Q213 A0A8I3Q9B0 A0A8I3QDX8 A0A8I3QYD0 A0A8I3RZ10 A0A8I3S0Z7 B3RFJ1 E2RFJ3 P63050 Q53VB8 Q95MP7	ABCG2 ACO1 Abcg2 CAND1 CP CUL1 CYBRD1 FBXL5 FLVCR1 FTH FTH1 FTL HEPH HMOX1 HMOX2 IREB2 LCN2 LOC119865338 LOC119878918 LOC608550 NEDD8 RPS27A SKP1 SLC11A2 SLC22A17 SLC40A1 SLC46A1 UBA52 UBB UBC UBCEP2	Canis familiaris (dog)
Phosphorylation of CD3 and TCR zeta chains	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase protein-tyrosine-phosphatase protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3NYA3 A0A8I3P4A1 A0A8I3P4Z0 A0A8I3P564 A0A8I3P598 A0A8I3PAB8 A0A8I3PC26 A0A8I3PV90 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 CSK DLA-DQA1 DLA-DRA HLA-DQB2 LCK PAG1 PTPN22 PTPRC PTPRJ TRAV29DV5	Canis familiaris (dog)
Cilium Assembly	Alpha-tubulin N-acetyltransferase 1 Histone deacetylase 6	A0A8I3MV46 A0A8I3Q5U6	ATAT1 HDAC6 MEC17	Canis familiaris (dog)
TNFR1-induced proapoptotic signaling	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 E3 ubiquitin-protein ligase XIAP Inhibitor of nuclear factor kappa B kinase subunit epsilon RBR-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Spermatogenesis associated 2 TANK binding kinase 1 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase CYLD	A0A8I3MDM0 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3NEJ2 A0A8I3NK16 A0A8I3NS04 A0A8I3P2P4 A0A8I3PS24 A0A8I3Q155 A0A8I3Q3L1 A0A8I3S2L7 A1E2V0 P51742 Q38IV1	BIRC2 BIRC3 BIRC4 CYLD IKBKE IRF9 MIB2 RBCK1 RIPK1 SPATA2 TBK1 TNF TNFA TNFRSF1A TNFSF2 TRADD TRAF2 XIAP	Canis familiaris (dog)
MET interacts with TNS proteins	Hepatocyte growth factor receptor Hepatocyte growth factor Integrin beta Tensin 3 Tensin 4	A0A8I3MMP8 A0A8I3N5C8 A0A8I3NGY1 A0A8I3NIW4 Q867B7	HGF ITGB1 MET TNS3 TNS4	Canis familiaris (dog)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 CD40 ligand LIGHT Lymphotoxin beta receptor Lymphotoxin-alpha Lymphotoxin-beta Mitogen-activated protein kinase kinase kinase 14 TNF receptor superfamily member 11a TNF receptor superfamily member 12A TNF receptor superfamily member 13C TNF receptor-associated factor TNF receptor-associated factor TNF superfamily member 13b Tumor necrosis factor (ligand) superfamily, member 12 Tumor necrosis factor ligand superfamily member Tumor necrosis factor receptor superfamily member 5	A0A8I3MDM0 A0A8I3MES0 A0A8I3MQC7 A0A8I3MWN3 A0A8I3NGJ3 A0A8I3NLQ1 A0A8I3NRP3 A0A8I3P6H0 A0A8I3PTD2 A0A8I3PZM4 A0A8I3RR83 A1E2V0 J9JHM5 J9P2Z1 J9P753 O97626 Q5WR07	BIRC2 BIRC3 CD40 CD40L CD40LG LTA LTB LTBR MAP3K14 TNFB TNFRSF11A TNFRSF12A TNFRSF13C TNFSF1 TNFSF11 TNFSF12 TNFSF13B TNFSF14 TNFSF5 TNLG1C TNLG1D TNLG7A TRAF2 TRAF3	Canis familiaris (dog)
EPHB-mediated forward signaling	Actin gamma 1 Actin, cytoplasmic 1 Actin-related protein 2/3 complex subunit 3 Actin-related protein 2/3 complex subunit 4 Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 Arp2/3 complex 34 kDa subunit Cell division control protein 42 homolog Focal adhesion kinase 1 GTPase HRas Glutamate receptor ionotropic, NMDA 1 Glutamate receptor ionotropic, NMDA 2B Intersectin 1 RAS p21 protein activator 1 Ras-related C3 botulinum toxin substrate 1 Ras-related C3 botulinum toxin substrate 1 Rho guanine nucleotide exchange factor 28 Rho-associated protein kinase 2 Rho-associated protein kinase TIAM Rac1 associated GEF 1 Transforming protein RhoA Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein WASP like actin nucleation promoting factor non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase	A0A8I3MEB5 A0A8I3ML64 A0A8I3MNR2 A0A8I3MPK0 A0A8I3MVD4 A0A8I3MXJ0 A0A8I3N156 A0A8I3N1W7 A0A8I3NE73 A0A8I3NEW9 A0A8I3NH46 A0A8I3NMF7 A0A8I3NMY1 A0A8I3P3X1 A0A8I3P9Q7 A0A8I3PDZ1 A0A8I3PGP9 A0A8I3PH24 A0A8I3PPA3 A0A8I3PPQ5 A0A8I3PUN0 A0A8I3PVV6 A0A8I3Q1I3 A0A8I3Q2I4 A0A8I3SAZ7 A0A8I3SBF9 F1PHV6 O18840 P60952 P62999 Q5R1P0 Q5R1P3	ACTB ACTG1 ACTR2 ACTR3 ARHGEF28 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 FYN GRIN1 GRIN2B HRAS KALRN LOC119867035 LYN NMDAR1 PAK1 PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SRC TIAM1 WASL YES1	Canis familiaris (dog)
TNFR1-induced NF-kappa-B signaling pathway	Baculoviral IAP repeat containing 2 Baculoviral IAP repeat-containing protein 3 E3 ubiquitin-protein ligase XIAP IkappaB kinase Inhibitor of nuclear factor kappa-B kinase subunit alpha Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator Optineurin RBR-type E3 ubiquitin transferase RanBP-type and C3HC4-type zinc finger-containing protein 1 Receptor interacting serine/threonine kinase 1 Small ribosomal subunit protein RACK1 Spermatogenesis associated 2 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TNF receptor-associated factor TNFR-Cys domain-containing protein Tumor necrosis factor receptor type 1-associated DEATH domain protein Tumor necrosis factor Ubiquitin carboxyl-terminal hydrolase CYLD Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Ubiquitin carboxyl-terminal hydrolase Uncharacterized protein ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1 ubiquitinyl hydrolase 1	A0A8I3MA34 A0A8I3MDM0 A0A8I3MQC7 A0A8I3MSL4 A0A8I3MYA4 A0A8I3N1V1 A0A8I3N4F2 A0A8I3N7L6 A0A8I3NEJ2 A0A8I3NMB6 A0A8I3NP69 A0A8I3P2P4 A0A8I3P499 A0A8I3P4Z1 A0A8I3PLL0 A0A8I3PS24 A0A8I3PWL6 A0A8I3Q3L1 A0A8I3RSQ2 A0A8I3RUY7 A0A8I3RZA9 A0A8I3S2L7 A0A8I3S792 A0A8I3S794 A1E2V0 P51742 Q38IV1	BIRC2 BIRC3 BIRC4 CHUK CYLD IKBKB IKBKG IRF9 MAP3K7 OPTN OTUD1 OTUD7B RACK1 RBCK1 RIPK1 SPATA2 TAB1 TAB2 TAB3 TNF TNFA TNFAIP3 TNFRSF1A TNFSF2 TRADD TRAF2 USP2 USP21 USP4 XIAP	Canis familiaris (dog)
Translocation of ZAP-70 to Immunological synapse	Ig-like domain-containing protein Immunoglobulin V-set domain-containing protein MHC class II DR alpha chain Major histocompatibility complex, class II, DQ alpha 1 Major histocompatibility complex, class II, DQ beta 2 T cell receptor alpha variable 29/delta variable 5 T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD4 Tyrosine-protein kinase Tyrosine-protein kinase Uncharacterized protein Uncharacterized protein Uncharacterized protein Uncharacterized protein protein-tyrosine-phosphatase	A0A8I3MED5 A0A8I3MFY1 A0A8I3MJ11 A0A8I3MKK6 A0A8I3MV98 A0A8I3MZ69 A0A8I3NAC6 A0A8I3NTK0 A0A8I3P4A1 A0A8I3P564 A0A8I3P8U2 A0A8I3PAB8 A0A8I3PC26 A0A8I3S023 A0A8I3S2N1 A0A8I3S3J5 P27597 P33705	CD247 CD3D CD3E CD3G CD4 DLA-DQA1 DLA-DRA HLA-DQB2 LCK PTPN22 TRAV29DV5 ZAP70	Canis familiaris (dog)

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