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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
rheumatic heart disease
Summary
- Synonym
-
- rheumatic carditis
- Definition
- A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.
- Super Class
- heart valve disease
External Links
- Disease Ontology
- DOID:0050827
- Mondo Disease Ontology
- MeSH
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 3624 | INHBA | inhibin subunit beta A | |
| 4318 | MMP9 | matrix metallopeptidase 9 | |
| 6615 | SNAI1 | snail family transcriptional repressor 1 | |
| 6935 | ZEB1 | zinc finger E-box binding homeobox 1 | |
| 7291 | TWIST1 | twist family bHLH transcription factor 1 | |
| 30835 | CD209 | CD209 molecule | |
| 51176 | LEF1 | lymphoid enhancer binding factor 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11475 | Acta2 | actin alpha 2, smooth muscle, aorta | |
| 12028 | Bax | BCL2-associated X protein | |
| 12491 | Cd36 | CD36 molecule | |
| 12825 | Col3a1 | collagen, type III, alpha 1 | |
| 12842 | Col1a1 | collagen, type I, alpha 1 | |
| 14433 | Gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 14960 | H2-Aa | histocompatibility 2, class II antigen A, alpha | |
| 14961 | H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | |
| 14969 | H2-Eb1 | histocompatibility 2, class II antigen E beta | |
| 16323 | Inhba | inhibin beta-A |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 174578 | gpd-4 | Glyceraldehyde-3-phosphate dehydrogenase 4 | |
| 174603 | gpd-1 | Glyceraldehyde-3-phosphate dehydrogenase 1 | |
| 176673 | scav-3 | Sensory neuron membrane protein 2 | |
| 176787 | scav-2 | SCAVenger receptor (CD36 family) related | |
| 179991 | zmp-4 | Hemopexin;Peptidase metallopeptidase domain-containing protein | |
| 180351 | W01F3.2 | Uncharacterized protein | |
| 180601 | gpd-3 | Glyceraldehyde-3-phosphate dehydrogenase 3 |
