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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alzheimer's disease
Summary
- Synonym
-
- Alzheimer disease
- Alzheimers dementia
- Definition
- A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
- Super Class
- tauopathy
External Links
- Disease Ontology
- DOID:10652
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- GARD
- MGI genotype (from TogoID)
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- 2174818
- 2174917
- 2174969
- 2174990
- 2174994
- 2174998
- 2177097
- 2177120
- 2652360
- 2652361
- 2652362
- 2652363
- 2652447
- 2652553
- 2662716
- 2684657
- 3029285
- 3044184
- 3045183
- 3045186
- 3510652
- 3577843
- 3582996
- 3589555
- 3611210
- 3611211
- 3618601
- 3624416
- 3639711
- 3639713
- 3653709
- 3663447
- 3663620
- 3663621
- 3663749
- 3663751
- 3665286
- 3665287
- 3693295
- 3693439
- 3693440
- 3693491
- 3696575
- 3696576
- 3697817
- 3702925
- 3709152
- 3709154
- 3709182
- 3710761
- 3710763
- 3710766
- 3717255
- 3717577
- 3718076
- 3718515
- 3720208
- 3720209
- 3720676
- 3720677
- 3720700
- 3720701
- 3720702
- 3720731
- 3720782
- 3720946
- 3721530
- 3721531
- 3721541
- 3721542
- 3721938
- 3722063
- 3722101
- 3722102
- 3722143
- 3722160
- 3722393
- 3769910
- 3771317
- 3784684
- 3829507
- 4355229
- 4355230
- 4366531
- 4367205
- 4367786
- 4412051
- 4417912
- 4438223
- 4818990
- 4819951
- 4843219
- 4847595
- 4882081
- 4943741
- 5003275
- 5003459
- 5003460
- 5003461
- 5003462
- 5003463
- 5003464
- 5003501
- 5008417
- 5008418
- 5014041
- 5050413
- 5051941
- 5051942
- 5052112
- 5052119
- 5052120
- 5140748
- 5294357
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- 5301407
- 5305067
- 5313530
- 5427915
- 5428425
- 5433612
- 5433613
- 5435319
- 5442379
- 5462366
- 5463430
- 5463438
- 5465558
- 5471581
- 5491627
- 5511058
- 5512698
- 5512699
- 5521287
- 5550547
- 5550582
- 5553465
- 5554193
- 5559229
- 5559449
- 5569760
- 5578629
- 5581429
- 5581681
- 5604616
- 5629689
- 5634332
- 5638672
- 5638675
- 5646171
- 5646215
- 5699096
- 5701399
- 5708587
- 5754382
- 5754385
- 5755045
- 5790841
- 5792143
- 5803810
- 5811870
- 5812135
- 5829782
- 6257021
- 6257025
- 6314698
- 6324682
- 6392258
- 7608058
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 3293 | HSD17B3 | hydroxysteroid 17-beta dehydrogenase 3 | |
| 3297 | HSF1 | heat shock transcription factor 1 | |
| 3303 | HSPA1A | heat shock protein family A (Hsp70) member 1A | |
| 3304 | HSPA1B | heat shock protein family A (Hsp70) member 1B | |
| 3313 | HSPA9 | heat shock protein family A (Hsp70) member 9 | |
| 3315 | HSPB1 | heat shock protein family B (small) member 1 | |
| 3320 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 | |
| 3329 | HSPD1 | heat shock protein family D (Hsp60) member 1 | |
| 3350 | HTR1A | 5-hydroxytryptamine receptor 1A | |
| 3356 | HTR2A | 5-hydroxytryptamine receptor 2A |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 18205 | Ntf3 | neurotrophin 3 | |
| 18211 | Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 | |
| 18212 | Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | |
| 18479 | Pak1 | p21 (RAC1) activated kinase 1 | |
| 18534 | Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | |
| 18591 | Pdgfb | platelet derived growth factor, B polypeptide | |
| 18708 | Pik3r1 | phosphoinositide-3-kinase regulatory subunit 1 | |
| 18751 | Prkcb | protein kinase C, beta | |
| 18799 | Plcd1 | phospholipase C, delta 1 | |
| 18979 | Pon1 | paraoxonase 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24153 | A2m | alpha-2-macroglobulin | |
| 24179 | Agt | angiotensinogen | |
| 24180 | Agtr1a | angiotensin II receptor, type 1a | |
| 24225 | Bdnf | brain-derived neurotrophic factor | |
| 24232 | C3 | complement C3 | |
| 24253 | Cebpb | CCAAT/enhancer binding protein beta | |
| 24255 | Cftr | CF transmembrane conductance regulator | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24318 | Drd2 | dopamine receptor D2 | |
| 24333 | Eno1 | enolase 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31002 | Appl | beta amyloid protein precursor-like | |
| 31248 | sgg | shaggy | |
| 31293 | N | Notch | |
| 31364 | Fas2 | Fasciclin 2 | |
| 31547 | Nep1 | Neprilysin 1 | |
| 31792 | Nrg | Neuroglian | |
| 32342 | amrt | amaretto | |
| 32545 | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 | |
| 33005 | Nep3 | Neprilysin 3 | |
| 33007 | Dop2R | Dopamine 2-like receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30262 | ins | preproinsulin | |
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 30705 | fgfr1a | fibroblast growth factor receptor 1a | |
| 30718 | notch1a | notch receptor 1a | |
| 58133 | ngfb | nerve growth factor b (beta polypeptide) | |
| 114549 | ache | acetylcholinesterase (Yt blood group) | |
| 317743 | gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 394082 | slc18a3b | solute carrier family 18 member 3b | |
| 406367 | gapdhs | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | |
| 436913 | tm2d2 | TM2 domain containing 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 100216145 | bace2 | beta-secretase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 108699855 | grin1.S | glutamate ionotropic receptor NMDA type subunit 1 S homeolog | Xenopus laevis (African clawed frog) | |
| 108705891 | drd5.S | dopamine receptor D5 S homeolog | Xenopus laevis (African clawed frog) | |
| 108710578 | drd1.L | dopamine receptor D1 L homeolog | Xenopus laevis (African clawed frog) | |
| 108718712 | plcd1.L | phospholipase C delta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 108719811 | plcd1.S | phospholipase C delta 1 S homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171782 | abt-2 | ABC transporter domain-containing protein | |
| 171905 | ace-2 | Carboxylic ester hydrolase | |
| 171999 | poml-2 | Arylesterase | |
| 172105 | unc-38 | Acetylcholine receptor subunit alpha-type unc-38 | |
| 172150 | unc-63 | Acetylcholine receptor subunit alpha-type unc-63 | |
| 172689 | sup-17 | Disintegrin and metalloproteinase domain-containing protein 10 homolog | |
| 172703 | unc-29 | Acetylcholine receptor subunit beta-type unc-29 | |
| 172905 | aph-2 | Nicastrin | |
| 173685 | nep-11 | Neprilysin-11 | |
| 173794 | vab-1 | Ephrin receptor 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850812 | YPS3 | aspartyl protease | |
| 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | |
| 851950 | YPS7 | putative aspartic endopeptidase | |
| 852264 | PEP1 | type I sorting receptor | |
| 852543 | VVS1 | Vvs1p | |
| 852702 | XRN1 | chromatin-binding exonuclease XRN1 | |
| 852806 | HSF1 | stress-responsive transcription factor HSF1 | |
| 853106 | TDH3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 | |
| 853169 | ENO1 | phosphopyruvate hydratase ENO1 | |
| 853233 | VTH2 | signal sequence-binding protein |
